Research Progress on Bioactivities of Oleuropein

WANG Qian; GE Yiqing; TONG Tao

doi:10.13386/j.issn1002-0306.2021110063

Volume 43 Issue 19

Sep. 2022

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Science and Technology of Food Industry > 2022 > 43(19): 479-486. > DOI: 10.13386/j.issn1002-0306.2021110063

WANG Qian, GE Yiqing, TONG Tao. Research Progress on Bioactivities of Oleuropein[J]. Science and Technology of Food Industry, 2022, 43(19): 479−486. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021110063.

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Research Progress on Bioactivities of Oleuropein

WANG Qian^1,,
GE Yiqing¹,
TONG Tao^{1, 2, 3, ,}

1.
Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
2.
Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), the Ministry of Agriculture and Rural Affairs of the P. R. China, Beijing 100083, China
3.
Beijing Laboratory for Food Quality and Safety, Beijing 100083, China

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Received Date: November 07, 2021
Available Online: July 27, 2022

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Abstract

Abstract

Oleuropein is a natural cleaved cyclic enol ether glucoside polyphenolic compound, which has bioactivities such as antioxidant, anti-inflammatory, and anti-apoptotic. It can improve human chronic diseases such as hyperglycemia, hypertension, hyperlipidemia, obesity, and cancer by regulating body metabolism, modulating gene expression and changing enzyme activity. At the same time, it has a protective and restorative effect on various organs. This article summarizes and compares the latest research on the bioactivities of oleuropein, with the aim of providing a scientific evidence for the development and application of oleuropein in food, medicine, and health products.
- olive,
- olive leaf extracts,
- oleuropein,
- bioactivities

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References (75)

