Citation: | XU Yao, XU Shulai, LIU Zhibin, et al. Research Progress on the Extraction, Purification and Biological Activity of Ttriterpenoids from the Ganoderma lucidum[J]. Science and Technology of Food Industry, 2022, 43(11): 458−464. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021070172. |
[1] |
李卫东, 林志彬. 灵芝的扶正固本及对“亚健康”者的保健作用[J]. 食药用菌,2016,24(1):29−32. [LI Weidong, LIN Zhibin. The effects of Ganoderma lucidum on the strengthening the body and improving sub-health[J]. Edible and Medicinal Mushrooms,2016,24(1):29−32.
|
[2] |
XIA Q, ZHANG H Z, SUN X F, et al. A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp.[J]. Molecules,2014,19(11):17478−17535. doi: 10.3390/molecules191117478
|
[3] |
TANG W, LIU J W, ZHAO W M, et al. Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells[J]. Life Sci,2006,80(3):205−211. doi: 10.1016/j.lfs.2006.09.001
|
[4] |
WU G H. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells[J]. Fitoterapia,2012,83(2):408−414. doi: 10.1016/j.fitote.2011.12.004
|
[5] |
RUAN W M, LIM A H H, HUANG L G, et al. Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth[J]. Natural Product Research,2014,28(24):2264−2272. doi: 10.1080/14786419.2014.938337
|
[6] |
侯敏娜, 刘剑. 灵芝三萜的提取分离及总三萜的含量测定[J]. 现代中药研究与实践,2010,24(5):70−71. [HOU Minna, LIU Jian. Ganoderma triterpenoids extraction and determination of the total triterpenoid[J]. Chin Med J Res Prac,2010,24(5):70−71.
|
[7] |
陈德力, 王小兵, 吕伟, 等. 弯柄灵芝总三萜加速溶剂提取工艺及其清除DPPH自由基活性研究[J]. 天然产物研究与开发,2016,28(10):1597−1601. [CHEN Deli, WANG Xiaobin, LV Wei, et al. Accelerated solvent extraction and DPPH free radical scavenging activity of triterpenoids from Ganoderma flexipes[J]. Nat Prod Res Dev,2016,28(10):1597−1601.
|
[8] |
ZHENG Shizhong, ZHANG Weirui, LIU Shengrong. Optimization of ultrasonic-assisted extraction of polysaccharides and triterpenoids from the medicinal mushroom Ganoderma lucidum and evaluation of their in vitro antioxidant capacities[J]. PloS One,2020,15(12):1−16.
|
[9] |
康同辉, 张一凡, 解婉莹, 等. 超声波辅助提取灵芝三萜工艺研究[J]. 农业科技与装备,2017(6):41−43. [KANG Tonghui, ZHANG Yifan, XIE Wanying, et al. Research on the technology extraction of the Ganoderma triterpenoids by ultrasonic-assisted[J]. Agricultural Science & Technology and Equipment,2017(6):41−43.
|
[10] |
贾瑞博, 赵慧, 刘凯丽, 等. 树舌灵芝总三萜提取工艺优化及其抗氧化作用研究[J]. 应用化工,2016,45(6):1030−1035. [JIA Ruibo, ZHAO Hui, LIU Kaili, et al. Extraction process optimization and its antioxidant activity of the total triterpenoids from Ganoderma applanatum[J]. Applied Chemical Industry,2016,45(6):1030−1035.
|
[11] |
亓小妮, 谢苗, 吴杨洋, 等. 灵芝三萜化合物的制备与药理活性研究进展[J]. 安徽农业科学,2021,49(5):38−42. [QI Xiaoni, XIE Miao, WU Yangyang, et al. Research progress on preparation and pharmacological activities of Ganoderma lucidum triterpenes[J]. J Anhui Agric Sci,2021,49(5):38−42. doi: 10.3969/j.issn.0517-6611.2021.05.010
|
[12] |
刘晓艳, 陈艺煊, 吴林秀, 等. 响应面法优化灵芝总三萜酶辅助提取工艺及其抗氧化活性研究[J]. 食品科技,2017,42(8):225−230. [LIU Xiaoyan, CHEN Yixuan, WU Linxiu, et al. Response surface optimization of enzyme-assisted extractiontriterpene from Juncao Ganoderma lucidum and its antioxidant activity[J]. Food Science and Technology,2017,42(8):225−230.
