毛豆对2型糖尿病小鼠血糖及血脂影响

Effects of edamame on blood glucose and blood lipid in type 2 diabetic mellitus mice

摘要: 目的:研究毛豆对链脲菌素致ICR糖尿病小鼠血糖、血脂的影响。方法:高脂饲料联合腹腔注射链脲菌素得到2型糖尿病模型小鼠,以二甲双胍作为阳性对照组,给药组分别为毛豆高剂量组4.35g/kg,毛豆低剂量组2.20g/kg进行28d灌胃实验。结果:给药28d后,毛豆低剂量组血糖降低作用明显,小鼠空腹血糖比实验前降低29.78%,曲线下面积(AUC)下降了12.52%;与模型对照组相比,TC、TG值都有显著降低(p<0.05)。结论:毛豆对2型糖尿病小鼠具有良好的降血糖、降血脂作用。

Abstract: Objective:To study the effect of edamame on blood glucose and blood lipids in (streptozotocin (STZ) -induced ICR diabetic mice. Methods:Models of type 2 diabetes mellitus (T2DM) mice) were induced by high fat chow and intraperitoneal injection of streptozotocin (STZ) , and were divided into different groups, which were given High dose of 4.35g/kg Edamame, low dose of 2.20g/kg Edamame and metformin respectively. Results: After 28d drug administration, symptoms of diabetic mice fed a dose of 2.20g/kg edamame were alleviated obviously. the level of blood glucose in this group decreased by 29.78% and the area under the curve (AUC) decreased by 12.52%. Compared with the model group, the levels of TC and TG in this group were lowered remarkably (p <0.05) . Conclusion:Edamame might be related to improving hypoglycemic and hypolipidemic effect in type 2 diabetic mellitus mice.