Effect of Corn Ferulic Acid on Lipid Metabolism and Liver Injury in Hyperlipidemia Rats

ZHANG Naidan; ZUO Zhaohang; WANG Ying; SUN Wei; PANG Weiqiao

doi:10.13386/j.issn1002-0306.2023020270

Volume 44 Issue 16

Aug. 2023

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2023 > 44(16): 8-14. > DOI: 10.13386/j.issn1002-0306.2023020270

ZHANG Naidan, ZUO Zhaohang, WANG Ying, et al. Effect of Corn Ferulic Acid on Lipid Metabolism and Liver Injury in Hyperlipidemia Rats[J]. Science and Technology of Food Industry, 2023, 44(16): 8−14. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023020270.

Citation:

PDF (10837 KB)

Effect of Corn Ferulic Acid on Lipid Metabolism and Liver Injury in Hyperlipidemia Rats

ZHANG Naidan^1,,
ZUO Zhaohang¹,
WANG Ying^{1, 2, 3, 4, ,},
SUN Wei¹,
PANG Weiqiao¹

1.
College of Food, Heilongjiang Bayi Agricultural University, Daqing 163319, China
2.
National Coarse Cereals Engineering Research Center, Daqing 163319, China
3.
Engineering Research Center of Processing and Utilization of Grain By-products, Ministry of Education, Daqing 163319, China
4.
Key Laboratory of Agro-Products Processing and Quality Safety of Heilongjiang province, Daqing 163319, China

More Information

Received Date: February 23, 2023
Available Online: June 13, 2023

Graphical Abstract

Abstract

Abstract

Objective: To investigate the effects of corn ferulic acid on lipid metabolism and liver injury in hyperlipidemic rats. Significance: To improve the added value of corn husk and provide theoretical basis and data support for the health effect of corn ferulic acid. Methods: Eight rats were randomly selected as the normal group, and the rest rats were fed with high-fat diet to establish the hyperlipidemia rat model. The hyperlipidemia rats were randomly divided into positive control group, model group and corn ferulic acid high, medium and low dose groups. After 42 days of gavage, the liver index, blood lipid, antioxidant index and liver sections were measured. Results: Compared with the model group, corn ferulic acid reduced 0.23% of the body weight growth rate and 0.14% of the liver index of the hyperlipidemic rats. The levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) in hyperlipidemic rats were decreased by 25.45%, 52%, 48.28%, 29.81%, 16.63%, and 51.95%, respectively. The contents of superoxide dismutase (SOD), glutathione peroxidase (GPH-Px), catalase (CAT) and high-density lipoprotein cholesterol (HDL-C) were increased by 123.54%, 153.89%, 209.9% and 56.76%. Corn ferulic acid can improve the liver tissue structure of hyperlipidemia rats. Conclusion: Corn ferulic acid can reduce the body weight and liver index of hyperlipidemia rats, improve blood lipid metabolism, improve antioxidant ability, and alleviate liver damage caused by hyperlipidemia.
- core ferulic acid,
- hyperlipidemia,
- lipid metabolism,
- liver antioxidant

FullText(HTML)

References (38)

