Abstract: K- B disk diffusion method was used to test antibiotic sensitive of eight pathogenic Vibrio parahaemolyticus strains to ten antibiotics, which showed six of them were antibiotic resistant strains, with one strain was resistant to 3 kinds of antibiotics, one was resistant to 2 kinds of antibiotics and the rest four strains were resistant to 1 antibiotic.The growth characteristic of these eight strains in TSB ( 3% NaCl, pH8.0) under 20, 25 and37℃ were compared.Bioscreen was applied to establish the primary growth models and then compared their most special growth rate ( μmax) , the lag phage ( λ) and the maximum growth quantity ( a) .Besides, ERIC-PCR was used to compare the differences of the patterns of these strains.The results suggested that there were some differences among different resistant strains about their growth parameters, but there was no necessary connection between the growth parameters and the antibiotic resistant.Furthermore, no necessary connection was found between ERIC-PCR pattern and antibiotic resistant.This study provided references for the risk assessment of antibiotic resistant pathogenic Vibrio parahaemolyticus.