Research Progress on Bioactivity and Product Development of <i>Codonopsis pilosula</i> Polysaccharide

TANG Mengjia; LIU Qingqing; LIU Yanxin; WANG Yicui

doi:10.13386/j.issn1002-0306.2021100038

Volume 43 Issue 20

Oct. 2022

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2022 > 43(20): 464-470. > DOI: 10.13386/j.issn1002-0306.2021100038

TANG Mengjia, LIU Qingqing, LIU Yanxin, et al. Research Progress on Bioactivity and Product Development of Codonopsis pilosula Polysaccharide[J]. Science and Technology of Food Industry, 2022, 43(20): 464−470. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021100038.

Citation:

PDF (2130 KB)

Research Progress on Bioactivity and Product Development of Codonopsis pilosula Polysaccharide

1.
College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
2.
College of Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China

More Information

Received Date: October 11, 2021
Available Online: August 09, 2022

Graphical Abstract

Abstract

Abstract

Codonopsis pilosula is one of the widely used medicinal materials for both food and medicine in China. Modern pharmacological studies have found that Codonopsis pilosula polysaccharide is one of the important active components of Codonopsis pilosula. There are a variety of biological activities in disease prevention, health care and treatment. It has been certainly applicated in the human health food and animal feed additives. In order to provide reference for further research and development of Codonopsis pilosula polysaccharides from the past five years, this paper reviews the biological activity of immune activity, antioxidant and anti-aging, anti-inflammatory and anti-ulcer, hypoglycemic, improving intestinal flora, anti-viral, anti-tumor, neuroprotective, physical fatigue relief of Codonopsis pilosula, development and application of Codonopsis pilosula polysaccharide in the field of human health food and annimal feed additives.
- Codonopsis pilosula,
- polysaccharide,
- bioactivity,
- products

FullText(HTML)

References (69)

