Effects of Processing on Structural Properties and Biological Activities of Polysaccharides from <i>Polygonatum</i> spp.: A Review

WU Weijing; CHEN Jiafeng; ZHAO Haijun; HUANG Junpeng; HUANG Ningwei; WU Lanlan; ZHAO Haiyi

doi:10.13386/j.issn1002-0306.2021090112

Volume 43 Issue 17

Aug. 2022

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2022 > 43(17): 482-493. > DOI: 10.13386/j.issn1002-0306.2021090112

WU Weijing, CHEN Jiafeng, ZHAO Haijun, et al. Effects of Processing on Structural Properties and Biological Activities of Polysaccharides from Polygonatum spp.: A Review[J]. Science and Technology of Food Industry, 2022, 43(17): 482−493. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021090112.

Citation:

PDF (3395 KB)

Effects of Processing on Structural Properties and Biological Activities of Polysaccharides from Polygonatum spp.: A Review

1.
Xiamen Medical College, Xiamen 361023, China
2.
Engineering Research Center of Natural Cosmeceuticals College of Fujian Province, Xiamen Medical College, Xiamen 361023, China
3.
Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361018, China

More Information

Received Date: September 08, 2021
Available Online: June 25, 2022

Graphical Abstract

Abstract

Abstract

Rhizomes from Polygonatum spp. have multi-functions of both medicine and foods. Three major species are Polygonatum sibiricum Red., Polygonatum kingianum Coll. et Hemsl and Polygonatum cyrtonema Hua. As the key component, the polysaccharides from Polygonatum spp. have various biological activities. The astringency of fresh rhizomes of Polygonatum spp. can cause throat irritation. Thus, the rhizomes of Polygonatum spp. must be processed before consumption as foods or medicine to reduce toxicity and enhance efficacy. However, both of traditional and modern processing methods lead to significant reduction in polysaccharide content, which also change its structure and biological value. Thus, based on literature research, this article summarizes common processing methods of Polygonatum spp., including steaming, stewing, with wine, and shining. In addition, effects of processing methods on polysaccharide content, its structural properties (including monosaccharide composition, molecular weight, etc.), and its physiological activities (including antioxidant activity, regulation of glucose and lipid metabolism, immune-enhancing activity, anti-fatigue activity, antibacterial activity, etc.) are reviewed. It is meaningful to provide references for efficiently industrial use and accurate control during processing of Polygonatum spp..
- processing,
- Polygonatum spp.,
- polysaccharide,
- structure,
- biological activities

FullText(HTML)

References (98)

