Effect of Polysaccharide from <i>Ilex kudingcha</i> C.J. Tseng on the Immune Regulation and Antioxidation of Spleen Lymphocytes from Mice

SHU Xiang; CHENG Ming; WANG Hui; ZHU Hongying; TAN Lehe; GU Wenliang; ZHU Kexue

doi:10.13386/j.issn1002-0306.2021100106

Volume 43 Issue 17

Aug. 2022

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Science and Technology of Food Industry > 2022 > 43(17): 387-393. > DOI: 10.13386/j.issn1002-0306.2021100106

SHU Xiang, CHENG Ming, WANG Hui, et al. Effect of Polysaccharide from Ilex kudingcha C.J. Tseng on the Immune Regulation and Antioxidation of Spleen Lymphocytes from Mice[J]. Science and Technology of Food Industry, 2022, 43(17): 387−393. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021100106.

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Effect of Polysaccharide from Ilex kudingcha C.J. Tseng on the Immune Regulation and Antioxidation of Spleen Lymphocytes from Mice

SHU Xiang^{1, 2,},
CHENG Ming^{1, 3},
WANG Hui^{1, 4},
ZHU Hongying^{1, 4},
TAN Lehe¹,
GU Wenliang¹,
ZHU Kexue^{1, 4, ,}

1.
Spice and Beverage Research Institute, Chinese Academy of Tropical Agriculture Science, Wanning 571533, China
2.
Patent Examination Cooperation Jiangsu Center of the Patent Office, China National Intellectual Property Administration, Suzhou 215011, China
3.
College of Food Science, Hainan University, Haikou 570100, China
4.
Hainan Key Laboratory of Tropical Crops Suitability Processing and Quality Control, Wanning 571533, China

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Received Date: October 12, 2021
Available Online: June 29, 2022

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Abstract

Abstract

To investigate the immune regulation and antioxidation effects of polysaccharide from Ilex kudingcha C.J. Tseng on mouse spleen lymphocytes in vitro. The proliferation, antioxidant capacity (SOD, T-AOC, GSH-Px and CAT) activity and malonic dialdehyde (MDA) content, as well as the secretion of cytokines (TNF-α, IFN-γ and IL-1β) were detected after treating with polysaccharide from Ilex kudingcha C.J. Tseng. The results showed that polysaccharide from Ilex kudingcha C.J. Tseng could promote the proliferation of spleen lymphocytes dose-dependently. Compared to the OD value of control group (0.31), the OD values at the concentration of 80 and 160 μg/mL were increased significantly (P<0.01) to 0.38 and 0.41, respectively. The activities of SOD, T-AOC, GSH-Px and CAT were increased with increasing concentration of polysaccharide from Ilex kudingcha C.J. Tseng. And there were significant differences (P<0.01) between control group and 160 μg/mL polysaccharide from Ilex kudingcha C.J. Tseng group, the activities of SOD, T-AOC, GSH-Px and CAT were of 4.54 U/mg protein, 1.06 mmol/mg protein, 799.01 mU/mg protein and 806.85 U/mg protein, respectively. Meanwhile, compared to control group, polysaccharide from Ilex kudingcha C.J. Tseng could significantly decrease the contents of MDA, increase NO production and promote the secretion of TNF-α, IFN-γ and IL-1β. In conclusion, the immunomodulatory effect of polysaccharide from Ilex kudingcha C.J. Tseng may be related to the promotion of splenic lymphocyte proliferation, the enhancement of antioxidant activity and the induction of cytokine secretion level. The results are beneficial to provide a theoretical basis for the development and utilization of Ilex kudingcha C.J. Tseng.
- polysaccharide from Ilex kudingcha C.J. Tseng,
- spleen lymphocytes,
- antioxidant activity,
- cytokines,
- immunomodulation

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