Abstract: The family of Myogenic regulatory factors (MRFs) , encodes four kinds of muscle specific transcription factors, including MyoD, MyoG, Myf5 and Myf6. MRFs members play important roles in the regulation of the generation of skeletal muscle, which control the myogenesis together. It has been reported that MRFs members have great correlation with muscle growth and meat quality. Character and action mechanism of MRFs gene family as well as their member's effect on meat quality were reviewed. And the potential applications of MRFs gene family were discussed in this paper.