|
[13] |
丁霄霄, 李凤伟, 余晓红. 响应面法优化复合酶提取灵芝总三萜工艺[J]. 食品工业,2018,39(8):40−44. [DING Xiaoxiao, LI Fengwei, YU Xiaohong. Optimization of complex enzyme extraction technology of total triterpenoids from Ganoderma lucidum by response surface methodology[J]. Food Industry,2018,39(8):40−44.
|
[14] |
CHEN Y, XIE M Y, GONG X F. Microwave-assisted extraction used for the isolation of total triterpenoid saponins from Ganoderma atrum[J]. Journal of Food Engineering,2007,81(1):162−170. doi: 10.1016/j.jfoodeng.2006.10.018
|
[15] |
林倩倩, 赵淑杰, 朱鹤. 树舌灵芝中三萜类化合物的提取工艺研究[J]. 安徽农业科学,2012,40(18):9669−9671. [LIN Qianqian, ZHAO Shujie, ZHU He. Study on the extraction technology of triterpenoids from Ganoderma applanatum (Pers.) Pat[J]. J Anhui Agric Sci,2012,40(18):9669−9671. doi: 10.3969/j.issn.0517-6611.2012.18.037
|
[16] |
篑霄云, 何晋浙, 王静, 等. 微波提取灵芝中三萜类化合物的研究[J]. 中国食品学报,2010(2):89−96. [KUI Xiaoyun, HE Jinzhe, WANG Jing, et al. The study on the microwave extraction of the triterpenoid saponins from Ganoderma lucidum[J]. Chinese Journal of Food,2010(2):89−96. doi: 10.3969/j.issn.1009-7848.2010.02.013
|
[17] |
王杉, 周科勤, 范青生, 等. 超临界CO2萃取菌草灵芝孢子油中三萜类物质和脂肪酸的测定[J]. 食品与机械,2006(1):74−76. [WANG Shan, ZHOU Keqin, FAN Qingsheng, et al. Determination of triterpenoids and fatty acid in grass-cultivated Ganoderma lucidum spores oil extracted by supercritical CO2[J]. Food and Machinery,2006(1):74−76. doi: 10.3969/j.issn.1003-5788.2006.01.025
|
[18] |
华正根, 王金亮, 朱丽萍, 等. 高压超临界CO2提取灵芝三萜和甾醇成分的研究[J]. 中国食用菌,2018,37(5):62−65,69. [HUA Zhenggen, WANG Jinliang, ZHU Liping, et al. Study on the extraction of triterpenes and sterols from Ganoderma lucidum by supercritical CO2 under high pressure[J]. Edible Fungi of China,2018,37(5):62−65,69.
|
[19] |
唐文. 高效液相色谱分离纯化灵芝酸条件的优化研究[J]. 食品工业,2013,34(11):74−77. [TANG Wen. Purification conditions of ganoderic acids optimized by HPLC[J]. Food Industry,2013,34(11):74−77.
|
[20] |
贾红岩, 王亚涛, 张芝华, 等. 高效液相色谱法测定不同产地及品种灵芝三萜类成分的含量[J]. 微生物学通报,2017,44(1):238−244. [JIA Hongyan, WANG Yatao, ZHANG Zhihua, et al. Determination of triterpenoids in Ganodema lingzhi from differentareas and species by HPLC[J]. Microbiol China,2017,44(1):238−244.
|
[21] |
钱竹. 灵芝酸的液体发酵及其分离纯化的研究[D]. 无锡: 江南大学, 2006.
