Science and Technology of Food Industry

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Volume 39 Issue 5
Feb.  2018
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LI Shi-yi, YANG Jing-ya, YU Wen-juan, LIU Xiao-yan, MA Yan. Effects on tumor cells by combination with carboxymethyl-chitosan and adriamycin[J]. Science and Technology of Food Industry, 2018, 39(5): 110-112,118.
Citation: LI Shi-yi, YANG Jing-ya, YU Wen-juan, LIU Xiao-yan, MA Yan. Effects on tumor cells by combination with carboxymethyl-chitosan and adriamycin[J]. Science and Technology of Food Industry, 2018, 39(5): 110-112,118.
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Effects on tumor cells by combination with carboxymethyl-chitosan and adriamycin

  • 1. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;

  • 2. Shanghai Engineering Research Center of Aquatic-Product Processing&Preservation, Shanghai Ocean University, Shanghai 201306, China;

  • 3. Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation(Shanghai), Ministry of Agriculture, Shanghai 201306, China;

  • 4. College of Aqua-life Science and Technology, Shanghai Ocean University, Shanghai 201306, China

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  • Received Date: March 26, 2017
  • Available Online: November 23, 2020
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    • Abstract
  • The effect of anti-tumor combining carboxymethyl-chitosan(CM-CTS)with adriamycin(ADM)was studied. Colony forming test and trauma test were used to evaluate the effects of CM-CTS and ADM on cell proliferation and cell migration of Hela in vitro. Animal experiment was used to evaluate the anti-tumor activity of CM-CTS and ADM in vivo. The results showed that combining CM-CTS with ADM could inhibit clone forming rate of Hela by 72.65%,which was significantly higher than treating Hela with CM-CTS(31.47%)or ADM(44.09%)only(p<0.01). The migration ability of Hela could be inhibited when Hela was treated by CM-CTS and ADM together. And the inhibition rate was 84.48%,which was significantly higher than that of CTS(37.47%)or ADM(56.29%)(p<0.01). Animal experiment showed that the suppression rate of CM-CTS or ADM was 16.96% or 27.68%(p<0.01). While two-drug combination had a synergistic effect,which inhibited the tumor growth by 47.32%. Therefore,synergistic effect of CM-CTS and ADM could effectively inhibit cell proliferation and migration of Hela.
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