Abstract: High temperature soybean meal was treated in two ways which was stirring extraction and ultrasonic.This study got the optimal processing conditions of defatted soybean milk produced by high temperature soybean meal by the single factor and orthogonal test.The optimal processing conditions of stirring extraction were as follows:extraction temperature 60℃, extraction time 60min, material to water ratio 1:18, protein leaching rate 80.9%.The optimal processing conditions of ultrasonication were as follows:ultrasonic temperature 50℃, ultrasonic time 30min, material to water ratio 1:16, protein leaching rate 81.8%.In order to save energy, ultrasonic had been chosen as the best way to produce skim milk by high-temperature soybean meal.