Citation: | ZHANG Fengting, HU Tan, PAN Siyi. Research Progress on Biological Activity and Modification Technology of Hesperidin[J]. Science and Technology of Food Industry, 2022, 43(10): 442−449. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021060069. |
[1] |
ZHANG M, ZHU S Y, YANG W J, et al. The biological fate and bioefficacy of citrus flavonoids: Bioavailability, biotransformation, and delivery systems[J]. Food and Function, 2021. DOI: 10.1039/d0fo03403g.
|
[2] |
黄睿, 沈淑妤, 陈虹霖, 等. 柑橘类黄酮的生物学活性及提高生物利用度技术研究进展[J]. 食品科学,2019,40(1):319−326. [HUANG R, SHENG S Y, CHEN H L, et al. Recent advances in bioactivities and technologies for bioavailability improvement of citrus flavonoids[J]. Food Science,2019,40(1):319−326. doi: 10.7506/spkx1002-6630-20170904-054
HUANG R, SHENG S Y, CHEN H L, et al. Recent advances in bioactivities and technologies for bioavailability improvement of citrus flavonoids[J]. Food Science, 2019, 40(1): 319-326. doi: 10.7506/spkx1002-6630-20170904-054
|
[3] |
刘畅, 王雨晴, 孟倩楠, 等. 橙皮及其中抑菌成分在养殖业中应用研究进展[J]. 饲料研究,2021(5):158−160. [LIU C, WANG Y Q, MENG Q N, et al. Advances in the application of orange peel and its antimicrobial components in aquaculture[J]. Feed Reseach,2021(5):158−160.
LIU C, WANG Y Q, MENG Q N, et al. Advances in the application of orange peel and its antimicrobial components in aquaculture[J]. Feed Reseach, 2021(5): 158-160.
|
[4] |
马宗敏, 段绪红, 秦梦, 等. 微生物发酵技术在中药苷类生物转化中的应用进展[J]. 世界科学技术-中医药现代化,2017,19(5):858−864. [MA Z M, DUAN X H, QIN M, et al. Microbial transformation of glycosides in Chinese herbal medicine[J]. Modernization of Traditional Chinese Medicine and Materia Medica,2017,19(5):858−864. doi: 10.11842/wst.2017.05.025
MA Z M, DUAN X H, QIN M, et al. Microbial transformation of glycosides in Chinese herbal medicine[J]. Modernization of Traditional Chinese Medicine and Materia Medica, 2017, 19(5): 858-864. doi: 10.11842/wst.2017.05.025
|
[5] |
王磊, 栗栖凤. 橙皮苷的生物活性及其在畜牧业中的应用[J]. 饲料研究,2021,44(1):147−150. [WANG L, LI Q F. Biological aactivity of hesperidin and its application in animal husbandry[J]. Food Research,2021,44(1):147−150.
WANG L, LI Q F. Biological aactivity of hesperidin and its application in animal husbandry[J]. Food Research, 2021, 44(1): 147-150.
|
[6] |
单艳. 产α-L-鼠李糖苷酶菌种的筛选及其制备橙皮素单葡萄糖苷的研究[D]. 南昌: 南昌大学, 2015: 13−14.
SHAN Y. Study on the preparation of hesperetin monoglucoside by separating an α-L-rhamnosidase from a strain[D]. Nanchang: Nanchang University, 2015: 13−14.
|
[7] |
王幻. 橙皮素单葡萄糖苷的酶法合成、分离纯化及其应用[D]. 广州: 华南理工大学, 2019: 12−13.
WANG H. Synthesis, purification and application of hesperetin-7-O-glucoside by enzymatic method[D]. Guangzhou: South China University of Technology, 2019: 12−13.
|
[8] |
刘学仁, 张莹, 林志群. 橙皮苷和橙皮素生物活性的研究进展[J]. 中国新药杂志,2011,20(4):329−333,381. [LIU X R, ZHANG Y, LIN Z Q. Advances in studies on the biological activities of hesperidin and hesperetin[J]. Chinese Journal of New Drugs,2011,20(4):329−333,381.
