乌贼墨多糖缓解环磷酰胺致大鼠骨髓功能抑制作用的研究

Study on squid ink polysaccharides weakens the suppression of bone marrow induced by cyclophosphamide in rats

摘要: 探讨乌贼墨多糖(SIPS)对环磷酰胺所致骨髓功能抑制的缓解效应。以SD大鼠为模型,灌服SIPS和腹腔注射环磷酰胺共处理,检测大鼠外周血像和骨髓DNA含量。环磷酰胺不仅显著降低了大鼠外周血红细胞、白细胞和血小板的数量以及血红蛋白的含量,骨髓细胞DNA含量也被显著下调(p<0.01orp<0.05)。SIPS十分明显的弱化了该化疗药物的骨髓抑制功能,环磷酰胺对以上指标参数所导致的负效应均被该海洋活性物质不同程度的消减(p<0.05orp<0.01)。SIPS可缓解环磷酰胺所致大鼠骨髓造血功能抑制作用。

Abstract: In order to explore the amelioratory effects of squid ink polysaccharides (SIPS) towards cyclophosphamide-induced suppression of bone marrow functions.Sprague-Dawley rats were employed to be co-treated with intraperitoneal cyclophosphamide and oral SIPS.Peripheral blood profile and DNA content in bone marrow were detected.Cyclophosphamide decreased significantly the quantities of erythrocytes, leukocytes and platelets in blood, contents of hemoglobin in blood and DNA in bone marrow (p<0.01 or p<0.05) .SIPS incoordinately impaired the negative changes induced by cyclophosphamide (p<0.05 or p<0.01) .It was implied that SIPS could protect bone marrow from chemotherapeutical damage caused by cyclophosphamide.