References

[1]	国家药典委员会. 中国药典, 一部[S]. 北京: 化学工业出版社, 2020: 117 National Pharmacopoeia Commission. Chinese pharmacopoeia, 1[S]. Beijing: Chemical Industry Press, 2020: 117.
[2]	HOSSEN M J, KIM M Y, KIM J H, et al. Codonopsis ianceolata: A review of its therapeutic potentials[J]. Phytother Res,2016,30(3):347−356. doi: 10.1002/ptr.5553
[3]	GAO S M, LIU J S, WANG M, et al. Traditional uses, phytochemistry, pharmacology and toxicology of Codonopsis: A review[J]. J Ethnopharmacol,2018,219:50−70. doi: 10.1016/j.jep.2018.02.039
[4]	ZOU Y F, ZHANG Y Y, FU Y P, et al. A polysaccharide isolated from Codonopsis pilosula with immunomodulation effects both in vitro and in vivo[J]. Molecules,2019,24(20):3632. doi: 10.3390/molecules24203632
[5]	DENG X, FU Y, LUO S, et al. Polysaccharide from Radix Codonopsis has beneficial effects on the maintenance of T-cell balance in mice[J]. Biomed Pharmacother,2019,112:108682. doi: 10.1016/j.biopha.2019.108682
[6]	FU Y P, FENG B, ZHU Z K, et al. The polysaccharides from Codonopsis pilosula modulates the immunity and intestinal microbiota of cyclophosphamide-treated immunosuppressed mice[J]. Molecules,2018,23(7):1801. doi: 10.3390/molecules23071801
[7]	李恺, 盛瑜, 於廉沁, 等. 中药提取物对兔出血症疫苗免疫效果的影响[J]. 中国养兔,2017(6):7−9. [LI K, SHENG Y, YU L Q, et al. The effect of Chinese herb extracts on rabbit hemorrhagic disease (RHD) vaccine[J]. Chinese Journal of Rabbit Farming,2017(6):7−9.
[8]	李开菊, 陈文倩, 周霞, 等. 素花党参多糖对乌鸡生长性能、免疫功能、血常规及肠道菌群的影响[J]. 四川畜牧兽医,2017,44(10):32−34,36. [LI K J, CHEN W Q, ZHOU X, et al. Effects of Codonopsis pilosula polysaccharides on the production performance, immune function, routine blood indexes and intestinal microflora of black-bone chicken[J]. Sichuan Animal & Veterinary Sciences,2017,44(10):32−34,36.
[9]	ANDERSON N R, MINUTOLO N G, GILL S, et al. Macrophage-based approaches for cancer immunotherapy[J]. Cancer Res,2021,81(5):1201−1208. doi: 10.1158/0008-5472.CAN-20-2990
[10]	史宝忠, 胡建燃, 李平, 等. 党参多糖对Ana-1巨噬细胞和小鼠的免疫调节作用[J]. 生物技术通报,2019,35(6):114−118. [SHI B ZH, HU J R, LI P, et al. Immunoregulatory effect of polysaccharides from Codonopsis pilosula on the Ana-1 macrophages in mice[J]. Biotechnology Bulletin,2019,35(6):114−118.
[11]	石轶男, 孙娜, 孙耀贵, 等. 党参多糖对巨噬细胞的诱导活化作用[J]. 畜牧兽医学报,2017,48(4):777−784. [SHI Y N, SUN N, SUN Y G, et al. Codonopsis pilosula polysaccharide-induced activation and proliferation of macrophage RAW264.7 cell[J]. Chinese Journal of Animal and Veterinary Sciences,2017,48(4):777−784. doi: 10.11843/j.issn.0366-6964.2017.04.022
[12]	王希春, 朱电锋, 尹莉莉, 等. 党参多糖对仔猪生长性能、血清细胞因子及肠黏膜分泌型免疫球蛋白A含量的影响[J]. 动物营养学报,2017,29(11):4069−4075. [WANG X CH, ZHU D F, YIN L L, et al. Effects of Codonopsis pilosula polysaccharide on growth performance, serum cytokines and intestinal mucosal secretory immunoglobulin A contents of piglets[J]. Chinese Journal of Animal Nutrition,2017,29(11):4069−4075. doi: 10.3969/j.issn.1006-267x.2017.11.028
[13]	李成, 尹莉莉, 朱电锋, 等. 党参多糖对仔猪小肠黏膜免疫功能的影响[J]. 江苏农业学报,2018,34(2):347−355. [LI CH, YIN L L, ZHU D F, et al. Effect of Codonopsis pilosula polysaccharide on small intestinal mucosa immunity of piglets[J]. Jiangsu Journal of Agricultural Sciences,2018,34(2):347−355. doi: 10.3969/j.issn.1000-4440.2018.02.018
[14]	BAI R B, ZHANG Y J, FAN J M, et al. Immune-enhancement effects of oligosaccharides from Codonopsis pilosula on cyclophosphamide induced immunosuppression in mice[J]. Food Funct,2020,11(4):3306−3315. doi: 10.1039/C9FO02969A
