Research Progress of Curcumin Intervening the Mycotoxin-induced Toxicity

LI Honglin; LI Yifang; ZHANG Chi; ZHOU Hongyuan; GUO Ting; ZHANG Yuhao; MA Liang

doi:10.13386/j.issn1002-0306.2021090341

Volume 43 Issue 17

Aug. 2022

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Science and Technology of Food Industry > 2022 > 43(17): 494-500. > DOI: 10.13386/j.issn1002-0306.2021090341

LI Honglin, LI Yifang, ZHANG Chi, et al. Research Progress of Curcumin Intervening the Mycotoxin-induced Toxicity[J]. Science and Technology of Food Industry, 2022, 43(17): 494−500. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021090341.

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Research Progress of Curcumin Intervening the Mycotoxin-induced Toxicity

LI Honglin^1,,
LI Yifang¹,
ZHANG Chi¹,
ZHOU Hongyuan^{1, 3},
GUO Ting^{1, 3},
ZHANG Yuhao^{1, 2, 3, 4},
MA Liang^{1, 3, 4, ,}

1.
College of Food Science, Southwest University, Chongqing 400715, China
2.
Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, Chongqing 400715, China
3.
Chongqing Key Laboratory of Speciality Food Co-built by Sichuan and Chongqing, Chongqing 400715, China
4.
Key Laboratory of Condiment Supervision Technology for State Market Regulation,Chongqing 400715, China

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Received Date: September 28, 2021
Available Online: June 27, 2022

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Abstract

Abstract

To intervene and control the toxic effects of the hazard factors using nature products is one of the research hotspots recently in the field of food safety. Curcumin, as a hydrophobic polyphenolic compound extracted from the traditional spice turmeric, has strong anti-inflammatory, anti-oxidation, anti-cancer, enhancing immunity and other activities. Recent studies have shown that curcumin can intervene some toxicities induced by mycotoxins such as Aflatoxin B₁, Ochratoxin A, Zearalenone, Fumonisin B₁ and Deoxynivalenol, thereby reducing damages and enhancing resistance in body. In this paper, the toxicities of main mycotoxins were briefly summarized at first. And then, the intervention effects and its related mechanism of curcumin on the mycotoxin-induced toxicities in the latest five years were emphatically elaborated, mainly from the aspects of reducing ROS production and lipid peroxidation, regulating related pathways and improving intestinal flora. Finally, the potential problems that to be urgently solved are discussed. Our review aimed at providing the theoretical bases for the in-depth development and utilization of curcumin in the health industry as well as to broaden the ideas for the research and development of other plant-derived functional components.
- curcumin,
- mycotoxin,
- toxicity,
- intervention mechanism,
- plant-derived

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References (57)