References

[1]	STEWART J, MCCALLIN T, MARTINEZ J, et al. Hyperlipidemia[J]. Pediatr Rev,2020,41(8):393−402. doi: 10.1542/pir.2019-0053
[2]	胡慧明, 朱彦陈, 朱巧巧, 等. 实验性高脂血症动物模型比较分析[J]. 中国中药杂志,2016,41(20):3709−3714. [HU H M, ZHU Y C, ZHU Q Q, et al. Analysis on animal models of experimental hyperlipidemia[J]. China Journal of Chinese Materia Medica,2016,41(20):3709−3714. HU Huiming, ZHU Yanchen, ZHU Qiaoqiao, et al. Analysis on animal models of experimental hyperlipidemia[J]. China Journal of Chinese Materia Medica, 2016, 41(20): 3709-3714.
[3]	KJELDSEN E W, NORDESTGAARD L T, FRIKKE-SCHMIDT R. HDL Cholesterol and non-cardiovascular disease: A narrative review[J]. Int J Mol Sci,2021,22(9):4547. doi: 10.3390/ijms22094547
[4]	SIRTORI CR. The pharmacology of statins[J]. Pharmacol Res,2014,88:3−11. doi: 10.1016/j.phrs.2014.03.002
[5]	HIROTA T, FUJITA Y, IEIRI I. An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins[J]. Expert Opin Drug Metab Toxicol,2020,16(9):809−822. doi: 10.1080/17425255.2020.1801634
[6]	DINI I, GRUMETTO L. Recent advances in natural polyphenol research[J]. Molecules,2022,27(24):8777. doi: 10.3390/molecules27248777
[7]	肖宇, 张涛, 陈爱君, 等. 玉米麸皮阿拉伯木聚糖提取工艺优化及其凝胶特性研究[J/OL]. 食品工业科技, 1−14[2023-02-24]. https://doi.org/10.13386/j.issn1002-0306.2022020191. XIAO Y, ZHANG T, CHEN A J, et al. Optimization of extraction method of arabinoxylan from maize bran and analysis of its gel properties[J/OL]. Science and Technology of Food Industry, 1−14 [2023-02-24]. https://doi.org/10.13386/j.issn1002-0306.2022020191.
[8]	CHAUDHARY A, JASWAL VS, CHOUDHARY S, et al. Ferulic acid: A promising therapeutic phytochemical and recent patents advances[J]. Recent Pat Inflamm Allergy Drug Discov,2019,13(2):115−123. doi: 10.2174/1872213X13666190621125048
[9]	QIN F, HUANG X. Guanxin II (II) for the management of coronary heart disease[J]. Chin J Integr Med,2009,15(6):472−6. doi: 10.1007/s11655-009-0472-6
[10]	文为, 杨芰, 姚琰. 阿魏酸钠对冠心病病人SOD, LPO及纤溶系统的影响[J]. 中国药师,2002(9):555−556. [WEN W, YANG Z, TAO Y. Effect of sodium ferulate injection on superoxide dismutase, lipid peroxide, and fibrinolysis system in patients with coronary disease[J]. China Pharmacist,2002(9):555−556. WEN Wei, YANG Zhi, TAO Yan. Effect of Sodium Ferulate Injection on Superoxide Dismutase, Lipid Peroxide, and Fibrinolysis System in Patients with Coronary Disease[J]. China Pharmacist, 2002(9): 555-556.
[11]	JIN C, CHEN D, ZHU T, et al. Poly(ferulic acid)-hybrid nanofibers for reducing thrombosis and restraining intimal hyperplasia in vascular tissue engineering[J]. Biomater Adv,2023,146:213278. doi: 10.1016/j.bioadv.2023.213278
[12]	SHI Y, CHEN X, QIANG S, et al. Anti-oxidation and anti-Inflammatory potency evaluation of ferulicacid derivatives obtained through virtual screening[J]. Int J Mol Sc,2021,22(21):11305. doi: 10.3390/ijms222111305
[13]	HAN H, DYE L, MACKIE A. The impact of processing on the release and antioxidant capacity of ferulic acid from wheat: A systematic review[J]. Food Res Int,2023,164:112371. doi: 10.1016/j.foodres.2022.112371