[15]	HEESTERBEEK D A C, ANGELIER M L, HARRISON R A, et al. Complement and bacterial infections: From molecular mechanisms to therapeutic applications[J]. J Innate Immun,2018,10(5-6):455−464. doi: 10.1159/000491439
[16]	李平, 胡建燃, 史宝忠. 潞党参多糖的抗补体活性分析[J]. 生命科学研究,2018,22(2):136−142. [LI P, HU J R, SHI B ZH. Anti-complementary activity of polysaccharides from lu Codonopsis pilosula[J]. Life Science Research,2018,22(2):136−142.
[17]	许朋, 余兰, 冯昆. 党参多糖的提取及体内外免疫作用的研究[J]. 哈尔滨医药,2018,38(4):301−303. [XU P, YU L, FENG K. Extraction of polysaccharides from Codonopsis pilosula in vivo,in vitro immunization of polysaccharide[J]. Harbin Medical Journal,2018,38(4):301−303. doi: 10.3969/j.issn.1001-8131.2018.04.001
[18]	GAO Z, ZHANG C, JING L, et al. The structural characterization and immune modulation activitives comparison of Codonopsis pilosula polysaccharide (CPPS) and selenizing CPPS (sCPPS) on mouse in vitro and vivo[J]. Int J Biol Macromol,2020,160:814−822. doi: 10.1016/j.ijbiomac.2020.05.149
[19]	QIN T, REN Z, LIN D, et al. Effects of selenizing Codonopsis pilosula polysaccharide on macrophage modulatory activities[J]. J Microbiol Biotechnol,2016,26(8):1358−1366. doi: 10.4014/jmb.1601.01094
[20]	LIU F, GENG C, QU Y K, et al. The feeding of dietary Codonopsis pilosula polysaccharide enhances the immune responses, the expression of immune-related genes and the growth performance of red swamp crayfish (Procambarus clarkii)[J]. Fish Shellfish Immunol,2020,103:321−331. doi: 10.1016/j.fsi.2020.05.034
[21]	韩天飞, 袁娜娜, 张洪宇, 等. 党参多糖和黄芪多糖对鸡球虫疫苗免疫增强作用的研究[J]. 黑龙江畜牧兽医,2018(11):172−175. [HAN T F, YUAN N N, ZHANG H Y, et al. Study on the immune enhancement effect of Codonopsis pilosula polysaccharides and Astragalus polysaccharides on chicken coccidiosis vaccine[J]. Heilongjiang Animal Science and Veterinary Medicine,2018(11):172−175.
[22]	刘宽辉, 田卫军, 高珍珍, 等. 硒化党参多糖和大蒜多糖协同增强鸡外周血淋巴细胞和新城疫疫苗的免疫功效[J]. 畜牧兽医学报,2017,48(7):1349−1356. [LIU K H, TIAN W J, GAO ZH Z H, et al. Selenizing Codonopsis pilosula polysaccharide and Garlic polysaccharide synergistically enhance immunological efficacy of chicken lymphocyte and newcastle disease vaccine[J]. Chinese Journal of Animal and Veterinary Sciences,2017,48(7):1349−1356. doi: 10.11843/j.issn.0366-6964.2017.07.020
[23]	时菲菲, 曹金花, 于生兰, 等. W/O/W型党参多糖纳米乳免疫增强剂制备及性质研究[J]. 中国农业科技导报,2021,23(8):106−113. [SHI F F, CAO J H, YU SH L, et al. Preparation and properties of W/O/W Codonopsis pilosula polysaccharide nanoemulsion immunopotentiator[J]. Journal of Agricultural Science and Technology,2021,23(8):106−113.
[24]	叶英, 李珊, 张景宜, 等. 不同产地党参多糖含量及抗氧化活性比较[J]. 安徽农业科学,2019,47(21):184−188. [YE Y, LI SH, ZHANG J Y, et al. Comparison of polysaccharide content and antioxidant activity of Codonopsis pilosula in different producing areas[J]. Journal of Anhui Agricultural Sciences,2019,47(21):184−188. doi: 10.3969/j.issn.0517-6611.2019.21.055
[25]	马铭, 白瑞斌, 刘景龙, 等. 3种党参提取物体外抗氧化活性探究[J]. 中成药,2020,42(9):2514−2517. [MA M, BAI R B, LIU J L, et al. Study on antioxidant activity of three Codonopsis pilosula extracts in vitro[J]. Chinese Traditional Patent Medicine,2020,42(9):2514−2517. doi: 10.3969/j.issn.1001-1528.2020.09.050
[26]	时菲菲, 陈毓, 周晨, 等. 响应面法优化党参多糖提取工艺及抗氧化活性研究[J]. 畜牧与兽医,2021,53(1):54−60. [SHI F F, CHEN Y, ZHOU C H, et al. Optimization of extracting polyphenols from Codonopsis pilosula by the response surface technique and their antioxidant activity[J]. Animal Husbandry & Veterinary Medicine,2021,53(1):54−60.
