Advances in Studies on Functional Components and Pharmacological Effects of <i>Dioscorea opposita</i> Thunb

PAN Jingzhi; MENG Qinglong; CUI Wenyu; ZHU Shuangjie

doi:10.13386/j.issn1002-0306.2022010212

Volume 44 Issue 1

Dec. 2022

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2023 > 44(1): 420-428. > DOI: 10.13386/j.issn1002-0306.2022010212

PAN Jingzhi, MENG Qinglong, CUI Wenyu, et al. Advances in Studies on Functional Components and Pharmacological Effects of Dioscorea opposita Thunb[J]. Science and Technology of Food Industry, 2023, 44(1): 420−428. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022010212.

Citation:

PDF (2774 KB)

Advances in Studies on Functional Components and Pharmacological Effects of Dioscorea opposita Thunb

1.
Postdoctoral Workstation of Chuzhou University, Chuzhou 239000, China
2.
School of Economics and Management, Jilin Engineering Normal University, Changchun 130052, China
3.
School of Food and Biological Science Engineering, Heifei University of Technology, Hefei 230009, China
4.
Key Laboratory of Chinese Medicine Prevention and Treatment of Infectious Diseases of State Administration of Traditional Chinese Medicine, Changchun Hospital of Infectious Diseases, Changchun 130123, China
5.
School of Biological Science and Food Engineering, Chuzhou University, Chuzhou 239000, China

More Information

Received Date: January 23, 2022
Available Online: October 30, 2022

Graphical Abstract

Abstract

Abstract

Dioscorea opposita Thunb, as homologous plant of traditional medicine and food in our country, is the important raw material for healthy food. D. opposita maily contains variety of functional components such as polysaccharides, saponins, polyphenols, proteins, and trace elements. Many researchers have confirmed that D. opposita has the effects of immune regulation, anti-tumor, anti-oxidation, anti-aging, lowering blood sugar, lowering blood lipids, and regulating the spleen and stomach. Consequently, D. opposita has good development potential and application prospects in the fields of medicine, health and food products. Recently, the extraction, separation and pharmacological effects of functional components from D. opposita have been drawing much attention from scholars around the world. However, different species, different extraction and separation methods affect the structure and efficacy of functional components. This paper systematically reviews the functional components and the hottest pharmacological effects of D. opposita to broaden the application scope of D. opposita in many fields and industries, and analyze the relationship between functional components and efficacy, to provide a reference for the development and utilization of D. opposita functional food and health medicine.
- Dioscorea opposita,
- functional components,
- pharmacological effects,
- review

FullText(HTML)

References (79)