References

[1]	杨永兴, 张军, 张正武, 等. 陇南市油橄榄产业对区域经济增长的实践分析[J]. 中国食品,2021(17):120−121. [YANG Y X, ZHANG J, ZHANG Z W, et al. Practice analysis on the regional economic growth of olive industry in Longnan[J]. China Food,2021(17):120−121. doi: 10.3969/j.issn.1000-1085.2021.17.050 YANG Y X, ZHANG J, ZHANG Z W, et al. Practice analysis on the regional economic growth of olive industry in Longnan[J]. China Food, 2021(17): 120-121. doi: 10.3969/j.issn.1000-1085.2021.17.050
[2]	王碧霞, 杜小奇, 邓燕, 等. 凉山主栽品种油橄榄叶中营养物质和酚类含量的季节性变化[J]. 南京林业大学学报(自然科学版),2022,46(4):169−176. [WANG B X, DU X Q, DENG Y, et al. Seasonal variations of the nutrients and phenols from olive leaves in main cultivation varieties at Liangshan[J]. Journal of Nanjing Forestry University (Natural Sciences Edition),2022,46(4):169−176. WANG B X, DU X Q, DENG Y, et al. Seasonal variations of the nutrients and phenols from olive leaves in main cultivation varieties at Liangshan[J]. Journal of Nanjing Forestry University (Natural Sciences Edition), 2022, 46(4): 169-176.
[3]	PAULO F, SANTOS L. Deriving valorization of phenolic compounds from olive oil by-products for food applications through microencapsulation approaches: A comprehensive review[J]. Critical Reviews in Food Science and Nutrition,2020,61:1−26.
[4]	王碧霞. 油橄榄叶提取物生物活性研究进展[J]. 绿色科技,2017(14):278−282. [WANG B X. Research progress on bioactivities of olea europaea leaf extract[J]. J Green Sci Tech,2017(14):278−282. WANG B X. Research progress on bioactivities of olea europaea leaf extract[J]. J Green Sci Tech, 2017(14): 278-282.
[5]	MARTIN B, ERIC B, DERRAIK G B, et al. Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract[J]. Mol Nutr Food Res,2013,57(11):2079−2085. doi: 10.1002/mnfr.201200795
[6]	VISIOLI F, GALLI C, BORNET F, et al. Olive oil phenolics are dose-dependentlyabsorbed in humans[J]. FEBS Lett,2000,468:159−160. doi: 10.1016/S0014-5793(00)01216-3
[7]	HAZAS M L, PIOL C, MACI A, et al. Differential absorption and metabolism of hydroxytyrosol and its precursors oleuropein and secoiridoids[J]. J Funct Foods,2016,22:52−63. doi: 10.1016/j.jff.2016.01.030
[8]	PETKOV V, MANOLOV P. Pharmacological analysis of the iridoid oleuropein[J]. Arzneimittel-Forsch,1972,22(9):1476−1486.
[9]	ENDANG S, NAFRIALDI A, IMAM E, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: Comparison with captopril[J]. Phytomedicine,2011,18(4):251−258. doi: 10.1016/j.phymed.2010.08.016
[10]	ZHENG S J, HUANG K L, TONG T. Efficacy and mechanisms of oleuropein in mitigating diabetes and diabetes complications[J]. J Agric Food Chem,2021,69:6145−6155. doi: 10.1021/acs.jafc.1c01404
[11]	JAVED A, IBRAHIM T, AHMED K M, et al. Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome[J]. Phytotherapy Res,2019,33(12):3112−3128. doi: 10.1002/ptr.6511
[12]	DEBORAH M O, FERNANDA M O, ALEXANDRE L, et al. Oleuropein: Methods for extraction, purifying and applying[J]. Rev Ceres,2020,67(4):315−329. doi: 10.1590/0034-737x202067040009
[13]	EMINE N, SEMIH O. The optimization of solid-liquid extraction of polyphenols from olive stone by response surface methodology[J]. J Food Measurement and Characterization,2019,13(2):1497−1507. doi: 10.1007/s11694-019-00065-z
[14]	GZELMERIC E, EVIK D, YEILADA E. Quality assessment of marketed food supplements and herbal tea products of olive leaf in Turkey[J]. J Res Pharm,2020,24:1−11.
