Effect of Electron Beam Irradiation on Main Components and Fingerprint of <i>Panax notoginseng</i> Powder

FU Meng; WANG Dan; WANG Gang; TANG Yiwen; LIN Yongjie; GAO Peng; HUANG Min

doi:10.13386/j.issn1002-0306.2022100243

Volume 44 Issue 16

Aug. 2023

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Science and Technology of Food Industry > 2023 > 44(16): 99-106. > DOI: 10.13386/j.issn1002-0306.2022100243

FU Meng, WANG Dan, WANG Gang, et al. Effect of Electron Beam Irradiation on Main Components and Fingerprint of Panax notoginseng Powder[J]. Science and Technology of Food Industry, 2023, 44(16): 99−106. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022100243.

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Effect of Electron Beam Irradiation on Main Components and Fingerprint of Panax notoginseng Powder

FU Meng^1,,
WANG Dan^1, ,,
WANG Gang¹,
TANG Yiwen¹,
LIN Yongjie¹,
GAO Peng^{2, 3},
HUANG Min^{2, 3}

1.
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China
2.
Sichuan Institute of Atomic Energy, Chengdu 610101, China
3.
Irradiation Preservation Key Laboratory of Sichuan Province, Chengdu 610101, China

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Received Date: October 23, 2022
Available Online: June 10, 2023

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Abstract

Abstract

In order to explore the effect of electron beam irradiation sterilization on the quality of Panax notoginseng powder, the effects of different irradiation doses (0, 2, 4, 6, 8, 13 kGy) on the number of microorganisms, moisture content, total ash, alcohol-soluble extracts, active ingredients, the antioxidant capacity and fingerprint of Panax notoginseng powder were investigated. The results showed that electron beam irradiation could effectively kill microorganisms in Panax notoginseng powder, the D₁₀ value of total aerobic microbial count was 2.04 kGy, and the number of microorganisms fell below the detection standard limit when the irradiation dose was 4 kGy. The antioxidant capacity was significantly improved (P<0.05). The moisture content, total ash, alcohol-soluble extracts, color, notoginsenoside R₁, ginsenoside Rb₁, ginsenoside Rg₁ and fingerprint had no significant change. Therefore, electron beam irradiation was an effective sterilization method for Panax notoginseng powder. The dose of electron beam irradiation within 13 kGy did not significantly affect the quality of Panax notoginseng powder, and could improved its antioxidant activity. This study would provide a theoretical reference for the quality control of Panax notoginseng powder and other processed products based on the electron beam irradiation technology.
- Panax notoginseng powder,
- electron beam irradiation,
- microorganism,
- active ingredients,
- fingerprint

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References (46)