LIU X R, ZHANG Y, LIN Z Q. Advances in studies on the biological activities of hesperidin and hesperetin[J]. Chinese Journal of New Drugs, 2011, 20(4): 329-333, 381.
|
[9] |
谢琪, 王强, 高淑清, 等. 橙皮苷生物活性作用及机制研究进展[J]. 肿瘤代谢与营养电子杂志,2020,7(1):13−17. [XIE Q, WANG Q, GAO S Q, et al. Advances on the biological activity and mechanism of hesperidin[J]. Electron J Metab Nutr Cancer,2020,7(1):13−17.
XIE Q, WANG Q, GAO S Q, et al. Advances on the biological activity and mechanism of hesperidin[J]. Electron J Metab Nutr Cancer, 2020, 7(1): 13-17.
|
[10] |
SUN Y Z, CHEN J F, SHEN L M, et al. Anti-atherosclerotic effect of hesperidin in LDL r-/-mice and its possible mechanism[J]. European Journal of Pharmacology,2017,815:109−117. doi: 10.1016/j.ejphar.2017.09.010
|
[11] |
MALESEV D, KUNTIC V. Investigation of metal-flavonoid chelates and the determination of flavonoids via metal-flavonoid complexing reactions[J]. Journal of the Serbian Chemical Society,2007,72(10):921−939. doi: 10.2298/JSC0710921M
|
[12] |
王晶. 江西蜜柑酚类化合物抗氧化、抗癌、抗衰老活性及作用机理研究[D]. 广州: 华南理工大学, 2020: 92−93.
WANG J. Research on antioxidant, anticancer and antiaging activities and their mechanisms of Citrus unshiu marc polyphenols[D]. Guangzhou: South China University of Technology, 2020: 92−93.
|
[13] |
段庆, 唐小丹, 郑希, 等. 新会陈皮提取物中四种黄酮成分含量测定及其抗炎活性研究[J]. 现代食品,2019(11):156−162. [DUAN Q, TANG X D, ZHENG X, et al. Determination of four flavonoids in extracts of citrus reticulata ‘Chachi’ and their anti-inflammatory activity[J]. Xiandaishipin,2019(11):156−162.
DUAN Q, TANG X D, ZHENG X, et al. Determination of four flavonoids in extracts of citrus reticulata ‘Chachi’ and their anti- inflammatory activity[J]. XIANDAISHIPIN, 2019, (11): 156-162.
|
[14] |
CAO R G, ZHAO Y L, ZHOU Z K, et al. Enhancement of the water solubility and antioxidant activity of hesperidin by chitooligosaccharide[J]. Journal of the Science of Food and Agriculture,2018,98(6):2422−2427. doi: 10.1002/jsfa.8734
|
[15] |
PARHIZ H, ROOHBAKHSH A, SOLTANI F, et al. Antioxidant and anti-Inflammatory properties of the citrus flavonoids hesperidin and hesperetin: An updated review of their molecular mechanisms and experimental models[J]. Phytotherapy Research,2015,29(3):323−331. doi: 10.1002/ptr.5256
|
[16] |
TEJADA S, PINYA S, MARTORELL M, et al. Potential anti-inflammatory effects of hesperidin from the genus citrus[J]. Current Medicinal Chemistry, 2018, 25(37): 4929-4945.
|
[17] |
汪晓辉, 郭溶, 聂晓彬, 等. 佛手抗菌活性及其药效成分橙皮苷对金黄色葡萄球菌的作用机制研究[J]. 中国抗生素杂志,2021(5):437−441. [WANG X H, GUO R, NIE X B, et al. Antibacterial activity of Citri Sarcodactylis Fructus and its antibacterial mechanism against Staphylococcus aureus[J]. Chinese Journal of Antibiotics,2021(5):437−441. doi: 10.3969/j.issn.1001-8689.2021.05.012
WANG X H, GUO R, NIE X B, et al. Antibacterial activity of Citri Sarcodactylis Fructus and its antibacterial mechanism against Staphylococcus aureus[J]. Chinese Journal of Antibiotics, 2021, (05): 437-441. doi: 10.3969/j.issn.1001-8689.2021.05.012
|
[18] |
刘光荣, 赵俊钢, 邓文娟, 等. 橙皮苷的抗痤疮作用研究[J]. 日用化学品科学,2020,43(3):42−46. [LIU G R, ZHAO J G, DENG W J, et al. Study of the anti-acne effects of hesperidin[J]. Household Chemicals Science,2020,43(3):42−46. doi: 10.3969/j.issn.1006-7264.2020.03.011
LIU G R, ZHAO J G, DENG W J, et al. Study of the anti-acne effects of hesperidin[J]. Household Chemicals Science, 2020, 43(3): 42-46. doi: 10.3969/j.issn.1006-7264.2020.03.011
|
[19] |
李丽, 任周新, 赵鹏, 等. 橙皮苷及橙皮素抗肿瘤药理活性研究进展[J]. 中医学报,2018,33(12):2304−2308. [LI L, REN Z X, ZHAO P, et al. Research progress in antitumor pharmacological activities of hesperidin and hesperetin[J]. Journal of Traditional Chinese Medicine,2018,33(12):2304−2308.