References

[1]	HORKY P, SKALICKOVA S, BAHOLET D, et al. Nanoparticles as a solution for eliminating the risk of mycotoxins[J]. Nanomaterials,2018,8(9):727. doi: 10.3390/nano8090727
[2]	MU U, CG O, A M. An overview of mycotoxin contamination of foods and feeds[J]. Journal of Biochemical and Microbial Toxicology,2017,1(1):11.
[3]	HAQUE M A, WANG Y, SHEN Z, et al. Mycotoxin contamination and control strategy in human, domestic animal and poultry: A review[J]. Microb Pathog,2020,142:104095.
[4]	SUN Q Y, QIN X S, CAO M J, et al. Oxidative stress induced by zearalenone in porcine granulosa cells and its rescue by curcumin in vitro[J]. Plos One,2015,10(6):0127551.
[5]	YANG C, SONG G, LI M W. Effects of mycotoxin-contaminated feed on farm animals[J]. Journal of Hazardous Materials,2020,389:122087. doi: 10.1016/j.jhazmat.2020.122087
[6]	BHARDWAJ H, SUMANA G, MARQUETTE C A. Gold nanobipyramids integrated ultrasensitive optical and electrochemical biosensor for aflatoxin B₁ detection[J]. Talanta,2020,222:12578.
[7]	CAI P R, ZHENG H, SHE J J, et al. Molecular mechanism of aflatoxin-induced hepatocellular carcinoma derived from a bioinformatics analysis[J]. Toxins (Basel),2020,12(3):203. doi: 10.3390/toxins12030203
[8]	KORDASHT H K, HASANZADEH M. Specific monitoring of aflatoxin M₁ in real samples using aptamer binding to DNFS based on turn-on method: A novel biosensor[J]. Journal of Molecular Recognition,2020,33(6):e2832.
[9]	LI H, LI S, YANG H, et al. l-Proline alleviates kidney injury caused by AFB₁ and AFM₁ through regulating excessive apoptosis of kidney cells[J]. Toxins (Basel),2019,11(4):226. doi: 10.3390/toxins11040226
[10]	DEY D K, SUN C K. Aflatoxin B₁ induces reactive oxygen species-dependent caspase-mediated apoptosis in normal human cells, inhibits allium cepa root cell division, and triggers inflammatory response in zebrafish larvae-sciencedirect[J]. Science of the Total Environment,2020,737:139704. doi: 10.1016/j.scitotenv.2020.139704
[11]	SOLIS-CRUZ B, HERNANDEZ-PATLAN D, PETRONE V, et al. Evaluation of cellulosic polymers and curcumin to reduce aflatoxin B₁ toxic effects on performance, biochemical, and immunolo-gical parameters of broiler chickens[J]. Toxins,2019,11(2):121. doi: 10.3390/toxins11020121
[12]	STOB M, BALDWIN R S, TUITE J, et al. Isolation of an anabolic, uterotrophic compound from corn infected with Gibberella zeae.[J]. Nature,1962,196(4861):1318.
[13]	BIOMIN. Mycotoxins report-world mycotoxin survey[M]. 2020.
[14]	SONG T T, YANG W R, HUANG L B, et al. Zearalenone exposure affects the wnt/β-catenin signaling pathway and related genes of porcine endometrial epithelial cells in vitro[J]. Animal Bioscience,2021,34(6):993−1005. doi: 10.5713/ajas.20.0292
[15]	ZHAO L J, XIAO Y Y, LI C M, et al. Zearalenone perturbs the circadian clock and inhibits testosterone synthesis in mouse leydig cells[J]. Journal of Toxicology and Environmental Health Part A,2021,84(3):112−124. doi: 10.1080/15287394.2020.1841699
[16]	WANG J J, LI M M, ZHANG W, et al. Protective effect of n-acetylcysteine against oxidative stress induced by zearalenone via mitochondrial apoptosis pathway in SIEC02 cells[J]. Toxins,2018,10(10):407. doi: 10.3390/toxins10100407
[17]	REN Z, HE H, ZUO Z, et al. ROS: Trichothecenes' handy weapon?[J]. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association,2020,142:111438. doi: 10.1016/j.fct.2020.111438
[18]	KANG R F, LI R N, DAI P Y, et al. Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production[J]. Environmental Pollution,2019,251(8):689−698.
[19]	XIAO K, LIU C G, QIN Q, et al. EPA and DHA attenuate deoxynivalenol-induced intestinal porcine epithelial cell injury and protect barrier function integrity by inhibiting necroptosis signaling pathway[J]. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology,2020,34(2):2483−2496. doi: 10.1096/fj.201902298R
[20]	CAO L, JIANG Y J, ZHU L, et al. Deoxynivalenol induces caspase-8-mediated apoptosis through the mitochondrial pathway in hippocampal nerve cells of piglet[J]. Toxins (Basel),2021,13(2):73. doi: 10.3390/toxins13020073
[21]	TAO Y, XIE S, XU F, et al. Ochratoxin A: Toxicity, oxidative stress and metabolism[J]. Food and Chemical Toxicology,2018,112:320−331. doi: 10.1016/j.fct.2018.01.002