References

[1]	国家药典委员会. 中华人民共和国药典: 一部[S]. 北京: 中国医药科技出版社, 2020. Pharmacopoeia committee pharmacopoeia of the People's Republic of China: Volume I [S]. Beijing: China Medical Science and Technology Press, 2020: 12.
[2]	CHEN J, ZHANG X, LIU X, et al. Ginsenoside Rg₁ promotes cerebral angiogenesis via the PI3K/Akt/mTOR signaling pathway in ischemic mice[J]. European Journal of Pharmacology,2019,856:172418. doi: 10.1016/j.ejphar.2019.172418
[3]	姚娟, 林佳, 吴平安, 等. 基于抗氧化研究三七提取物对6-OHDA损伤PC12细胞的保护作用[J]. 中药药理与临床,2022,38(2):115−119. [YAO J, LIN J, WU P A, et al. Protective effect of Sanqi extract on 6-OHDA-injured PC12 cells based on antioxidation study[J]. Pharmacology and Clinics of Chinese Materia Medica,2022,38(2):115−119. YAO J, LIN J, WU P A, et al. Protective effect of Sanqi extract on 6-OHDA-injured PC12 cells based on antioxidation study[J]. Pharmacology and Clinics of Chinese Materia Medica, 2022, 38(2): 115-119.
[4]	DING S, WANG M, FANG S, et al. D-dencichine regulates thrombopoiesis by promoting megakaryocyte adhesion, migration and proplatelet formation[J]. Front Pharmacol,2018,9:297. doi: 10.3389/fphar.2018.00297
[5]	高利超, 徐兵, 刘永安, 等. 三七皂苷R₁抑制TGF-β1/Smad3信号传导对糖尿病肾病大鼠肾脏纤维化和炎症细胞因子的调节作用研究[J]. 中国免疫学杂志,2020,36(10):1188−1193. [GAO L C, XU B, LIU Y A, et al. Regulatory effect of notoginsenoside R₁ on renal fibrosis and inflammatory cytokines in diabetic nephropathy rats via inhibiting of TGF-β12/Smad3 signal transduction[J]. Cellular & Molecular Immunology,2020,36(10):1188−1193. GAO L C, XU B, LIU Y A, et al. Regulatory effect of Notoginsenoside R₁ on renal fibrosis and inflammatory cytokines in diabetic nephropathy rats via inhibiting of TGF-β12/Smad3 signal transduction[J]. Cellular & Molecular Immunology, 2020, 36(10): 1188-1193.
[6]	ZHOU Y J, CHEN J M, SAPKOTA K, et al. Pananx notoginseng saponins attenuate CCL2-induced cognitive deficits in rats via anti-inflammation and anti-apoptosis effects that involve suppressing over-activation of NMDA receptors[J]. Biomed Pharmacother,2020,127:110139. doi: 10.1016/j.biopha.2020.110139
[7]	KIM B K, EUN-YEONG L, EUN-JI H, et al. Panax notoginsenginhibits tumor growth through activating macrophage to M1 polarization[J]. The American Journal of Chinese Medicine,2018,46(6):1369−1385. doi: 10.1142/S0192415X18500726
[8]	赵文娟. 三七总皂苷调节哮喘小鼠气道炎症及Th亚群相关细胞因子的实验研究[D]. 昆明: 云南大学, 2012. ZHAO W J. Study on Panax notoginseng saponins adjust asthma mice airway inflammation and Thlymphocyte`s cytokines[D]. Kunming: Yunnan University, 2012.
[9]	朱安妮, 田芷睿, 唐俊妮, 等. 三七保健酸乳的制备和工艺优化[J]. 食品工业,2016,37(3):177−182. [ZHU A N, TIAN Z R, TANG J N, et al. Preparation and optimization of fermented yoghurt with Panax notoginseng (Burk. ) F. H. Chen[J]. The Food Industry,2016,37(3):177−182. ZHU A N, TIAN Z R, TANG J N, et al. Preparation and Optimization of Fermented Yoghurt with Panax notoginseng (Burk. ) F. H. Chen[J]. The Food Industry, 2016, 37(3): 177-182.
[10]	白雯静, 李志俊, 周斌, 等. 三七药材中微生物污染的研究[J]. 食品安全质量检测学报,2021,12(8):3405−3409. [BAI W J, LI Z J, ZHOU B, et al. Study on microbial contamination of Panax notoginseng[J]. Journal of Food Safety and Quality,2021,12(8):3405−3409. doi: 10.19812/j.cnki.jfsq11-5956/ts.2021.08.065 BAI W J, LI Z J, ZHOU B, et al. Study on microbial contamination of Panax notoginseng[J]. Journal of Food Safety and Quality, 2021, 12(8): 3405-3409. doi: 10.19812/j.cnki.jfsq11-5956/ts.2021.08.065
[11]	MCCORMICK P J, SCHOENE M J, PEDEVILLE D, et al. Verification testing of biological indicators for moist heat sterilization[J]. Biomedical Instrumentation & Technology,2018,52(3):199−207.