[27]	张涛, 杨婉羚, 曹喻, 等. 党参多糖的分离纯化及抗衰老作用研究[J]. 江苏农业科学,2018,46(23):235−237. [ZHANG T, YANG W L, CAO Y, et al. Study on purification and anti-aging effects of polysaccharide from Codonopsis pilosula Nannf[J]. Jiangsu Agricultural Sciences,2018,46(23):235−237.
[28]	QIN T, REN Z, LIU X, et al. Study of the selenizing Codonopsis pilosula polysaccharides protects RAW264.7 cells from hydrogen peroxide-induced injury[J]. International Journal of Biological Macromolecules,2018,125:534−543.
[29]	黄圆圆, 张元, 康利平, 等. 党参属植物化学成分及药理活性研究进展[J]. 中草药,2018,49(1):239−250. [HUANG Y Y, ZHANG Y, KANG L P, et al. Research progress on chemical constituents and their pharmacological activities of plant from Codonopsis[J]. Chinese Traditional and Herbal Drugs,2018,49(1):239−250. doi: 10.7501/j.issn.0253-2670.2018.01.033
[30]	MENG Y, XU Y, CHANG C, et al. Extraction, characterization and anti-inflammatory activities of an inulin-type fructan from Codonopsis pilosula[J]. Int J Biol Macromol,2020,163:1677−1686. doi: 10.1016/j.ijbiomac.2020.09.117
[31]	LI J, WANG T, ZHU Z, et al. Structure features and anti-gastric ulcer effects of Inulin-type fructan CP-A from the roots of Codonopsis pilosula (Franch.) Nannf[J]. Molecules,2017,22(12):2258. doi: 10.3390/molecules22122258
[32]	CHU X, LIU X J, QIU J M, et al. Effects of Astragalus and Codonopsis pilosula polysaccharides on alveolar macrophage phagocytosis and inflammation in chronic obstructive pulmonary disease mice exposed to PM2.5[J]. Environ Toxicol Pharmacol,2016,48:76−84. doi: 10.1016/j.etap.2016.10.006
[33]	MA RCW. Epidemiology of diabetes and diabetic complications in China[J]. Diabetologia,2018,61(6):1249−1260. doi: 10.1007/s00125-018-4557-7
[34]	LIU W, LV X, HUANG W, et al. Characterization and hypoglycemic effect of a neutral polysaccharide extracted from the residue of Codonopsis pilosula[J]. Carbohydr Polym,2018,197:215−226. doi: 10.1016/j.carbpol.2018.05.067
[35]	李思维, 卫倩倩, 宋宵, 等. 党参多糖的抗氧化及降糖活性研究[J]. 临床医学研究与实践,2020,5(32):8−11. [LI S W, WEI Q Q, SONG X, et al. Study on antioxidant and hypoglycemic activities of Codonopsis pilosula polysaccharide[J]. Clinical Research and Practice,2020,5(32):8−11.
[36]	LI J, ZHANG X, CAO L, et al. Three inulin-type fructans from Codonopsis pilosula (Franch.) Nannf. roots and their prebiotic activity on bifidobacterium longum[J]. Molecules,2018,23(13):3123.
[37]	JING Y, LI A, LIU Z, et al. Absorption of Codonopsis pilosula saponins by coexisting polysaccharides alleviates gut microbial dysbiosis with dextran sulfate sodium-induced colitis in model mice[J]. Biomed Res Int,2018,2018:1781036.
[38]	TANG S, LIU W, ZHAO Q, et al. Combination of polysaccharides from Astragalus membranaceus and Codonopsis pilosula ameliorated mice colitis and underlying mechanisms[J]. J Ethnopharmacol,2021,264:113280. doi: 10.1016/j.jep.2020.113280
[39]	王欢, 张能英, 李海英, 等. 硫酸化修饰对党参多糖体外抗Ⅰ型单纯疱疹病毒的影响[J]. 中国科技论文,2015,10(6):705−709. [WANG H, ZHANG N Y, LI H Y, et al. Effect of sulfated modification on Codonopsis pilosula polysaccharide against HSV-Ⅰ[J]. China Sciencepaper,2015,10(6):705−709. doi: 10.3969/j.issn.2095-2783.2015.06.018
[40]	LIU C, CHEN J, LI E, et al. Solomonseal polysaccharide and sulfated Codonopsis pilosula polysaccharide synergistically resist Newcastle disease virus[J]. PLoS One,2015,10(2):e0117916. doi: 10.1371/journal.pone.0117916