[22]	LEE H J, PYO M C, SHIN H S, et al. Renal toxicity through AhR, PXR, and Nrf2 signaling pathway activation of ochratoxin A-induced oxidative stress in kidney cells[J]. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association,2018,122:59−68. doi: 10.1016/j.fct.2018.10.004
[23]	HOU L, YUAN X, LE G N, et al. Fumonisin B₁ induces nephrotoxicity via autophagy mediated by mTORC1 instead of mTORC2 in human renal tubule epithelial cells[J]. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association,2021,149:112037.
[24]	XU W X, WANG M Y, CUI G Y, et al. Astaxanthin protects OTA-induced lung injury in mice through the Nrf2/NF-κB pathway[J]. Toxins (Basel),2019,11(9):10.
[25]	LU Y J, ZHANG Y, LIU J Q, et al. Comparison of the toxic effects of different mycotoxins on porcine and mouse oocyte meiosis[J]. PeerJ,2018,6:e5111. doi: 10.7717/peerj.5111
[26]	CHEN J, WEI Z, WANG Y, et al. Fumonisin B (1): Mechanisms of toxicity and biological detoxification progress in animals[J]. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association,2021,149:111977. doi: 10.1016/j.fct.2021.111977
[27]	ARUMUGAM T, GHAZI T, CHUTURGOON A A. Fumonisin B (1) alters global m6A RNA methylation and epigenetically regulates Keap1-Nrf2 signaling in human hepatoma (HepG2) cells[J]. Arch Toxicol,2021,95:1367−1378. doi: 10.1007/s00204-021-02986-5
[28]	WANGIA-DIXON R N, NISHIMWE K. Molecular toxicology and carcinogenesis of fumonisins: A review[J]. Journal of Environmental Science and Health Part C, Toxicology and Carcinogenesis,2021,39(1):44−67. doi: 10.1080/26896583.2020.1867449
[29]	LEDUR P C, SANTURIO J M. Cytoprotective effects of curcumin and silymarin on PK-15 cells exposed to ochratoxin A, fumonisin B₁ and deoxynivalenol[J]. Toxicon,2020,185:97−103. doi: 10.1016/j.toxicon.2020.06.025
[30]	LOVATO F L, DE OLIVEIRA C R, ADEDARA I A, et al. Quercetin ameliorates polychlorinated biphenyls-induced testicular DNA damage in rats[J]. Andrologia,2016,48(1):51−58. doi: 10.1111/and.12417
[31]	DANG Y H, LI Z L, WEI Q, et al. Protective effect of apigenin on acrylonitrile-induced inflammation and apoptosis in testicular cells via the NF-κB pathway in rats[J]. Inflammation,2018,41(4):1448−1459. doi: 10.1007/s10753-018-0791-x
[32]	食品安全国家标准审评委员会. 食品安全国家标准食品添加剂使用标准: GB 2760-2014[S]. 北京: 中国质检出版社, 2014. National Food Safety Standard Review Committee. National food safety standard food additives use standard: GB 2760-2014[S]. Beijing: China Quality Inspection Press, 2014.
[33]	刘玲红, 许国娟, 程荣, 等. 不同环境因子对栀子黄/姜黄共混色素体系稳定性的影响[J]. 食品与发酵工业,2021,10:1−13. [LIU H L, XU G J, CHENG R, et al. Effects of different environmental factors on the stability of gardenia/turmeric blend pigment system[J]. Food And Fermentation Industry,2021,10:1−13. doi: 10.13995/j.cnki.11-1802/ts.028215 LIU H L, XU G J, CHEN R, et al. Effects of different environmental factors on the stability of gardenia/turmeric blend pigment system[J]. Food And Fermentation Industry, 2021, 10: 1-13. doi: 10.13995/j.cnki.11-1802/ts.028215
[34]	SUZUKI M, NAKAMURA T, IYOKI S, et al. Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities[J]. Biological & Pharmaceutical Bulletin,2005,28(8):1438−1443.
[35]	XIANG L, HE B, LIU Q, et al. Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT-116 cells[J]. Oncology Reports,2020,44:1997−2008.
[36]	NETA J F D F, VERAS V S, SOUSA D F D, et al. Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: A randomised double-blind placebo-controlled clinical trial[J]. International Journal of Food Sciences and Nutrition,2021,72(3):1−10.
[37]	LI S, MUHAMMAD I, YU H, et al. Detection of aflatoxin adducts as potential markers and the role of curcumin in alleviating AFB₁-induced liver damage in chickens[J]. Ecotoxicology and Environmental Safety,2019,176:137−145. doi: 10.1016/j.ecoenv.2019.03.089
[38]	LIMAYE A, YU R C, CHOU C C, et al. Protective and detoxifying effects conferred by dietary selenium and curcumin against AFB₁-mediated toxicity in livestock: A review[J]. Toxins,2018,10(1):25. doi: 10.3390/toxins10010025
[39]	MUHAMMAD I, SUN X, WANG H, et al. Curcumin successfully inhibited the computationally identified CYP2A6 enzyme-mediated bioactivation of aflatoxin B₁ in arbor acres broiler[J]. Frontiers in Pharmacology,2017,8:143.