[12]	肖满, 吴艳, 马江南, 等. ⁶⁰Co-γ辐照灭菌对三七药材质量的影响[J]. 湖南中医杂志,2020,36(3):150−152,175. [XIAO M, WU Y, MA J N, et al. Influence of ⁶⁰Co-γ irradiation sterilization on the quality of the medicinal material Panax notoginseng[J]. HuNan Journal of Traditional Chinese Medicine,2020,36(3):150−152,175. XIAO M, WU Y, MA J N, et al. Influence of ⁶⁰Co-γ irradiation sterilization on the quality of the medicinal material Panax notoginseng[J]. HuNan Journal of Traditional Chinese Medicine, 2020, 36(3): 150-152, 175.
[13]	崔琳琳, 陈宁, 曹玲, 等. 三七生药粉乙醇灭菌工艺优化及不同灭菌方式对质量的影响[J]. 中国现代中药,2022,24(12):2462−2470. [CUI L L, CHENG N, CAO L, et al. Optimization of ethanol sterilization technology for Notoginseng Radix et Rhizoma powder and impact of sterilization methods on quality[J]. Modern Chinese Medicine,2022,24(12):2462−2470. CUI L L, CHENG N, CAO L, et al. Optimization of ethanol sterilization technology for Notoginseng Radix et Rhizoma powder and impact of sterilization methods on quality[J]. Modern Chinese Medicine, 2022, 24(12): 2462-2470.
[14]	王梁燕, 洪奇华, 孙志明, 等. 电子束辐照技术在生命科学中的应用[J]. 核农学报,2018,32(2):283−290. [WANG L Y, HONG Q H, SUN Z M, et al. Application of electron beam irradiation in life sciences[J]. Journal of Nuclear Agricultural Sciences,2018,32(2):283−290. doi: 10.11869/j.issn.100-8551.2018.02.0283 WANG L Y, HONG Q H, SUN Z M, et al. Application of electron beam irradiation in life sciences[J]. Journal of Nuclear Agricultural Sciences, 2018, 32(2): 283-290. doi: 10.11869/j.issn.100-8551.2018.02.0283
[15]	白洁, 迟玉明, 金红宇, 等. 《中药辐照灭菌技术指导原则》解读[J]. 中成药,2017,39(7):1537−1538. [BAI J, CHI Y M, JIN H Y, et al. Interpretation of guiding principles of irradiation sterilization of traditional Chinese medicine[J]. Chinese Traditional Patent Medicine,2017,39(7):1537−1538. BAI J, CHI Y M, JIN H Y, et al. Interpretation of guiding principles of irradiation sterilization of traditional chinese medicine[J]. Chinese Traditional Patent Medicine, 2017, 39(7): 1537-1538.
[16]	中华人民共和国农业部. NY/T2209-2012 食品电子束辐照通用技术规范[S]. 北京: 中国标准出版社, 2013. Ministry of Agriculture of the People's Republic of China. NY/T2209-2012 General technical specification for food irradiation by electron beam[S]. Beijing: Standards Press of China, 2013.
[17]	国家药典委员会. 中华人民共和国药典: 四部[S]. 2020版. 北京: 中国医药科技出版社, 2020. Pharmacopoeia committee pharmacopoeia of the People's Republic of China: Volume Ⅳ [S]. Beijing: China Medical Science and Technology Press, 2020: 524−528.
[18]	刘格. 不同产地三七药材质量综合评价研究[D]. 北京: 北京中医药大学, 2020. LIU G. Study on quality comprehensive evaluation of Panax notoginseng from different producing areas[D]. Beijing: Beiiing University of Chinese Medicine, 2020.
[19]	徐宏化, 程慧, 王正加, 等. 美国山核桃总多酚与总黄酮含量及抗氧化活性[J]. 核农学报,2016,30(1):72−78. [XU H H, CHENG H, WANG Z J, et al. The study of total polyphenols, total flavonoids and antioxidant capacity in Pecan [Carya illinoinensis (Wangenh. ) K. Koch] Kernerls[J]. Journal of Nuclear Agricultural Sciences,2016,30(1):72−78. XU H H, CHENG H, WANG Z J, et al. The study of total polyphenols, total flavonoids and antioxidant capacity in Pecan [Carya illinoinensis (Wangenh. ) K. Koch] Kernerls[J]. Journal of Nuclear Agricultural Sciences, 2016, 30(1): 72-78.