[41]	MING K, HE M, SU L, et al. The inhibitory effect of phosphorylated Codonopsis pilosula polysaccharide on autophagosomes formation contributes to the inhibition of duck hepatitis A virus replication[J]. Poult Sci,2020,99(4):2146−2156. doi: 10.1016/j.psj.2019.11.060
[42]	ROY P S, SAIKIA B J. Cancer and cure: A critical analysis[J]. Indian J Cancer,2016,53(3):441−442.
[43]	SUI X, ZHANG M, HAN X, et al. Combination of traditional Chinese medicine and epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of non-small cell lung cancer: A systematic review and meta-analysis[J]. Medicine (Baltimore),2020,99(32):e20683. doi: 10.1097/MD.0000000000020683
[44]	CHEN M, LI Y, LIU Z, et al. Exopolysaccharides from a Codonopsis pilosula endophyte activate macrophages and inhibit cancer cell proliferation and migration[J]. Thorac Cancer,2018,9(5):630−639. doi: 10.1111/1759-7714.12630
[45]	BAI R, LI W, LI Y, et al. Cytotoxicity of two water-soluble polysaccharides from Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen against human hepatocellular carcinoma HepG2 cells and its mechanism[J]. Int J Biol Macromol, 2018, 120(Pt B): 1544-1550.
[46]	刘云鹤, 蔡金保, 王红丽. 党参多糖抑制PI3K/AKT通路对人肝癌HepG2细胞生长和运动能力的影响[J]. 中国免疫学杂志,2020,36(9):1108−1113. [LIU Y H, CAI J B, WANG H L. Effects of Codonopsis pilosum polysaccharide on PI3K/AKT pathway on growth and motility of HepG2 cells in human liver cancer[J]. Chinese Journal of Immunology,2020,36(9):1108−1113. doi: 10.3969/j.issn.1000-484X.2020.09.016
[47]	邱晓, 宫晓庆, 李学涛, 等. 党参总多糖提取工艺优化及其对胃癌细胞的抑制作用考察[J]. 中医药导报,2019,25(3):74−79. [QIU X, GONG X Q, LI X T, et al. Optimization of extracting Codonopsis pilosula polysaccharide and the inhibition effect on gastric cancer cells[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy,2019,25(3):74−79.
[48]	胡建燃, 李平, 雷海英, 等. 潞党参多糖对宫颈癌细胞SiHa增殖和迁移的影响[J]. 生物技术通报,2017,33(5):159−163. [HU J R, LI P, LEI H Y, et al. Effects of polysaccharides from Lu Dangshen (Codonopsis pilosula) on proliferation and migration of human cervical SiHa[J]. Biotechnology Bulletin,2017,33(5):159−163. doi: 10.13560/j.cnki.biotech.bull.1985.2016-0953
[49]	REVI M. Alzheimer’s disease therapeutic approaches[J]. Adv Exp Med Biol,2020,1195:105−116.
[50]	HERMAN L, ATRI A, SALLOWAY S. Alzheimer's disease in primary care: The significance of early detection, diagnosis, and intervention[J]. Am J Med,2017,130(6):756. doi: 10.1016/j.amjmed.2017.04.001
[51]	WAN L, ZHANG Q, LUO H, et al. Codonopsis pilosula polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice[J]. Aging (Albany NY),2020,12(13):13422−13436.
[52]	ZHANG Q, XIA Y, LUO H, et al. Codonopsis pilosula polysaccharide attenuates Tau hyperphosphorylation and cognitive impairments in htau infected mice[J]. Front Mol Neurosci,2018,11:437. doi: 10.3389/fnmol.2018.00437
[53]	XIE Q, SUN Y, CAO L, et al. Antifatigue and antihypoxia activities of oligosaccharides and polysaccharides from Codonopsis pilosula in mice[J]. Food Funct,2020,11(7):6352−6362. doi: 10.1039/D0FO00468E
[54]	程艺, 张彦昀, 黄婷, 等. 党参多糖对运动力竭小鼠疲劳的影响[J]. 中国老年学杂志,2021(16):3498−3501. [CHEN Y, ZHANG Y Y, HUANG T, et al. Effect of Codonopsis polysaccharide on fatigue of exhaustion of motion mice[J]. Chinese Journal of Gerontology,2021(16):3498−3501. doi: 10.3969/j.issn.1005-9202.2021.16.031
[55]	YIP W, FU H, CHEN A T, et al. 10 years of health-care reform in China: Progress and gaps in universal health coverage[J]. Lancet,2019,394(10204):1192−1204. doi: 10.1016/S0140-6736(19)32136-1
