NI Weiwei, HU Chaoqun, BAI Fulai, et al. Research Progress on the Production Technology and Physiological Function of D-mannose[J]. Science and Technology of Food Industry, 2022, 43(17): 458−465. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021080363.
Citation: NI Weiwei, HU Chaoqun, BAI Fulai, et al. Research Progress on the Production Technology and Physiological Function of D-mannose[J]. Science and Technology of Food Industry, 2022, 43(17): 458−465. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021080363.

Research Progress on the Production Technology and Physiological Function of D-mannose

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  • Received Date: August 30, 2021
  • Available Online: June 29, 2022
  • D-mannose is the C-2 epimer of D-glucose. The production methods of D-mannose include plant extraction, chemical synthesis, and biotransformation. In particular, the biotransformation method has received more and more attention. D-mannose has been found to have a variety of important physiological functions. On the one hand, D-mannose can protect the urinary system by preventing bacteria from adhering to the urothelium. On the other hand, D-mannose can interfere with glucose metabolism, transport and modified anti-cancer drug carriers play an anti-tumor effect. In addition, D-Mannose can regulate the immune system by enhancing the transformation of naive T cells into regulatory T cells (Treg cells). In the future, the physiological functions of D-mannose need to be further confirmed by more research data, in order to provide support for the application of D-mannose in functional foods and biomedicine. This review introduces the recent progress of studies on the production technology, metabolic pathways, physiological functions and application of D-mannose.
  • [1]
    FENG D, SHI B, BI F, et al. Elevated serum mannose levels as a marker of polycystic ovary syndrome[J]. Frontiers in Endocrino-logy,2019,10:711. doi: 10.3389/fendo.2019.00711
    [2]
    滕碧蔚. 甘露糖的制备及其功能性保健作用[J]. 轻工科技,2014(7):67−68. [TENG B W. Preparation of mannose and its functional health function[J]. Light Industrial Science and Technology,2014(7):67−68.

    TENG B W. Preparation of mannose and its functional health function[J]. Light Industrial Science and Technology, 2014(7): 67-68.
    [3]
    刘登瑞. 甘露糖受体和miRNA-1260B在胃肠道肿瘤中预后价值的研究[D]. 兰州: 兰州大学, 2017

    LIU D R. Study on the prognostic value of mannose receptor and mirNA-1260B in gastrointestinal tumors[D]. Lanzhou: Lanzhou University, 2017.
    [4]
    梅湘. 青藤碱对类风湿关节炎模型大鼠甘露糖受体表达及相关抗体影响的实验研究[D]. 成都: 成都中医药大学, 2014

    MEI X. Experimental study on the effect of sinomenine on mannose receptor expression and related antibodies in rats with rheumatoid arthritis[D]. Chengdu: Chengdu University of Traditional Chinese Medicine, 2014.
    [5]
    黄程荣, 李太平, 汪静, 等. 血清可溶性甘露糖受体在肝癌患者中的表达及其临床意义[J]. 安徽医科大学学报,2021,56(7):1127−1131. [HUANG C R, LI T P, WANG J, et al. Expression and clinical significance of serum soluble mannose receptor in patients with hepatocellular carcinoma[J]. Journal of Anhui Medical University,2021,56(7):1127−1131. doi: 10.19405/j.cnki.issn1000-1492.2021.07.023

    HUANG C R, LI T P, WANG J, et al. Expression and clinical significance of serum soluble mannose receptor in patients with hepatocellular carcinoma[J]. Journal of Anhui Medical University, 2021, 56(7): 1127-1131. doi: 10.19405/j.cnki.issn1000-1492.2021.07.023
    [6]
    卢根生, 宋波, 金锡御. 泌尿道感染防御机制的研究进展[J]. 第三军医大学学报,2000,22(11):1116−1118. [LU G S, SONG B, JIN X Y. Research progress on the defense mechanism of urinary tract infection[J]. Journal of Third Military Medical University,2000,22(11):1116−1118. doi: 10.3321/j.issn:1000-5404.2000.11.032

    LU G S, SONG B, JIN X Y. Research progress on the defense mechanism of urinary tract infection[J]. Journal of Third Military Medical University, 2000, 22(11): 1116-1118. doi: 10.3321/j.issn:1000-5404.2000.11.032
    [7]
    衣俊羽, 王圆媛, 刘相萍, 等. 甘露糖对乳癌细胞增殖及表柔比星化疗敏感度影响[J]. 青岛大学学报:医学版,2020,57(3):350−355. [YI J Y, WANG Y Y, LIU X P, et al. Effect of mannose on the proliferation of breast cancer cells and chemotherapeutic sensitivity of epirubicin[J]. Journal of Qingdong University: Med,2020,57(3):350−355.

