Abstract: To explore and optimize the extraction procedure for Pueraria-Yuqi capsule ingredients.Orthogonal experimental design method was used, and factors of the extraction procedure for Pueraria-Yuqi capsule ingredients were optimized to achieve the highest yield of puerarin and crude polysaccharide.The optimized procedure was:Pueraria, Morus alba, fenugreek and salvia were reflux-extracted with tenfold volume of 60% ethanol for 3 times, 2h, respectively.Wolfberry, Astragalus and Polygonatum were reflux-extracted with tenfold volume of water for 3 times, 1.5h each.The optimized procedure was then verified again after amplification, the average puerarin and crude polysaccharide yield was 13.89mg/g and 4.23mg/g respectively during verification, these results were stable and had reference value.