[20]	徐远芳, 李文革, 邓钢桥, 等. ⁶⁰Co-γ射线和电子束辐照灭菌对葛根提取物抗氧化活性及指纹图谱的影响[J]. 核农学报,2020,34(08):1713−1721. [XU Y F, LI W G, DENG G Q, et al. Effect of ⁶⁰Co-γ ray and electron beam irradiation sterilization on antioxidant activity and fingerprint of Pueraria extract[J]. Journal of Nuclear Agricultural Sciences,2020,34(08):1713−1721. XU Y F, LI W G, DENG G Q, et al. Effect of ⁶⁰Co-γ ray and electron beam irradiation sterilization on antioxidant activity and fingerprint of Pueraria extract[J]. Journal of Nuclear Agricultural Sciences, 2020, 34(08): 1713-1721.
[21]	王海英, 孙彩华. ⁶⁰Co-γ射线辐照灭菌对三七粉中三七皂苷R₁含量的影响[J]. 中国现代应用药学,2018,35(6):875−877. [WANG H Y, SUN C H. Effect of the ⁶⁰Co-γ ray irradiation sterilization on the content of notoginsenoside R₁ in Sanqi powder[J]. Chinese Journal of Modern Applied Pharmacy,2018,35(6):875−877. WANG H Y, SUN C H. Effect of the ⁶⁰Co-γ ray irradiation sterilization on the content of Notoginsenoside R₁ in Sanqi powder[J]. Chinese Journal of Modern Applied Pharmacy, 2018, 35(06): 875-877.
[22]	KHAWORY M H, SAIN A A, ROSLI M A A, et al. Effects of gamma radiation treatment on three different medicinal plants: Microbial limit tes, total phenolic content, in vitro cytotoxicity effect and antioxidant assay[J]. Applied Radiation and Isotopes,2020,157:109013. doi: 10.1016/j.apradiso.2019.109013
[23]	KYUNG H K, RAMAKRISHNAN S R, KWON J H. Dose rates of electron beam and gamma ray irradiation affect microbial decontamination and quality changes in dried red pepper (Capsicum annuum L.) powder[J]. Journal of the Science of Food and Agriculture,2019,99(2):632−638.
[24]	EGEA M I, SANXHEZ-BEL P, MMRTIAZEN-MADRID M C, et al. The effect of beta ionization on the antioxidant potential of 'Búlida' apricot and its relationship with quality[J]. Postharvest Biology and Technology,2007,46(1):63−70. doi: 10.1016/j.postharvbio.2007.04.002
[25]	于明, 王丹, 王钢, 等. 电子束辐照对天麻粉灭菌效果及品质的影响[J]. 核农学报,2022,36(11):2175−2182. [YU M, WANG D, WANG G, et al. Effects of electron beam irradiation on sterilization and quality of Gastrodia rhizoma powder[J]. Journal of Nuclear Agricultural Sciences,2022,36(11):2175−2182. YU M, WANG D, WANG G, et al. Effects of electron beam irradiation on sterilization and quality of Gastrodia rhizoma powder[J]. Journal of Nuclear Agricultural Sciences, 2022, 36(11): 2175-2182.
[26]	何毅, 王丹, 梅星月, 等. 电子束辐照对川麦冬品质及抗氧化活性的影响[J]. 核农学报,2021,35(8):1816−1824. [HE Y, WANG D, MEI X Y, et al. Effects of electron-beam irradiation on quality and antioxidant properties of Ophiopogon japonicus[J]. Journal of Nuclear Agricultural Sciences,2021,35(8):1816−1824. doi: 10.11869/j.issn.100-8551.2021.08.1816 HE Y, WANG D, MEI X Y, et al. Effects of electron-beam irradiation on quality and antioxidant properties of Ophiopogon japonicus[J]. Journal of Nuclear Agricultural Sciences, 2021, 35(8): 1816-1824. doi: 10.11869/j.issn.100-8551.2021.08.1816
[27]	韩振明, 关永霞, 张微, 等. ⁶⁰Co-γ射线辐照灭菌对蜈蚣药粉品质的影响研究[J]. 中国药业,2021,30(9):42−45. [HAN Z M, GUAN Y X, ZHANG W, et al. Effect of ⁶⁰Co-γ rays irradiation sterilization on the quality of Scolopendra subspinipes mutilans medicinal powder[J]. China Pharmaceuticals,2021,30(9):42−45. doi: 10.3969/j.issn.1006-4931.2021.09.012 HAN Z M, GUAN Y X, ZHANG W, et al. Effect of ⁶⁰Co-γ Rays irradiation sterilization on the quality of Scolopendra Subspinipes mutilans medicinal powder[J]. China Pharmaceuticals, 2021, 30(9): 42-45. doi: 10.3969/j.issn.1006-4931.2021.09.012
[28]	付孟, 王丹, 何毅, 等. 电子束辐照对大黄品质及抗氧化活性的影响[J]. 核农学报,2022,36(9):1789−1796. [FU M, WANG D, HE Y, et al. Effects of electron-beam irradiation on quality and antioxidant properties of Rheum palmatum L J]. Journal of Nuclear Agricultural Sciences,2022,36(9):1789−1796.
