Research Progress on Extraction, Purification and Functional Activity of Seabuckthorn Flavonoids

WANG Meng; WANG Zichun; HUANG Jingmei; ZHANG Lu; GAO Ming; DING Fangli; WANG Qing; YUAN Peng; DUAN Shenglin; JIANG Hui; WANG Yongxia; TAN Zhichao; LIU Jia

doi:10.13386/j.issn1002-0306.2022040134

Volume 44 Issue 2

Jan. 2023

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2023 > 44(2): 487-496. > DOI: 10.13386/j.issn1002-0306.2022040134

WANG Meng, WANG Zichun, HUANG Jingmei, et al. Research Progress on Extraction, Purification and Functional Activity of Seabuckthorn Flavonoids[J]. Science and Technology of Food Industry, 2023, 44(2): 487−496. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022040134.

Citation:

PDF (2272 KB)

Research Progress on Extraction, Purification and Functional Activity of Seabuckthorn Flavonoids

WANG Meng^{1, 2,},
WANG Zichun³,
HUANG Jingmei³,
ZHANG Lu^{1, 2},
GAO Ming^{1, 2},
DING Fangli^{1, 2},
WANG Qing^{1, 2},
YUAN Peng^{1, 2},
DUAN Shenglin^{1, 2},
JIANG Hui⁴,
WANG Yongxia⁵,
TAN Zhichao⁶,
LIU Jia^{1, 2, ,}

1.
China National Research Institute of Food and Fermentation Industries Co., Ltd., Beijing 100015, China
2.
Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic Disease, Beijing 100015, China
3.
College of Biological Sciences & Technology, Beijing Forestry University, Beijing 100083, China
4.
College of Tourism, Beijing Union University, Beijing 100101, China
5.
College of Life Science and Food Engineering, Hebei University of Engineering, Handan 056038, China
6.
Zhangbei Baodekang Food Co., Ltd., Zhangjiakou 076450, China

More Information

Received Date: April 12, 2022
Available Online: November 14, 2022

Graphical Abstract

Abstract

Abstract

As a kind of medicinal and edible plant, sea buckthorn is a high-quality source of flavonoids, and its main functional component is flavonoids. In this paper, the published literature is sorted out to compare and analyze the different extraction and purification methods, and structural detection methods of seabuckthorn flavonoids. In addition, the physiological metabolism of seabuckthorn flavonoids is summarized, and the mechanisms of action on various physiological functions such as anti-virus, anti-inflammatory, liver protection, obesity improvement and hypoglycemia are described from the perspective of regulating intestinal micro-ecology. Although seabuckthorn flavonoids have various physiological functions, the underlying mechanism between its low bioavailability and the physiological effects has not been fully elucidated. It is necessary to focus on the related research area for promoting the development, utilization, and deep processing of sea buckthorn.
- seabuckthorn flavonoids,
- extraction and purification,
- structural detection,
- physiological function,
- intestinal micro-ecology

FullText(HTML)

References (59)