References

[1]	董俊美, 李锦超, 孟义江, 等. 山药种质资源鉴评与品种选育研究进展[J]. 河南农业科学,2021,50(11):6−14. [DONG J M, LI J C, MENG Y J, et al. Research progress on germplasm resources identification and breeding of Chinese yam[J]. Journal of Henan Agricultural Sciences,2021,50(11):6−14. doi: 10.15933/j.cnki.1004-3268.2021.11.002
[2]	冯学锋, 黄璐琦, 格小光, 等. 山药道地药材形成源流考[J]. 中国中药杂志,2008(7):859−862. [FENG X F, HUANG L Q, GE X G, et al. Textual research on origin and developmnt of genuine medicinal herbs of Shanyao[J]. China Journal of Chinese Materia Medica,2008(7):859−862. doi: 10.3321/j.issn:1001-5302.2008.07.040
[3]	国家药典委员会. 中华人民共和国药典: 2020年版一部[M]. 北京: 中国医药科技出版社, 2020. National Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China: Volume 1, 2020 edition[M]. Beijing: China Medical Science and Technology Press, 2020.
[4]	ZENG M, REN Y, ZHANG B, et al. In vitro non-small cell lung cancer inhibitory effect by new diphenylethane isolated from stems and leaves of Dioscorea oppositifolia L. via ER β-STAT3 pathway[J]. Frontiers in Pharmacology,2021,12:34.
[5]	YUE G G L, WONG L S, LEUNG H W, et al. Evaluation of the safety profiles of estrogenic Chinese herbal medicines in breast cancer[J]. Phytomedicine,2019,56:103−117. doi: 10.1016/j.phymed.2018.10.003
[6]	ZHOU S, HUANG G, CHEN G. Extraction, structural analysis, derivatization and antioxidant activity of polysaccharide from Chinese yam[J]. Food Chemistry,2021,361:130089. doi: 10.1016/j.foodchem.2021.130089
[7]	JIA X, WANG X, LIU Y, et al. Structural characterization of an alkali-extracted polysaccharide from Dioscorea opposita Thunb. with initial studies on its anti-inflammatory activity[J]. Journal of Carbohydrate Chemistry,2021:1−17.
[8]	李哲, 陈斐斐, 韩小康, 等. 山药多糖关节腔注射对兔膝关节骨性关节炎炎症因子及关节软骨代谢的影响[J]. 中国实验方剂学杂志,2021,27(23):88−96. [LI Z, CHEN F F, HAN X K, et al. Effect of joint cavity injection of Dioscoreae rhizoma polysaccharides on inflammatory factors and articular cartilage metabolism in rabbit knee osteoarthritis[J]. Chinese Journal of Experimental Traditional Medical Formulae,2021,27(23):88−96. doi: 10.13422/j.cnki.syfjx.20212104
[9]	ZHI F, YANG T L, WANG Q, et al. Isolation, structure and activity of a novel water-soluble polysaccharide from Dioscorea opposita Thunb[J]. International Journal of Biological Macromolecules,2019:1201−1209.
[10]	许春平, 孙懿岩, 白家峰, 等. 怀山药多糖的提取、硫酸酯化修饰及抗氧化活性研究[J]. 河南工业大学学报(自然科学版),2019,40(3):50−55. [XU C P, SUN Y Y, BAI J F, et al. Study on the extraction, sulfation modification and antioxidant activity of yam polysaccharides[J]. Journal of Henan University of Technology (Natural Science Edition),2019,40(3):50−55. doi: 10.16433/j.cnki.issn1673-2383.2019.03.009
[11]	MA F, WANG R, LI X, et al. Physical properties of mucilage polysaccharides from Dioscorea opposita Thunb[J]. Food Chem,2020,311:126039. doi: 10.1016/j.foodchem.2019.126039
[12]	ZHANG C Q, CHEN X, DING K. Structural characterization of a galactan from Dioscorea opposita Thunb. and its bioactivity on selected Bacteroides strains from human gut microbiota[J]. Carbohydrate Polymers,2019,218:299−306. doi: 10.1016/j.carbpol.2019.04.084
[13]	于海芬. 铁棍山药多糖的纯化、结构及胃肠调节活性研究[D]. 天津: 天津科技大学, 2019. YU H F. Study on purification, structure and gastrointestinal regulating activity of Dioscora opposita Thunb. cv. Tiegun polysaccharide[D]. Tianjin: Tianjin University of Science & Technology, 2019.
