Research Progress of Milk-derived Blood Pressure-lowering Peptides

CHEN Shurou; XU Huagen; PAN Jiali; LI Jing; LI Xia; JIANG Tiemin; DONG Xinhong

doi:10.13386/j.issn1002-0306.2022090285

Volume 44 Issue 20

Oct. 2023

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Science and Technology of Food Industry > 2023 > 44(20): 422-430. > DOI: 10.13386/j.issn1002-0306.2022090285

CHEN Shurou, XU Huagen, PAN Jiali, et al. Research Progress of Milk-derived Blood Pressure-lowering Peptides[J]. Science and Technology of Food Industry, 2023, 44(20): 422−430. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022090285.

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Research Progress of Milk-derived Blood Pressure-lowering Peptides

CHEN Shurou^{1, 2,},
XU Huagen^{1, 2},
PAN Jiali^{1, 2},
LI Jing^{1, 2},
LI Xia^{1, 2},
JIANG Tiemin^{1, 2},
DONG Xinhong^{1, 2, ,}

1.
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541000, China
2.
South Asia Branch of National Engineering Center of Dairy for Maternal and Child Health, Guilin University of Technology, Guilin 541000, China

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Received Date: September 26, 2022
Available Online: July 25, 2023

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Abstract

Abstract

Hypertension is a "silent killer" that threatens human health. Milk-derived antihypertensive peptides with antihypertensive activity are prepared from milk protein by enzymatic hydrolysis or fermentation. Recent years, milk-derived antihypertensive peptides have been regarded as a natural and relatively safe bioactive peptide, which have attracted increasing attention due to their high biological activity, low toxicity, easy metabolism and good antihypertensive effect. And milk-derived antihypertensive peptides have been gradually applied to health care products, functional foods and other fields. In this paper, the research progress in the sources (chemically synthesized and natural food sources) and preparation methods (digestibility in vitro and microbial fermentation). This paper summarizes the separation and purification, and structure-activity relationship of milk-derived antihypertensive peptides is reviewed, and the future development prospects for food and clinical applications are outlined, which will provide reference for promoting the development of antihypertensive peptide products in China.

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References (91)

References

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