Protective Effect of Medicine Vinegar Extract of Panax ginseng, Glycyrrhiza and Schisandra chinensis on Acute Liver Injury in Mice

LI Yu; XIA Ting; KANG Chaoyan; TIAN Yinglei; FANG Bin; YAN Yufeng; LANG Fanfan; ZHENG Yu; WANG Min

doi:10.13386/j.issn1002-0306.2021060059

Volume 43 Issue 4

Feb. 2022

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Science and Technology of Food Industry > 2022 > 43(4): 366-372. > DOI: 10.13386/j.issn1002-0306.2021060059

LI Yu, XIA Ting, KANG Chaoyan, et al. Protective Effect of Medicine Vinegar Extract of Panax ginseng, Glycyrrhiza and Schisandra chinensis on Acute Liver Injury in Mice[J]. Science and Technology of Food Industry, 2022, 43(4): 366−372. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021060059.

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Protective Effect of Medicine Vinegar Extract of Panax ginseng, Glycyrrhiza and Schisandra chinensis on Acute Liver Injury in Mice

1.
State Key Laboratory of Food Nutrition and Safety, Tianjin Engineering Center for Microbial Metabolism and Fermentation Process Control, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
2.
Shanxi Zilin Vinegar Co., Ltd., Taiyuan 030400, China

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Received Date: June 07, 2021
Available Online: December 17, 2021

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Abstract

Abstract

Objective: Investigating the protective effect of MVE was the purpose of this study, which performed on LPS-induced liver injury in aged mice. Methods: The mice were randomized into the groups of normal control, MVE, LPS and LPS+MVE. The pathological changes of liver tissue and the expression of myeloperoxidase were observed by hematoxylin-eosin staining and immunohistochemical staining. The levels of IL-1β, IL-17, CXCL1, CXCL17 and other factors in liver were measured. Western blotting was used to detect the expressions of TLR4 and NF-κB p65 in liver tissue samples. Results: The MVE could effectively decline the infiltration of neutrophils and inflammatory cells, significantly decrease the levels of ALT, AST, ROS (P<0.01), pro-inflammatory cytokines and neutrophil chemokines (P<0.05) in the liver of LPS model mice, and decrease protein expressions of TLR4 and NF-κB p65 in inflammatory pathway (P<0.001). Conclusion: The MVE could improve the liver injury of mice with acute inflammation induced by LPS, and exert its hepatoprotective mechanism by regulating the balance of pro-inflammatory and anti-inflammatory factors and inhibiting TLR4-NF-κB signal pathway.
- medicine vinegar extract,
- lipopolysaccharide (LPS),
- liver injury,
- inflammatory reaction,
- TLR4-NF-κB signal pathway

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