[14]	HOU L X, LI S, ZHANG F R, et al. Effect of exogenous jasmonic acid on physiology and steroidal saponin accumulation in Dioscorea zingiberensis[J]. Plant Physiology and Biochemistry,2022,186:1−10. doi: 10.1016/j.plaphy.2022.06.025
[15]	SALEHI B, SENER B, KILIC M, et al. Dioscorea plants: A genus rich in vital nutra-pharmaceuticals-A review[J]. Iranian Journal of Pharmaceutical Research: IJPR,2019,18(Suppl1):68.
[16]	WANG R, LI X, LIU L, et al. Preparation and characterization of edible films composed of Dioscorea opposita Thunb. mucilage and starch[J]. Polymer Testing,2020,90:106708. doi: 10.1016/j.polymertesting.2020.106708
[17]	ZHANG F, SHEN B, JIANG W, et al. Hydrolysis extraction of diosgenin from Dioscorea nipponica Makino by sulfonated magnetic solid composites[J]. Journal of Nanoparticle Research,2019,21(12):1−11.
[18]	XUE Z, CAO Z, JIN M, et al. New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect[J]. Food & Function,2021,12(18):8314−8325.
[19]	NAN S, WANG P, ZHU Q, et al. Comprehensive characterization of yam tuber nutrition and medicinal quality of Dioscorea opposita and D. alata from different geographic groups in China[J]. Journal of Integrative Agriculture,2020,19(11):2839−2848. doi: 10.1016/S2095-3119(20)63270-1
[20]	LEBOT V, MALAPA R, MOLISALÉ T. Development of HP-TLC method for rapid quantification of sugars, catechins, phenolic acids and saponins to assess yam (Dioscorea spp.) tuber flour quality[J]. Plant Genetic Resources,2019,17(1):62−72. doi: 10.1017/S1479262118000333
[21]	SHI Y, ZHOU S, FAN S, et al. Encapsulation of bioactive polyphenols by starch and their impacts on gut microbiota[J]. Current Opinion in Food Science,2021,38:102−111. doi: 10.1016/j.cofs.2020.11.001
[22]	LI Q M, LI Y, ZOU J H, et al. Influence of adding Chinese yam (Dioscorea opposita Thunb.) flour on dough rheology, gluten structure, baking performance, and antioxidant properties of bread[J]. Foods,2020,9(3):256. doi: 10.3390/foods9030256
[23]	CAO Y, LI H, HAO Z, et al. Two new diarylheptanoids and a new phenylhexanol derivative from the bulbils of Dioscorea opposita Thunb. and their α-glucosidase inhibitory activity[J]. Phytochemistry Letters,2021,44:142−148. doi: 10.1016/j.phytol.2021.06.016
[24]	CHANIAD P, TEWTRAKUL S, SUDSAI T, et al. Anti-inflammatory, wound healing and antioxidant potential of compounds from Dioscorea bulbifera L. bulbils[J]. Plos One,2020,15(12):e0243632. doi: 10.1371/journal.pone.0243632
[25]	NGAN N T T, HOANG N H, HIEN N T, et al. Cytotoxic phenanthrenes and phenolic constituents from the tubers of Dioscorea persimilis[J]. Phytochemistry Letters,2020,40:139−143. doi: 10.1016/j.phytol.2020.10.005
[26]	HOU L, LI S, TONG Z, et al. Geographical variations in fatty acid and steroid saponin biosynthesis in Dioscorea zingiberensis rhizomes[J]. Industrial Crops and Products,2021,170:113779. doi: 10.1016/j.indcrop.2021.113779
[27]	ZHANG N, LIANG T, JIN Q, et al. Chinese yam (Dioscorea opposita Thunb.) alleviates antibiotic-associated diarrhea, modifies intestinal microbiota, and increases the level of short-chain fatty acids in mice[J]. Food Research International,2019,122:191−198. doi: 10.1016/j.foodres.2019.04.016
[28]	刘露, 张雁, 魏振承, 等. 肠道益生菌体外发酵山药低聚糖产短链脂肪酸的研究[J]. 食品科学技术学报,2019,37(4):49−56. [LIU L, ZHANG Y, WEI Z C, et al. Study on production of short chain fatty acids from yam oligosaccharides by intestinal probiotics fermentation in vitro[J]. Journal of Food Science and Technology,2019,37(4):49−56. doi: 10.3969/j.issn.2095-6002.2019.04.007