LI L, REN Z X, ZHAO P, et al. Research progress in antitumor pharmacological activities of hesperidin and hesperetin[J]. Journal of traditional Chinese medicine, 2018, 33(12): 2304-2308.
|
[20] |
曾佑炜. 黄酮抗癌作用研究进展[J]. 天然产物研究与开发,2016,28(11):1838−1844. [ZENG Y W. Review on anticancer effects of plant-based flavonoids[J]. Natural Product Research and Development,2016,28(11):1838−1844.
ZENG Y W. Review on anticancer effects of plant-based flavonoids[J]. Natural product research and development, 2016, 28(11): 1838-1844.
|
[21] |
程翠林, 王荣春, 杨雨茗, 等. 橙皮苷半合成香叶木苷及其抑癌作用[J]. 精细化工,2020,37(11):2308−2312, 2341. [CHENG C L, WANG R C, YANG Y M, et al. Semi-synthesis of diosmin from hesperidin and its anticancer effect[J]. Fine Chemicals,2020,37(11):2308−2312, 2341.
CHENG C L, WANG R C, YANG Y M, et al. Semi-synthesis of diosmin from hesperidin and its anticancer effect[J]. Fine Chemicals, 2020, 37(11): 2308-2312, 2341.
|
[22] |
HERMAWAN A, KHUMAIRA A, IKAWATI M, et al. Identification of key genes of hesperidin in inhibition of breast cancer stem cells by functional network analysis[J]. Computational Biology and Chemistry,2021,90:107427−107427. doi: 10.1016/j.compbiolchem.2020.107427
|
[23] |
KARIM N, SHISHIR M R I, GOWD V, et al. Hesperidin-an emerging bioactive compound against metabolic diseases and its potential biosynthesis pathway in microorganism[J]. Food Reviews International,2021:1−23.
|
[24] |
李晓霞, 许莹, 徐波, 等. 橙皮苷对果糖饮食诱导的非酒精性脂肪肝小鼠的作用研究[J]. 世界中医药,2021,16(2):249−253. [LI X X, XU Y, XU B, et al. Effect of hesperidin on nonalcoholic fatty liver rats induced by high fructose diet[J]. World Chinese Medicine,2021,16(2):249−253. doi: 10.3969/j.issn.1673-7202.2021.02.011
LI X X, XU Y, XU B, et al. Effect of Hesperidin on Nonalcoholic Fatty Liver Rats Induced by High Fructose Diet[J]. World Chinese Medicine, 2021, 16(2): 249-253. doi: 10.3969/j.issn.1673-7202.2021.02.011
|
[25] |
ARTS I, SESINK A, FAASSEN-PETERS M, et al. The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides[J]. British Journal of Nutrition,2004,91(6):841−847. doi: 10.1079/BJN20041123
|
[26] |
GROHMANN K, MANTHEY J A, CAMERON R G. Acid-catalyzed hydrolysis of hesperidin at elevated temperatures[J]. Carbohydrate Research,2000,328(2):141−146. doi: 10.1016/S0008-6215(00)00081-1
|
[27] |
马丽萍. 桔皮中活性成分的提取与转化[D]. 无锡: 江南大学, 2008: 47−60.
MA L P. Extraction and conversion of active ingredients in citrus peel[D]. Wuxi: Jiangnan University, 2008: 47−60.
|
[28] |
LI J, WANG S. Molecular spectroscopic on interaction between Methyl hesperidin and Buman serum albumin[J]. Spectrochimica Acta-Part A: Molecular and Biomolecular Spectroscopy,2013,102:200−204. doi: 10.1016/j.saa.2012.10.012
|
[29] |
尚曼, 张文亮, 黄军, 等. 甲基橙皮苷的研究进展[J]. 煤炭与化工,2019,42(7):121−123,149. [SHANG M, ZHANG W L, HAUNG J, et al. Research progress of methyl hesperidin[J]. Coal and Chemical Industry,2019,42(7):121−123,149.