[15]	CONTRERAS M M, LAMA A, ESPNOLA F, et al. Valorization of olive mill leaves through ultrasound-assisted extraction[J]. Food Chem,2020:314.
[16]	HUGUET A, LPEZ T B, GAINZA E, et al. Development and validation of an eco-friendly HPLC-DAD method for the determination of oleuropein and its applicability to several matrices: Olive oil, olive leaf extracts and nanostructured lipid carriers[J]. Green Chem,2020(22):3495−3505.
[17]	FKI I, SAYADI S, MAHMOUDI A, et al. Comparative study on beneficial effects of hydroxytyrosol- and oleuropein-rich olive leaf extracts on high-fat diet-induced lipid metabolism disturbance and liver injury in rats[J]. Biomed Res Int,2020,2020:1315202.
[18]	STEVENS Y, WINKENS B, JONKERS D, et al. The effect of olive leaf extract on cardiovascular health markers: A randomized placebo-controlled clinical trial[J]. Eur J Nutr,2020,60(4):2111−2120.
[19]	JEMAI H, MAHMOUDI A, FERYENI A, et al. Hepatoprotective effect of oleuropein-rich extract from olive leaves against cadmium-induced toxicity in mice[J]. Biotech Week,2020,2020:4398924.
[20]	DA G S, VANGA S K, GARIEPY Y, et al. Development of biodegradable films with improved antioxidant properties based on the addition of carrageenan containing olive leaf extract for food packaging applications[J]. J Polym Environ,2020,28(1):123−130. doi: 10.1007/s10924-019-01589-7
[21]	KURTULBAS E, YAZAR S, ORTABOY S, et al. Evaluation of the phenolic antioxidants of olive (Olea europaea) leaf extract obtained by a green approach: Use of reduced graphene oxide for electrochemical analysis[J]. Chem Eng Commun,2020,207:920−932. doi: 10.1080/00986445.2019.1630397
[22]	MAETNEZ E M, CEBRIN C, MORATALLA N, et al. Development and validation of an HPLC-DAD method for determination of oleuropein and other bioactive compounds in olive leaf by-products[J]. J Sci Food Agric,2020,101:1447−1453.
[23]	PASKOVI I, HERAK M, PECINA M, et al. Manganese soil and foliar fertilization of olive plantlets: The effect on leaf mineral and phenolic content and root mycorrhizal colonization[J]. J Sci Food Agric,2019,99:360−367. doi: 10.1002/jsfa.9196
[24]	ROJAS D, DELLA P F, DEL CARLO M, et al. Nanohybrid carbon black-molybdenum disulfide transducers for preconcentration-free voltammetric detection of the olive oil o-diphenols hydroxytyrosol and oleuropein[J]. MCA Acta,2019,186:363.
[25]	CECCHI L, GUERRINI L, BELLUMORI M, et al. Optimization of the production process of dried unripe olives (Olea europaea L.) as a nutraceutical ingredient naturally rich in phenolic compounds[J]. LWT-Food Sci Technol,2020,129:109569. doi: 10.1016/j.lwt.2020.109569
[26]	CABRERA M, SCHAIDE T, MANZANO R, et al. Optimization and validation of a rapid liquid chromatography method for determination of the main polyphenolic compounds in table olives and in olive paste[J]. Food Chem,2017,233:164−173. doi: 10.1016/j.foodchem.2017.04.052
[27]	MECHRI B, TEKAYA M, ATTIA F, et al. Drought stress improved the capacity of Rhizophagus irregularis for inducing the accumulation of oleuropein and mannitol in olive (Olea europaea) roots[J]. Plant Physiol Bioch,2020,156:178−191.