References

[1]	王丹, 张鸿, 刘嘉丽, 等. 不同产地多花黄精生物活性成分含量比较[J]. 湖南农业科学,2020,7:89−92, 96. [WANG Dan, ZHANG Hong, LIU Jiali, et al. Comparative analysis of bioactive components of Polygonatum cyrtonema Hua from different habitats[J]. Hunan Agricultural Sciences,2020,7:89−92, 96. doi: 10.16498/j.cnki.hnnykx.2020.007.023 WANG Dan, ZHANG Hong, LIU Jiali, et al. Comparative analysis of bioactive components of Polygonatum cyrtonema Hua from different habitats[J]. Hunan Agricultural Sciences, 2020, 7: 89-92, 96 doi: 10.16498/j.cnki.hnnykx.2020.007.023
[2]	LI Ruoshi, TAO Aien, YANG Runmei, et al. Structural characterization, hypoglycemic effects and antidiabetic mechanism of a novel polysaccharides from Polygonatum kingianum Coll. et Hemsl[J]. Biomedicine Pharmacotherapy,2020,131:110687. doi: 10.1016/j.biopha.2020.110687
[3]	ZHAO Ping, ZHOU Huifang, ZHAO Chengcheng, et al. Purification, characterization and immunomodulatory activity of fructans from Polygonatum odoratum and P. cyrtonema[J]. Carbohydrate Polymers,2019,214:44−52. doi: 10.1016/j.carbpol.2019.03.014
[4]	WANG Yongjie, LIU Na, XUE Xia, et al. Purification, structural characterization and in vivo immunoregulatory activity of a novel polysaccharide from Polygonatum sibiricum[J]. International Journal of Biological Macromolecules,2020,160:688−694. doi: 10.1016/j.ijbiomac.2020.05.245
[5]	杨圣贤, 杨正明, 陈奕军, 等. 黄精"九蒸九制"炮制过程中多糖及皂苷的含量变化[J]. 湖南师范大学学报,2015,5:141−144. [YANG Shengxian, YANG Zhengming, CHEN Yijun, et al. Study on the polysaccharides and saoonins constituents of Polygonatum sibiricum Red. in "Nine-steam-nine-bask" processing[J]. Journal of Medical Science of Huan Normal University,2015,5:141−144. YANG Shengxian, YANG Zhengming, CHEN Yijun, et al. Study on the polysaccharides and saoonins constituents of Polygonatum sibiricum Red. in "Nine-steam-nine-bask" processing[J]. Journal of Medical Science of Huan Normal University, 2015, 5: 141-144.
[6]	何兰香, 丁科, 谢明华, 等. 酶法-超声提取黄精总黄酮及其抗氧化活性研究[J]. 中国现代应用药学,2019,36(9):1075−1080. [HE Lanxiang, DING Ke, XIE Minghua, et al. Study on enzymatic-ultrasonic assisted extraction of total flavonoids from Polygonatum Sibirici and its antioxidant activities[J]. Chinese Journal of Modern Drug Application,2019,36(9):1075−1080. doi: 10.13748/j.cnki.issn1007-7693.2019.09.009 HE Lanxiang, DING Ke, XIE Minghua, et al. Study on enzymatic-ultrasonic assisted extraction of total flavonoids from Polygonatum Sibirici and its antioxidant activities[J]. Chinese Journal of Modern Drug Application, 2019, 36(9): 1075-1080. doi: 10.13748/j.cnki.issn1007-7693.2019.09.009
[7]	巫永华, 刘恩岐, 张建萍, 等. 黄精多酚的闪式提取及抗氧化活性研究[J]. 食品科技,2017,42(8):231−236. [WU Yonghua, LIU Enqi, ZHANG Jianping, et al. Extraction and antioxidant activities of polyphenols from Polygonatum[J]. Food Science and Technology,2017,42(8):231−236. doi: 10.13684/j.cnki.spkj.2017.08.042 WU Yonghua , LIU Enqi, ZHANG Jianping, et al. Extraction and antioxidant activities of polyphenols from Polygonatum[J]. Food Science and Technology, 2017, 42 (8): 231-236. doi: 10.13684/j.cnki.spkj.2017.08.042
[8]	陈克克, 强毅. 响应面法优化超声波辅助黄精多酚的提取及其抗菌活性[J]. 陕西师范大学学报,2018,46(1):91−96. [CHEN Keke, QIANG Yi. Optimization of ultrasonic assisted extraction of polyphenols from Polygonatum sibiricum Red. using resopnse surface methodology and its antibacterial activity[J]. Journal of Shanxi Normal University(Natural Science Edition),2018,46(1):91−96. CHEN Keke, Qiang Yi. Optimization of ultrasonic assisted extraction of polyphenols from Polygonatum sibiricum Red. using resopnse surface methodology and its antibacterial activity[J]. Journal of Shanxi Normal University(Natural Science Edition), 2018, 46(1): 91-96.
[9]	张国强, 郭晓东, 薛文华, 等. 西藏野生卷叶黄精多酚的提取及其抗氧化活性分析[J]. 食品科学,2017,38(6):236−241. [ZHANG Guoqiang, GUO Xiaodong, XUE Wenhua, et al. Extraction and antioxidant activities of polyphenols from Tibetan wild Polygonatum cirrhifolium[J]. Food Science,2017,38(6):236−241. doi: 10.7506/spkx1002-6630-201706037 ZHANG Guoqiang, GUO Xiaodong, XUE Wenhua, et al. Extraction and antioxidant activities of polyphenols from Tibetan wild Polygonatum cirrhifolium[J]. Food Science, 2017, 38(6): 236-241. doi: 10.7506/spkx1002-6630-201706037
[10]	巫永华, 张建萍, 赵节昌, 等. 大孔树脂纯化黄精多酚及其抗氧化性与组成分析[J]. 农业工程学报,2020,36(1):318−326. [WU Yonghua, ZHANG Jianping, ZHAO Jiechang, et al. Antioxidant and purification of Polygonatum sibiricum polyphenols using macroporous resin[J]. Transactions of the Chinese Society of Agricultural Engineering,2020,36(1):318−326. doi: 10.11975/j.issn.1002-6819.2020.01.038 WU Yonghua, ZHANG Jianping, ZHAO Jiechang, et al. Antioxidant and purification of Polygonatum sibiricum polyphenols using macroporous resin[J]. Transactions of the Chinese Society of Agricultural Engineering. 2020, 36(1): 318-326. doi: 10.11975/j.issn.1002-6819.2020.01.038
[11]	秦宇雯, 张丽萍, 赵祺, 等. 九蒸九晒黄精炮制工艺的研究进展[J]. 中草药,2020,51(21):5631−5637. [QIN Yuwen, ZHANG Liping, ZHAO Qi, et al. Research progress on Polygonatum cyrtonema processed by nine times steaming and nine times shining[J]. Chinese Traditional and Herbal Drugs,2020,51(21):5631−5637. QIN Yuwen, ZHANG Liping ZHAO Qi, et al. Research progress on Polygonatum cyrtonema processed by nine times steaming and nine times shining[J]. Chinese Traditional and Herbal Drugs, 51(21): 5631-5637.
[12]	国家药典委员会. 中华人民共和国药典[M]. 北京: 中国医药科技出版社, 2020. Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China[M]. Beijing: China Medical and Technology Press, 2020.
[13]	林雨, 佘亮, 魏馨瑶, 等. 黄精炮制前后的化学成分变化及其减毒增效研究[J]. 中药材,2021,6:1353−1359. [LIN Yu, SHE Liang, WEI Xinyao, et al. Study on chemical constituents, detoxification and synergism of Polygonati Rhizoma before and after processing[J]. Journal of Chinese Medicinal Materials,2021,6:1353−1359. doi: 10.13863/j.issn1001-4454.2021.06.012 LIN Yu, SHE Liang, WEI Xinyao, et al. Study on chemical constituents, detoxification and synergism of Polygonati Rhizoma before and after processing[J]. Journal of Chinese Medicinal Materials, 2021, 6: 1353-1359. doi: 10.13863/j.issn1001-4454.2021.06.012
[14]	任洪民, 邓亚羚, 张金莲, 等. 药用黄精炮制的历史沿革, 化学成分及药理作用研究进展[J]. 中国中药杂志,2020,45(17):153−172. [REN Hongmin, DENG Yaling, ZHANG Jinlian, et al. Research progress on processing history evolution, chemical components and pharmacological effects of Polygonati Rhizoma[J]. China Journal of Chinese Materia Medica,2020,45(17):153−172. REN Hongmin, DENG Yaling, ZHANG Jinlian, et al. Research progress on processing history evolution, chemical components and pharmacological effects of Polygonati Rhizoma[J]. China Journal of Chinese Materia Medica, 2020, 45(17): 153-172.