[56]	WANG F. The roles of preventive and curative health care in economic development[J]. PLoS One,2018,13(11):e0206808. doi: 10.1371/journal.pone.0206808
[57]	HENSHER M, CANNY B, ZIMITAT C, et al. Health care, overconsumption and uneconomic growth: A conceptual framework[J]. Soc Sci Med,2020,266:113420. doi: 10.1016/j.socscimed.2020.113420
[58]	CHEN J, TSIM K W K. A review of edible jujube, the Ziziphus jujuba fruit: A heath food supplement for anemia prevalence[J]. Front Pharmacol,2020,11:593655. doi: 10.3389/fphar.2020.593655
[59]	HUANG R, SHEN M, YU Y, et al. Physicochemical characterization and immunomodulatory activity of sulfated Chinese yam polysaccharide[J]. Int J Biol Macromol, 2020, 165(Pt A): 635−644.
[60]	NIU B, FENG S, XUAN S, et al. Moisture and caking resistant Tremella fuciformis polysaccharides microcapsules with hypoglycemic activity[J]. Food Res Int,2021,146:110420. doi: 10.1016/j.foodres.2021.110420
[61]	杜景涛, 郑贞, 陈骏, 等. 党参枸杞复合饮料的制备及其抗氧化活性研究[J]. 保鲜与加工,2021,21(2):109−115,121. [DU J T, ZHENG ZH, CHEN J, et al. Study on preparation of composite sports beverage made with Codonopsis pilosula and wolfberry and its antioxidant activity[J]. Storage and Process,2021,21(2):109−115,121. doi: 10.3969/j.issn.1009-6221.2021.02.017
[62]	秦楠, 崔政, 刘丽君, 等. 党参多糖提取工艺优化及其保健醋饮料的研制[J]. 食品工业科技,2018,39(12):210−215. [QIN N, CUI ZH, LIU L J, et al. Optimization of extraction process of Codonopsis polysaccharides and development of its health vinegar beverage[J]. Science and Technology of Food Industry,2018,39(12):210−215. doi: 10.13386/j.issn1002-0306.2018.12.037
[63]	王艳萍, 王瑞婕. 党参多糖提取工艺研究及党参多糖口服液的制备[J]. 运城学院学报,2021(6):22−25. [WANG Y P, WANG R J. Study on extraction technology of polysaccharide from Codonopsis Radix and preparation of oral liquid[J]. Journal of Yuncheng University,2021(6):22−25. doi: 10.3969/j.issn.1008-8008.2021.06.003
[64]	赵曼孜, 陈惠杰, 刁磊. 响应面分析法优化党参、黄芪多糖泡腾颗粒剂的制备工艺研究[J]. 吉林农业,2018(7):107. [ZHAO M Z, CHEN H J, DIAO L. Optimization of preparation technology of Codonopsis pilosula and Astragalus polysaccharide effervescent granules by response surface methodology[J]. Agriculture of Jilin,2018(7):107. doi: 10.14025/j.cnki.jlny.2018.07.052
[65]	李早慧, 王建明. 党参多糖片的制备及其质量考察[J]. 黑龙江畜牧兽医,2015(23):206−208. [LI Z H, WANG J M. Preparation and quality study of Codonopsis pilosula polysaccharide tablets[J]. Heilongjiang Animal Science and Veterinary Medicine,2015(23):206−208. doi: 10.13881/j.cnki.hljxmsy.2015.2101
[66]	石轶男, 杨绒娟, 扆妍妍, 等. 党参多糖可溶性粉对肉仔鸡血清ND抗体水平、IgG及肠道SIgA含量的影响[J]. 中国兽药杂志,2016,50(9):47−52. [SHI Y N, YANG R J, YI Y Y, et al. Effects of soluble powder of Codonopsis pilosum polysaccharide on serum ND antibody IgG and intestinal SIgA content of broilers[J]. Chinese Journal of Veterinary Medicine,2016,50(9):47−52.
[67]	ZOU Y F, ZHANG Y Y, ZHU Z K, et al. Characterization of inulin-type fructans from two species of radix Codonopsis and their oxidative defense activation and prebiotic activities[J]. J Sci Food Agric,2021,101(6):2491−2499. doi: 10.1002/jsfa.10875
[68]	WU L, PENG M, JING Y, et al. Immunomodulatory effect of polysaccharides from the extraction of Codonopsis javanica (Blume) Hook. f. et Thomson (Campanulaceae) roots in female rats[J]. Nat Prod Res,2020:1−5.
[69]	FENG G, ZHANG X F. Production of a Codonopsis polysaccharide iron complex and evaluation of its properties[J]. Int J Biol Macromol,2020,162:1227−1240. doi: 10.1016/j.ijbiomac.2020.06.210