    YI J Y, WANG Y Y, LIU X P, et al. Effect of mannose on the proliferation of breast cancer cells and chemotherapeutic sensitivity of epirubicin[J]. Journal of Qingdong University: Med, 2020, 57(3): 6.
    [8]
    MUSSATTO S I, CARNEIRO L M, SILVA J P A, et al. A study on chemical constituents and sugars extraction from spent co-ffee grounds[J]. Carbohydrate Polymers,2011,83(2):368−374. doi: 10.1016/j.carbpol.2010.07.063
    [9]
    WANG B. Chemical characterization and Ameliorating effect of polysaccharide from Chinese jujube on intestine oxidative injury by ischemia and reperfusion[J]. International Journal of Biological Macromolecules,2011,48(3):386−391. doi: 10.1016/j.ijbiomac.2010.12.005
    [10]
    TAO Z, PAN Z, CHAO Q, et al. Isolation and purification of D-mannose from palm kernel[J]. Carbohydrate research,2009,344(13):1687−1689. doi: 10.1016/j.carres.2009.06.018
    [11]
    裴俊, 盛艳花, 高力群. 一种制备高纯度D-甘露糖的方法[P]. 中国: CN105087712A, 2015-11-25

    PEI J, SHENG Y H, GAO L Q. Preparation of high purity D-mannose[P]. China: CN105087712A, 2015-11-25.
    [12]
    MONTEIRO A F, MIGUEZ I S, SILVA J P R B, et al. High concentration and yield production of mannose from aaí (Euterpe oleracea Mart.) seeds via mannanase-catalyzed hydrolysis[J]. Scientific Reports,2019,9(1):10939. doi: 10.1038/s41598-019-47401-3
    [13]
    胡朝辉, 尹艳, 岳强. 酿酒酵母甘露糖蛋白的研究进展[J]. 酿酒,2007,34(4):64−66. [HU C H, YIN Y, YUE Q. Research progress of mannoprotein in Saccharomyces cerevisiae[J]. Wine Making,2007,34(4):64−66. doi: 10.3969/j.issn.1002-8110.2007.04.025

    HU C H, YIN Y, YUE Q. Research progress of mannoprotein in Saccharomyces cerevisiae[J]. Wine Making, 2007, 34(4): 64-66. doi: 10.3969/j.issn.1002-8110.2007.04.025
    [14]
    WU H, ZHANG W, MU W. Recent studies on the biological production of D-mannose[J]. Applied Microbiology and Biotechnology,2019,103(21-22):8753−8761. doi: 10.1007/s00253-019-10151-3
    [15]
    HUANG J, CHEN Z, ZHANG W, et al. D-lyxose isomerase and its application for functional sugar production[J]. Applied Microbiology & Biotechnology,2018,102(6):2051−2062.
    [16]
    张荆, 童群义. 假单胞菌属No. 2120生产D甘露糖异构酶发酵培养基的优化[J]. 生物加工过程,2010(1):37−42. [ZHANG J, TONG Q Y. Optimization of the fermentation medium for producing D-mannose-isomerase from Pseudomonas No. 2120[J]. Bioprocess,2010(1):37−42.

    ZHANG J, TONG Q Y. Optimization of the fermentation medium for producing D-mannose-isomerase from Pseudomonas No. 2120[J]. Bioprocess, 2010, (1): 37-42.
    [17]
    ZHAO G H, WANG G B, PING L J, et al. The orthogonal experiment analysis on the producing mannose from dextrose by catalyzing effect of ammonium molybdate[J]. Shenyang Chemical Industry,2005(1):39−41.
    [18]
    HU H, LIU S, ZHANG W, et al. Efficient epimerization of glucose to mannose over molybdenum-based catalyst in aqueous media[J]. Chemistry Select,2020,5(5):1728−1733. doi: 10.1002/slct.201903417
    [19]
    金鹏, 杜琪珍, 王圆圆. 一种D-甘露糖异构酶及其应用[P]. 浙江: CN111944796A, 2020-11-17

    JIN P, DU Q Z, WANG Y Y. A novel D-mannose-isomerase and its application[P]. Zhejiang: CN111944796A, 2020-11-17.
    [20]
    华晓晗, 李延啸, 马俊文, 等. 链霉菌来源D-甘露糖异构酶的性质及其在制备D-甘露糖中的应用[J]. 微生物学通报,2021,48(6):1930−1941. [HUA X H, LI Y X, MA J W, et al. Characterization of D-mannose isomerase from Streptomyces and its application in the preparation of D-mannose[J]. Chinese Journal of Microbiology,2021,48(6):1930−1941. doi: 10.13344/j.microbiol.china.200926