QIAN Zhu. Study on liquid fermentation and its separation and purification of Ganoderma acid[D]. Wuxi: Jiangnan University, 2006.
|
[22] |
檀琪, 阮文辉, 杨官娥, 等. 大孔吸附树脂纯化桦褐孔菌三萜类化合物工艺优化[J]. 食品工业,2021,42(3):142−146. [TAN Qi, RUAN Wenhui, YANG Guane, et al. Optimization of purification of triterpenoids from Inonotus obliquus by macro-porous resin[J]. Food Industry,2021,42(3):142−146.
|
[23] |
崔月花, 缪婧, 陈清颖, 等. 大孔树脂对灵芝发酵液中抗氧化物质的分离纯化的研究[J]. 食品工业,2018,39(11):49−52. [CUI Yuehua, MIAO Jing, CHEN Qingying, et al. Study on isolation effect of antioxidant component in GLCB by macro porous adsorption resin[J]. Food Industry,2018,39(11):49−52.
|
[24] |
WENG C J, CHAU C F, CHEN K D, et al. The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain[J]. Molecular Nutrition & Food Research,2017,51(12):1472−1477.
|
[25] |
朱忠敏, 李晔, 周岩飞, 等. 大孔树脂层析结合高速逆流色谱分离纯化灵芝酸[A]. 2013年灵芝产品研究与开发学术研讨会论文摘要[C]. 南京: 2013, 9.
ZHU Zhongmin, LI Ye, ZHOU Yanfeng, et al. Separation of the ganodenic acid by HSCCC and macro porous adsorption resin[A]. Research and development symposium of the ganoderic products in 2013[C]. Nanjing: 2013, 9.
|
[26] |
SHIAO M S, LEE K R, LIN L J, et al. Natural products and biological activities of the Chinese medicinal fungus Ganoderma lucidum[J]. Chem Inform,1994,25(15):342−354.
|
[27] |
FENG J, FENG N, YANG Y, et al. Simple and reproducible two-stage agitation speed control strategy for enhanced triterpene production by Lingzhi or Reishi medicinal mushrooms, Ganoderma lucidum ACCC G0119 (higher basidiomycetes) based on submerged liquid fermentation[J]. International Journal of Medicinal Mushrooms,2015,17(12):1151−1159. doi: 10.1615/IntJMedMushrooms.v17.i12.50
|
[28] |
SU Limin. Ganoderma triterpenes retard renal cyst development by down regulating Ras/MAPK signaling and promoting cell differentiation[J]. Kidney International,2017,92:1404−1418. doi: 10.1016/j.kint.2017.04.013
|
[29] |
REISMAN S A, CHERTOW G M, HEBBAR S, et al. Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.[J]. Journal of the American Society of Nephrology:JASN,2012,23(10):1663−1673. doi: 10.1681/ASN.2012050457
|
[30] |
YAN Yongming. Lingzhilactones from Ganoderma lingzhi ameliorate adriamycin-induced nephropathy in mice[J]. Journal of Ethnopharmacology,2015,176:385−393. doi: 10.1016/j.jep.2015.11.024
|
[31] |
王涛. 灵芝三萜的提纯及其对前列腺癌细胞生长的影响[D]. 深圳: 南方医科大学, 2016.
WANG Tao. Purification of triterpenoids from Ganoderma lucidum and its effect on the growth of prostatecancer cells[D]. Shenzhen: Southern University of Science and Technology, 2016.
|
[32] |
SMINA T P, MATHEW J, JANARDHANAN K K. Ganoderma lucidum total triterpenes attenuate DLA induced ascites and EAC induced solid tumours in Swiss albino mice[J]. Cellular and Molecular Biology (Noisy-le-Grand, France),2016,62(5):55−59.
|
[33] |
MIN B S. Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against Meth-A and LLC tumor cells[J]. Chemical and Pharmaceutical Bulletin,2000,48(7):1026−1033. doi: 10.1248/cpb.48.1026
|
[34] |
WANG Tao, XIE Ziping, HUANG Zhansen, et al. Total triterpenoids from Ganoderma lucidum suppresses prostate cancer cell growth by inducing growth arrest and apoptosis[J]. Journal of Huazhong University of Science and Technology [Medical Sciences],2015,35(5):736−741. doi: 10.1007/s11596-015-1499-x
|
[35] |
SHAO Yanyan, QIAO Liansheng, WU Lingfang, et al. Structure identification and anti-cancer pharmacological prediction of triterpenes from Ganoderma lucidum[J]. Molecules (Basel, Switzerland),2016,21(5):865−878.