[1]	FENG Lifeng, HUANG Qian, YE Mengwei, HUANG Yonghui, HUANG Yan, LIN Haoxue, LIANG Min, XU Hui. Determination of 30 Kinds of Antiparasitic Drugs in Animal-derived Foods by QuEChERS-UPLC-MS/MS[J]. Science and Technology of Food Industry, 2024, 45(6): 280-288. DOI: 10.13386/j.issn1002-0306.2023050175
[2]	WU Yanlei, SU Min, ZHOU Chunjie, TIAN Yuan, WANG Min. Simultaneous Determination of 76 Veterinary Drugs and Their Metabolites in Pork by QuEChERS-Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry[J]. Science and Technology of Food Industry, 2023, 44(20): 311-321. DOI: 10.13386/j.issn1002-0306.2022110330
[3]	YU Ling, SONG Lihua. Rapid Determination of Five Alkaloids in Catering Crayfish by QuEChERS-UPLC-MS/MS[J]. Science and Technology of Food Industry, 2023, 44(2): 324-331. DOI: 10.13386/j.issn1002-0306.2022030219
[4]	XU Xing, ZHANG Yan, SHU Ping, YANG Weihua. Determination of 20 Kinds of Cephalosporins Residues in Animal Derived Food by QuEChERS-LC-MS/MS with Isotope Internal Standards Method[J]. Science and Technology of Food Industry, 2022, 43(24): 320-330. DOI: 10.13386/j.issn1002-0306.2022030194
[5]	WANG Jing, ZHANG Haichao, JIA Haitao, AI Lianfeng. Determination of 14 Anabolic Androgenic Steroids in Animal Derived Foods by QuEChERS-High Performance Liquid Chromatography-Tandem Mass Spectrometry[J]. Science and Technology of Food Industry, 2022, 43(20): 291-299. DOI: 10.13386/j.issn1002-0306.2021120163
[6]	TAN Gaohao, WANG Chengye, ZHENG Jinming, YIN Qingchun, XU Bin, WU Jiren. Simultaneous Determination of 37 Veterinary Drugs in Animal-Derived Foods by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry（UPLC-MS/MS）[J]. Science and Technology of Food Industry, 2021, 42(17): 225-234. DOI: 10.13386/j.issn1002-0306.202009030
[7]	ZHOU Jia, SU A-long, ZHU Shu-qiang, WANG Li-jun, YU Jie. Determination of Insecticide of Phenylpyrazole Derivatives in Poultry Derived Foods by QuEChERS Method Combined with Liquid Chromatography-Mass Spectrometry[J]. Science and Technology of Food Industry, 2019, 40(16): 206-211,217. DOI: 10.13386/j.issn1002-0306.2019.16.035
[8]	YANG Lu-ping, SHAO Li-jun, WANG Guo-ling, WANG Xi-ning, REN Xiao-fei, LIU Yong-jun. Determination of Thirteen Pesticides in Edible Mushrooms by QuEChERS with UPLC MS/MS[J]. Science and Technology of Food Industry, 2019, 40(14): 247-253. DOI: 10.13386/j.issn1002-0306.2019.14.040
[9]	GAO Hai-rong. Determination of Nitromidazoles in Fish by QuEChERS Extraction with ZrO₂Coupled to High Performance Liquid Chromatography-tandem Mass Spectrometry[J]. Science and Technology of Food Industry, 2019, 40(4): 266-270. DOI: 10.13386/j.issn1002-0306.2019.04.044
[10]	WANG Ke-yu, YANG Hong-xu, WANG Chao-ying, RUAN Hua-ping, CHEN Dong-po, ZHOU Peng. Application of Baking,Boiling,Microwaving Heating Techniques in Animal-derived Food Processing[J]. Science and Technology of Food Industry, 2018, 39(13): 325-330. DOI: 10.13386/j.issn1002-0306.2018.13.060