[29]	DOSS A, TRESINA P S, MOHAN V R. Amino acid composition of wild yam (Dioscorea spp.)[J]. Food Research,2019,3(5):617−621.
[30]	LI C, LU Y, CHEN X, et al. Analysis of the N-glycoforms and immunoactivity of Chinese yam (Dioscorea opposita Thunb.) glycoprotein 30CYGP[J]. J Proteome Res,2020,19(1):28−35. doi: 10.1021/acs.jproteome.9b00102
[31]	罗海玲, 龚明霞, 周芸伊, 等. 山药块茎发育过程中淀粉积累及差异蛋白分析[J]. 华南农业大学学报,2018,39(6):61−69. [LUO H L, GONG M X, ZHOU Y Y, et al. Analysis of starch accumulation and differentially expressed proteins during the development of Chinese yam tuber[J]. Journal of South China Agricultural University,2018,39(6):61−69. doi: 10.7671/j.issn.1001-411X.2018.06.010
[32]	蒋方程, 李傲然, 何静仁, 等. 不同品种山药的营养成分分析及其水提物的体外抗氧化能力研究[J]. 食品工业科技,2018,39(4):6−11. [JIANG F C, LI A R, HE J R, et al. Analysis of nutritious compositions in Rhizoma dioscoreae from different varieties and antioxidant properties of their water extracts in vitro[J]. Science and Technology of Food Industry,2018,39(4):6−11.
[33]	杨李东, 高林, 周长兵, 等. 火焰原子吸收光谱法测定山药中微量元素的含量[J]. 化工技术与开发,2019,48(3):42−44. [YANG L D, GAO L, ZHOU C B, et al. Content determination of metal elements in Chinese yam by flame atomic absorption spectrometry[J]. Technology & Development of Chemical Industry,2019,48(3):42−44. doi: 10.3969/j.issn.1671-9905.2019.03.013
[34]	CHEN W Z, YANG G Z. Comparison and analysis of ten elements in Dioscorea alata Linn. from Lianjiang and Dioscorea opposita Thunb. from Henan[J]. Storage and Process,2018,18(1):113−117.
[35]	康艳萍. 黄芪、山药、黄精、银杏叶、五味子中微量元素测定研究[J]. 广州化工,2020,48(15):127−129. [KANG Y P. Study on determination of trace elements in the traditional Chinese medicine[J]. Guangzhou Chemical Industry,2020,48(15):127−129. doi: 10.3969/j.issn.1001-9677.2020.15.041
[36]	马蕊, 王露露, 陈随清. 山药商品规格及其质量特性分析[J]. 中成药,2020,42(7):1936−1942. [MA R, WANG L L, CHEN S Q. Analysis of commodity specifications and quality characteristics of Dioscorea opposita Thunb[J]. Chinese Traditional Patent Medicine,2020,42(7):1936−1942.
[37]	杨静, 白冰, 刘绣华, 等. HPLC法同时测定山药中的植物甾醇[J]. 食品科技,2019,44(6):321−325. [YANG J, BAI B, LIU X H, et al. Determination of phytosterols in Dioscorea opposita Thunb[J]. Food Science and Technology,2019,44(6):321−325.
[38]	冯文明, 韩竹箴, 王峥涛. 山药化学成分研究[J]. 中草药,2018,49(21):5034−5039. [FENG W M, HAN Z Z, WANG Z T. Chemical constituents from Dioscorea opposite[J]. Chinese Traditional and Herbal Drugs,2018,49(21):5034−5039. doi: 10.7501/j.issn.0253-2670.2018.21.013
[39]	MENG X, HU W, WU S, et al. Chinese yam peel enhances the immunity of the common carp (Cyprinus carpio L.) by improving the gut defence barrier and modulating the intestinal microflora[J]. Fish & Shellfish Immunology,2019,95:528−537.
[40]	许远征, 庞红利, 李洪影, 等. 山药多糖对肿瘤小鼠的抗肿瘤作用和免疫调节作用的研究[J]. 医药论坛杂志,2020,41(9):8−10,15. [XU Y Z, PANG H L, LI H Y, et al. Research on anti-tumor and immunomodulatory effects of yam polysaccharides on tumor mice[J]. Journal of Medical Forum,2020,41(9):8−10,15.
[41]	孔晨先, 肖波, 柳全文, 等. 山药多糖对动物机体免疫调节作用的Meta分析[J]. 食品研究与开发,2021,42(19):206−213. [KONG C X, XIAO B, LIU Q W, et al. Meta-analysis of the immunomodulatory effect of Chinese yam (Dioscorea opposita rhizoma) polysaccharides on the animal body[J]. Food Research and Development,2021,42(19):206−213. doi: 10.12161/j.issn.1005-6521.2021.19.029
[42]	樊乃境, 王冬梅, 高悦, 等. 山药蛋白肽对免疫能力低下小鼠的免疫调节作用[J]. 食品与发酵工业,2020,46(6):101−107. [FAN N J, WANG D M, GAO Y, et al. Immunomodulatory effects of the iron yam peptides on mice with immunocompromised[J]. Food and Fermentation Industries,2020,46(6):101−107. doi: 10.13995/j.cnki.11-1802/ts.021716
