Research Progress of Mitochondrial-Mediated Docosahexaenoic Acid (DHA) Antioxidation

SUN Xiaoting; XU Le; XIAO Baoping; CUI Dongyue; LIU Jingwen; LI Jian; LIN Jingyu; LI Guiling

doi:10.13386/j.issn1002-0306.2021060190

Volume 43 Issue 10

May 2022

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Science and Technology of Food Industry > 2022 > 43(10): 475-481. > DOI: 10.13386/j.issn1002-0306.2021060190

SUN Xiaoting, XU Le, XIAO Baoping, et al. Research Progress of Mitochondrial-Mediated Docosahexaenoic Acid (DHA) Antioxidation[J]. Science and Technology of Food Industry, 2022, 43(10): 475−481. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021060190.

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Research Progress of Mitochondrial-Mediated Docosahexaenoic Acid (DHA) Antioxidation

SUN Xiaoting^{1, 2, 3,},
XU Le^{1, 2, 3},
XIAO Baoping^{1, 2, 3},
CUI Dongyue^{1, 2, 3},
LIU Jingwen¹,
LI Jian^{1, 2, 3},
LIN Jingyu^{1, 2, 3, ,},
LI Guiling^{1, 2, 3, ,}

1.
College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China
2.
Engineering Research Center for Marine Functional Food of Fujian Province, Xiamen 361021, China
3.
Xiamen Key Laboratory of Marine Functional Food, Xiamen 361021, China

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Received Date: June 22, 2021
Available Online: March 20, 2022

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Abstract

Abstract

Docosahexaenoic acid (DHA) is an essential omega-3 polyunsaturated fatty acid (PUFA) for human body, which is highly rich in deep sea fish oil and marine microalgae. Mitochondria are the energy factory of cells. Mitochondrial functions and biogenesis can be regulated by DHA which exhibits antioxidation, anti-inflammatory and anti-cancer activities. This article reviews the research progress of mitochondrial-mediated DHA antioxidation and the possible underlying mechanism. The effects of DHA in eliminating reactive oxygen species (ROS) and regulating mitochondrial biogenesis and functions, as well as the microRNA-mediated DHA antioxidant epigenetic mechanism are addressed, which may provide evidence for better DHA product exploration and application.
- ω-3 polyunsaturated fatty acid,
- docosahexaenoic acid,
- mitochondria,
- antioxidation,
- epigenetics

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References (70)

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