[29]	JUNG K, SONG B S, KIM M J, et al. Effect of X-ray, gamma ray, and electron beam irradiation on the hygienic and physicochemical qualities of red pepper powder[J]. LWT-Food Science and Technology,2015,63(2):846−851. doi: 10.1016/j.lwt.2015.04.030
[30]	RATHER S A, HUSSAIN P R, SURADKAR P P, et al. Comparison of gamma and electron beam irradiation for using phyto-sanitary treatment and improving physico-chemical quality of dried apricot and quince[J]. Journal of Radiation Research and Applied Sciences,2019,12(1):245−259. doi: 10.1080/16878507.2019.1650223
[31]	黄卉, 郑陆红, 李来好, 等. 不同预冷温度对鲈鱼冰藏期间质构和色差的影响[J]. 食品工业科技,2018,39(24):302−308. [HUANG H, ZHENG L H, LI H L, et al. Effects of different precooling temperature on texture and color of Micropterus salmoides during ice storage[J]. Science and Technology of Food Industry,2018,39(24):302−308. HUANG H, ZHENG L H, LI H L, et al. Effects of different precooling temperature on texture and color of Micropterus salmoides during ice storage[J]. Science and Technology of Food Industry, 2018, 39(24): 302−308.
[32]	张铁军, 郭海彪, 许浚, 等. 三七粉质量标志物研究[J]. 世界科学技术-中医药现代化,2022,24(1):1−8. [ZHANG T J, GUO H B, XU J, et al. Study on quality marker of Panax notoginseng powder[J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology,2022,24(1):1−8. ZHANG T J, GUO H B, XU J, et al. Study on quality marker of Panax notoginseng Powder[J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 2022, 24(1): 1-8.
[33]	LIU L, NING B, CUI J, et al. miR-29c is implicated in the cardioprotective activity of Panax notoginseng saponins against isopro-terenol-induced myocardial fibrogenesis[J]. Journal of ethnophar-macology,2017,198:1−4. doi: 10.1016/j.jep.2016.12.036
[34]	刘耀晨, 张铁军, 郭海彪, 等. 三七的研究进展及其质量标志物预测分析[J]. 中草药,2021,52(9):2733−2745. [LIU Y C, ZHANG T J, GUO H B, et al. Research progress on Notoginseng Radix et Rhizoma and predictive analysis on its Q-Marker[J]. Chinese Traditional and Herbal Drugs,2021,52(9):2733−2745. LIU Y C, ZHANG T J, GUO H B, et al. Research progress on Notoginseng Radix et Rhizoma and predictive analysis on its Q-Marker[J]. Chinese Traditional and Herbal Drugs, 2021, 52(9): 2733-2745.
[35]	蔡杨靖, 潘云. ⁶⁰Co-γ射线辐照灭菌对康尔心胶囊指纹图谱和有效成分含量的影响[J]. 中国药师,2020,23(6):1188−1192. [CAI Y J, PAN Y. Influence of ⁶⁰Co-γ rays radiation sterilization on the fingerprint chromatography and contents of effective constituents in Kangerxin capsules[J]. China Pharmacist,2020,23(6):1188−1192. CAI Y J, PAN Y. Influence of ⁶⁰Co-γ Rays radiation sterilization on the fingerprint chromatography and contents of effective constituents in Kangerxin capsules[J]. China Pharmacist, 2020, 23(6): 1188-1192.
[36]	白羽. ⁶⁰Co-γ射线辐照对中药化学成分影响及辐照中药鉴定的热释光分析法研究[D]. 长春: 吉林大学, 2014. BAI Y. Effect of Gamma irradiation on the ingredients of herbs and detection analysis methods for irradiated herbs by thermoluminescence[D]. Changchun: Jilin University, 2014.
[37]	许德星, 万发银, 张静怡, 等. 三七总黄酮通过miR-223-3p/FOXO1分子轴缓解病毒性心肌炎炎症反应和细胞损伤[J]. 病毒学报,2021,37(4):781−789. [XU D X, WAN F Y, ZHANG J Y, et al. Radix notoginseng flavone alleviated inflammatory response and cell damage of viral myocarditis via miR-223-3p/FOXO1 axis[J]. Chinese Journal of Virology,2021,37(4):781−789. doi: 10.13242/j.cnki.bingduxuebao.003897 XU D X, WAN F Y, ZHANG J Y, et al. Radix notoginseng flavone alleviated inflammatory response and cell damage of viral myocarditis via miR-223-3p/FOXO1 axis[J]. Chinese Journal of Virology, 2021, 37(4): 781-789. doi: 10.13242/j.cnki.bingduxuebao.003897