[43]	NIU X F, HE Z H, LI W F, et al. Immunomodulatory activity of the glycoprotein isolated from the Chinese yam (Dioscorea opposita Thunb)[J]. Phytotherapy Research,2017,31(10):1557−1563. doi: 10.1002/ptr.5896
[44]	HAO L X, ZHAO X H. Immunomodulatory potentials of the water-soluble yam (Dioscorea opposita Thunb) polysaccharides for the normal and cyclophosphamide-suppressed mice[J]. Food and Agricultural Immunology,2016,27(5):667−677. doi: 10.1080/09540105.2016.1148666
[45]	徐俊杰, 王珺, 杨占群. 山药多糖对低强度连续微波辐射小鼠免疫系统功能的影响[J]. 上海中医药杂志,2019,53(11):82−85. [XU J J, WANG J, YANG Z Q. Effect of yam polysaccharides on immune system function of mice exposed to continuous low-density microwave radiation[J]. Shanghai Journal of Traditional Chinese Medicine,2019,53(11):82−85. doi: 10.16305/j.1007-1334.2019.11.017
[46]	高长曌, 李方琪, 严婧, 等. 淮山药等4种药食同源中药对免疫抑制小鼠免疫功能影响的对比研究[J]. 中国实验诊断学,2020,24(5):837−841. [GAO C Z, LI F Q, YAN J, et al. Comparative study on the effects of Dioscorea opposita Thunb. and other three kinds of medicine and food homology of traditional Chinese medicine on immune function in immunosuppressive mice[J]. Chinese Journal of Laboratory Diagnosis,2020,24(5):837−841. doi: 10.3969/j.issn.1007-4287.2020.05.034
[47]	WANG F, LIU H, LIU F, et al. Effects of Chinese yam (Dioscorea oppositifolia L.) dietary supplementation on intestinal microflora, digestive enzyme activity and immunity in rainbow trout (Oncorhynchus mykiss)[J]. Aquaculture Research,2020,51(11):4698−4712. doi: 10.1111/are.14815
[48]	赵伟鑫, 曹猛猛, 靳艳, 等. 山药多糖对断奶仔猪免疫性能和肠道形态结构的影响研究[J]. 中国饲料,2021(11):37−41. [ZHAN W X, CAO M M, JIN Y, et al. Effect of Chinese yam polysaccharide on immune performance and intestinal morphology of weaned piglets[J]. China Feed,2021(11):37−41. doi: 10.15906/j.cnki.cn11-2975/s.20211107
[49]	KANU A N, EZEOCHA C V, OGUNKA N P. A review on bioactive compounds of yam varieties for human disease management[J]. Asian Food Science Journal,2018:1−10.
[50]	孙雯雯, 窦金霞, 张琳, 等. 山药提取物联合DC-CIK细胞疗法对结肠癌HT29干细胞荷瘤裸鼠的体内抗肿瘤研究[J]. 中草药,2017,48(7):1362−1368. [SUN W W, DOU J X, ZHANG L, et al. In vivo antitumor effect of Chinese yam extract combined with DC-CIK on nude mice bearing colon cancer HT29 stem cells[J]. Chinese Traditional and Herbal Drugs,2017,48(7):1362−1368.
[51]	谭辉, 耿耘, 杨洋. 紫山药花青素提取工艺及抗肿瘤活性筛选[J]. 现代中药研究与实践,2018,32(2):41−44. [TAN H, GENG Y, YANG Y, et al. Extraction process and antitumor activity screening of anthocyanin from purple Dioscorea alata L doi: 10.13728/j.1673-6427.2018.02.013 J]. Research and Practice on Chinese Medicines,2018,32(2):41−44. doi: 10.13728/j.1673-6427.2018.02.013
[52]	周丽, 史新敏, 任香梅, 等. 淮山药叶乙醇提取物黄酮和皂苷含量及抗氧化抗肿瘤活性研究[J]. 食品科技,2015,40(8):204−207. [ZHOU L, SHI X M, REN X M, et al. Antioxidant and cytotoxic activity of ethanol extract of Rhizoma Dioscoreae leaves[J]. Food Science and Technology,2015,40(8):204−207. doi: 10.13684/j.cnki.spkj.2015.08.045
[53]	WANG Y, LIU Y, ZHANG Y, et al. Effects of the polysaccharides extracted from Chinese yam (Dioscorea opposita Thunb.) on cancer-related fatigue in mice[J]. Food & Function,2021,12(21):10602−10614.
[54]	ZHANG Z, WANG X, LIU C, et al. The degradation, antioxidant and antimutagenic activity of the mucilage polysaccharide from Dioscorea opposita[J]. Carbohydrate Polymers,2016,150:227−231. doi: 10.1016/j.carbpol.2016.05.034