Supplements (0)

Cited By

Cited by

Periodical cited type(18)

1.	温雅君，王全红，杨红菊，孙志伟，刘希艳，高利文，肖志勇. 胶体金免疫层析法快速检测韭菜中腐霉利的质量分析与评价. 农药科学与管理. 2025(01): 29-33 .
2.	杨静，方芳，沈媛，孙娟，吴仑，陈翔，贾晨，李英. 水产品中地西泮快速检测产品技术评价. 食品安全质量检测学报. 2025(07): 102-108 .
3.	姚南南，刘芳，高会群，张学龙，杜斌，张郢，杨梅，蒲小容. 基于荧光微球的多菌灵残留快速检测试纸条的研制. 食品科技. 2024(01): 344-350 .
4.	陈喆，高文分，刘屹. 快速显色法筛查祛斑美白类化妆品中糖皮质激素. 化学分析计量. 2024(07): 7-11+22 .
5.	薛芳，张照红，殷慧龄. 胶体金免疫层析法在农残快速检测中的研究与探讨. 新疆农业科技. 2024(06): 39-41 .
6.	骆丽清，伍浚铧，胡茗淇，黎喜萍. 氟虫腈和水胺硫磷胶体金试剂盒性能考察与分析. 食品安全导刊. 2024(35): 72-75 .
7.	杨睿，蔡琳，卢灿鑫，李乐诗，张洁吟，刘晓晗，王韦达. 致病菌测试片质量评价方法研究. 食品安全质量检测学报. 2024(23): 41-51 .
8.	陈振东. 食品安全快速检测技术在食品安全监督中的运用浅析. 食品安全导刊. 2023(03): 121-123 .
9.	王元清，周巧，李莎，韩静，王惠，李建龙，何利，陈姝娟，刘爱平，李琴，胡凯弟，刘书亮. 市售原粮农药残留快速检测产品的质量评价与分析. 中国粮油学报. 2023(04): 122-128 .
10.	刘海虹，刘耀慧，雷毅. 基于真实食品的兽药残留快检结果准确性验证及应用探索. 食品安全导刊. 2023(33): 63-67 .
11.	罗俊霞，张刚，申战宾，杨华，叶茂，段鹿梅，李艳珍，赵建波，桑丽雅，马蕾，张威. 胶体金免疫层析技术应用于农药残留检测的研究进展. 农产品质量与安全. 2022(01): 41-49 .
12.	倪诗瑶，刘欠欠. 草莓农药残留快速检测方法对比分析. 上海农业科技. 2022(01): 30-32 .
13.	顾晔，张爽，王成军，李悦，杨雨柔. 基于免疫原理的7种磺胺类兽药残留快速检测试剂结果准确性评估. 食品安全质量检测学报. 2022(03): 992-1000 .
14.	陈振东. 食品安全检测技术在保障食品质量安全中的作用. 食品安全导刊. 2022(35): 166-168 .
15.	叶秋雄，毛新武，梁俊发，张彬彬，林嘉健，彭程，易云婷. 农贸市场食用农产品快速检测工作监督评价与效果分析. 食品安全质量检测学报. 2021(19): 7826-7830 .
16.	泮秋立，胡明燕，沈祥震，孙嵛林，李峥，王骏. 食用农产品批发市场自建快检室运行中存在的问题及建议. 食品安全导刊. 2021(29): 7-10 .
17.	占绣萍，刘彬，黄兰淇，陈秀，马琳，陈建波，赵莉. 应用胶体金法检测叶类蔬菜中吡虫啉、多菌灵、啶虫脒、噻虫嗪的残留量分析. 农药科学与管理. 2021(10): 24-31 .
18.	岳绪辉，杜斌，林栋，令狐克勇，杨梅，付秋平，李丙凤，杨曦. 草甘膦胶体金免疫层析试纸条的研制. 食品科技. 2021(12): 301-307 .

Other cited types(1)

Get Citation

PDF

XML

Article Metrics

Article views (485) PDF downloads (51) Cited by(19)

Science and Technology of Food Industry

Research Progress on Bioactivity and Product Development of Codonopsis pilosula Polysaccharide