References

[1]	PICHIAH P B, MOON H J, PARK J E, et al. Ethanolic extract of seabuckthorn (Hippophae rhamnoides L.) prevents high-fat diet-induced obesity in mice through down-regulation of adipogenic and lipogenic gene expression[J]. Nutrition Research,2012,32(11):856−864. doi: 10.1016/j.nutres.2012.09.015
[2]	OLAS B. The beneficial health aspects of sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) oil[J]. Journal of Ethnopharmacology,2018,213:183−190.
[3]	王春艳. 沙棘品种(系)果实营养成分比较分析研究[J]. 沙棘,2005(2):20−23. [WANG C Y. Comparative analysis of fruit nutritional components of Seabuckthorn varieties (lines)[J]. Sea Buckthorn,2005(2):20−23.
[4]	白晓州, 韩小存, 张镒飞. 不同种类的沙棘果渣营养成分及抗氧化活性研究[J]. 食品研究与开发,2018,39(23):179−183. [BAI X Z, HAN X C, ZHANG Y F. Study on the antioxidant activity of different kinds of seabuckthorn pomes[J]. Food Research and Development,2018,39(23):179−183.
[5]	FEREIRA R, MENDONA L, RIBEIRO C, et al. Relationship between intestinal microbiota, diet and biological systems: An integrated view[J]. Critical Reviews in Food Science and Nutrition,2020(4):1−21.
[6]	OSBORN L J, CLAESEN J, BROWN J M. Microbial flavonoid metabolism: A cardiometabolic disease perspective[J]. Annual Review of Nutrition,2021,41:433−454. doi: 10.1146/annurev-nutr-120420-030424
[7]	邢津津. 西藏林芝沙棘成分分析、黄酮提取优化及抗氧化性研究[D]. 林芝: 西藏农牧学院, 2021 XING J J. Extraction optimization and antioxidant activity of flavonoids from Hippophae rhamnoides in Nyingchi, Tibet[D]. Linzhi: Xizang Agriculture and Animal Husbandry University, 2021.
[8]	REN Q C, LI X H, LI Q Y, et al. Total flavonoids from sea buckthorn ameliorates lipopolysaccharide/cigarette smoke-induced airway inflammation[J]. Phytotherapy Research,2019,33(8):2102−2117. doi: 10.1002/ptr.6404
[9]	贾丛, 杜亚蓉, 孙坤. 沙棘总黄酮抑制肺癌A549增殖和迁移作用及机理[J]. 天然产物研究与开发,2020,32(6):937−945,952. [JIA C, DU Y R, SUN K. Effects of total flavonoids of hippophae rhamnoides on proliferation and migration of A549 in lung cancer[J]. Natural Products Research and Development,2020,32(6):937−945,952.
[10]	焦艳, 谢世静, 李喆. 沙棘黄酮对大鼠动脉粥样硬化斑块的影响及作用机制[J]. 中国老年学杂志,2022,42(6):1472−1475. [JIAO Y, XIE S J, LI Z. Effects of flavonoids from Hippophae rhamnoides on atherosclerotic plaque in rats and its mechanism[J]. Chinese Journal of Gerontology,2022,42(6):1472−1475.
[11]	李艺文, 唐志书, 张珍, 等. 沙棘总黄酮抗单侧输尿管梗阻大鼠肾脏纤维化作用及机制[J]. 中南药学,2021,19(5):845−850. [LI Y W, TANG Z S, ZHANG Z, et al. Effect and mechanism of total flavonoids of Hippophae rhamnoides on renal fibrosis in rats with unilateral ureteral obstruction[J]. Central South Pharmacy,2021,19(5):845−850.
[12]	周欣, 卫培峰, 王丽平, 等. 沙棘叶和果实中总黄酮提纯工艺研究进展[J]. 亚太传统医药,2019,15(3):188−190. [ZHOU X, WEI P F, WANG L P, et al. Advances in the purification process of total flavonoids from sea buckthorn leaves and fruits[J]. Asia-Pacific Traditional Medicine,2019,15(3):188−190.
[13]	JAYASHANKAR B, MISHRA K P, KUMAR M S Y, et al. A supercritical CO₂ extract from seabuckthorn leaves inhibits pro-inflammatory mediators via inhibition of mitogen activated protein kinase p38 and transcription factor nuclear factor-kappaB[J]. International Immunopharmacology,2012,13(4):461−467. doi: 10.1016/j.intimp.2012.05.011
[14]	蔡锦源, 王萌璇, 唐念, 等. 亚临界水萃取技术及其在有效成分提取和分析领域中的应用[J]. 应用化工,2017,46(6):1210−1213. [CAI J Y, WANG M X, TANG N, et al. Subcritical water extraction technology and its application in extraction and analysis of active components[J]. Applied Chemical Industry,2017,46(6):1210−1213.
[15]	KUMAR M S, DUTTA R, PRASAD D, et al. Subcritical water extraction of antioxidant compounds from seabuckthorn (Hippophae rhamnoides) leaves for the comparative evaluation of antioxidant activity[J]. Food Chemistry,2011,127(3):1309−1316.