SHANG M, ZHANG W L, HAUNG J, et al. Research progress of methyl hesperidin[J]. Coal and chemical industry, 2019, 42(7): 121-123, 149.
|
[30] |
陈平, 樊瑞胜, 聂芊. 水溶性橙皮苷的合成及结构表征[J]. 食品科学,2007(08):143−147. [CHEN P, FAN R S, NIE Q. Synthesis and structure characterization of water-soluble hesperidin[J]. Food Science,2007(08):143−147. doi: 10.3321/j.issn:1002-6630.2007.08.030
CHEN P, FAN R S, NIE Q. Synthesis and structure characterization of water-soluble hesperidin[J]. Food Science, 2007, (08): 143-147. doi: 10.3321/j.issn:1002-6630.2007.08.030
|
[31] |
于进永, 赵永会, 杨璐, 等. 饲料添加剂橙皮苷磺化工艺研究[J]. 中国奶牛,2015(21):6−8. [YU J Y, ZHAO Y H, YANG L, et al. Research on feed additive of hesperidin modification[J]. China Dairy Cattle,2015(21):6−8. doi: 10.3969/j.issn.1004-4264.2015.21.002
YU J Y, ZHAO Y H, YANG L, et al. Research on feed additive of hesperidin modification[J]. China Dairy Cattle, 2015(21): 6-8. doi: 10.3969/j.issn.1004-4264.2015.21.002
|
[32] |
FRANCESCHINI SARRIA A L, LOPES VILELA A F, FRUGERI B M, et al. Copper (II) and zinc (II) complexes with flavanone derivatives: Identification of potential cholinesterase inhibitors by on-flow assays[J]. Journal of Inorganic Biochemistry,2016,164:141−149. doi: 10.1016/j.jinorgbio.2016.09.010
|
[33] |
ETCHEVERRY S B, FERRER E G, NASO L, et al. Antioxidant effects of the VO (IV) hesperidin complex and its role in cancer chemoprevention[J]. Journal of Biological Inorganic Chemistry,2008,13(3):435−447. doi: 10.1007/s00775-007-0332-9
|
[34] |
申丽静. 橙皮苷酶的制备及其催化性质的研究[D]. 杭州: 浙江工业大学, 2006: 13-19.
SHEN L J. Study on preparation and catalytic propertie of the hesperidinase[D]. Hangzhou: Zhejiang University of Technology, 2006: 13-19.
|
[35] |
张红城, 吴正双, 高文宏, 等. 黄酮类化合物改性方法的研究进展[J]. 食品科学,2011,32(3):256−261. [ZHANG H C, WU Z S, GAO W H, et al. Research progress on modification methods for flavonoids[J]. Food Science,2011,32(3):256−261.
ZHANG H C, WU Z S, GAO W H, et al. Research progress on modification methods for flavonoids[J]. Food Science, 2011, 32(3): 256-261.
|
[36] |
XIAO J, CAO H, WANG Y, et al. Glycosylation of dietary flavonoids decreases the affinities for plasma protein[J]. Journal of Agricultural & Food Chemistry,2009,57(15):6642.
|
[37] |
WANG J, MA Y L, WU X Y, et al. Selective hydrolysis by commercially available hesperidinase for isoquercitrin production[J]. Journal of Molecular Catalysis B-Enzymatic,2012,81:37−42. doi: 10.1016/j.molcatb.2012.05.005
|
[38] |
WANG J, GONG A, YANG C F, et al. An effective biphase system accelerates hesperidinase-catalyzed conversion of rutin to isoquercitrin[J]. Scientific Reports,2015,5(1):8682. doi: 10.1038/srep08682
|
[39] |
ZHU Y P, JIA H Y, XI M L, et al. Purification and characterization of a naringinase from a newly isolated strain of Bacillus amyloliquefaciens 11568 suitable for the transformation of flavonoids[J]. Food Chemistry,2017,214:39−46. doi: 10.1016/j.foodchem.2016.06.108
|
[40] |
郑美瑜, 陆胜民, 陈剑兵, 等. 糖苷酶对橙皮苷和柚皮苷的酶解作用研究[J]. 中国食品学报,2010,10(4):141−146. [ZHENG M Y, LU S M, CHEN J B, et al. Study on enzymatic hydrolysis of hesperidin and naringin with glycoside hydrolase[J]. Journal of Chinese Institute of Food Science and Technology,2010,10(4):141−146. doi: 10.3969/j.issn.1009-7848.2010.04.022
ZHENG M Y, LU S M, CHEN J B, et al. Study on Enzymatic Hydrolysis of Hesperidin and Naringin with Glycoside hydrolase[J]. Journal of Chinese Institute of Food Science and Technology, 2010, 10(4): 141-146. doi: 10.3969/j.issn.1009-7848.2010.04.022
|
[41] |
盛占武. 橙皮苷的超滤提取及其酶法改性研究[D]. 重庆: 西南大学, 2008: 41−51.