[55]	陈丽叶, 常希光, 冯晓光, 等. 山药多糖的体外抗氧化活性[J]. 食品科学,2021,42(19):122−128. [CHEN L Y, CHANG X G, FENG X G, et al. In vitro antioxidant activity of Chinese yam polysaccharides[J]. Food Science,2021,42(19):122−128. doi: 10.7506/spkx1002-6630-20201107-073
[56]	王彦平, 杨会会, 钱志伟, 等. 响应面法优化紫山药中原花青素超声提取工艺及抗氧化性研究[J]. 食品工业科技,2017,38(13):181−185,190. [WANG Y P, YANG H H, QIAN Z W, et al. Optimization of ultrasonic-assisted extraction of procyanidins from purple yam by response surface methodology and antioxidant activity[J]. Science and Technology of Food Industry,2017,38(13):181−185,190. doi: 10.13386/j.issn1002-0306.2017.13.034
[57]	LI Q, LI X, REN Z, et al. Physicochemical properties and antioxidant activity of Maillard reaction products derived from Dioscorea opposita polysaccharides[J]. LWT,2021:111833.
[58]	陈建双, 李佳欣, 杨洋, 等. 山药水提物提取工艺优化及抗氧化活性分析[J]. 粮食与油脂,2021,34(6):155−159. [CHEN J S, LI J X, YANG Y, et al. Optimization of water extract process from yam and its antioxidant activity analysis[J]. Cereals & Oils,2021,34(6):155−159. doi: 10.3969/j.issn.1008-9578.2021.06.036
[59]	王静, 韩莹, 连珺怡, 等. 山药多糖对丙烯酰胺诱导的巨噬细胞氧化损伤的保护作用[J]. 食品与发酵工业,2021,47(20):52−59. [WANG J, HAN Y, LIAN J Y, et al. Protective effect of Rhizoma dioscoreae polysaccharides on oxidative damage induced by acrylamide in macrophages[J]. Food and Fermentation Industries,2021,47(20):52−59.
[60]	孟永海, 孟祥瑛, 付敬菊, 等. 超声波协同酶解法对山药总多酚提取及抗氧化活性影响研究[J]. 辽宁中医药大学学报,2020,22(4):63−66. [MENG Y H, MENG X Y, FU J, et al. Extraction and antioxidant activity of total polyphenols from Chinese yam by ultrasound-assisted enzymatic hydrolysis[J]. Journal of Liaoning University of Traditional Chinese Medicine,2020,22(4):63−66. doi: 10.13194/j.issn.1673-842x.2020.04.016
[61]	CHEN G, HUANG C, SHI P, et al. Mechanism of Chinese yam for the treatment of aging-related diseases based on network pharmacology[J]. European Journal of Integrative Medicine,2021,41:101254. doi: 10.1016/j.eujim.2020.101254
[62]	胡聪, 孟祥龙, 宁晨旭, 等. 山药的研究进展及其抗衰老的网络药理学分析[J]. 世界科学技术-中医药现代化,2020,22(7):2348−2365. [HU C, MENG X L, NING C X, et al. Research progress of Chinese yam and its network pharmacological analysis of anti-aging[J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology,2020,22(7):2348−2365.
[63]	WANG X, HUO X, LIU Z, et al. Investigations on the anti-aging activity of polysaccharides from Chinese yam and their regulation on Klotho gene expression in mice[J]. Journal of Molecular Structure,2020,1208:127895. doi: 10.1016/j.molstruc.2020.127895
[64]	刘哲. 怀山药多糖分离纯化、抗衰老活性及其对Klotho基因的表达调控研究[D]. 郑州: 郑州大学, 2019. LIU Z. Study on isolation, purification, anti-aging activity of Huai yam polysaccharide and its regulation on Klotho gene expression[D]. Zhengzhou: Zhengzhou University, 2019.
[65]	张丽梅, 程永强, 宋曙辉. 紫山药多糖对D-半乳糖衰老模型大鼠肝、脑的影响[J]. 食品科学,2017,38(13):196−200. [ZHANG L M, CHENG Y Q, SONG S H. Effect of purple yam polysaccharide on the liver and brain of D-galactose induced aging rats[J]. Food Science,2017,38(13):196−200. doi: 10.7506/spkx1002-6630-201713032
[66]	朱海清, 杨倩倩, 王冰, 等. 2型糖尿病患者饮食自我管理与糖化血红蛋白控制情况的关系研究[J]. 中华糖尿病杂志,2021,13(12):1123−1129. [ZHU H Q, YANG Q Q, WANG B, et al. Diet self-management and control of glycated hemoglobin A_1c in patients with type 2 diabetes mellitus[J]. Chinese Journal of Diabetes,2021,13(12):1123−1129. doi: 10.3760/cma.j.cn115791-20210606-00314
[67]	LIANG X, HUANG Y Q, CHEN J P, et al. Antioxidant activity of polysaccharides in yam bulbils and their hypoglycemic effect in diabetic mice[J]. Agricultural Science & Technology,2015,16(7):1332−1335.