[15]	李瑞, 廖念, 周逸群, 等. 基于功效成分优选多蒸黄精炮制工艺[J]. 时珍国医国药,2019,30(2):331−333. [LI Rui, LIAO Nian, ZHOU Yiqun, et al. Optimization of processing technology of multi-steamed Polygonatum based on efficacy components[J]. Lishizhen Medicine and Materia Medica Research,2019,30(2):331−333. LI Rui, LIAO Nian, ZHOU Yiqun, et al. Optimization of processing technology of multi-steamed Polygonatum based on efficacy components[J]. Lishizhen Medicine and Materia Medica Research, 2019, 30(2): 331-333.
[16]	曹冠华, 李泽东, 赵荣华, 等. 生黄精多糖与制黄精多糖抑菌效果比较研究[J]. 食品科技,2017(9):202−206. [CAO Guanhua, LI Zedong, ZHAO Ronghua, et al. Compare of antibacterial effect produced by polysaccharides between raw materials and processing Polygonatum sibiricum[J]. Food Science and Technology,2017(9):202−206. doi: 10.13684/j.cnki.spkj.2017.09.038 CAO Guanhua, LI Zedong, ZHAO Ronghua, et al. Compare of antibacterial effect produced by polysaccharides between raw materials and processing Polygonatum sibiricum[J]. Food Science and Technology, 2017(9): 202-206. doi: 10.13684/j.cnki.spkj.2017.09.038
[17]	廖念. 多花黄精产地加工炮制及其质量标准的研究[D]. 长沙: 湖南中医药大学, 2018. LIAO Nian. Study on processing and quality standard of Polygonum cyrtonema from producing area[J]. Changsha: Hunan University of Chinese Medicine, 2018.
[18]	FAN Baolei, WEI Guoliang, GAN Xiaofeng, et al. Study on the varied content of Polygonatum cyrtonema polysaccharides in the processing of steaming and shining for nine times based on HPLC-MS/MS and chemometrics[J]. Microchemical Journal,2020,159:105352. doi: 10.1016/j.microc.2020.105352
[19]	马佳丽, 蒋殷盈, 蒋福升, 等. 九蒸九制多花黄精炮制过程变化研究[J]. 浙江中医药大学学报,2020,44(5):480−485. [MA Jiali, JIANG Yinying, JIANG Fusheng, et al. Study on the changes of “Nine-steam-nine-bask” of Polygonatum cyrtonema[J]. Journal of Zhejiang Chinese Medical University,2020,44(5):480−485. doi: 10.16466/j.issn1005-5509.2020.05.018 MA Jiali, JIANG Yinying, JIANG Fusheng, et al. Study on the changes of “Nine-steam-nine-bask” of Polygonatum cyrtonema[J]. Journal of Zhejiang Chinese Medical University, 2020, 44(5): 480-485. doi: 10.16466/j.issn1005-5509.2020.05.018
[20]	陈靓雯, 柯晓燕. 古法炮制多花黄精提取物抗疲劳作用研究及其机制探讨[J]. 科学技术创新,2019(4):3−4. [CHEN Liangwen, KE Xiaoyan. Study on anti-fatigue effect and mechanism of extract of Polygonum cyrtonema processed by ancient method[J]. Scientific and Technological Innovation,2019(4):3−4. doi: 10.3969/j.issn.1673-1328.2019.04.003 CHEN Liangwen, KE Xiaoyan. Study on anti-fatigue effect and mechanism of extract of Polygonum cyrtonema processed by ancient method[J]. Ke Xue Ji Shu Chuang Xin, 2019, (4): 3-4. doi: 10.3969/j.issn.1673-1328.2019.04.003
[21]	胡叶青, 胡云飞, 吴其国. 九华黄精九蒸九晒炮制过程中总多糖的含量变化研究[J]. 佛山科学技术学院学报(自然科学版),2019,37(6):58−62. [HU Yeqing, HU Yunfei, WU Qiguo. Study on the total polysaccharides content of Jiuhua Rhizoma Polygnoati in nine-steam-nine-bask processing[J]. Journal of Foshan University(Natural Science Edition),2019,37(6):58−62. doi: 10.13797/j.cnki.jfosu.1008-0171.2019.0085 HU Yeqing, HU Yunfei, WU Qiguo. Study on the total polysaccharides content of Jiuhua Rhizoma Polygnoati in nine-steam-nine-bask processing[J]. Journal of Foshan University(Natural Science Edition), 2019, 37(6): 58-62. doi: 10.13797/j.cnki.jfosu.1008-0171.2019.0085
[22]	张洪坤, 吴桂芳, 黄玉瑶, 等. 黄精不同九制炮制的过程研究[J]. 时珍国医国药,2019,30(3):602−605. [ZHANG Hongkun, WU Guifang, HUANG Yuyao, et al. Study on the process of Polygonatum sibiricum Red. in different nine fold processing[J]. Lishizhen Medicine and Materia Medica Research,2019,30(3):602−605. ZHANG Hongkun, WU Guifang, HUANG Yuyao, et al. Study on the process of Polygonatum sibiricum Red. in different nine fold processing[J]. Lishizhen Medicine and Materia Medica Research, 2019, 30(3): 602-605.
[23]	马慕秾. 炮制方法对黄精多糖成分和“补气养阴”功效相关药理作用的影响[D]. 杭州: 浙江中医药大学, 2019. MA Munong. Effects of processing methods on the components of Polygonatum polysaccharide and the related pharmacological effects of "Invigorating Qi and Nourishing Yin"[D]. Hangzhou: Zhejiang Chinese Medical University, 2019.
[24]	宋艺君, 郭涛, 周晓程. 不同产地黄精经不同方法炮制后多糖, 5-羟甲基糠醛的含量变化[J]. 中国药房,2017,28(16):2256−2258. [SONG Yijun, GUO Tao, ZHOU Xiaocheng. Contents changes of polysaccharide and 5-HMF in Polygonati Rhizoma from different producing areas after different processing[J]. China Pharmacy,2017,28(16):2256−2258. doi: 10.6039/j.issn.1001-0408.2017.16.26 SONG Yijun, GUO Tao, ZHOU Xiaocheng. Contents changes of polysaccharide and 5-HMF in Polygonati Rhizoma from different producing areas after different processing[J]. China Pharmacy, 2017, 28(16): 2256-2258. doi: 10.6039/j.issn.1001-0408.2017.16.26
[25]	周改莲, 李健, 徐梦云, 等. 广西产多花黄精不同炮制工艺研究[J]. 中国民族民间医药,2018,27(327):38−41. [ZHOU Gailian, LI Jian, XU Mengyun, et al. Study on different processing techniques of Guangxi Polygonatum cyrtonema[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy,2018,27(327):38−41. ZHOU Gailian, LI Jian, XU Mengyun, et al. Study on different processing techniques of Guangxi Polygonatum cyrtonema[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2018, 27(327): 38-41.
[26]	刘明研, 冯亚娟, 黄秋正, 等. 蒸制时间对滇黄精色泽、可溶性成分及糖含量的影响[J]. 食品工业科技,2019,40(5):43−47, 53. [LIU Mingyan, FENG Yajuan, HUANG Qiuzheng, et al. Influence of steaming time on color, the content of soluble substance and sugar in Polygonatum kingianum[J]. Science and Technology of Food Industry,2019,40(5):43−47, 53. doi: 10.13386/j.issn1002-0306.2019.05.007 LIU Mingyan, FENG Yajuan, HUANG Qiuzheng, et al. Influence of steaming time on color, the content of soluble substance and sugar in Polygonatum kingianum[J]. Science and Technology of Food Industry, 2019, 40(5): 43-47, 53. doi: 10.13386/j.issn1002-0306.2019.05.007
[27]	金鹏程, 吴丽华, 吴昕怡, 等. Box-Behnken响应面法优化滇黄精产地加工炮制一体化工艺对黄精多糖的影响[J]. 中国现代中药,2021,23(4):674−679. [JIN Pengcheng, WU Lihua, WU Xinyi, et al. Effect of integrative technology of primary processing of Polygonatum kingianum optimization by Box-Benhken response surface method on polysaccharide[J]. Modern Chinese Medicine,2021,23(4):674−679. doi: 10.13313/j.issn.1673-4890.20200410001 JIN Pengcheng, WU Lihua, WU Xinyi, et al. Effect of integrative technology of primary processing of Polygonatum kingianum optimization by Box-Benhken response surface method on polysaccharide[J]. Modern Chinese Medicine, 2021, 23(4): 674-679. doi: 10.13313/j.issn.1673-4890.20200410001
[28]	衡银雪, 郑旭煦, 殷钟意, 等. 不同干燥方法对黄精干燥特性和品质的影响[J]. 食品工业科技,2018,39(7):158−161. [HENG Yinxue, ZHENG Xuxu, YIN Zhongyi, et al. The effects of different drying methods on the drying characteristics and quality of Polygonatum odoratum[J]. Science and Technology of Food Industry,2018,39(7):158−161. doi: 10.13386/j.issn1002-0306.2018.07.029 HENG Yinxue, ZHENG Xuxu, YIN Zhongyi, et al. The effects of different drying methods on the drying characteristics and quality of Polygonatum odoratum[J]. Science and Technology of Food Industry, 2018, 39(7): 158-161. doi: 10.13386/j.issn1002-0306.2018.07.029
