Advance on Inflammation-mediated Relationship between Obesity and Type 2 Diabetes Mellitus and Developments in Corresponding Treatment of Dietary Intervention

PU Xinyi; ZHANG Linling; BAO Bin

doi:10.13386/j.issn1002-0306.2022040111

Volume 44 Issue 4

Feb. 2023

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Science and Technology of Food Industry > 2023 > 44(4): 472-479. > DOI: 10.13386/j.issn1002-0306.2022040111

PU Xinyi, ZHANG Linling, BAO Bin. Advance on Inflammation-mediated Relationship between Obesity and Type 2 Diabetes Mellitus and Developments in Corresponding Treatment of Dietary Intervention[J]. Science and Technology of Food Industry, 2023, 44(4): 472−479. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022040111.

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Advance on Inflammation-mediated Relationship between Obesity and Type 2 Diabetes Mellitus and Developments in Corresponding Treatment of Dietary Intervention

PU Xinyi^1,,
ZHANG Linling^{1, +,},
BAO Bin^{2, 3, ,}

1.
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China
2.
Shanghai Engineering Research Center of Aquatic Product Processing and Preservation, Shanghai 201306, China
3.
Institute of Marine Science, Shanghai Ocean University, Shanghai 201306, China

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Received Date: April 11, 2022
Available Online: December 12, 2022

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Abstract

Type 2 diabetes mellitus arising from obesity is one of the most serious noncommunicable diseases which currently have serious impacts on human health. Chronic inflammation in adipose tissue is the key to developing type 2 diabetes mellitus in obese people. This paper firstly reviews the progress in the relationship between obesity mediated by inflammation and type 2 diabetes mellitus from the cellular and molecular levels, focusing on immune cells and signaling pathways. Secondly, it summarizes the results of dietary intervention in targeting immunocytes and signaling pathways, which can adjust the polarization of macrophages, the function of T cells and the activities of various signaling pathways in order to seek the special medical purposes with safe, healthy and efficient lowering blood glucose, so as to provide ideas and programs for the dietary intervention of type 2 diabetes mellitus.
- type 2 diabetes mellitus,
- obesity,
- inflammation,
- immunocytes,
- dietary intervention

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References

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