[68]	张文杰, 赖星海, 陈佳薇. 山药多糖治疗肥胖糖尿病肾病大鼠的效果观察及对其肾功能和肠道微生态的影响[J]. 中国微生态学杂志,2021,33(1):37−42. [ZHANG W J, LAI X H, CHEN J W. Effect of yam polysaccharides in the treatment of obese diabetic nephropathy rats and its effect on renal function and intestinal microecology[J]. Chinese Journal of Microecology,2021,33(1):37−42. doi: 10.13381/j.cnki.cjm.202101006
[69]	赵磊, 姜飞, 王成涛, 等. 南瓜、山药、葛根和桑叶配方辅助降血糖作用的研究[J]. 中国食品学报,2018,18(7):46−56. [ZHAO L, JIANG F, WANG C T, et al. Studies on assistant hypoglycemic effect of a diet formula prepared with pumpkin, yam, kudzuvine root, and mulberry leave[J]. Journal of Chinese Institute of Food Science and Technology,2018,18(7):46−56. doi: 10.16429/j.1009-7848.2018.07.006
[70]	ZHANG Y, KHAN M Z H, YUAN T, et al. Preparation and characterization of D. opposita Thunb polysaccharide-zinc inclusion complex and evaluation of anti-diabetic activities[J]. International Journal of Biological Macromolecules,2019,121:1029−1036. doi: 10.1016/j.ijbiomac.2018.10.068
[71]	NTCHAPDA F, TCHATCHOUANG F C, MIAFFO D, et al. Hypolipidemic and anti-atherosclerogenic effects of aqueous extract of Ipomoea batatas leaves in diet-induced hypercholesterolemic rats[J]. Journal of Integrative Medicine,2021,19(3):243−250. doi: 10.1016/j.joim.2021.02.002
[72]	UTHIRAPATHY S, AHAMAD J, PORWAL O, et al. GCMS analysis and hypolipidemic activity of Dioscorea bulbifera L. in high fat diet induced hypercholesterolemic rats[J]. Research Journal of Phytochemistry,2021,15(1):23−29. doi: 10.3923/rjphyto.2021.23.29
[73]	雷艳, 胡吉蕾, 刘青青, 等. 决明子山药黄豆复配对高脂血症大鼠血脂代谢的影响[J]. 食品研究与开发,2019,40(5):48−53. [LEI Y, HU J L, LIU Q Q, et al. Effects of semen cassia yam soybean on blood lipid metabolism in hyperlipidemic rats[J]. Food Research and Development,2019,40(5):48−53. doi: 10.3969/j.issn.1005-6521.2019.05.009
[74]	SUN Y, LIU T, SI Y, et al. Integrated metabolomics and 16S rRNA sequencing to investigate the regulation of Chinese yam on antibiotic-induced intestinal dysbiosis in rats[J]. Artificial Cells, Nanomedicine and Biotechnology,2019,47(1):3382−3390. doi: 10.1080/21691401.2019.1649271
[75]	宋俊杰, 陈英, 范军朝, 等. 山药多糖对小鼠肝缺血再灌注损伤中的肝脾组织的保护作用[J]. 实用医药杂志,2018,35(4):343−346. [SONG J J, CHEN Y, FAN J C, et al. Protection of Chinese yam polysaccharides on liver and spleen tissue in hepatic ischemia-reperfusion injury mice[J]. Practical Journal of Medicine & Pharmacy,2018,35(4):343−346. doi: 10.14172/j.issn1671-4008.2018.04.019
[76]	王巧俐, 陈辉, 向未, 等. 山药芝麻糊调理习惯性便秘脾肺气虚型效果观察[J]. 实用中医药杂志,2020,36(8):996−997. [WANG Q L, CHEN H, XIANG W, et al. Observation on the effect of Chinese yam and sesame paste on habitual constipation with deficiency of spleen and lung deficiency[J]. Journal of Practical Traditional Chinese Medicine,2020,36(8):996−997.
[77]	DOMÉNIENÉ A, VENSKUTONIS P R. Dioscorea spp: Comprehensive review of antioxidant properties and their relation to phytochemicals and health benefits[J]. Molecules,2022,27(8):2530. doi: 10.3390/molecules27082530
[78]	ZHONG Y, LIU J, SUN D, et al. Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control[J]. Food & Function,2022,13(6):3660−3673.
[79]	高子涵, 李瑞芳, 吕行直, 等. 山药多糖对糖尿病肾病小鼠肾功能和醛糖还原酶通路的影响[J]. 中药材,2019,42(3):643−646. [GAO Z H, LI R F, LÜ X Z, et al. Effects of Dioscorea opposita polysaccharide on renal function and aldose reductase pathway in mice with diabetic nephropathy[J]. Journal of Chinese Medicinal Materials,2019,42(3):643−646.