[16]	XIAO J, CHEN G, LI N. Ionic liquid solutions as a green tool for the extraction and isolation of natural products[J]. Molecules,2018,23(7):1765. doi: 10.3390/molecules23071765
[17]	LI C Y, ZHANG J J, ZHAO C J, et al. Separation of the main flavonoids and essential oil from seabuckthorn leaves by ultrasonic/microwave-assisted simultaneous distillation extraction[J]. Royal Society Open Science,2018,5(7):180133. doi: 10.1098/rsos.180133
[18]	樊旭, 周鸿立. 响应面法优化沙棘黄酮的提取和抗氧化活性的研究[J]. 河南工业大学学报(自然科学版),2018,39(4):85−90. [FAN X, ZHOU H L. Optimization of flavonoids extraction and antioxidant activity of Hippophae rhamnoides by response surface methodology[J]. Journal of Henan University of Technology (Natural Science edition),2018,39(4):85−90.
[19]	冯纪南, 黄海英, 邓斌. 微波辅助提取沙棘总黄酮的工艺研究[J]. 安徽农业科学,2011,39(26):15952−15953,15955. [FENG J N, HUANG H Y, DENG B. Microwave-assisted extraction of total flavonoids from Hippophae rhamnoides[J]. Journal of Anhui Agricultural Sciences,2011,39(26):15952−15953,15955.
[20]	黄彬彬. 沙棘叶总黄酮的精制工艺及抗氧化性能研究[D]. 厦门: 华侨大学, 2016 HUANG B B. Study on purification technology and antioxidant activity of total flavonoids from seabuckthorn leaves[D]. Xiamen: Huaqiao University, 2016.
[21]	焦岩. 大果沙棘黄酮分离纯化及生物活性研究[D]. 哈尔滨: 东北林业大学, 2010 JIAO Y. Solation, purification and biological activity of flavonoids from Hippophae rhamnoides[D]. Harbin: Northeast Forestry University, 2010.
[22]	张海容, 史振华. 响应面法优化超声波辅助提取沙棘籽粕中黄酮工艺[J]. 中国油脂,2017,42(3):117−121. [ZHANG H R, SHI Z H. Optimization of ultrasonic-assisted extraction of flavonoids from seabuckthorn seed meal by response surface methodology[J]. China Oils and Fats,2017,42(3):117−121.
[23]	张程慧, 祁玉霞, 冯叙桥. 沙棘黄酮分离纯化方法的研究进展[J]. 保鲜与加工,2019,19(4):201−206. [ZHANG C H, QI Y X, FENG X Q. Research progress on isolation and purification methods of flavonoids from Hippophae rhamnoides[J]. Preservation and Processing,2019,19(4):201−206.
[24]	周浩楠, 胡娜, 董琦, 等. 沙棘化学成分及药理作用的研究进展[J]. 华西药学杂志,2020,35(2):211. [ZHOU H N, HU N, DONG Q, et al. Research progress on the chemical composition and pharmacological action of Hippophae rhamnoides[J]. West China Journal of Pharmaceutical Sciences,2020,35(2):211.
[25]	魏永生, 王永宁, 石玉平, 等. 分光光度法测定总黄酮含量的实验条件研究[J]. 青海大学学报(自然科学版),2003(3):61−63. [WEI Y S, WANG Y N, SHI Y P, et al. Determination of total flavonoids by spectrophotometry[J]. Journal of Qinghai University (Natural Science Edition),2003(3):61−63.
[26]	郝娟. 沙棘果实和叶片中黄酮类物质测定方法研究进展[J]. 食品安全导刊,2021(18):81−83. [HAO J. Progress in the determination of flavonoids in seabuckthorn fruits and leaves[J]. Food Safety Guide,2021(18):81−83.
[27]	ZHOU W, YUAN Z, LI G, et al. Isolation and structure determination of a new flavone glycoside from seed residues of seabuckthorn (Hippophae rhamnoides L.)[J]. Natural Product Research,2018,32(8):892−897. doi: 10.1080/14786419.2017.1366481
[28]	KUMAR M S Y, TITPUDE R J, MAHESHWARI D T, et al. Antioxidant and antimicrobial properties of phenolic rich fraction of seabuckthorn (Hippophae rhamnoides L.) leaves in vitro[J]. Food Chemistry,2013,141(4):3443−50. doi: 10.1016/j.foodchem.2013.06.057
[29]	蔡爽, 阮成江, 杜维, 等. 高效液相色谱-串联质谱法同时测定沙棘中的11种黄酮类物质[J]. 分析科学学报,2019,35(3):311−316. [CAI S, RUAN C J, DU W, et al. Simultaneous determination of 11 flavonoids in Hippophae rhamnoides by high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Analytical Science,2019,35(3):311−316.