[14]	GUPTA A, SINGH A K, LOKA M, et al. Ferulic acid-mediated modulation of apoptotic signaling pathways in cancer[J]. Adv Protein Chem Struct Biol,2021,125:215−257.
[15]	VILLANUEVA M P, GIOIA C, SISTI L, et al. Valorization of ferulic acid from agro-industrial by-products for application in agriculture[J]. Polymers,2022,14(14):2874. doi: 10.3390/polym14142874
[16]	谢伊莎, 傅新鑫, 郑佳楠, 等. 天然保鲜剂对预制南美白对虾贮藏品质的影响[J]. 食品工业科技,2021,42(4):264−270. [XIE Y S, FU X X, ZHENG J N, et al. Effects of bio-preservatives on the quality of pre-cooked pacific white shrimp (Penaeus vannamei) during refrigerated storage[J]. Science and Technology of Food Industry,2021,42(4):264−270. XIE Yisha, FU Xinxin, ZHENG Jianan, et al. Effects of bio-preservatives on the quality of pre-cooked pacific white shrimp (Penaeus vannamei) during refrigerated storage[J]. Science and Technology of Food Industry, 2021, 42(4): 264-270.
[17]	KAWABATA K, YAMAMOTO T, HARA A, et al. Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats[J]. Cancer Lett,2000,157(1):15−21. doi: 10.1016/S0304-3835(00)00461-4
[18]	张明, 林钦汉, 李少娟, 等. 乌司他丁和胸腺肽α1对脓毒症大鼠心肌的保护作用[J]. 中国现代医药杂志,2016,18(3):17−20. [ZHANG M, LIN Q H, LI S J, et al. The protective effect of ulinastatin and thymosin α1 against myocardial damage in septic rats[J]. China Journal of Modern Medicine,2016,18(3):17−20. ZHANG Ming, LIN Qinhan, LI Shaojuan, et al. The protective effect of ulinastatin and thymosin α1 against myocardial damage in septic rats[J]. China Journal of Modern Medicine, 2016, 18(3): 17-20.
[19]	秦楠, 王辉敏, 杨金梅, 等. 复合沙棘原液对高脂血症大鼠的降脂作用[J/OL]. 食品工业科技, 1−14[2023-03-07]. https://doi.org/10.13386/j.issn1002-0306.2022050091. QIN N, WANG H M, YANG J M, et al. Lipid-lowering effect of compound seabuckthorn concentrate on hyperlipidemic rats[J/OL]. Science and Technology of Food Industry, 1−14[2023-03-07]. https://doi.org/10.13386/j.issn1002-0306.2022050091.
[20]	JAIN PG, SURANA SJ. Isolation, characterization and hypolipidemic activity of ferulic acid in high-fat-diet-induced hyperlipidemia in laboratory rats[J]. EXCLI J,2016,15:599−613.
[21]	万雪琦. 低氧运动对肥胖大鼠血脂、肝脂、肝脏脂联素mRNA以及血清AST、ALT、FFA的影响[D]. 南昌: 江西师范大学, 2020. WAN X Q. Effects of hypoxia exercise on blood lipids, liver lipids, liver adiponectin mRNA and seurm AST, ALT in obese rats[D]. Nanchang: Jiangxi Normal University, 2020.
[22]	刘畅, 柴逸峰, 刘峰群. 中药有效成分降血脂作用和机制研究进展[J]. 药学实践杂志,2010,28(3):167−169, 195. [LIU C, CHAI Y F, LIU F Q. Research progress on the hypolipidemic effect and mechanism of effective components of traditional Chinese medicine[J]. Journal of Pharmaceutical Practice,2010,28(3):167−169, 195. LIU Chang, CHAI Yifeng, LIU Fengqun. Research progress on the hypolipidemic effect and mechanism of effective components of traditional Chinese medicine[J]. Journal of Pharmaceutical Practice, 2010, 28(3): 167-169, 195.
[23]	钱珊珊, 冯雪, 于彤, 等. 大豆活性肽对肥胖小鼠降脂作用的研究[J]. 食品工业科技,2021,42(3):310−314, 319. [QIAN S S, FENG X, YU T, et al. Study on the lipid-lowering effect of soybean active peptide on obese mice[J]. Science and Technology of Food Industry,2021,42(3):310−314, 319. QIAN Shanshan, FENG Xue, YU Tong, et al. Study on the lipid-lowering effect of soybean active peptide on obese mice[J]. Science and Technology of Food Industry, 2021, 42(3): 310-314, 319.