    HUA X H, LI Y X, MA J W, et al. Characterization of d-mannose isomerase from Streptomyces and its application in the preparation of D-mannose[J]. Chinese Journal of Microbiology, 2021, 48(6): 1930-1941. doi: 10.13344/j.microbiol.china.200926
    [21]
    余丽娜. D-来苏糖异构酶的性质鉴定与酶法制备甘露糖的研究[D]. 无锡: 江南大学, 2017

    YU L N. Characterization of D-lysol isomerase and enzymatic preparation of mannose[D]. Wuxi: Jiangnan University, 2017.
    [22]
    HUA X, LI Y, JIANG Z, et al. Biochemical properties of a novel d-mannose isomerase from Pseudomonas syringae for D-mannose production[J]. Applied Biochemistry and Biotechnology,2021,193(5):1482−1495. doi: 10.1007/s12010-021-03487-y
    [23]
    HU X, ZHANG P, MIAO M, et al. Development of a recombinant d-mannose isomerase and its characterizations for D-Mannose synthesis[J]. International Journal of Biological Macromolecules,2016:328−335.
    [24]
    LIU Z, LI Y, WU J, et al. A Novel Pseudomonas geniculata AGE family epimerase/isomerase and its application in D-mannose synthesis[J]. Foods,2020,9(12):1809. doi: 10.3390/foods9121809
    [25]
    ZHANG W, HUANG J, JIA M, et al. Characterization of a novel D-lyxose isomerase from Thermoflavimicrobium dichotomicum and its application for D-mannose production[J]. Process Biochemistry,2019,83(8):131−136.
    [26]
    HU X, SHI Y, ZHANG P, et al. D-mannose: Properties, production, and applications: An overview[J]. Comprehensive Reviews in Food Science and Food Safety,2016,15(4):773−785. doi: 10.1111/1541-4337.12211
    [27]
    SHARMA V, ICHIKAWA M, FREEZE H H. Mannose metabolism: More than meets the eye[J]. Biochem Biophys Res Commun,2014,453(2):220−228. doi: 10.1016/j.bbrc.2014.06.021
    [28]
    GORDON A, MARTIN H, RALF N, et al. Direct utilization of mannose for mammalian glycoprotein biosynthesis[J]. Glycobio-logy,1998(3):285.
    [29]
    SHARMA V, FREEZE H H. Mannose efflux from the cells a potential source of mannose in blood[J]. Journal of Biological Chemistry,2011:286.
    [30]
    杨俊, 熊剑旭, 熊伟伟. 尿路感染病原体分布及耐药性的调查分析[J]. 实验与检验医学,2012,30(5):125−126. [YANG J, XIONG J X, XIONG W W. Investigation and analysis of pathogen distribution and drug resistance of urinary tract infection[J]. Lab Med,2012,30(5):125−126. doi: 10.3969/j.issn.1674-1129.2012.05.039

    YANG J, XIONG J X, XIONG W W. Investigation and analysis of pathogen distribution and drug resistance of urinary tract infection[J]. Lab Med, 2012, 30(5): 3. doi: 10.3969/j.issn.1674-1129.2012.05.039
    [31]
    王剑飞. FimH基因对尿路致病性大肠埃希菌1型菌毛粘附功能影响的初步探索[D]. 天津: 天津医科大学, 2014

