Abstract: To investigate the effect of chlorogenic acid extracted from Eucommia Ulmoides Oliv on lipid metabolism of hyperlipemia mice, fifty Kunming mice were randomly divided into 5 groups:negative control group, model control group, low dose (25mg/kg BW) , medium dose (50mg/kg BW) , and high dose (100mg/kg BW) groups of chlorogenic acid.The latter 4 groups were fed with high fat feed.Chlorogenic acid was given by gavage.Serum and liver lipid metabolic indices and their antioxidant enzymes activities and peroxidation product were measured.When chlorogenic acid was fed, the contents of serum TC, TG, LDL-C levels and liver TC, TG were significantly lower.Furthermore, MDA contents in serum and liver were decreased, and activities of antioxidant enzymes were increased.AI and R-CHR were also lower than that of the model group.These results indicated that chlorogenic acid from Eucommia Ulmoides Oliv could effectively reduce the blood and liver lipid accumulation and regulate lipid metabolism by improving their antioxidant activities.Among them the group at the dose of 50mg/kg BW showed best effect.