[29]	朱新焰, 丛琨, 石亚娜, 等. 不同初加工方法对黄精品质的影响研究[J]. 中国药房,2019,30(18):2537−2541. [[ZHU Xinyan, CONG Kun, SHI Yana, et al. Study on the effects of different primary processing methods on the quality of Polygonatum sibiricum[J]. China Pharmacy,2019,30(18):2537−2541. [ZHU Xinyan, CONG Kun, SHI Yana, et al. Study on the effects of different primary processing methods on the quality of Polygonatum sibiricum[J]. China Pharmacy, 2019, 30(18): 2537-2541.
[30]	潘克琴, 李丹丹, 王华磊, 等. 九蒸九制对不同龄节多花黄精品质的影响[J]. 特产研究,2021,43(3):23−27. [PAN Keqin, LI Dandan, WANG Hualei, et al. Effects of nine steaming and nine processing systems on the quality of Polygonatum cyrtonema Hua in different ages[J]. Special Wild Economic Animal and Plant Research,2021,43(3):23−27. doi: 10.16720/j.cnki.tcyj.2021.058 PAN Keqin, LI Dandan, WANG Hualei, et al. Effects of nine steaming and nine processing systems on the quality of Polygonatum cyrtonema Hua in different ages[J]. Special Wild Economic Animal and Plant Research , 2021, 43(3): 23-27. doi: 10.16720/j.cnki.tcyj.2021.058
[31]	陈文华, 谭会颖, 邴帅, 等. 传统炮制工艺对热河黄精多糖含量的影响[J]. 时珍国医国药,2018,29(12):2940−2942. [CHEN Wenhua, TAN Huiying, BING Shuai, et al. Effects of traditional processing technology on polysaccharide content of JeholZeolium[J]. Lishizhen Medicine and Materia Medica Research,2018,29(12):2940−2942. CHEN Wenhua, TAN Huiying, BING Shuai, et al. Effects of traditional processing technology on polysaccharide content of JeholZeolium[J]. Lishizhen Medicine and Materia Medica Research, 2018, 29(12): 2940-2942.
[32]	吴丰鹏, 李芹英, 吴彦超, 等. 九蒸九制对黄精多糖单糖组成及其抗氧化性的影响[J]. 食品工业科技,2021,42(2):42−46. [WU Fengpeng, LI Qinying, WU Yanchao, et al. Effects of nine-steam-nine-bask on the monosaccharide composition and antioxidant activities of Polygonatum sibiricum polysaccharide[J]. Science and Technology of Food Industry,2021,42(2):42−46. doi: 10.13386/j.issn1002-0306.2020030160 WU Fengpeng, LI Qinying, WU Yanchao, et al. Effects of nine-steam-nine-bask on the monosaccharide composition and antioxidant activities of Polygonatum sibiricum polysaccharide[J]. Science and Technology of Food Industry, 2021, 42(2): 42-46. doi: 10.13386/j.issn1002-0306.2020030160
[33]	瞿昊宇, 冯楚雄, 谢梦洲, 等. 不同炮制方法对黄精多糖含量的影响[J]. 湖南中医药大学学报,2015,35(12):53−55. [QU Haoyu, FENG Chuxiong, XIE Mengzhou, et al. Effcet of different processing methods on the content of polygahatous polysaccharides[J]. Journal of Traditional Chinese Medicine University of Hunan,2015,35(12):53−55. doi: 10.3969/j.issn.1674-070X.2015.12.015 QU Haoyu, FENG Chuxiong, XIE Mengzhou, et al. Effcet of different processing methods on the content of Polygahatous polysaccharides[J]. Journal of Traditional Chinese Medicine University of Hunan, 2015, 35(12): 53-55. doi: 10.3969/j.issn.1674-070X.2015.12.015
[34]	陈瑞瑞, 祖艳红, 石丁夫, 等. 多花黄精从生粉到九蒸九晒过程中多糖的变化[J]. 安徽农业科学,2019,47(18):181−182. [CHEN Ruirui, ZU Yanhong, SHI Dingfu, et al. Changes of polysaccharides in the process of Polygonatum cyrtonema from raw flour to nine steaming and nine drying[J]. Journal of Anhui Agricultural Sciences,2019,47(18):181−182. doi: 10.3969/j.issn.0517-6611.2019.18.049 CHEN Ruirui, ZU Yanhong, SHI Dingfu, et al. Changes of polysaccharides in the process of Polygonatum cyrtonema from raw flour to nine steaming and nine drying[J]. Journal of Anhui Agricultural Sciences, 2019, 47(18): 181-182. doi: 10.3969/j.issn.0517-6611.2019.18.049
[35]	王迎香, 唐子惟, 彭腾, 等. 苯酚-硫酸法测定酒蒸多花黄精多糖含量的优化[J]. 食品工业科技,2021,42(18):300−308. [WANG Yingxiang, TANG Ziwei, PENG Teng, et al. Optimization of phenol sulfuric acid method for the polysaccharide content of wine-steamed Polygonatum cyrtonema Hua[J]. Science and Technology of Food Industry,2021,42(18):300−308. doi: 10.13386/j.issn1002-0306.2021010069 WANG Yingxiang, TANG Ziwei, PENG Teng, et al. Optimization of phenol sulfuric acid method for the polysaccharide content of wine-steamed Polygonatum cyrtonema Hua[J]. Science and Technology of Food Industry, 2021, 42(18): 300-308. doi: 10.13386/j.issn1002-0306.2021010069
[36]	陶爱恩. 滇黄精多糖的理化性质、活性筛选与质量评价研究[D]. 大理: 大理大学, 2019. TAO Aien. Study on physicochemical properties, activity screening and quality evaluation of polysaccharides from Polygonatum kingianum[D]. Dali: Dali University, 2019.
[37]	胡叶青, 胡云飞, 祝凌丽, 等. 九华黄精"九蒸九晒"炮制过程中5-羟甲基糠醛的含量变化[J]. 德州学院学报,2019,35(4):29−32. [HU Yeqing, HU Yunfei, ZHU Lingli, et. al. Study on the 5-hydroxymethylfurfural constituents of Jiuhua Rhizoma Polygnoatiin "Nine-steam-nine-bask" processing[J]. Journal of Dezhou University,2019,35(4):29−32. doi: 10.3969/j.issn.1004-9444.2019.04.008 HU Yeqing, HU Yunfei, ZHU Lingli, et. al. Study on the 5-hydroxymethylfurfural constituents of Jiuhua Rhizoma Polygnoatiin "Nine-steam-nine-bask" processing[J]. Journal of Dezhou University, 2019, 35(4): 29-32. doi: 10.3969/j.issn.1004-9444.2019.04.008
[38]	杨婧娟, 张希, 马雅鸽. 发酵对黄精主要活性成分及其抗氧化活性和刺激性的影响[J]. 食品工业科技,2020,41(2):52−58. [YANG Jingjuan, ZHANG Xi, MA Yage. Effects of fermentation on main bioactive components, antioxidant activities and irritation of Polygonatum sibiricum[J]. Science and Technology of Food Industry,2020,41(2):52−58. doi: 10.13386/j.issn1002-0306.2020.02.009 YANG Jingjuan, ZHANG Xi, MA Yage. Effects of fermentation on main bioactive components, antioxidant activities and irritation of Polygonatum sibiricum[J]. Science and Technology of Food Industry, 2020, 41(2): 52-58. doi: 10.13386/j.issn1002-0306.2020.02.009
[39]	XIE Songzi, YANG Guang, JIANG Xianmin, et al. Polygonatum cyrtonema Hua polysaccharide promotes GLP-1 secretion from enteroendocrine L-cells through sweet taste receptor-mediated cAMP signaling[J]. Journal of Agricultural and Food Chemistry,2020,68(25):6864−6872. doi: 10.1021/acs.jafc.0c02058
[40]	杨光. 多花黄精多糖对GLP-1分泌与表达的调节及其分子机制研究[D]. 合肥: 合肥工业大学, 2018. YANG Guang. The effect of Polygonatum cyrtonema Hua polysaccharides (PCP) on the expression and secretion of GLP-1 and its molecular mechanism[D]. Hefei: Hefei University of Technology, 2018.
[41]	LIU Fen, LIU Yinghua, MENG Yiwen, et al. Structure of polysaccharide from Polygonatum cyrtonema Hua and the antiherpetic activity of its hydrolyzed fragments[J]. Antiviral Research,2004,63(3):183−189. doi: 10.1016/j.antiviral.2004.04.006
[42]	LIU Xiaoxiao, WAN Zhenjiang, SHI Lin, et al. Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua[J]. Carbohydrate Polymers,2011,83(2):737−742. doi: 10.1016/j.carbpol.2010.08.044
[43]	SHEN Wendi, LI Xueying, DENG Yuanyuan, et al. Polygonatum cyrtonema Hua polysaccharide exhibits anti-fatigue activity via regulating osteocalcin signaling[J]. International Journal of Biological Macromolecules,2021,175:235−241. doi: 10.1016/j.ijbiomac.2021.01.200
[44]	ZHAO Ping, LI Xia, WANG Ying, et al. Characterisation and saccharide mapping of polysaccharides from four common Polygonatum spp[J]. Carbohydrate Polymers,2020,233:115836. doi: 10.1016/j.carbpol.2020.115836
