Study on the Anti-aging Effect of Cherry Ethanol Extract Based on <i>Caenorhabditis elegans</i> Model

Meng YUAN; Fei QUE; Chuxiang XIAO; Yu LI; Fengwu WANG

doi:10.13386/j.issn1002-0306.2022070218

Volume 44 Issue 13

Jun. 2023

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Science and Technology of Food Industry > 2023 > 44(13): 375-382. > DOI: 10.13386/j.issn1002-0306.2022070218

YUAN Meng, QUE Fei, XIAO Chuxiang, et al. Study on the Anti-aging Effect of Cherry Ethanol Extract Based on Caenorhabditis elegans Model[J]. Science and Technology of Food Industry, 2023, 44(13): 375−382. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022070218.

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Study on the Anti-aging Effect of Cherry Ethanol Extract Based on Caenorhabditis elegans Model

1.
School of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China
2.
College of Applied Engineering, Zhejiang Institute of Economics and Trade, Hangzhou 310018, China

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Received Date: July 18, 2022
Available Online: May 03, 2023

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Abstract

Abstract

In this paper, the anti-aging effects of two varieties of cherry, Red Light and Yellow Honey in Jiaodong region were investigated and compared , for further development and utilization of cherries. The components of pulp and kernels in the two kinds of cherries were extracted by ethanol and the antioxidant activity was evaluated by the scavenging ability of DPPH and hydroxyl radicals, the ability to inhibit the aggregation of β-amyloid protein (Aβ) was investigated. The effects of four components on the life span, locomotor ability, reproductive ability, paralysis relief ability and the inhibition of Aβ deposition of Caenorhabditis elegans were studied. The results showed that antioxidant activity of two cherry pulp was outstanding, with DPPH radical scavenging rates of 80.88% and 83.19% and hydroxyl radical scavenging rates of 88.19% and 92.85% for Yellow Honey and Red Light, respectively, when the sample concentration was 1 mg/mL. While the antioxidant activity of fruit kernels was relatively low, with DPPH and hydroxyl radical scavenging rates of Yellow Honey and Red Light were 20.76% and 44.93%, 28.65% and 38.75%, respectively. Compared with the blank group, the life span of Caenorhabditis elegans in the four groups was prolonged by 2~4 days and their locomotor ability was enhanced, and it did not damage the reproduction ability and reduced the paralysis rate of Caenorhabditis elegans and Aβ deposition. In conclusion, the four samples were able to produce certain anti-aging effects by scavenging free radicals and inhibiting the production of Aβ, which have potential applications.
- cherry,
- antioxidant,
- beta-amyloid,
- anti-aging,
- Caenorhabditis elegans

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