[40]	LI S H, LIU R M, WEI G Q, et al. Curcumin protects against aflatoxin B₁-induced liver injury in broilers via the modulation of long non-coding RNA expression[J]. Ecotoxicol Environ Saf,2021,208:111725. doi: 10.1016/j.ecoenv.2020.111725
[41]	VERMA R J, CHAKRABORTY B S, PATEL C, et al. Curcumin ameliorates aflatoxin-induced changes in SDH and ATPase activities in liver and kidney of mice[J]. Acta Poloniae Pharmaceutica,2008,65(4):415−419.
[42]	RUAN D, WANG W C, LIN C X, et al. Effects of curcumin on performance, antioxidation, intestinal barrier and mitochondrial function in ducks fed corn contaminated with ochratoxin A[J]. Animal,2018,13(1):42−52.
[43]	CATANZARO M, CORSINI E, ROSINI M, et al. Immunomodulators inspired by nature: A review on curcumin and echinacea[J]. Molecules,2018,23(11):2778. doi: 10.3390/molecules23112778
[44]	DAMIANO S, ANDRETTA E, LONGOBARDI C, et al. Effects of curcumin on the renal toxicity induced by ochratoxin A in rats[J]. Antioxidants,2020,9(4):332. doi: 10.3390/antiox9040332
[45]	COSTA J G, SARAIVA N, GUERREIRO P S, et al. Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints[J]. Food and Chemical Toxicology,2016,87:65−76. doi: 10.1016/j.fct.2015.11.018
[46]	ZHAI S S, RUAN D, ZHU Y W, et al. Protective effect of curcumin on ochratoxin A-induced liver oxidative injury in duck is mediated by modulating lipid metabolism and the intestinal microbiota[J]. Poultry Science,2020,99(2):1124−1134. doi: 10.1016/j.psj.2019.10.041
[47]	AHERN P P, MALOY K J. Understanding immune-microbiota interactions in the intestine[J]. Immunology,2020,159(1):4−14. doi: 10.1111/imm.13150
[48]	SHIN N R, BOSE S, WANG J H, et al. Flos lonicera combined with metformin ameliorates hepatosteatosis and glucose intolerance in association with gut microbiota modulation[J]. Frontiers in Microbiology,2017,8:2271. doi: 10.3389/fmicb.2017.02271
[49]	MOQUET P C A, ONRUST L, VAN IMMERSEEL F, et al. Importance of release location on the mode of action of butyrate derivatives in the avian gastrointestinal tract[J]. World's Poultry Science Journal,2019,72(1):61−80.
[50]	CHEN S, YANG S H, WANG M, et al. Curcumin inhibits zearalenone-induced apoptosis and oxidative stress in leydig cells via modulation of the PTEN/Nrf2/Bip signaling pathway[J]. Food and Chemical Toxicology,2020,141:111−385.
[51]	WANG M Y, WANG N, TONG J J, et al. Transcriptome analysis to identify the ras and Rap1 signal pathway genes involved in the response of TM3 leydig cells exposed to zearalenone[J]. Environmental Science and Pollution Research,2018,25(31):31230−31239. doi: 10.1007/s11356-018-3129-1
[52]	GALLI G M, GRISS L G, FORTUOSO B F, et al. Feed contaminated by fumonisin (Fusarium spp.) in chicks has a negative influence on oxidative stress and performance, and the inclusion of curcumin-loaded nanocapsules minimizes these effects[J]. Microbial Pathogenesis,2020,148:104−496.
[53]	YIN S T, GUO X, LI J H, et al. Fumonisin B₁ induces autophagic cell death via activation of ERN1-MAPK8/9/10 pathway in monkey kidney MARC-145 cells[J]. Archives of Toxicology,2015,90(4):985−996.
[54]	ASLAN A, AGAR G, ALPSOY L, et al. Protective role of methanol extracts of two lichens on oxidative and genotoxic damage caused by AFB₁ in human lymphocytes in vitro[J]. Toxicology and Industrial Health,2011,28(6):505−512.
[55]	AMALRAJ A, VARMA K, JACOB J, et al. Efficacy and safety of a gut health product (actbiome) prepared by incorporation of asafoetida-curcumin complex onto the turmeric dietary fiber in the management of gut health and intestinal microflora in healthy subjects: A randomized, double-blind, placebo controlled study[J]. Bioactive Carbohydrates and Dietary Fibre,2021,26:233−215.
[56]	SAMY M, ABDELAZEEM M G, ASHRY M A, et al. Ameliorative effect of flavonoid antioxidant on the histology and ultrastructure of albino rats` liver treated with radiation and/or acrylonitrile[J]. Journal of Scientific Research in Science,2016,33(1):295−306.
[57]	LAWAL A O. Air particulate matter induced oxidative stress and inflammation in cardiovascular disease and atherosclerosis: The role of Nrf2 and Ahr-mediated pathways[J]. Toxicol Lett,2017,270:88−95. doi: 10.1016/j.toxlet.2017.01.017