|
[36] |
GILL B S, NAVGEET, MEHRA R, et al. Ganoderic acid, lanostanoid triterpene: A key player in apoptosis[J]. Investigational New Drugs,2018,36(1):136−143. doi: 10.1007/s10637-017-0526-0
|
[37] |
DEDI S. Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)[J]. Natural Product Research,2019,33(2):189−195. doi: 10.1080/14786419.2018.1440229
|
[38] |
LIN T Y, HSU H Y, SUN W H, et al. Induction of Cbl-dependent epidermal growth factor receptor degradation in Lingzhi-8 suppressed lung cancer[J]. International Journal of Cancer,2017,140(11):2596−2607. doi: 10.1002/ijc.30649
|
[39] |
SITTICHAI S, SOMCHAI Y, DARAWAN P, et al. Molecular docking based screening of triterpenoids as potential G-quadruplex stabilizing ligands with anti-cancer activity[J]. Bioinformation,2017,13(9):284−292.
|
[40] |
ZHENG Dongshu, CHEN Liangshu. Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors.[J]. Experimental and Therapeutic Medicine,2017,14(4):3273−3278. doi: 10.3892/etm.2017.4883
|
[41] |
LIU Daolu, LI Yingjie, YANG Donghua, et al. Ganoderma lucidum derived ganoderenic acid B reverses ABCB1-mediated multidrug resistance in HepG2/ADM cells[J]. International Journal of on Cology,2015,46(5):2029−2038.
|
[42] |
MIYAMOTO I, LIU J, SHIMIZU K, et al. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum[J]. European Journal of Pharmacology,2009,602(1):1−7. doi: 10.1016/j.ejphar.2008.11.005
|
[43] |
LIU Jie, JUN Shiono, SHIMIZU Kuniyoshi, et al. Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor[J]. Bioorganic & Medicinal Chemistry Letters,2009,19(8):2154−2157.
|
[44] |
SHIV B, LEEK E, VIVEK D D, et al. Density functional theory and molecular dynamics simulation support Ganoderma lucidum triterpenoids as broad range antagonist of matrix metalloproteinases[J]. Journal of Molecular Liquids,2020,37(11):311−321.
|
[45] |
CHERIAN E, SUDHEESH N P, JANARDHANAN K K, et al. Free radical scavenging and mitochondrial antioxidant activities of Reishi-Ganoderma lucidum (Curt: Fr) P. Karst and Arogyapacha-Trichopus zeylanicus gaertn extracts[J]. Journal of Basic and Clinical Physiology and Pharmacology,2009,20(4):289−308.
|
[46] |
AJITH T A, SUDHEESH N P, ROSHNY D, et al. Effect of Ganoderma lucidum on the activities of mitochondrial dehydrogenases and complex I and II of electron transport chain in the brain of aged rats[J]. Experimental Gerontology,2009,44(3):219−223. doi: 10.1016/j.exger.2008.11.002
|
[47] |
SUDHEESH N P, AJITH T A, RAMNATH V, et al. Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the mitochondria of post-mitotic tissues of aged mice[J]. Clinical Nutrition (Edinburgh, Scotland),2010,29(3):406−412. doi: 10.1016/j.clnu.2009.12.003
|
[48] |
SU Haiguo, PENG Xingrong, SHI Qiangqiang, et al. Lanostane triterpenoids with anti-inflammatory activities from Ganoderma lucidum[J]. Phytochemistry,2020,60:173−181.
|
[49] |
WU Huihui, TANG Shanshan, HUANG Zhaoqin, et al. Hepatoprotective effects and mechanisms of action of triterpenoids from Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (Agaricomycetes) on α-amanitin-induced liver injury in mice[J]. International Journal of Medicinal Mushrooms,2016,18(9):841−850. doi: 10.1615/IntJMedMushrooms.v18.i9.80
|
[50] |
ZHANG X Q, FANNY C F, ZHANG D M, et al. Triterpenoids with neurotrophic activity from Ganoderma lucidum[J]. Natural Product Research,2011,25(17):1607−1613. doi: 10.1080/14786419.2010.496367
|
[51] |
SU Haiguo, WANG Qian, LIN Zhou, et al. Highly oxygenated lanostane triterpenoids from Ganoderma applanatum as a class of agents for inhibiting lipid accumulation in adipocytes[J]. Bioorganic Chemistry,2020,10(4):263−276.