SHENG Z W. Studies on the technology of extracting hesperidin by ultrafiltration and enzyme modification[D]. Chongqing: Southwest University, 2008: 41−51.
|
[42] |
陈曾三. 酶处理橙皮苷的特性和利用[J]. 江苏食品与发酵,1999(4):18−21. [CHEN Z S. Characteristics and utilization of enzymatic treatment of hesperidin[J]. Jiangsu Shipin Yu Fajiao,1999(4):18−21.
CHEN Z S. Characteristics and utilization of enzymatic treatment of hesperidin[J]. JIANGSU SHIPIN YU FAJIAO, 1999(4): 18-21.
|
[43] |
HIJIYA H, MIYAKE T. Alpha-glycosyl hesperidin, and its preparation and uses: EP 0402049A2[P]. 1989-06-03.
|
[44] |
杨红亚, 吴少华, 王兴红, 等. 开展中药生物转化研究意义深远[J]. 中草药,2004(12):4−7. [YANG H Y, WU S H, WANG X H, et al. Significance of biotransformation of Chinese materia medica[J]. Chinese Traditional and Herbal Drugs,2004(12):4−7.
YANG H Y, WU S H, WANG X H, et al. Significance of biotransformation of Chinese materia medica[J]. Chinese Traditional and Herbal Drugs, 2004(12): 4-7.
|
[45] |
徐萌萌, 王建芳, 徐春, 等. 微生物转化苷类中药的机理及应用[J]. 世界科学技术,2006(2):24−27. [XU M M, WANG J F, XU C, et al. Mechanism and application of microbe-transformed glycosides in traditional Chinese medicine[J]. World Science and Technology,2006(2):24−27.
XU M M, WANG J F, XU C, et al. Mechanism and application of microbe-transformed glycosides in traditional Chinese medicine[J]. World Science and Technology, 2006(2): 24-27.
|
[46] |
RAJAL V B, CID A G, ELLENRIEDER G, et al. Production, partial purification and characterization of α-l-rhamnosidase from Penicillium ulaiense[J]. World Journal of Microbiology & Biotechnology,2009,25(6):1025−1033.
|
[47] |
靳梦琦, 李军, 朱凤妹, 等. 黑曲霉代谢组学研究进展[J]. 食品工程,2017(4):1−4,37. [JIN M Q, LI J, ZHU F M, et al. Advances in metabolomics of aspergillus niger[J]. Food Engineering,2017(4):1−4,37. doi: 10.3969/j.issn.1673-6044.2017.04.001
JIN M Q, LI J, ZHU F M, et al. Advances in metabolomics of aspergillus niger[J]. Food Engineering, 2017(4): 1-4, 37. doi: 10.3969/j.issn.1673-6044.2017.04.001
|
[48] |
杨丹, 杨放晴, 燕娜娜, 等. 黑曲霉发酵对陈皮黄酮类成分及抗氧化活性的影响[J]. 食品科技,2019,44(12):23−27. [YANG D, YANG F Q, YAN N N, et al. Effects of Aspergillus niger fermentation on flavonoids and antioxidant activity of pericarpium citri reticulatae(PCR)[J]. Food Science and Technology,2019,44(12):23−27.