Supplements (0)

Cited By

Cited by

Periodical cited type(6)

1.	吕素媛，商冰清，孙璐颜，刘国龙，赵发，梁秀清，吴秋，耿越. 微波辅助萃取油松松针精油的工艺优化及抗氧化活性研究. 食品工业科技. 2025(02): 184-191 . 本站查看
2.	杨媛媛，唐语谦，杨继国. 亚临界萃取琥珀精油工艺优化及活性分析. 现代食品科技. 2024(04): 225-235 .
3.	太美灵，江岭，李宛钊，韩萍，林丽，杜志云. 3D皮肤模型法评价五味子油对H_2O_2诱导的HaCaT细胞氧化损伤的保护作用. 广东工业大学学报. 2023(01): 130-136 .
4.	刘庆璇，庄连玉，马文局，孙光辉，刘亚辉，李冠喜. 樟树叶片精油对微生物生长的抑制作用. 曲阜师范大学学报(自然科学版). 2023(02): 88-92 .
5.	张家旭，董学凤，王信，叶倩女，郭玉儿，石晓峰. 不同品种6种松针中氨基酸含量测定及营养价值评价. 中国食品添加剂. 2023(05): 281-290 .
6.	李成辉，董宏标，郑晓婷，桂福坤，曾祥兵，明俊超，陈飞，陈健，张家松. 春砂仁精油对尼罗罗非鱼幼鱼生长、消化、抗氧化能力和血清生化指标的影响. 南方水产科学. 2023(06): 51-59 .