Abstract: Patulin ( PAT) is a secondary metabolite of fungi which has carcinogenic, teratogenic, cytotoxic, immunosuppressive and embryotoxic effects, which is usually found in moldy fruits and their products, especial in the apple and its products. China is the largest producer of apple products in the world. It must be pay more attention on contamination and elimination of patulin. In this review, it was introduced that the latest research on reduction and elimination of PAT with physical, chemical and biological methods in the world. In addition, advantages and disadvantages of various technologies were discussed, which provided a reference to reduce PAT of apple products in industrial production.