鱼卵肽钙复合物对大鼠体内促钙吸收作用的研究

Study of the effect of fish egg peptides binding with calcium on increasing calcium bioavailability in rats

摘要: 通过构造缺钙大鼠模型,研究鱼卵肽钙复合物（EPP-Ca）对缺钙大鼠的补钙效果。结果表明,经过4周的补钙,EPP-Ca使缺钙大鼠增重25.53%,钙吸收率达65.28%,血清钙和血清碱性磷酸酶分别恢复到2.58mmol/L和177.13U/L,股骨重量、骨密度和骨钙含量分别达到877.31mg、0.22g/cm2和254.75mg/g,补钙效果显著优于无机钙,与酪蛋白磷酸肽钙复合物（CPP-Ca）效果相当。EPP-Ca有望成为新型的补钙制剂。

Abstract: The promoting effect of fish egg peptides binding with calcium ( EPP- Ca) on increasing calcium bioavailability in rats was studied in this paper. After EPP- Ca supplement for 4 weeks, the rats' body weight increased 25.53%, calcium absorption rate reached 65.28%, serum calcium and the activity of serum alkaline phosphatase came back to 2.58mmol /L and 177.13U /L respectively, femur weight, calcium content and bone mineral density respectively arrived to 877.31mg、0.22g /cm2and 254.75mg /g. Furthermore, EPP- Ca was more efficient than inorganic calcium on increasing calcium bioavailability in rats and had similar effect with casein phospeptides binding with calcium ( CPP- Ca) . Thus, it is possible to provide utilization of EPP- Ca as a novel calcium nutraceutical additive in food industry.