[28]	THAMMARAT A, SUCHADA J. Structure-antioxidant activity relationship of β-cyclodextrin inclusion complexes with olive tyrosol, hydroxytyrosol and oleuropein: Deep insights from X-ray analysis, DFT calculation and DPPH assay[J]. Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2018,199:661−669.
[29]	吴遵秋, 姜友军, 苏光灿, 等. 油橄榄叶中橄榄苦苷的体外抗氧化和抑菌活性[J]. 食品科学,2014,35(21):94−99. [WU Z Q, JIANG Y J, SU G C, et al. Antioxidant and antimicrobial activities of oleuropein in vitro[J]. Food Chem,2014,35(21):94−99. doi: 10.7506/spkx1002-6630-201421019 WU Z Q, JIANG Y J, SU G C, et al. Antioxidant and antimicrobial activities of oleuropein in vitro[J]. Food Chem, 2014, 35(21): 94-99. doi: 10.7506/spkx1002-6630-201421019
[30]	李文杰, 李静. 橄榄苦苷对H₂O₂诱导的PC12氧化应激损伤的保护作用[J]. 中医药学报,2019,47(3):37−41. [LI W J, LI J. Effect of oleuropein against H₂O₂-induced oxidative stress damage in PC12[J]. Journal of Traditional Chinese Medicine,2019,47(3):37−41. LI W J, LI J. Effect of oleuropein against H₂O₂-induced oxidative stress damage in PC12[J]. Journal of Traditional Chinese Medicine, 2019, 47(3): 37-41.
[31]	王昱, 秦序. 橄榄苦苷对D-半乳糖致衰老小鼠衰老相关生化指标的影响[J]. 安徽农业大学学报,2016,43(1):17−20. [WANG Y, QIN X. Effect of oleuropein on the aging related biochemical indexes in aging mice induced by D-galactose[J]. Journal of Anhui Agricultural University,2016,43(1):17−20. WANG Y, QIN X. Effect of oleuropein on the aging related biochemical indexes in aging mice induced by D-galactose[J]. Journal of Anhui Agricultural University, 2016, 43(1): 17-20.
[32]	SHAFIQUE K, MIRZA S S, VART P, et al. Areca nut chewing and systemic inflammation: Evidence of a common pathway for systemic diseases[J]. J Inflam,2012,9(1):22−30. doi: 10.1186/1476-9255-9-22
[33]	NEDIANI C, RUZZOLINI J, ROMANI A, et al. Oleuropein, a bioactive compound from Olea europaea L., as a potential preventive and therapeutic agent in non-communicable diseases[J]. Antioxidants,2019,8(12):578. doi: 10.3390/antiox8120578
[34]	曹位平, 郭建淑, 冯文静, 等. 橄榄苦苷对缺血再灌注大鼠心肌应激性炎症损伤的保护作用[J/OL]. 中国免疫学杂志: 1−15. https://kns.cnki.net/kcms/detail/22.1126.R.20210930.1633.002.html CAO W P, GUO J S, FENG W J, et al. Protective effect of oleuropein on stress-induced inflammatory injury in myocardial ischemia-reperfusion rats[J]. Chinese Journal of Immunology: 1−15.
[35]	KHALAF F A, ABDULRAHEEM A, OSAMA A, et al. Oleuropein protects against lipopolysaccharide-induced sepsis and alleviates inflammatory responses in mice[J]. IUBMB Life,2020,72(10):2121−2132. doi: 10.1002/iub.2347
[36]	MURAT T M, HATICE B Y, OZKAN K, et al, Evaluation of the effect of oleuropein on alveolar bone loss, inflammation, and apoptosis in experimental periodontitis[J]. Journal of Periodonatal Research, 2019, 54(6): 624-632.
[37]	韩珊, 王琴琴, 李新星, 等. 基于Nrf2/HO-1信号通路研究橄榄苦苷的体外抗炎作用[J]. 药物评价研究,2020,43(2):193−198. [HAN S, WANG Q Q, LI X X, et al. Oleuropein exerts anti-inflammatory effect in vitro via Nrf2/HO-1 signaling pathway[J]. Drug Evaluation Research,2020,43(2):193−198. HAN S, WANG Q Q, LI X X, et al. Oleuropein exerts anti-inflammatory effect in vitro via Nrf2/HO-1 signaling pathway[J]. Drug Evaluation Research, 2020, 43(2): 193-198.
[38]	SIEGEL R L, MILLER K D, DVM A J. Cancer statistics, 2019[J]. CA Cancer J Clin,2019,69:7−34. doi: 10.3322/caac.21551
[39]	GAETANO L, CARLA F, MARILENA C, et al. Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases[J]. Life Sci,2021:279.
