Effects of Phycobiliprotein and Phycocyanin from <i>Nostoc sphaeroides</i> Kützing on the Growth of S180 Tumor-bearing Mice and Its Mechanism

YU Jia; CHEN Ying; MA Shumei; ZHANG Ruihua; WANG Yulan

doi:10.13386/j.issn1002-0306.2021080288

Volume 43 Issue 8

Apr. 2022

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Science and Technology of Food Industry > 2022 > 43(8): 399-405. > DOI: 10.13386/j.issn1002-0306.2021080288

YU Jia, CHEN Ying, MA Shumei, et al. Effects of Phycobiliprotein and Phycocyanin from Nostoc sphaeroides Kützing on the Growth of S180 Tumor-bearing Mice and Its Mechanism[J]. Science and Technology of Food Industry, 2022, 43(8): 399−405. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021080288.

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Effects of Phycobiliprotein and Phycocyanin from Nostoc sphaeroides Kützing on the Growth of S180 Tumor-bearing Mice and Its Mechanism

YU Jia^1,,
CHEN Ying^2, ,,
MA Shumei^{3, 4},
ZHANG Ruihua¹,
WANG Yulan¹

1.
Hunan Micro Algae Biological Engineering Technology Research Center, Hunan Yandi Bioengineering Co., Ltd., Zhuzhou 412007, China
2.
Hunan University of Technology, Zhuzhou 412007, China
3.
China State Institute of Pharmaceutical Industry, Shanghai 200040, China
4.
State Key Laboratory of New Drug & Pharmaceutial Process, Shanghai Institute of Pharmaceutial Industry, Shanghai 200437, China

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Received Date: August 25, 2021
Available Online: February 11, 2022

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Abstract

Abstract

Objective: Effects of phycobiliprotein and phycocyanin from artifically raised Nostoc sphaeroides Kützing on the growth of tumor in S180 tumor-bearing mice and its mechanism. Methods: The in vivo antitumor activity of phycobiliprotein and phycocyanin from Nostoc sphaeroides Kützing was evaluated by examining the tumor volume of S180 tumor-bearing mice, mouse organ indices and tumor tissue section observation, and its mechanism of action was initially studied. Results: The results of in vivo antitumor effect showed that the tumor inhibition rates of phycobiliprotein 12.5, 25 and 50 mg/kg dose groups were 11.19%, 20.14% and 37.65%, respectively, against mouse sarcoma S180. The tumor inhibition rates of phycocyanin 12.5, 25 and 50 mg/kg dose groups were 19.74%, 35.00% and 52.06%, respectively, against mouse sarcoma S180. Phycocyanin significantly promoted the expression of oncoprotein P53 and pro-apoptotic protein Bax, and inhibited the expression of apoptosis suppressor protein Bcl2. Conclusion: Phycocyanin high dose group significantly reduced the proliferation of S180 sarcoma cells. Phycocyanin low and medium doses and phycocyanin high doses also had some inhibitory effects. Phycobiliprotein and phycocyanin from artifically raised Nostoc sphaeroides Kützing have better in vivo antitumor activity.
- Nostoc sphaeroides Kützing,
- phycobiliprotein,
- phycocyanin,
- S180 tumor-bearing mice,
- antitumor

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References (30)

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