[30]	孙燕, 冯峰, 张峰, 等. 基于 UPLC-Q-Exactive 技术结合 OTCML数据库快速分析沙棘的功效成分[J]. 天然产物研究与开发,2019,31(7):1192−1202. [SUN Y, FENG F, ZHANG F, et al. Rapid analysis of functional components of Hippophae rhamnoides by UPLC-Q-exactive and OTCML database[J]. Natural Product Research and Development,2019,31(7):1192−1202.
[31]	SANTANGELO R, SILVESTRINI A, MANCUSO C. Ginsenosides, catechins, quercetin and gut microbiota: Current evidence of challenging interactions[J]. Food and Chemical Toxicology,2019,123:42−49. doi: 10.1016/j.fct.2018.10.042
[32]	CARROSCO-POZO C, GOTTELAND M, CASILLO R L, et al. 3, 4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol[J]. Experimental Cell Research,2015,334(2):270−282. doi: 10.1016/j.yexcr.2015.03.021
[33]	XUE H, XIE W, JIANG Z, et al. 3, 4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2[J]. Xenobiotica,2016,46(10):931−939. doi: 10.3109/00498254.2016.1140847
[34]	杨艳, 杨荣玲, 邹宇晓, 等. 肠道微生物菌群生物转化天然多酚类化合物研究进展[J]. 食品科学,2014,35(17):319−325. [YANG Y, YANG R L, ZOU Y X, et al. Recent advances in biotransformation of natural polyphenolsby gut microflora[J]. Food Science,2014,35(17):319−325.
[35]	ESSER D, GELEIJNSE J M, MATUALATUPAUW J C, et al. Pure flavonoid epicatechin and whole genome gene expression profiles in circulating immune cells in adults with elevated blood pressure: A randomised double -blind, placebo -controlled, crossover trial[J]. PLoS One,2018,13(4):e0194229. doi: 10.1371/journal.pone.0194229
[36]	李涛, 李绮丽, 张群, 等. 基于肠道菌群的黄酮类化合物生理功能研究进展[J]. 中国食品学报,2022,22(2):357−368. [LI T, LI Q L, ZHANG Q, et al. Research progress on physiological functions of flavonoids based on gut microbes[J]. Journal of Chinese Institute of Food Science and Technology,2022,22(2):357−368.
[37]	WILLIAMS R J, SPENCER J P, RICE-EVANS C. Flavonoids: antioxidants or signalling molecules?[J]. Free Radical Biology and Medicine,2004,36:838−849. doi: 10.1016/j.freeradbiomed.2004.01.001
[38]	STEED A L, CHRISTOPHI G P, KAIKO G E, et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon[J]. Science,2017,357(6350):498−502. doi: 10.1126/science.aam5336
[39]	丰茂秀, 崔清华, 刘苗苗, 等. 黄酮类化合物抗甲型流感病毒活性研究进展[J]. 中华中医药学刊,2021,39(3):151−155. [FENG M X, CUI Q H, LIU M M, et al. Research progress on activity of flavonoids against influenza A virus[J]. Chinese Journal of Traditional Chinese Medicine,2021,39(3):151−155.
[40]	SHAHRAJABIAN M H, SUN W L, CHENG Q. The importance of flavonoids and phytochemicals of medicinal plants with antiviral activities[J]. Mini-Reviews in Organic Chemistry,2022,19:293−318. doi: 10.2174/1570178618666210707161025
[41]	ENKHTAIVAN G, JOHN K M, PANDURANGAN M, et al. Extreme effects of Seabuckthorn extracts on influenza viruses and human cancer cells and correlation between flavonol glycosides and biological activities of extracts[J]. Saudi Journal of Biological Sciences,2017,24:1646−1656. doi: 10.1016/j.sjbs.2016.01.004
[42]	刘川, 苏锦松, 李轩豪, 等. 基于网络药理学和分子对接法筛选藏药五味沙棘散治疗新型冠状病毒肺炎(COVID-19)活性成分的研究[J]. 世界科学技术-中医药现代化,2020,22(3):632−641. [LIU C, SU J S, LI X H, et al. Screening of active ingredients of Tibetan medicine Wuwei sea-buckthorn powder for the treatment of COVID-19 based on Network pharmacology and molecular docking method[J]. World Science and Technology-Modernization of Traditional Chinese Medicine,2020,22(3):632−641.
[43]	ZHANG A, HUI S, WANG X. Recent advances in natural products from plants for treatment of liver diseases[J]. European Journal of Medicinal Chemistry,2013,63(33):570−577.
[44]	SUN W L, LI X Y, DOU H Y, et al. Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota[J]. Cell Reports,2021,36:109641. doi: 10.1016/j.celrep.2021.109641