    WANG J F. Effect of fimH gene on the adhesion function of urinary tract pathogenic Escherichia coli type 1 pili [D]. Tianjin: Tianjin Medical University, 2014.
    [32]
    HATTON N E, BAUMANN C G, FASCIONE M A. Developments in mannose-based treatments for uropathogenic Escherichia coli induced urinary tract infections[J]. Chem Bio Chem,2020,22(4):613−629.
    [33]
    LENGE R S, BRADLEY M S, THOMAS D, et al. 39: D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: A systematic review and meta-analysis[J]. American Journal of Obstetrics and Gynecology,2020,222(3):S797−S798.
    [34]
    KYRIAKIDES R, JONES P, SOMANI B K. Role of D-mannose in the prevention of recurrent urinary tract infections: Evidence from a systematic review of the literature[J]. European Urology Focus,2020,7(5):1166−1169.
    [35]
    JARVIS C, HAN Z, KALAS V, et al. Antivirulence isoquinolone Mannosides: Optimization of the biaryl aglycone for FimH lectin binding affinity and efficacy in the treatment of chronic UTI[J]. Chem Med Chem,2016,11(4):367−373. doi: 10.1002/cmdc.201600006
    [36]
    HAN Z, PINKNER J S, FORD B, et al. Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides[J]. Journal of Medicinal Chemistry,2012,55(8):3945−3959. doi: 10.1021/jm300165m
    [37]
    SPAULDING C N, KLEIN R D, RUER S, et al. Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist[J]. Nature,2017,546(7659):528−532. doi: 10.1038/nature22972
    [38]
    RDULESCU, DAVID, TURCU, et al. Combination of cranberry extract and D-mannose-possible enhancer of uropathogen sensitivity to antibiotics in acute therapy of urinary tract infections: Results of a pilot study[J]. Experimental and Therapeutic Medicine,2020,20(4):3399−3406.
    [39]
    刘戈, 宋关斌. 肿瘤细胞的糖代谢调控与肿瘤治疗[J]. 生物医学工程学杂志,2019(4):691−695. [LIU G, SONG G B. The role of glucose metabolism in tumor therapy[J]. Journal of Biomedical Engineering,2019(4):691−695. doi: 10.7507/1001-5515.201812025

    LIU G SONG G B. The role of glucose metabolism in tumor therapy[J]. Journal of Biomedical Engineering, 2019, (4): 691-695. doi: 10.7507/1001-5515.201812025
    [40]
    GONZALEZ P S, O'PREY J, CARDACI S, et al. Mannose impairs tumour growth and enhances chemotherapy[J]. Nature, 2018, 563(7733).
    [41]
    王浩, 李海涛. 甘露糖通过下调GLUT1抑制结直肠癌发生及增殖[J]. 食品与发酵工业,2020,406(10):58−64. [WANG H, LI H T. Mannose inhibits the occurrence and proliferation of colorectal cancer by down-regulating GLUT1[J]. Food and Fermentation Industry,2020,406(10):58−64. doi: 10.13995/j.cnki.11-1802/ts.023474

    WANG H, LI H T. Mannose inhibits the occurrence and proliferation of colorectal cancer by down-regulating GLUT1[J]. Food and Fermentation Industry, 2020, 406 (10): 58-64. doi: 10.13995/j.cnki.11-1802/ts.023474
    [42]
    葛红, 罗辉, 刘康栋, 等. 甘露糖对6个人非小细胞肺癌细胞系放射敏感性影响[J]. 中华放射肿瘤学杂志,2020,29(7):558−562. [GE H, LUO H, LIU K D, et al. Effect of mannose on radiosensitivity of 6 human non-small cell lung cancer cell lines[J]. Chin J Radiol Oncology,2020,29(7):558−562. doi: 10.3760/cma.j.cn113030-20190529-00204

    GE H, LUO H, LIU K D, et al. Effect of mannose on radiosensitivity of 6 human non-small cell lung cancer cell lines[J]. Chin J Radiol Oncology, 2020, 29(7): 558-562. doi: 10.3760/cma.j.cn113030-20190529-00204
    [43]
    单婷婷. 甘露糖对人肝癌细胞株HepG2的抑制作用[D]. 长沙: 湖南中医药大学, 2020

    SHAN T T. Inhibitory effect of mannose on human hepatoma cell line HepG2[D]. Changsha: Hunan University of Traditional Chinese Medicine, 2020.
    [44]
    褚旭新, 卜凡雪, 殷婷婕, 等. 基于肿瘤相关巨噬细胞靶向调控的抗肿瘤策略[J]. 中国药科大学学报,2021,52(3):9. [CHU X X, BU F X, YIN T J, et al. Antitumor strategies based on targeted regulation of tumor-associated macrophages[J]. Journal of China Pharmaceutical University,2021,52(3):9. doi: 10.11665/j.issn.1000-5048.20210301

    CHU X X, BU F X, YIN T J, et al. Antitumor strategies based on targeted regulation of tumor-associated macrophages[J]. Journal of China Pharmaceutical University, 2021, 52(3): 9. doi: 10.11665/j.issn.1000-5048.20210301
    [45]
    杨梅, 高雨彤, 张馨予, 等. 糖类修饰的纳米递送系统[J]. 生命的化学,2021,41(3):10. [YANG M, GAO Y T, ZHANG X Y, et al. Saccharide modified nanoscale delivery system[J]. Chemistry of Life,2021,41(3):10. doi: 10.13488/j.smhx.20200564