YANG D, YANG F Q, YAN N N, et al. Effects of Aspergillus niger fermentation on flavonoids and antioxidant activity of pericarpium citri reticulatae(PCR)[J]. Food Science and Technology, 2019, 44(12): 23-27.
|
[49] |
DIAZ-MALVAEZ F I, GARCIA-ALMENDAREZ B E, HERNANDEZ-ARANA A, et al. Isolation and properties of β-xylosidase from Aspergillus niger GS1 using corn pericarp upon solid state fermentation[J]. Process Biochemistry,2013,48(7):1018−1024. doi: 10.1016/j.procbio.2013.05.003
|
[50] |
孟娜, 魏胜华, 郑长龙. 黑曲霉发酵产橙皮苷酶的工艺优化[J]. 生物技术,2011,21(2):77−80. [MENG N, WEI S H, ZHENG C L. Optimization of fermentation conditions for production of hesperidinase by Aspergillus niger[J]. Biotechnology,2011,21(2):77−80.
MENG N, WEI S H, ZHENG C L. Optimization of Fermentation Conditions for Production of Hesperidinase by Aspergillus niger[J]. Biotechnology, 2011, 21(02): 77-80.
|
[51] |
CANDELARIAPEREZ-NAJERA V, LUGO-CERVANTES E, AMAYA-DELGADO L, et al. Biotransformation of hesperidin from lime peel (Citrus limetta Risso) in solid fermentation by Aspergillus saitoi[J]. Cyta-Journal of Food,2018,16(1):537−543.
|
[52] |
ARAKI Y, YUZUKI M, MASAKARI Y, et al. High-level heterologous protein production using an attenuated selection marker in Aspergillus sojae[J]. The Journal of General and Applied Microbiology, 2020, 67(2): 77-80.
|
[53] |
CHANG H Y, LEE Y B, BAE H A, et al. Purification and characterisation of Aspergillus sojae naringinase: The production of prunin exhibiting markedly enhanced solubility within vitro inhibition of HMG-CoA reductase[J]. Food Chemistry,2011,124(1):234−241.
|
[54] |
LEE Y S, HUH J Y, NAM S H, et al. Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: Enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori[J]. Food Chemistry,2012,135(4):2253−2259.
|
[55] |
李小莉. 产橙皮苷酶菌株的筛选及发酵提取耦合制备橙皮素单葡萄糖苷的研究[D]. 南京: 南京农业大学, 2012: 36−61.
LI X L. Study on screening of hesperidinase-producing strain and preparation of hesperetin monoglucoside by ferment-extracted coupling[D]. Nanjing: Nanjing Agricultural University, 2012: 36−61.
|
[56] |
刘晓晶. 雪腐镰刀菌6238发酵产橙皮苷酶及橙皮苷酶纯化和性质研究[D]. 杭州: 浙江大学, 2015: 48-58.
LIU X J. Fermentation, purification and characterization of hesperidinase produced by Snow rot fusarium 6238[D]. Hangzhou: Zhejiang University, 2015: 48-58.
|
[57] |
WU F, SHI Z J, LEI H H, et al. Short-term intake of hesperetin-7-O-glucoside affects fecal microbiota and host metabolic homeostasis in mice[J]. Journal of Agricultural and Food Chemistry,2021,69(5):1478−1486.
|
[58] |
CÉLIZ G, RODRIGUEZ J, SORIA F, et al. Synthesis of hesperetin 7-O-glucoside from flavonoids extracted from citrus waste using both free and immobilized α-L-rhamnosidases[J]. Biocatalysis and Agricultural Biotechnology,2015,4(3):335−341.
|
[59] |
WAN W J, XIA N, ZHU S M, et al. Synthesis and characterization of a novel soluble hesperetin monoglucoside-copper(II) complex using ion exchange column[J]. Inorganica Chimica Acta,2020,512:119857.
|
[60] |
王超, 马旭亮, 程瑞卿, 等. 橙皮素调控miR-182-5p对口腔鳞癌BcaCD885细胞迁移和分泌IL-6、IL-8的影响[J]. 中国免疫学杂志,2021,37(4):463−468. [WANG C, MA X L, CHENG R Q, et al. Hesperetin regulates effect of miR-182-5p on migration and secretion of IL-6, IL-8 in oral squamous cell carcinoma BcaCD885 cells[J]. Chinese Journal of Immunology,2021,37(4):463−468.
WANG C, MA X L, CHENG R Q, et al. Hesperetin regulates effect of miR-182-5p on migration and secretion of IL-6, IL-8 in oral squamous cell carcinoma BcaCD885 cells[J]. Chinese Journal of Immunology, 2021, 37(4): 463-468.
|