[45]	付依依, 王永霞, 李月, 等. 大果沙棘中黄酮的体外抗炎及抗氧化活性研究[J]. 中国食品添加剂,2021,32(10):67−74. [FU Y Y, WANG Y X, LI Y, et al. Study on anti-inflammatory and antioxidant activities of flavonoids from Hippophae rhamnoides[J]. China Food Additives,2021,32(10):67−74.
[46]	徐凤英. 沙棘叶总黄酮对DSS诱导的小鼠溃疡性结肠炎的缓减作用及机制研究[D]. 呼和浩特: 内蒙古医科大学, 2020 XU F Y. Effects of total flavonoids from seabuckthorn leaves on DSS induced ulcerative colitis in mice and its mechanism[D]. Hohhot: Inner Mongolia Medical University, 2020.
[47]	李军民, 高秉红, 李平. 抗肝损伤天然药物活性成分研究进展[J]. 中国药业,2021,30(24):128−134. [LI J M, GAO B H, LI P. Research progress of active ingredients of natural medicines against hepatic injury[J]. China Pharmaceuticals,2021,30(24):128−134.
[48]	欧阳香, 程虹毓, 胡伟琼, 等. 黄酮类化合物抗酒精性肝损伤作用及机制研究进展[J]. 中国药理学通报,2020,36(9):1200−1205. [OUYANG X, CHENG H Y, HU W Q, et al. Research progress on the anti-alcoholic liver injury effects and mechanism of flavonoids[J]. Chinese Pharmacological Bulletin,2020,36(9):1200−1205.
[49]	李欣益, 王昕旭, 颜妍, 等. 沙棘黄酮对于大鼠非酒精性脂肪肝病的改善作用及机制研究[C]//上海: 第十三届全国免疫学学术大会, 2018 LI X Y, WANG X X, YAN Y, et al. Ameliorative effect and mechanism of sea buckthorn flavonoids on nonalcoholic fatty liver disease in rats[C]//Shanghai: The 13th National Congress of Immunology, 2018.
[50]	ZHAO H, KONG L Z, SHAO M T, et al. Protective effect of flavonoids extract of Hippophae rhamnoides L. on alcoholic fatty liver disease through regulating intestinal flora and inhibiting TAK1/p38MAPK/p65NF-κB pathway[J]. Journal of Ethnopharmacology,2022,292:115225. doi: 10.1016/j.jep.2022.115225
[51]	POPKIN B M, ADIR L S, NG S W. Global nutrition transition and the pandemic of obesity in developing countries[J]. Nutrition Reviews,2012,70(4):256−256. doi: 10.1111/j.1753-4887.2012.00483.x
[52]	俞玥, 李占明, 叶华, 等. 植物黄酮重塑肠道菌群干预高脂膳食肥胖的研究进展[J]. 江苏科技大学学报(自然科学版),2021,35(5):87−94. [YU Y, LI Z M, YE H, et al. Gut microbiota reconstruction by dietary flavonoids improves high-fat-diet induced obesity and inflammation[J]. Journal of Jiangsu University of Science and Technology (Natural Science Edition),2021,35(5):87−94.
[53]	钟港, 陈东. 黄酮类化合物在脂肪代谢中的作用机制研究进展[J]. 动物营养学报,2022,34(6):1−12. [ZHONG G, CHEN D. Research progress on the mechanism of flavonoids in fat metabolism[J]. Chinese Journal of Animal Nutrition,2022,34(6):1−12.
[54]	杨鑫. 沙棘籽黄酮对机体脂代谢的调控及机理探究[D]. 上海: 华东师范大学, 2016 YANG X. Study on the regulation and mechanism of seabuckthorn seed flavonoids on lipid metabolism[D]. Shanghai: East China Normal University, 2016.
[55]	KWON E Y, LEE J, KIM Y J, et al. Seabuckthorn leaves extract and flavonoid glycosides extract from seabuckthorn leaves ameliorates adiposity, hepatic steatosis, insulin resistance, and inflammation in diet-induced obesity[J]. Nutrients,2017,9(6):569. doi: 10.3390/nu9060569
[56]	LI Y, TENG D, SHI X, et al. Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study[J]. BMJ-British Medical Journal,2020,369:m997.
[57]	王雪竹. 天然产物中降血糖功能因子研究进展[J]. 河南预防医学杂志,2018,29(4):241−243. [WANG X Z. Research progress on hypoglycemic function factors of natural product[J]. Henan Journal of Preventive Medicine,2018,29(4):241−243.
[58]	孙琛, 冯野, 谢培, 等. 沙棘果渣总黄酮的降血脂及降血糖作用[J]. 世界中医药,2018,13(1):142−145. [SUN C, FENG Y, XIE P, et al. Effects of total flavonoids from seabuckthorn fruit residue on blood lipid and blood glucose[J]. World Traditional Chinese Medicine,2018,13(1):142−145.
[59]	康莹. 中国沙棘叶黄酮提取精制工艺优化及其活性的初步评价[D]. 北京: 北京中医药大学, 2019 KANG Y. Extraction and purification of flavonoids from seabuckthorn leaves in China and preliminary evaluation of their activity[D]. Beijing: Beijing University of Traditional Chinese Medicine, 2019.