[24]	刘淑婷, 王颖, 王志辉, 等. 紫花芸豆抗性淀粉对高脂血症大鼠肝脏及肠屏障损伤的修复作用[J]. 食品科学,2020,41(21):106−112. [LIU S T, WANG Y, WANG Z H, et al. Repairing effect of resistant starch from purple speckled kidney beans (Phaseolus vulgaris) on liver and intestinal barrier injury in rats with hyperlipidemia[J]. Food Science,2020,41(21):106−112. LIU Shuting, WANG Ying, WANG Zhihui, et al. Repairing effect of resistant starch from purple speckled kidney beans (Phaseolus vulgaris) on liver and intestinal barrier injury in rats with hyperlipidemia[J]. Food Science, 2020, 41(21): 106-112.
[25]	贺茜影, 郑红梅, 陈心涛, 等. 阿托伐他汀联合维生素B₁₂对冠心病合并高脂血症患者的治疗效果及内皮功能的影响[J]. 临床研究,2023,31(3):85−88. [HE X Y, ZHENG H M, CHEN X T, et al. Effect of atorvastatin combined with vitamin B₁₂ on the therapeutic effect and endothelial function of patients with coronary heart disease complicated with hyperlipidemia[J]. Clinical Research,2023,31(3):85−88. HE Xiying, ZHENG Hongmei, CHEN Xintao, et al. Effect of atorvastatin combined with vitamin b₁₂ on the therapeutic effect and endothelial function of patients with coronary heart disease complicated with hyperlipidemia[J]. Clinical Research, 2023, 31(3): 85-88.
[26]	姜金池. 益生菌对高胆固醇血症的缓解作用及机制研究[D]. 无锡: 江南大学, 2021. JIANG J C. Alleviating effects of probiotics on hypercholesterolemia and potential mechanisms[D]. Wuxi: Jiangnan University, 2021.
[27]	魏连会, 宋淑敏, 董艳, 等. 火麻籽多肽对高脂饮食喂养大鼠血脂的影响[J]. 食品科学,2021,42(11):161−167. [WEI L H, SONG S M, DONG Y, et al. Effect of hemp seed peptide on blood lipids in high-fat diet fed rats[J]. Food Science,2021,42(11):161−167. WEI Lianhui, SONG Shumin, DONG Yan, et al. Effect of hemp seed peptide on blood lipids in high-fat diet fed rats[J]. Food Science, 2021, 42(11): 161-167.
[28]	潘奕鸥, 王薇薇, 李爱科, 等. 阿魏酸对ob/ob小鼠脂肪沉积及腹脂脂肪酸组成的影响[J]. 动物营养学报,2016,28(7):2140−2146. [PAN Y O, WANG W W, LI A K, et al. Effects of ferulic acid on lipid deposition and fatty acid composition in abdominal lipid of ob/ob mice[J]. Chinese Journal of Animal Nutrition,2016,28(7):2140−2146. PAN Yiou, WANG Weiwei, LI Aike, et al. Effects of ferulic acid on lipid deposition and fatty acid composition in abdominal lipid of ob/ob Mice[J]. Chinese Journal of Animal Nutrition, 2016, 28(7): 2140-2146.
[29]	LUO Y, KANG J, LUO J, et al. Hepatocytic AP-1 and STAT3 contribute to chemotaxis in alphanaphthylisothiocyanate-induced cholestatic liver injury[J]. Toxicol Lett,2023,373:184−193. doi: 10.1016/j.toxlet.2022.11.020
[30]	LU Y, WANG Q, YU L, et al. Revision of serum ALT upper limits of normal facilitates assessment of mild liver injury in obese children with non-alcoholic fatty liver disease[J]. J Clin Lab Anal,2020,34(7):e23285.
[31]	黄丹, 贾忠萍, 白雪琴, 等. 谷草转氨酶与代谢综合征的相关性研究[J]. 中国医药导报,2017,14(23):114−117. [HUANG D, JIA Z P, BAI X Q, et al. Association between aspartate aminotransferase and metabolic syndrome[J]. China Medical Herald,2017,14(23):114−117. HUANG Dan, JIA Zhongping, BAI Xueqin, et al. Association between aspartate aminotransferase and metabolic syndrome[J]. China Medical Herald, 2017, 14(23): 114-117.
