Regulation Effects of Blueberry Anthocyanins on Glucose-Lipid Metabolism in Type 2 Diabetic Mice

Objective: To investigate the effects of blueberry anthocyanins (BA) on glucose metabolism and lipid metabolism in type 2 diabetic mice. Methods: The mice model of type 2 diabetes mellitus was established by high-fat and high-sugar diet combined with intraperitoneal injection of streptomycin (STZ), and the normal group, model group, positive drug group (250 mg/kg) and blueberry anthocyanin group (300, 200, 100 mg/kg) were set up. The food intake, water intake, body weight and fasting blood glucose (FBG) of mice were measured during the experiment. Oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), serum insulin (INS), homeostasis model assessment insulin resistance (HOMA-IR) and blood lipid related indexes of mice were determined after 4 weeks of continuous intragastric administration. Results: Compared with model group, blueberry anthocyanin group could significantly improve the typical symptoms of weight loss of type 2 diabetic mice with polydipsia, improve the glucose metabolism level of mice, promote the secretion of insulin and reduce insulin resistance. The contents of total cholesterol, triglyceride and low density lipoprotein cholesterol were significantly decreased in type 2 diabetic mice, while the contents of high density lipoprotein cholesterol were increased in a dose-effect relationship. Conclusion: Blueberry anthocyanins can inhibit dyslipidemia and regulate related diabetes indicators by controlling blood glucose concentration and insulin resistance pathway in diabetic mice.