[45]	雍潘. 多花黄精的多糖提取、纯化、结构解析及活性研究[D]. 成都: 西南民族大学, 2019. YONG Pan. Isolation, purification, structural characterization and biological activity of polysaccharides from Polygonatum cyrtonema Hua[D]. Chengdu: Southwest Minzu University, 2019.
[46]	LI Ning, SHI Chenchen, SHI Songshan, et al. An inulin-type fructan isolated from Artemisia japonica and its anti-arthritic effects[J]. Journal of Functional Foods,2017,29:29−36. doi: 10.1016/j.jff.2016.11.033
[47]	ZHANG Jiaozhen, LIU Na, SUN Chao, et al. Polysaccharides from Polygonatum sibiricum Delar. ex Redoute induce an immune response in the RAW264.7 cell line via an NF-κB/MAPK pathway[J]. RSC Advances,2019,9(31):17988−17994. doi: 10.1039/C9RA03023A
[48]	SUN Tingting, ZHANG Hong, LI Ye, et al. Physicochemical properties and immunological activities of polysaccharides from both crude and wine-processed Polygonatum sibiricum[J]. International Journal of Biological Macromolecules,2020,143:255−264. doi: 10.1016/j.ijbiomac.2019.11.166
[49]	YELITHAO K, SURAYOT U, PARK W, et al. Effect of sulfation and partial hydrolysis of polysaccharides from Polygonatum sibiricum on immune-enhancement[J]. International Journal of Biological Macromolecules,2019,122:10−18. doi: 10.1016/j.ijbiomac.2018.10.119
[50]	LIU Liu, DONG Qun, DONG Xiaotang, et al. Structural investigation of two neutral polysaccharides isolated from rhizome of Polygonatum sibiricum[J]. Carbohydrate Polymers,2007,70(3):304−309. doi: 10.1016/j.carbpol.2007.04.012
[51]	刘娜. 黄精多糖的分离、鉴定及免疫调节功效研究[D]. 济南: 山东大学, 2017. LIU Na. Isolation, identification and study on the immunomodulatory effect of polysaccharide from Polygonatum sibiricum[D]. Jinan: Shangdong University, 2017.
[52]	ZHANG Hui, CAI Xiuting, TIAN Qinghua, et al. Microwave-assisted degradation of polysaccharide from Polygonatum sibiricum and antioxidant activity[J]. Journal of Food Science and Technology (Mysore),2019,84(4):754−761.
[53]	张遥遥, 张梦, 胡悦, 等. 黄精多糖的提纯, 硫酸化和羧甲基化修饰及其抗氧化活性研究[J]. 食品工业科技,2019,40(21):45−51. [ZHANG Yaoyao, ZHANG Meng, HU Yue, et al. Purification, sulfation modification and carboxymethylation modification of polysaccharides from Polygonatum sibiricum and its antioxidant activity[J]. Science and Technology of Food Industry,2019,40(21):45−51. ZHANG Yaoyao, ZHANG Meng, HU Yue, et al. Purification, sulfation modification and carboxymethylation modification of polysaccharides from Polygonatum sibiricum and its antioxidant activity[J]. Science and Technology of Food Industry, 2019, 40(21): 45-51.
[54]	LI Qinying, ZENG Jun, GONG Pixian, et al. Effect of steaming process on the structural characteristics and antioxidant activities of polysaccharides from Polygonatum sibiricum rhizomes[J]. Glycoconjugate Journal,2021,38(5):561−572. doi: 10.1007/s10719-021-10013-z
[55]	杜泽飞. 黄精的化学成分、炮制与结构修饰研究及黄精属植物系统发育分析[D]. 大理: 大理大学, 2020. DU Zefei. Studies on the chemical constituents, processing and structural modification from the Polygonati Rhizoma and phylogenetic analysis in plants of Polygonatum species[D]. Dali: Dali University, 2020.
[56]	JIN Jian, LAO Jia, ZHOU Rongrong, et al. Simultaneous identification and dynamic analysis of saccharides during steam processing of rhizomes of Polygonatum cyrtonema by HPLC-QTOF-MS/MS[J]. Molecules,2018,23(11):2855. doi: 10.3390/molecules23112855
[57]	王婧, 陶爱恩, 杨燕, 等. 滇黄精中多糖的分离与抗氧化活性研究[J]. 中草药,2021,52(16):4789−4796. [WANG Jing, TAO Aien, YANG Yan, et al. Separation, physicochemical properties and anti-oxidant activities of three polysaccharides from Polygonatum kingianum[J]. Chinese Traditional and Herbal Drugs,2021,52(16):4789−4796. WANG Jing, TAO Aien, YANG Yan, et al. Separation, physicochemical properties and anti-oxidant activities of three polysaccharides from Polygonatum kingianum[J]. Chinese Traditional and Herbal Drugs, 52(16): 4789-4796.
[58]	顾健. 滇黄精多糖的制备与质量分析[D]. 苏州: 苏州大学, 2018. GU Jian. Preparation and determination of polysaccharide in Polygonatum kingianum[D]. Suzhou: Soochow University, 2018.
[59]	万晓莹, 刘振丽, 宋志前, 等. 黄精炮制前后多糖的相对分子质量分布和免疫活性比较[J]. 中国实验方剂学杂志,2021,27(15):83−90. [WAN Xiaoying, LIU Zhenli, SONG Zhiqian, et al. Comparison of relative molecular weight distribution and immune activity of polysaccharides in Polygonati Rhizoma before and after processing[J]. Chinese Journal of Experimental Traditional Medical Formulae,2021,27(15):83−90. doi: 10.13422/j.cnki.syfjx.20210446 WAN Xiaoying, LIU Zhenli, SONG Zhiqian. Comparison of relative molecular weight distribution and immune activity of polysaccharides in Polygonati Rhizoma before and after processing[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2021, 27(15): 83-90. doi: 10.13422/j.cnki.syfjx.20210446
[60]	王坤, 岳永德, 汤锋, 等. 多花黄精多糖的分级提取及结构初步分析[J]. 天然产物研究与开发,2014,26(3):364−369. [WANG Kun, YUE Yongde, TANG Feng, et al. Sequential extraction and structural analysis of polysaccharides from Polygonatum cyrtonema Hua[J]. Natural Product Research and Development,2014,26(3):364−369. doi: 10.16333/j.1001-6880.2014.03.015 WANG Kun, YUE Yongde, TANG Feng, et al. Sequential extraction and structural analysis of polysaccharides from Polygonatum cyrtonema Hua[J]. Natural Product Research and Development, 2014, 26(3): 364-369. doi: 10.16333/j.1001-6880.2014.03.015
[61]	徐如静, 梁娟, 俞年军, 等. 九华黄精炮制前后多糖类成分结构变化研究[J]. 安徽中医药大学学报,2021,40(2):91−96. [XU Rujing, LIANG Juan, YU Nianjun, et al. Structural change of polysaccharide constituents from Polygonatum cyrtonema in Jiuhua Mountain after processing[J]. Journal of Anhui University of Chinese Medicine,2021,40(2):91−96. doi: 10.3969/j.issn.2095-7246.2021.02.022 XU Rujing, LIANG Juan, YU Nianjun, et al. Structural change of polysaccharide constituents from Polygonatum cyrtonema in Jiuhua Mountain after processing[J]. Journal of Anhui University of Chinese Medicine, 2021, 40(2): 91-96. doi: 10.3969/j.issn.2095-7246.2021.02.022
[62]	LI Xiaojun, CHEN Qi, LIU Guoku, et al. Chemical elucidation of an arabinogalactan from rhizome of Polygonatum sibiricum with antioxidant activities[J]. International Journal of Biological Macromolecules,2021,190:730−738. doi: 10.1016/j.ijbiomac.2021.09.038
[63]	张玉琴, 刘垚君, 王欣垚, 等. 黄精多糖对H₂O₂诱导HT22细胞氧化损伤的保护作用[J]. 江西中医药大学学报,2021,33(2):4. [ZHANG Yuqin, LIU Yaojun, WANG Xinyao, et al. Protective effect of Polygonatum polysaccharides on oxidative injury induced by hydrogen peroxide in HT22 cells[J]. Journal of Jiangxi University of Traditional Chinese Medicine,2021,33(2):4. ZHANG Yuqin, LIU Yaojun, WANG Xinyao. Protective effect of Polygonatum polysaccharides on oxidative injury induced by hydrogen peroxide in HT22 cells[J]. Journal of Jiangxi University of Traditional Chinese Medicine, 2021, 33(2): 4.
