Abstract: In order to obtain high quality collagen peptide with low cost, collagen was extracted by two different methods that were microwave assisting with water extraction and without microwave water extraction, and fish scale collagen low poly peptide was obtained by enzymolysis. The rates and qualities of collagen peptide obtained by the two methods were analyzed respectively. The results showed that the rate and quality attained utilizing 10 kW microwave assisting with 15 s was higher than water extraction method. The highest yield of the collagen peptide up to 57.8%, the proportion of the collagen peptide which molecular weight were less than1000 u collagen accounted for 87.84%, and the sensory value was 9. However, the clarity had no significant differents between the treats methods.