Effect of Corn Ferulic Acid on Lipid Metabolism and Liver Injury in Hyperlipidemia Rats

ZHANG Naidan; ZUO Zhaohang; WANG Ying; SUN Wei; PANG Weiqiao

doi:10.13386/j.issn1002-0306.2023020270

Volume 44 Issue 16

Aug. 2023

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Science and Technology of Food Industry > 2023 > 44(16): 8-14. > DOI: 10.13386/j.issn1002-0306.2023020270

ZHANG Naidan, ZUO Zhaohang, WANG Ying, et al. Effect of Corn Ferulic Acid on Lipid Metabolism and Liver Injury in Hyperlipidemia Rats[J]. Science and Technology of Food Industry, 2023, 44(16): 8−14. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023020270.

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Effect of Corn Ferulic Acid on Lipid Metabolism and Liver Injury in Hyperlipidemia Rats

ZHANG Naidan^1,,
ZUO Zhaohang¹,
WANG Ying^{1, 2, 3, 4, ,},
SUN Wei¹,
PANG Weiqiao¹

1.
College of Food, Heilongjiang Bayi Agricultural University, Daqing 163319, China
2.
National Coarse Cereals Engineering Research Center, Daqing 163319, China
3.
Engineering Research Center of Processing and Utilization of Grain By-products, Ministry of Education, Daqing 163319, China
4.
Key Laboratory of Agro-Products Processing and Quality Safety of Heilongjiang province, Daqing 163319, China

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Received Date: February 23, 2023
Available Online: June 13, 2023

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Abstract

Abstract

Objective: To investigate the effects of corn ferulic acid on lipid metabolism and liver injury in hyperlipidemic rats. Significance: To improve the added value of corn husk and provide theoretical basis and data support for the health effect of corn ferulic acid. Methods: Eight rats were randomly selected as the normal group, and the rest rats were fed with high-fat diet to establish the hyperlipidemia rat model. The hyperlipidemia rats were randomly divided into positive control group, model group and corn ferulic acid high, medium and low dose groups. After 42 days of gavage, the liver index, blood lipid, antioxidant index and liver sections were measured. Results: Compared with the model group, corn ferulic acid reduced 0.23% of the body weight growth rate and 0.14% of the liver index of the hyperlipidemic rats. The levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) in hyperlipidemic rats were decreased by 25.45%, 52%, 48.28%, 29.81%, 16.63%, and 51.95%, respectively. The contents of superoxide dismutase (SOD), glutathione peroxidase (GPH-Px), catalase (CAT) and high-density lipoprotein cholesterol (HDL-C) were increased by 123.54%, 153.89%, 209.9% and 56.76%. Corn ferulic acid can improve the liver tissue structure of hyperlipidemia rats. Conclusion: Corn ferulic acid can reduce the body weight and liver index of hyperlipidemia rats, improve blood lipid metabolism, improve antioxidant ability, and alleviate liver damage caused by hyperlipidemia.
- core ferulic acid,
- hyperlipidemia,
- lipid metabolism,
- liver antioxidant

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