[64]	WANG Yi, LAN Changjun, LIAO Xuan, et al. Polygonatum sibiricum polysaccharide potentially attenuate diabetic retinal injury in a diabetic rat model[J]. Journal of Diabetes Investigation,2019,10(4):915−924. doi: 10.1111/jdi.12976
[65]	YAN Hongli, LU Jianmei, WANG Yanfang, et al. Intake of total saponins and polysaccharides from Polygonatum kingianum affects the gut microbiota in diabetic rats[J]. Phytomedicine,2017,26:45−54. doi: 10.1016/j.phymed.2017.01.007
[66]	杨明琛, 袁梦欣, 陆维, 等. 黄精多糖体外消化特性及对Ⅱ型糖尿病小鼠肠道菌群的调节作用[J]. 现代食品科技,2021,37(8):14−21. [YANG Mingchen, YUAN Mengxin, LU Wei, et al. In vitro digestion properties of Polygonatum sibiricum polysaccharide and its regulatory action on the gut microbiota in T2DM mice[J]. Modern Food Science & Technology,2021,37(8):14−21. doi: 10.13982/j.mfst.1673-9078.2021.8.1181 YANG Mingchen, YUAN Mengxin, LU Wei, et al. In vitro digestion properties of Polygonatum sibiricum polysaccharide and its regulatory action on the gut microbiota in T2DM mice[J]. Modern Food Science & Technology, 2021, 37(8): 14-21. doi: 10.13982/j.mfst.1673-9078.2021.8.1181
[67]	LU Yi, SHI Zhenfeng, LI Lei. Effects of polysaccharide from Polygonatum cyrtonema Hua on blood glucose, survival rate and liver cell protection in type I diabetic mice[J]. Acta Microscopica,2020,29(5):2711−2717.
[68]	王艳芳. 滇黄精多糖改善大鼠脂代谢紊乱的作用研究[D]. 昆明: 云南中医学院, 2017. WANG Yanfang. Effects and mechanisms of polysaccharide from Polygonatum kingianum on lipid metabolism disorder in rats[D]. Kunming: Yunnan University of Chinese Medicine, 2017.
[69]	LIU Bo, TANG Yuan, SONG Zhenyan, et al. Polygonatum sibiricum F. Delaroche polysaccharide ameliorates HFD-induced mouse obesity via regulation of lipid metabolism and inflammatory response[J]. Molecular Medicine Reports,2021,24(1):1−10.
[70]	GU Wen, WANG Yanfang, ZENG Linxi, et al. Polysaccharides from Polygonatum kingianum improve glucose and lipid metabolism in rats fed a high fat diet[J]. Biomedicine and Pharmacotherapy,2020,125:109910. doi: 10.1016/j.biopha.2020.109910
[71]	王曦. 基于线粒体功能调节的滇黄精缓解非酒精脂肪肝药效及机制探究[D]. 昆明: 云南中医药大学, 2019. WANG Xi. Study on the efficacy and mechanism of Polygonatum kingianum on relieving nonalcoholic fatty liver based on mitochondrial function regulation[D]. Kunming: Yunnan University of Chinese Medicine, 2019.
[72]	YANG Xingxin, WEI Jiadi, MU Jiankang, et al. Integrated metabolomic profiling for analysis of antilipidemic effects of Polygonatum kingianum extract on dyslipidemia in rats[J]. World Journal of Gastroenterology,2018,24(48):5505−5524. doi: 10.3748/wjg.v24.i48.5505
[73]	LONG Tingting, LIU Zijing, SHANG Jingchuan, et al. Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK/NF-κB signaling pathways[J]. International Journal of Biological Macromolecules,2018,111:813−821. doi: 10.1016/j.ijbiomac.2018.01.070
[74]	傅圣斌, 钱建鸿, 陈乐意, 等. 黄精多糖的提取及其对小鼠免疫活性的影响[J]. 中国食品学报,2013,13(1):68−72. [FU Shengbin, QIAN Jianhong, CHEN Leyi, et al. Extracting of Polygonatum polysaccharides and effecting on the immunological activity in immunosuppressed mice[J]. Journal of Chinese Institute of Food Science and Technology,2013,13(1):68−72. doi: 10.16429/j.1009-7848.2013.01.002 FU Shengbin, QIAN Jianhong, CHEN Leyi, et al. Extracting of Polygonatum polysaccharides and effecting on the immunological activity in immunosuppressed mice[J]. Journal of Chinese Institute of Food Science and Technology, 2013, 13(1): 68-72. doi: 10.16429/j.1009-7848.2013.01.002
[75]	于思文, 张妍, 田海玲, 等. 黄精粗多糖对体外培养小鼠脾淋巴细胞及巨噬细胞免疫活性的影响[J]. 延边大学医学学报,2019,42(2):33−36. [YU Siwen, ZHANG Yan, TIAN Hailing, et al. Effects of crude polysaccharide from Polygonatum sibiricum on the immune activity of mouse spleen lymphocytes and macrophages cultured in vitro[J]. Journal of Medical Science Yanbian University,2019,42(2):33−36. YU Siwen, ZHANG Yan, TIAN Hailing, et al. Effects of crude polysaccharide from Polygonatum sibiricum on the immune activity of mouse spleen lymphocytes and macrophages cultured in vitro[J]. Journal of Medical Science Yanbian University, 2019, 42(2): 33-36.
[76]	付莉慧. 滇黄精粗多糖含片制备工艺及其抗疲劳作用的初步研究[D]. 昆明: 云南中医药大学, 2019. FU Lihui. Preliminary study on preparation process and anti- fatigue effect of Polygonatum kingianum crude polysaccharide tablets[D]. Kuming: Yunnan University of Chinese Medicine, 2019.
[77]	刘诗琼, 秦晓群, 李世胜. 黄精多糖对小鼠抗疲劳作用的实验研究[J]. 中国当代医药,2009,16(10):31−32. [LIU Shiqiong, QIN Xiaoqun, LI Shisheng. Effects of polysaccharides from Polygonatum on fatigue in mice[J]. China Modern Medicine,2009,16(10):31−32. doi: 10.3969/j.issn.1674-4721.2009.10.017 LIU Shiqiong, QIN Xiaoqun, LI Shisheng. Effects of polysaccharides from Polygonatum on fatigue in mice[J]. China Modern Medicine, 2009, 16(10): 31-32. doi: 10.3969/j.issn.1674-4721.2009.10.017
[78]	王玉勤, 于晓婷, 吴晓岚, 等. 黄精多糖对力竭小鼠脑组织自由基代谢影响[J]. 中国公共卫生,2014,30(9):1165−1167. [WANG Yuqin, YU Xiaoting, WU Xiaolan, et al. Effects of Polygonatum sibiricum polysaccharides on free radical metabolism in brain tissue of mice at exhaustion and recovery[J]. Chinese Journal of Public Health,2014,30(9):1165−1167. doi: 10.11847/zgggws2014-30-09-18 WANG Yuqin, YU Xiaoting, WU Xiaolan, et al. Effects of Polygonatum sibiricum polysaccharides on free radical metabolism in brain tissue of mice at exhaustion and recovery[J]. Chinese Journal of Public Health, 2014, 30(9): 1165-1167. doi: 10.11847/zgggws2014-30-09-18
[79]	卢焕俊, 刘思源, 李香兰. 黄精提取液对正常小鼠抗疲劳能力的影响及机制探讨[J]. 山东医药,2014,54(27):39−41. [LU Huanjun, LIU Siyuan, LI Xianglan. Study on the efficacy and mechanism of antifatigue ability of Polygonatum extract on normal mice[J]. Shandong Medical Journal,2014,54(27):39−41. doi: 10.3969/j.issn.1002-266X.2014.27.013 LU Huanjun, LIU Siyuan, LI Xianglan. Study on the efficacy and mechanism of antifatigue ability of Polygonatum extract on normal mice[J]. Shandong Medical Journal, 2014, 54(27): 39-41. doi: 10.3969/j.issn.1002-266X.2014.27.013
[80]	石娟, 赵煜, 雷杨, 等. 黄精粗多糖抗疲劳抗氧化作用的研究[J]. 时珍国医国药,2011,22(6):1409−1410. [SHI Juan, ZHAO Yu, LEI Yang, et al. Study on the anti-fatigue and anti-oxidation effect of crude polysaccharide from Polygonatum sibiricum[J]. Lishizhen Medicine and Materia Medica Research,2011,22(6):1409−1410. SHI Juan, ZHAO Yu, LEI Yang, et al. Study on the anti-fatigue and anti-oxidation effect of crude polysaccharide from Polygonatum sibiricum[J]. Lishizhen Medicine and Materia Medica Research, 2011, 22(6): 1409-1410.
[81]	张士凯, 王敏, 程欣欣, 等. 超高压提取黄精多糖及提高运动耐力机制[J]. 核农学报,2021,35(9):2094−2101. [ZHANG Shikai, WANG Min, CHENG Xinxin, et al. Ultrahigh pressure extraction of Polygonatum sibiricum polysaccharide and mechanism of improving exercise endurance[J]. Journal of Nuclear Agricultural Sciences,2021,35(9):2094−2101. doi: 10.11869/j.issn.100-8551.2021.09.2094 ZHANG Shikai, WANG Min, CHENG Xinxin, et al. Ultrahigh pressure extraction of Polygonatum sibiricum polysaccharide and mechanism of improving exercise endurance[J]. Journal of Nuclear Agricultural Sciences, 2021, 35(9): 2094-2101. doi: 10.11869/j.issn.100-8551.2021.09.2094