[1]	WU Zelong, CHEN Meixiang, HE Jianlin, BAI Kaikai, YU Lin, ZHANG Yi, HONG Bihong. Composite Edible Film Containing Microcapsules Composed of Shrimp-derived Bioactive Peptide Preparation and Preservation Potential[J]. Science and Technology of Food Industry, 2024, 45(4): 273-281. DOI: 10.13386/j.issn1002-0306.2023040069
[2]	HU Wanting, LUO Man, LU Jieyi, HUANG Yuchun, QIAO Dongling. Preparation and Properties of Agar/Konjac Glucomannan/Ethyl Cellulose Composite Film[J]. Science and Technology of Food Industry, 2022, 43(11): 260-266. DOI: 10.13386/j.issn1002-0306.2021090150
[3]	ZHAO Yaying, SHI Qiao, WANG Xinrui, WANG Guiying, LIAO Guozhou, LI Hong. Research Progress of Edible Film in Meat and Meat Products[J]. Science and Technology of Food Industry, 2021, 42(19): 411-417. DOI: 10.13386/j.issn1002-0306.2020080044
[4]	DONG Shuang, LI Xiaoyu, SANG Weicai, CHEN Ye, LI Hongjun. Process Optimization and Performance Analysis of Modified Zein Film by High Pressure Heat-Moisture (HPHM) Treatment[J]. Science and Technology of Food Industry, 2021, 42(16): 207-212. DOI: 10.13386/j.issn1002-0306.2020120059
[5]	XU Jing, YE Rui, SHI Rui, CHENG Wen-jian, CHEN Li-jiao, LIANG Peng. Preparation and Properties of Fish Skin Collagen Fiber-starch Composite Film[J]. Science and Technology of Food Industry, 2020, 41(7): 30-36. DOI: 10.13386/j.issn1002-0306.2020.07.006
[6]	XIANG Fei, WU Kao, XIAO Man, NI Xue-wen. Progress in the Mechanism of Formation of Konjac Glucomannan-based Edible Film[J]. Science and Technology of Food Industry, 2020, 41(5): 340-347,353. DOI: 10.13386/j.issn1002-0306.2020.05.055
[7]	WANG Zi-xuan, XIE Jing, XUE Bin, SHAO Ze-huai, GAN Jian-hong, SUN Tao. Research Progress of Chitosan Food Packaging Film[J]. Science and Technology of Food Industry, 2019, 40(6): 303-307,311. DOI: 10.13386/j.issn1002-0306.2019.06.052
[8]	SUN Li-na, JIANG Shu-juan, GUO Lian-dong, QIAN Fang, TUO Yan-feng, MU Guang-qing. TGase and hydroxypropyl methyl cellulose improved properties of whey protein edible film[J]. Science and Technology of Food Industry, 2018, 39(10): 236-239,250. DOI: 10.13386/j.issn1002-0306.2018.10.043
[9]	WANG Kai, XU Shi-tao, XIAO Man, WU Kao, JIANG Fa-tang, NI Xue-wen. Effects of span-80 on the properties of konjac glucomannan-zein blend films[J]. Science and Technology of Food Industry, 2016, (23): 267-271. DOI: 10.13386/j.issn1002-0306.2016.23.042
[10]	HUANG Yan, ZHANG Yuan, XU Xiao-qing, ZHONG Geng. Formulation optimization of edible films based on konjac glucomammanby response surface analysis[J]. Science and Technology of Food Industry, 2016, (04): 330-336. DOI: 10.13386/j.issn1002-0306.2016.04.058