[32]	白迎春, 石松利, 周红兵, 等. 长柄扁桃正丁醇提取物对高脂饮食大鼠的降血脂作用[J]. 内蒙古中医药,2022,41(3):120−123. [BAI Y C, SHI S L, ZHOU H B, et al. Effect of n-butanol extract of Amygdalus pedunculata on lowering blood lipid in rats on high-fat diet[J]. Nei Mongol Journal of Traditional Chinese Medicine,2022,41(3):120−123. BAI Yingchun, SHI Songli, ZHOU Hongbing, et al. Effect of n-butanol extract of Amygdalus pedunculata on lowering blood lipid in rats on high-fat diet[J]. Nei Mongol Journal of Traditional Chinese Medicine, 2022, 41(3): 120-123.
[33]	徐诗雨, 唐子婷, 孙雅荻, 等. 阿魏酸对镉致小鼠急性肝损伤的保护作用[J]. 饲料工业,2022,43(14):36−41. [XU S Y, TANG Z T, SUN Y D, et al. Protective effect of ferulic acid on acute liver injury induced by cadmium in mice[J]. Feed Industry,2022,43(14):36−41. XU Shiyu, TANG Ziting, SUN Yadi, et al. Protective effect of ferulic acid on acute liver injury induced by cadmium in mice[J]. Feed Industry, 2022, 43(14): 36-41.
[34]	王欣卉, 王颖, 徐炳政, 等. 酵母源金属硫蛋白排汞及对汞致肝脏及机体氧化损伤的修复作用[J]. 食品科学,2017,38(17):233−237. [WANG X H, WANG Y, XU B Z, et al. Effect of yeast metallothioneins on mercury elimination and repairing of mercury-induced acute body and liver injury[J]. Food Science,2017,38(17):233−237. doi: 10.7506/spkx1002-6630-201717038 WANG Xinhui, WANG Ying, XU Bingzheng, et al. Effect of yeast metallothioneins on mercury elimination and repairing of mercury-induced acute body and liver injury[J]. Food Science, 2017, 38(17): 233-237. doi: 10.7506/spkx1002-6630-201717038
[35]	綦文涛, 王世霞, 李笑蕊, 等. 荞麦粉对高脂血症小鼠血脂和肝脏抗氧化功能的调节作用[J]. 中国食品学报,2018,18(2):63−70. [QI W T, WANG S X, LI X R, et al. Regulation function of buckwheat on blood lipid and liver anti-oxidation of hyperlipemia mice[J]. Journal of Chinese Institute of Food Science and Technology,2018,18(2):63−70. QI Wentao, WANG Shixia, LI Xiaorui, et al. Regulation function of buckwheat on blood lipid and liver anti-oxidation of hyperlipemia mice[J]. Journal of Chinese Institute of Food Science and Technology, 2018, 18(2): 63-70.
[36]	杨文娟, 程世蕊, 马养民, 等. 裂叶荨麻对糖尿病小鼠肝脏损伤的保护作用[J]. 食品工业科技,2019,40(11):313−317. [YANG W J, CHENG S R, MA Y M, et al. Protective effect of Urtica fissa on the liver injury in diabetic mice[J]. Science and Technology of Food Industry,2019,40(11):313−317. YANG Wenjuan, CHENG Shirui, MA Yangmin, et al. Protective effect of Urtica fissa on the liver injury in diabetic mice[J]. Science and Technology of Food Industry, 2019, 40(11): 313-317.
[37]	REITER RJ, TAN DX, BURKHARDT S. Reactive oxygen and nitrogen species and cellular and organismal decline: Amelioration with melatonin[J]. Mech Ageing Dev,2002,123(8):1007−1019. doi: 10.1016/S0047-6374(01)00384-0
[38]	唐祯, 许军, 徐彭, 等. 阿魏酸结构改造新化合物对大鼠高脂血症的影响及机制[J]. 时珍国医国药,2013,24(6):1369−1371. [TANG Z, XU J, XU P, et al. Effect and mechanism of ferulic acid structural modification compound on hyperlipidemia in rats[J]. Lishizhen Medicine and Materia Medica Research,2013,24(6):1369−1371. TANG Zhen, XU Jun, XU Peng, et al. Effect and mechanism of ferulic acid structural modification compound on hyperlipidemia in rats[J]. Lishizhen Medicine and Materia Medica Research, 2013, 24(6): 1369-1371.