[82]	杨华杰, 龚千锋, 于欢, 等. 黄精不同炮制品抗疲劳及抗氧化作用比较研究[J]. 江西中医药,2018,49(2):64−67. [YANG Huajie, GONG Qianfeng, YU Huan, et al. Study on anti-fatigue and anti-oxidation effect of different processed products of Polygonatum sibiricum[J]. Jiangxi Journal of Traditional Chinese Medicine,2018,49(2):64−67. YANG Huajie, GONG Qianfeng, YU Huan, et al. Study on anti-fatigue and anti-oxidation effect of different processed products of Polygonatum sibiricum[J]. Jiangxi Journal of Traditional Chinese Medicine, 2018, 49(2): 64-67.
[83]	吴晓岚, 王玉勤, 车光异, 等. 黄精和玉竹抗疲劳作用的实验研究[J]. 中国冶金工业医学杂志,2009,26(3):271−272. [WU Xiaolan, WANG Yuqin, CHE Guangyi, et al. Study on anti-fatigue effect of Polygonatum sibiricum and Polygonatum odoratum[J]. Chinese Medical Journal of Metallurgical Industry,2009,26(3):271−272. doi: 10.13586/j.cnki.yjyx1984.2009.03.011 WU Xiaolan, WANG Yuqin, CHE Guangyi, et al. Study on anti-fatigue effect of Polygonatum sibiricum and Polygonatum odoratum[J]. Chinese Medical Journal of Metallurgical Industry, 2009, 26(3): 271-272. doi: 10.13586/j.cnki.yjyx1984.2009.03.011
[84]	陈杨杨, 胡慧玲, 奉关妹, 等. 多花黄精炮制前后对游泳力竭小鼠抗疲劳抗氧化的影响[J]. 中药药理与临床,2021,37(2):92−97. [CHEN Yangyang, HU Huiling, FENG Guanmei, et al. Anti-fatigue and anti-oxidant effects of crude and processed Polygonatum cyrtonema on exhaustive swimming mice[J]. Pharmacology and Clinics of Chinese Materia Medica,2021,37(2):92−97. doi: 10.13412/j.cnki.zyyl.2021.02.011 CHEN Yangyang, HU Huiling, FENG Guanmei, et al. Anti-fatigue and anti-oxidant effects of crude and processed Polygonatum cyrtonema on exhaustive swimming mice[J]. Pharmacology and Clinics of Chinese Materia Medica, 2021, 37(2): 92-97. doi: 10.13412/j.cnki.zyyl.2021.02.011
[85]	LI Ling, LIAO Buyan, THAKUR Kiran, et al. The rheological behavior of polysaccharides sequential extracted from Polygonatum cyrtonema Hua[J]. International Journal of Biological Macromolecules,2018,109:761−771. doi: 10.1016/j.ijbiomac.2017.11.063
[86]	LI Ling, THAKUR Kiran, LIAO Buyan, et al. Antioxidant and antimicrobial potential of polysaccharides sequentially extracted from Polygonatum cyrtonema Hua[J]. International Journal of Biological Macromolecules,2018,114:317−323. doi: 10.1016/j.ijbiomac.2018.03.121
[87]	LI Ling, THAKUR Kiran, CAO Yuyao, et al. Anticancerous potential of polysaccharides sequentially extracted from Polygonatum cyrtonema Hua in human cervical cancer Hela cells[J]. International Journal of Biological Macromolecules,2020,148:843−850. doi: 10.1016/j.ijbiomac.2020.01.223
[88]	李玲. 连续制备的多花黄精多糖的理化性质及活性研究[D]. 合肥: 合肥工业大学, 2018. LI Ling. Studies on the physicochemical properties and activities of polysaccharides sequentially extracted from Polygonatum cyrtonema Hua[D]. Hefei: Hefei University of Technology, 2018.
[89]	叶红翠, 张小平, 余红, 等. 多花黄精粗多糖抗肿瘤活性研究[J]. 中国实验方剂学杂志,2008(6):34−36. [YE Hongcui, ZHANG Xiaoping, YU Hong, et al. Study on anti-tumor function of polysaccharide from Polygonatum cyrtonema Hua[J]. Chinese Journal of Experimental Traditional Medical Formulae,2008(6):34−36. doi: 10.3969/j.issn.1005-9903.2008.06.014 YE Hongcui, ZHANG Xiaoping, YU Hong, et al. Study on anti-tumor function of polysaccharide from Polygonatum cyrtonema Hua[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2008(6): 34-36. doi: 10.3969/j.issn.1005-9903.2008.06.014
[90]	ZHENG Shaoyang. Protective effect of Polygonatum sibiricum polysaccharide on D-galactose-induced aging rats model[J]. Scientific Reports,2020,10:2246. doi: 10.1038/s41598-020-59055-7
[91]	陈毅飞, 刘凯菲, 吴世敏, 等. 黄精多糖对阿尔茨海默病模型斑马鱼p38MAPK/N-cadherin的影响[J]. 中国药理学与毒理学杂志,2021,35(9):659−660. [CHEN Yifei, LIU Kaifei, WU Shimi, et al. Effect of rhynchophylline on p38MAPK/N-cadherin in zebrafish with Alzheimer disease[J]. Chinese Journal of Pharmacology and Toxicology,2021,35(9):659−660. CHEN Yifei, LIU Kaifei, WU Shimi, et al. Effect of rhynchophylline on p38MAPK/N-cadherin in zebrafish with Alzheimer disease[J]. Chinese Journal of Pharmacology and Toxicology, 2021, 35(9): 659-660.
[92]	吴燊荣, 李友元, 吴曦, 等. 黄精多糖对阿尔茨海默病模型小鼠学习记忆力影响及作用机制研究[J]. 中华老年医学杂志,2008(4):291−295. [WU Shenrong, LI Youyuan, WU Xi, et al. Effect of polygona-polysaccharose on learning and memorizing ability and its possible mechanism in Alzheimer disease mice[J]. Chinese Journal of Geriatrics,2008(4):291−295. WU Shenrong, LI Youyuan, WU Xi, et al. Effect of polygona-polysaccharose on learning and memorizing ability and its possible mechanism in Alzheimer disease mice[J]. Chinese Journal of Geriatrics, 2008(4): 291-295.
[93]	HAN Chunyang, SUN Taotao, LIU Yawei, et al. Protective effect of Polygonatum sibiricum polysaccharides on gentamicin-induced acute kidney injury in rats via inhibiting p38 MAPK/ATF2 pathway[J]. International Journal of Biological Macromolecules,2020,151:595−601. doi: 10.1016/j.ijbiomac.2020.02.049
[94]	ZHAI Zhaohui, LI Zhaoxin, JI Zhonglei, et al. Protective effect of Polygonatum sibiricum polysaccharides on apoptosis, inflammation, and oxidative stress in nucleus pulposus cells of rats with the degeneration of the Intervertebral disc[J]. International Journal of Polymer Science,2019,2019:8925807.
[95]	王一飞, 薛锋. 黄精多糖对胫骨骨折大鼠骨折愈合的作用机制[J]. 中国老年学杂志,2021,41(17):3803−3807. [WANG Yifei, XUE Feng. Mechanism of Polygonatum polysaccharide on fracture healing of tibia fracture in rats[J]. Chinese Journal of Gerontology,2021,41(17):3803−3807. doi: 10.3969/j.issn.1005-9202.2021.17.046 WANG Yifei, XUE Feng. Mechanism of Polygonatum polysaccharide on fracture healing of tibia fracture in rats[J]. Chinese Journal of Gerontology, 2021, 41(17): 3803-3807. doi: 10.3969/j.issn.1005-9202.2021.17.046
[96]	王艺. 黄精, 滇黄精多糖的结构表征与降血糖活性分析[D]. 西安: 陕西师范大学, 2019. WANG Yi. Structural characterization and hypoglycemic activity analysis of polysaccharides from Polygonatum dioscorea[D]. Xi'an: Shaanxi Normal University, 2019.
[97]	魏炜, 李彦伟, 刘凤霞, 等. 响应面法优化超高压提取黄精多糖工艺[J]. 精细化工,2019,36(5):875−881. [WEI Wei, LI Yanwei, LIU Fengxia, et al. Optimization of ultrahigh pressure extraction of polysaccharides from Polygonatum cyrtonema Hua by response surface methodology[J]. Fine Chemicals,2019,36(5):875−881. doi: 10.13550/j.jxhg.20180756 WEI Wei, LI Yanwei, LIU Fengxia, et al. Optimization of ultrahigh pressure extraction of polysaccharides from Polygonatum cyrtonema Hua by response surface methodology[J]. Fine Chemicals, 2019, 36(5): 875-881. doi: 10.13550/j.jxhg.20180756
[98]	李彦伟. 超高压提取黄精多糖工艺优化、结构分析及抗氧化性研究[D]. 大连: 大连理工大学, 2020. LI Yanwei. Study on the process optimization, structure and antioxidant activity of Polygonatum polysaccharides by ultra-high pressure extraction[D]. Dalian: Dalian University of Technology, 2020.