Supplements (0)

Cited By

Cited by

Periodical cited type(6)

1.	徐于珽，于泓博，王晶，高文越，关云鹏，易思彤，任广辉，白长川，朱英. 基于肠肝轴中医药调节肠道功能防治肝细胞癌作用机制的研究进展. 中国中西医结合消化杂志. 2024(03): 222-225+232 .
2.	闫晓慧，姜思亮，刘雪晴，梁军，夏永刚. 灵芝多糖的构效关系、提取工艺及药理作用研究进展. 中医药学报. 2024(04): 117-122 .
3.	李秀清，纪宝玉，何江龙，李盼盼，吴婉阁，陈随清，董诚明，裴莉昕. 基于“习性-生境-部位-药性”的菌类中药相关性分析. 中国实验方剂学杂志. 2024(10): 133-139 .
4.	罗世博，刘伟，谢星，冯亚萍，彭春彦，张露. 紫色野生樱桃李提取物抗氧化和降血糖活性研究及化学成分鉴定. 食品与发酵工业. 2024(19): 191-200 .
5.	池妍，王雅芝，王昊，汲晨锋. 基于Citespace可视化分析5种真菌多糖研究进展. 中草药. 2024(23): 8130-8152 .
6.	周美伶，范春艳，王宏艳. 中药多糖在非酒精性脂肪性肝病中的研究进展. 现代畜牧兽医. 2023(12): 89-93 .