    YANG M, GAO Y T, ZHANG X Y, et al. Saccharide modified nanoscale delivery system[J]. Chemistry of Life, 2021, 41(3): 10. doi: 10.13488/j.smhx.20200564
    [46]
    王世江. 甘露糖结合的PH敏感靶向递送吉非替尼纳米载体的研制及抗肿瘤研究[D]. 济南: 山东大学, 2018

    WANG S J. Development and antitumor study of mannose-bound ph-sensitive targeted delivery of gefitinib nanocarriers[D]. Jinan: Shandong University, 2018.
    [47]
    陈静. 甘露糖化胆固醇配体修饰甘草次酸脂质体的肝靶向研究[D]. 广州: 广州中医药大学, 2018

    CHEN J. Liver targeting study of glycyrrhetinic acid liposomes modified by mannosylated cholesterol ligands[D]. Guangzhou: Guangzhou University of Traditional Chinese Medicine, 2018.
    [48]
    FAN Z, WANG Y, XIANG S, et al. Dual-self-recognizing, stimulus-responsive and carrier-free methotrexate-mannose conjugate nanoparticles with highly synergistic chemotherapeutic effects[J]. Journal of Materials Chemistry B,2020,8(9):1922−1934. doi: 10.1039/D0TB00049C
    [49]
    WEI Z, HUANG L, CUI L, et al. Mannose: Good player and assister in pharmacotherapy[J]. Biomedicine & Pharmacotherapy,2020,129:110420.
    [50]
    杨贵兰, 秦松, 李文军. 光敏剂的纳米修饰技术及新型纳米材料在肿瘤光动力疗法中的应用研究进展[J]. 山东医药,2020,60(35):84−87. [YANG G L, QIN S, LI W J. Research progress in the application of novel nanomaterials in tumor photodynamic therapy[J]. Shandong Medicine,2020,60(35):84−87. doi: 10.3969/j.issn.1002-266X.2020.35.023

    YANG G L, QIN S, LI W J. Research progress in the application of novel nanomaterials in tumor photodynamic therapy[J]. Shandong Medicine, 2020, 60(35): 84-87. doi: 10.3969/j.issn.1002-266X.2020.35.023
    [51]
    蔡颖, 王胜涛, 魏朋, 等. 负载光敏剂D-甘露糖修饰胶束的制备及其在靶向光动力治疗中的应用[J]. 食品与生物技术学报,2019,38(10):43−51. [CAI Y, WANG S T, WEI P, et al. Preparation of d-mannose-modified micelles and its application in targeted photodynamic therapy[J]. Journal of Food And Biotechnology,2019,38(10):43−51. doi: 10.3969/j.issn.1673-1689.2019.10.007

    CAI Y, WANG S T, Wei P, et al. Preparation of d-mannose-modified micelles and its application in targeted photodynamic therapy[J]. Journal of Food And Biotechnology, 2019, 038(10): 43-51. doi: 10.3969/j.issn.1673-1689.2019.10.007
    [52]
    尹创新, 侯振江. 调节性T细胞及其细胞因子在自身免疫性疾病中的研究进展[J]. 医学综述,2021,27(7):1284−1290. [YIN C X, HOU Z J. Research progress of regulatory T cells and their cytokines in autoimmune diseases[J]. Medical Review,2021,27(7):1284−1290. doi: 10.3969/j.issn.1006-2084.2021.07.007

    YIN C X, HOU Z J. Research progress of regulatory T cells and their cytokines in autoimmune diseases[J]. Medical Review, 2021, 27(7): 1284-1290. doi: 10.3969/j.issn.1006-2084.2021.07.007
    [53]
    ZHANG D, CHIA C, JIAO X, et al. D-mannose induces regulatory T cells and suppresses immunopathology[J]. Nature Medicine,2017,23(9):1036. doi: 10.1038/nm.4375
    [54]
    WANG H, TENG X, ABBOUD G, et al. D-mannose ameliorates autoimmune phenotypes in mouse models of lupus[J]. Bmc Immunology,2021,22(1):1−12. doi: 10.1186/s12865-020-00392-7
    [55]
    LIU Y, WANG L, KIKUIRI T, et al. Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α[J]. Nature Medicine,2012,17(12):1594−1601.
    [56]
    LIU H, GU R, ZHU Y, et al. D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects[J]. Therapeutic Advances in Chronic Disease,2020,11:1−17.
    [57]
    MEUNIER M, CHAPUIS E, LAPIERRE L, et al. Mannosehosphate complex and improvement in biomechanical properties of the skin[J]. Journal of Cosmetic Dermatology,2021,20(2):1−13.
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