Supplements (0)

Cited By

Cited by

Periodical cited type(12)

1.	黄靖，胡利利，何婉莺，王鹏，张润光，田洪磊，詹萍，耿敬章. 九蒸九制对滇黄精呈香品质及抗氧化活性的影响. 食品研究与开发. 2025(01): 70-79 .
2.	马永强，张一鹏，王鑫，张丝瑶. 九蒸九制对黄精中AGEs含量、多糖结构及体外活性的影响. 食品工业科技. 2024(03): 226-234 . 本站查看
3.	许梦粤，丁泽宇，李锦鹏，王灿，王铭阳，刘琴，曾长立，王红波. 大豆多糖与纳豆多糖结构特征和主要生物活性比较. 食品科学. 2024(07): 78-86 .
4.	李得天，封亮，贾晓斌，杨冰. 黄精炮制原理解析及工艺优化策略. 中草药. 2024(20): 7110-7121 .
5.	杨庆雄，李欣. 林下经济作物黄精的研究进展. 贵州师范大学学报(自然科学版). 2024(06): 1-34+140 .
6.	毛子俊，王金兰，张树军，赵英楠，王丹，孙立秋，赵明，时志春，李军. 干鲜2种马齿苋多糖的提取及其抗氧化活性与吸湿保湿性能研究. 中国野生植物资源. 2024(11): 1-10 .
7.	刘心洁，周安，刘亚鹏，陈文迪，陈雪莉，俞年军，吴振东，梁娟. “九蒸九制”对黄精滋味品质及多糖结构变化的影响. 中医药导报. 2023(04): 46-52 .
8.	吴兰兰，吴钢，谭强来，林锦峰，甘淑娇，熊梅惠，吴伟菁. 煮制对多花黄精多糖结构及其体外免疫刺激活性的影响. 中国食物与营养. 2023(06): 28-34 .
9.	程亚楠，张金华，田胜兰，杨超然，司靖宇，黄丽莉，胡晓波，余强. 不同来源多花黄精多糖的结构特性及抗氧化活性比较. 现代食品科技. 2023(07): 145-153 .
10.	屈雅宁，许梦粤，唐双庆，刘琴，陈禅友，王亚珍，王红波. 枯草芽孢杆菌发酵对豆类粗多糖结构与抗氧化活性的影响. 食品工业科技. 2023(17): 129-138 . 本站查看
11.	唐军，杨欣，杨鑫，胡琦，高继海，杨明，贺亚男，张定堃. 附子多糖的结构、构效关系与生物活性研究进展. 中国中药杂志. 2023(20): 5410-5418 .
12.	王超，孙浩然，苏为耿，阚欢，刘云. 响应面法优化低糖滇黄精果脯制备工艺. 山东农业科学. 2022(12): 129-135 .