[40]	李天柱, 崔凤姬, 白雪, 等. 橄榄苦苷对肝癌HepG2细胞迁移和侵袭能力的影响[J]. 赤峰学院学报(自然科学版),2021,37(3):41−43. [LI T Z, CUI F J, BAI X, et al. Effect of oleuropein on the migration and invasion ability of hepatocellular carcinoma HepG2 cells[J]. Journal of Chifeng College (Natural Science Edition),2021,37(3):41−43. LI T Z, CUI F J, BAI X, et al. Effect of oleuropein on the migration and invasion ability of hepatocellular carcinoma HepG2 cells[J]. Journal of Chifeng College (Natural Science Edition), 2021, 37(3): 41-43.
[41]	田凤. 橄榄苦苷对胃癌的抑制作用及分子机制研究[D]. 咸宁: 湖北科技学院, 2021. TIAN F. Research on the inhibitory effect and molecular mechanism of oleuropein on gastric cancer[D]. Xianning: Hubei University of Science and Technology, 2021.
[42]	SOMAYEH H S, ZEINAB A, SHIMA R, et al. Oleuropein reduces cisplatin resistance in ovarian cancer by targeting apoptotic pathway regulators[J]. Life Sci,2021:278.
[43]	田凤, 龙梦晖, 宁志丰, 等. 橄榄苦苷对人前列腺癌PC-3细胞增殖、迁移侵袭及凋亡的影响[J]. 湖北科技学院学报(医学版),2021,35(4):289−291, 272. [TIAN F, LONG M H, NING Z F, et al. Effects of oleuropein on the proliferation, migration invasion and apoptosis of human prostate cancer PC-3 cells[J]. Journal of Hubei Science and Technology College (Medical Edition),2021,35(4):289−291, 272. TIAN F, LONG M H, NING Z F, et al. Effects of oleuropein on the proliferation, migration invasion and apoptosis of human prostate cancer PC-3 cells[J]. Journal of Hubei Science and Technology College(Medical Edition), 2021, 35(4): 289-291, 272.
[44]	HAMED M M, HANDOUSSA H, HUSSEIN N H, et al. Oleuropein controls miR-194/XIST/PD-L1 loop in triple negative breast cancer: New role of nutri-epigenetics in immune-oncology[J]. Life Sci,2021,277:119353. doi: 10.1016/j.lfs.2021.119353
[45]	SANTINI S J, PORCU C, TARANTINO G, et al. Antioxidant and anti-inflammatory effect of oleuropein in hepatic steatosis[J]. Digest Liver Dis,2020,52(Supl 1):e32.
[46]	ARCIELLO M, BARBARO B, LONGO A, et al. Oleuropein reduces inflammatory mediators and hepatic immune cells infiltration in a mouse model of NAFLD[J]. Digest Liver Dis,2015,47:e24.
[47]	CRISTIANA P, SILVIA S, MAURIZIO M, et al. Oleuropein induces AMPK-dependent autophagy in NAFLD mice, regardless of the gender[J]. Int J Mol Sci,2018,19(12):3948. doi: 10.3390/ijms19123948
[48]	AYAT K, ALI S, MOHAMMAD A, et al. The effect of oleuropein on unilateral ureteral obstruction induced-kidney injury in rats: The role of oxidative stress, inflammation and apoptosis[J]. Molecular Biology Reports,2020,47(2):1371−1379. doi: 10.1007/s11033-019-05237-0
[49]	NASRALLAH H, AISSA I, SLIM C, et al. Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney[J]. Life Sciences,2020,255(C):117833.
[50]	YIN M, JIANG N, GUO L H, et al. Oleuropein suppresses oxidative, inflammatory, and apoptotic responses following glycerol-induced acute kidney injury in rats[J]. Life Sciences,2019,232(C):116634.
[51]	KAIS M, LAKHDAR G, RAOUF H, et al. Oleuropein protects against cerebral ischemia injury in rats: Molecular docking, biochemical and histological findings[J]. Neurochem Res,2021:1−12.