|
[52] |
JIANG Chunjiao, JI Jiancheng, LI Peihai, et al. New lanostane-type triterpenoids with proangiogenic activity from the fruiting body of Ganoderma applanatum[J]. Natural Product Research,2021,34(1):1−7.
|
[53] |
萨翼. 从灵芝类保健食品批准情况看未来中药类保健食品发展方[J]. 中国现代中,2020,22(7):1124−119. [SA Yi. Development trend of traditional Chinese medicine dietary supplement from approval of Ganoderma dietary supplements[J]. Mod Chin Med,2020,22(7):1124−119.
|
[54] |
马超, 马传贵, 戚俊, 等. 灵芝孢子粉破壁技术及灵芝类保健食品开发研究进展[J]. 中国食用菌,2020,39(12):8−12,17. [MA Chao, MA Chuangui, QI Jun, et al. Progress in research on sporoderm-breaking technology of Ganoderma lucidum spore powder and development of Ganoderma health food[J]. Edible Fungi of China,2020,39(12):8−12,17.
|
[55] |
林花, 王霞, 车成来, 等. 灵芝功能性食品对小鼠免疫功能促进作用的研究[J]. 农业与技术,2018,38(17):10−13. [LIN Hua, WANG Xia, CHE Chenglai, et al. Study on the effect of Ganoderma health food on the Immune function of mice[J]. Agriculture & Technology,2018,38(17):10−13.
|
[56] |
张瑞婷, 张述仁, 海娟, 等. 灵芝在保健食品中的应用研究进展[J]. 安徽农业科学,2018,46(10):33−35. [ZHANG Ruiting, ZHAGN Shuyin, HAI Juan, et al. Research progress on application of Ganoderma lucidum in health food[J]. J Anhui Agric Sci,2018,46(10):33−35. doi: 10.3969/j.issn.0517-6611.2018.10.009
|
1. |
郭培洁,王占斌,夏永桥,王兴沛. 水杨酸对树舌菌丝三萜合成及活性氧含量的影响. 食品科学. 2025(03): 56-63 .
![]() | |
2. |
张明,孟晓峰,吴茂玉,和法涛,范祺,张博华,王崇队,马超. 不同干燥方式对灵芝子实体干燥品质的影响. 中国果菜. 2024(03): 43-47 .
![]() | |
3. |
孙楠,王惠纳,张薇,张钰瑶,赵育,贺博,张海生,张宝善. 硒的来源、富集及富硒食物资源研究进展. 食品科学. 2024(07): 299-309 .
![]() | |
4. |
王艳辉,郑光耀,闫林林. 磁性分子印迹聚合物在天然活性物质分离纯化中的研究进展. 食品工业科技. 2023(11): 442-450 .
![]() | |
5. |
张萍,张芳,孙德清. 灵芝酸类成分抑制前列腺癌生长及其机制研究. 药物生物技术. 2023(04): 348-353 .
![]() | |
6. |
吕婷婷,王妍妍,张越,孟祥宇,丁卫健,彭代银,王雷,姚亮,陈卫东. 茯苓皮总三萜大孔树脂纯化工艺及体外抗炎活性研究. 安徽中医药大学学报. 2023(06): 86-92 .
![]() | |
7. |
云浩程,于繁华,程杜,刘震,牛华周,侯万超,李赛男,刘春明,张语迟. NSGA-Ⅱ遗传算法结合响应面法优化桦褐孔菌活性成分提取工艺. 食品工业科技. 2022(17): 185-193 .
![]() | |
8. |
徐树来,徐瑶,尤婷婷,刘志彬,祝嗣臣. 超高压辅助提取灵芝三萜的工艺优化及抗氧化活性评价. 食品工业科技. 2022(20): 274-280 .
![]() | |
9. |
崔馨戈,张静,袁抒捷,李思雨,祝朋玲,王雯,阚家义,周俊,彭灿. 赤芝、紫芝孢子粉总三萜的提取工艺优化. 化学试剂. 2022(10): 1475-1481 .
![]() |