Improvement of Astaxanthin Lipid Emulsion on the Structure and Dysfunction of Gut Microbiota Induced by High-fat Diet

YUAN Shihan; Robert W. Li; LIU Fang; YANG Lu; XUE Changhu; TANG Qingjuan

doi:10.13386/j.issn1002-0306.2020040033

Volume 42 Issue 2

Jan. 2021

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Science and Technology of Food Industry > 2021 > 42(2): 63-69. > DOI: 10.13386/j.issn1002-0306.2020040033

YUAN Shihan, Robert W. Li, LIU Fang, YANG Lu, XUE Changhu, TANG Qingjuan. Improvement of Astaxanthin Lipid Emulsion on the Structure and Dysfunction of Gut Microbiota Induced by High-fat Diet[J]. Science and Technology of Food Industry, 2021, 42(2): 63-69. DOI: 10.13386/j.issn1002-0306.2020040033

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Improvement of Astaxanthin Lipid Emulsion on the Structure and Dysfunction of Gut Microbiota Induced by High-fat Diet

1. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China;
2. Laboratory of Animal Genomics and Improvement, United States Department of Agriculture, Beltsville, MD 20705, USA

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Received Date: April 03, 2020
Available Online: January 20, 2021

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Abstract

Abstract

This article focused on the regulation of astaxanthin lipid emulsion(ASTE)on high-fat diet-induced gut microbiota disturbance. 32 C57/BL6J male mice were randomly divided into normal group(N),model group(M),astaxanthin group(MA)and astaxanthin lipid emulsion group(MAL). The mice were fed with 45% high-fat diet for 56 d to establish a high-fat model. After continuous gavage of astaxanthin(AST)or ASTE at 30 mg/(kg·bw)for 28 d,the contents of the colon were taken and total DNA was extracted. The gut microbiota was detected and analyzed by metagenome sequencing technology and bioinformatics analysis software. The results showed that high-fat diets caused a significant decrease in the gut microbiota α-diversity in mice by 8.00%(P<0.05),and AST and ASTE could restore the diversity. In addition,ASTE could regulate the relative abundance of Bacteroidetes,Clostridiales,Oscillospiraceae related to lipid-lowering and weight-loss. It was speculated that it could improve host lipid metabolism by affecting the structure and function of gut microbiota. This research lays a theoretical foundation for the development of health foods with ASTE as the functional factor.
- astaxanthin lipid emulsion,
- astaxanthin,
- high-fat diet,
- gut microbiota,
- metagenome

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References

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