[52]	王昱, 秦序. 橄榄苦苷对小鼠脑缺血再灌注损伤的保护作用[J]. 中国畜牧兽医,2016,43(9):2388−2394. [WANG Y, QIN X. Protective effect of oleuropein on cerebral ischemia-reperfusion injury in mice[J]. China Animal Husbandry and Medicine,2016,43(9):2388−2394. WANG Y, QIN X. Protective effect of oleuropein on cerebral ischemia-reperfusion injury in mice[J]. China Animal Husbandry and Medicine, 2016, 43(09): 2388-2394.
[53]	于海龙, 姜超, 徐耀, 等. 橄榄苦苷对脑缺血再灌注损伤的神经保护作用[A]. 中华医学会第十七次全国神经病学学术会议论文汇编(下), 2014. YU H L, JIANG C, XU Y, et al. Neuroprotective effect of oleuropein on cerebral ischemia-reperfusion injury[A]. Compilation of papers from the 17th National Neurology Conference of the Chinese Medical Association, 2014.
[54]	FARHAD S, ALI S, IMAN F, et al. Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats[J]. Naunyn-Schmiedeberg's Archives of Pharmacology,2019,392(11):1383−1391. doi: 10.1007/s00210-019-01678-3
[55]	ZHENG S J, WANG Y N, FANG J J, et al. Oleuropein ameliorates advanced stage of type 2 diabetes in db/db mice by regulating gut microbiota[J]. Nutrition,2021,13(7):2131.
[56]	候丹, 刘铜华. 橄榄苦苷对糖尿病小鼠肝脏糖代谢的作用及机制[J]. 中国实验方剂学杂志,2018,24(23):134−139. [HOU D, LIU T H. Effect and mechanism of oleuropein on glucose metabolism of liver in diabetic mice[J]. Chinese Journal of Experimental Traditional Medical Formulae,2018,24(23):134−139. HOU D, LIU TH. Effect and mechanism of oleuropein on glucose metabolism of liver in diabetic mice[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2018, 24(23): 134-139.
[57]	ALI C. Inhibition of human islet amyloid polypeptide aggregation and cellular toxicity by oleuropein and derivatives from olive oil[J]. Alzheimer's and Dementia,2020,16(53):e047624.
[58]	ZHANG Z W, ZHAO H, WANG A X. Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling[J]. Endocr Connect,2021,10(1):45−53. doi: 10.1530/EC-20-0466
[59]	CARNEVAL R, SILVESTRI R, LOFFREDO L, et al. Oleuropein, a component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects[J]. Brit J Clin Pharmaco,2018,84(7):1566−1574. doi: 10.1111/bcp.13589
[60]	许二平. 橄榄降脂胶囊调节高脂血症大鼠血脂及载脂蛋白AI、B的研究[J]. 中国中医基础医学杂志,2009,15(10):745−747. [XU E P. Effect of olive antihyperlipidemia capsule on lipids and apolipoprotein AI, B in hyperlipmia rat liver[J]. Chinese Journal of Basic Medicine in Traditional Chinese Medicine,2009,15(10):745−747. XU E P. Effect of olive antihyperlipidemia Capsule on Lipids and apolipoprotein AI、B in hyperlipmia rat liver[J]. Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 2009, 15(10): 745-747.
[61]	MALLIOU F, ANDREADOU I, GONZALEZ F J, et al. The olive constituent oleuropein, as a PPARα agonist, markedly reduces serum triglycerides[J]. J Nutr Bio chem,2018,59:17−28. doi: 10.1016/j.jnutbio.2018.05.013
[62]	ASMA M, FATMA H, INES F, et al. Oleuropein and hydroxytyrosol rich extracts from olive leaves attenuate liver injury and lipid metabolism disturbance in bisphenol a-treated rats[J]. Food Funct,2018,9(6):3220−3234. doi: 10.1039/C8FO00248G
[63]	段文达, 冯玥, 黄新异, 等. 油橄榄叶提取物对三种实验动物模型的降糖降脂作用研究[J]. 中药药理与临床,2020,36(6):125−130. [DUAN W D, FENG Y, HUANG X Y, et al. Study of hypoglycaemic and antihyperlipidemic effects of Olea europaea L. leaves extract on three experimental animal models[J]. Chinese Pharmacology and Clinical,2020,36(6):125−130. DUAN W D, FENG Y, HUANG X Y, et al. Study of hypoglycaemic and antihyperlipidemic effects of Olea europaea L. Leaves extract on three experimental animal models[J]. Chinese Pharmacology and Clinical, 2020, 36(06): 125-130.