[38]	黄周艳, 刘玟君, 陈勇, 等. 三七黄酮研究进展[J]. 辽宁中医药大学学报,2020,22(1):81−84. [HUANG Y Z, LIU W J, CHENG Y, et al. Research progress of Panaxnotoginseng flavonoids[J]. Journal of Liaoning University of TCM,2020,22(1):81−84. doi: 10.13194/j.issn.1673-842x.2020.01.022 HUANG Y Z, LIU W J, CHENG Y, et al. Research progress of Panaxnotoginseng flavonoids[J]. Journal of Liaoning University of TCM, 2020, 22(1): 81-84. doi: 10.13194/j.issn.1673-842x.2020.01.022
[39]	李俊杰, 张帮磊, 师睿, 等. 电子束辐照灭菌对昭通酱挥发性成分的影响[J]. 食品工业科技,2023,44(4):326−336. [LI J J, ZHANG B L, SHI R, et al. Effect of electron beam irradiation sterilization on volatile components of Zhaotong soybean paste[J]. Science and Technology of Food Industry,2023,44(4):326−336. LI J J, ZHANG B L, SHI R, et al. Effect of electron beam irradiation sterilization on volatile components of Zhaotong soybean paste[J]. Science and Technology of Food Industry, 2023, 44(4): 326-336.
[40]	顾可飞, 秦秋伟, 张栩. 电子束辐照技术对甜高粱鲜品营养品质的影响[J]. 食品工业,2021,42(10):315−319. [GU K F, QIN Q W, ZHANG X. Effect of electron beam irradiation on nutritional quality of fresh sweet sorghum[J]. The Food Industry,2021,42(10):315−319. GU K F, QIN Q W, ZHANG X. Effect of electron beam irradiation on nutritional quality of fresh sweet sorghum[J]. The Food Industry, 2021, 42(10): 315-319.
[41]	刘力源, 陈敏, 赵海田, 等. 天然产物抗辐射活性研究进展[J]. 食品科学,2018,39(17):269−274. [LIU L Y, CHENG M, ZHAO H T, et al. Recent advances in understanding the radioprotective effect of natural products[J]. Food Science,2018,39(17):269−274. LIU L Y, CHENG M, ZHAO H T, et al. Recent advances in understanding the radioprotective effect of natural products[J]. Food Science, 2018, 39(17): 269-274.
[42]	项昌培, 周瑞, 张毅, 等. 三七中皂苷类成分及其抗脑缺血分子机制研究进展[J]. 中国中药杂志,2020,45(13):3045−3054. [XIANG C P, ZHOU R, ZHANG Y, et al. Research progress on saponins in Panax notoginseng and their molecular mechanism of anti-cerebral ischemia[J]. China Journal of Chinese Materia Medica,2020,45(13):3045−3054. doi: 10.19540/j.cnki.cjcmm.20200302.403 XIANG C P, ZHOU R, ZHANG Y, et al. Research progress on saponins in Panax notoginseng and their molecular mechanism of anti-cerebral ischemia[J]. China Journal of Chinese Materia Medica, 2020, 45(13): 3045-3054. doi: 10.19540/j.cnki.cjcmm.20200302.403
[43]	KRISHNAN V, GOTHWAL S, DAHUJA A, et al. Enhanced nutraceutical potential of gamma irradiated black soybean extracts. Food Chemistry, 2018, 245: 246-253.
[44]	VARIYAR P S, LIMAYE A, SHARMA A. Radiation-induced enhancement of antioxidant contents of soybean (Glycine max Merrill)[J]. Famlilies in Society the Journal of Contemporary Social Services,2004,52(11):3385−3388.
[45]	CHAWLA S P, CHANDER R, AND SHARMA A. Antioxidant formation by γ-irradiation of glucose–amino acid model systems[J]. Food Chemistry,2007,103(4):1297−1304. doi: 10.1016/j.foodchem.2006.10.035
[46]	白羽辛, 王玥玥, 贡济宇, 等. 不同灭菌方式人参粉的皂苷含量、指纹图谱分析及灭菌效果评价[J]. 食品工业科技,2021,42(10):229−235. [BAI Y X, WANG Y Y, GONG J Y, et al. Fingerprint analysis of saponins contents of ginseng powder in different sterilization methods and evaluation of sterilization effect[J]. Science and Technology of Food Industry,2021,42(10):229−235. doi: 10.13386/j.issn1002-0306.2020060074 BAI Y X, WANG Y Y, GONG J Y, et al. Fingerprint analysis of saponins contents of ginseng powder in different sterilization methods and evaluation of sterilization effect[J]. Science and Technology of Food Industry, 2021, 42(10): 229−235. doi: 10.13386/j.issn1002-0306.2020060074

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