[64]	TONG T, WANG Y N, ZHANG C M, et al. In vitro andin vivo antihypertensive and antioxidant activities of fermented roots of Allium hookeri[J]. Chin Herb Med,2021,13(4):541−548.
[65]	田志祥, 冯坤苗, 狄志彪, 等. 橄榄苦苷的提取优化及其降压活性研究[J]. 中国食品添加剂,2015(10):82−87. [TIAN Z X, FENG K M, DI Z B, et al. The optimization of extracting conditions of oleuropein and its antihypertension effect[J]. China Food Additives,2015(10):82−87. doi: 10.3969/j.issn.1006-2513.2015.10.007 TIAN Z X, FENG K M, DI Z B, et al. The optimization of extracting conditions of oleuropein and its antihypertension effect[J]. China Food Additives, 2015(10): 82-87. doi: 10.3969/j.issn.1006-2513.2015.10.007
[66]	SONJA I, NENAD S, NIKOLA S, et al. Effects of oleuropein on rat's atria and thoracic aorta: A study of antihypertensive mechanisms[J]. Can J Physiol Pharm,2021,99(1):110−114. doi: 10.1139/cjpp-2020-0363
[67]	SUN W Y, WANG X, HOU C, et al. Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats[J]. Neuropharmacology,2017,113(Pt A):556−566.
[68]	王以撒, 李文兰, 孙加琳, 等. 天然产物抗肥胖活性的研究进展[J]. 中药药理与临床,2021,37(3):235−240. [WANG Y S, LI W L, SUN J L, et al. Research progress on anti-obesity activity of natural products[J]. Pharmacology and Clinics of Chinese Materia Medica,2021,37(3):235−240. WANG Y S, LI W L, SUN J L, et al. Research progress on anti-Obesity activity of natural products[J]. Pharmacology and Clinics of Chinese Materia Medica, 2021, 37(03): 235-240.
[69]	LEPORE S M, MORITTU V M, CELANO M, et al. Oral administration of oleuropein and its semisynthetic peracetylated derivative prevents hepatic steatosis, hyperinsulinemia, and weight gain in mice fed with high fat cafeteria diet[J]. Int J Endocrinol,2015:431453.
[70]	NARAE K, SONG S J, YU R N, et al. Oleuropein attenuates visceral adiposity in high-fat diet-induced obese mice through the modulation of WNT10b- and galanin-mediated signalings[J]. Mol Nutr Food Res,2014,58(11):2166−2176. doi: 10.1002/mnfr.201400159
[71]	INGE S, ELISE F, HANS J M, et al. Nutraceutical oleuropein supplementation prevents high fat diet-induced adiposity in mice[J]. Journal of Functional Foods,2015,14:702−715. doi: 10.1016/j.jff.2015.02.040
[72]	RIHAM G, MAHA R, NOHA M, et al. Oleuropein as a novel topical antipsoriaticnutraceutical: Formulation in microemulsion nanocarrier and exploratory clinical appraisal[J]. Expert Opin Drug Del,2021,18(10):1523−1532. doi: 10.1080/17425247.2021.1932813
[73]	TONG T, KIM N, PARK T. Topical application of oleuropein induces anagen hair growth in telogen mouse skin[J]. PLoS One,2017,10(6):e0129578.
[74]	陈静, 魏鉴腾, 裴栋, 等. 橄榄苦苷对酪氨酸酶抑制作用的研究[J]. 天然产物研究与开发, 2021, 33(12): 1998-2003. CHEN J, WEI J T, PEI D, et al. Study on the inhibitory effect of oleuropein on tyrosinase[J]. Nat Prod Res Dev, 2021, 33(12): 1998-2003.
[75]	杨阳, 鲁军, 孙冰洁, 等. 白藜芦醇对酪氨酸酶体外抑制活性的动力学研究[J]. 食品与生物技术学报,2011,30(4):632−635. [YANG Y, LU J, SUN B J, et al. Inhibitory kinetics study of resveratrol on tyrosinase activity in vitro[J]. J Food Sci Biotech,2011,30(4):632−635. YANG Y, LU J, SUN BJ, et al. Inhibitory kinetics study of resveratrol on tyrosinase activity in vitro[J]. J Food Sci Biotech, 2011, 30(04): 632-635.

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