Hepatoprotective Effects of Grape Seed Oil on Acute Liver Injury

DONG Ying; CHEN Xinpei; YANG Haoduo; WANG Yingying; WANG Dongying; Wang Xuede

doi:10.13386/j.issn1002-0306.2021040247

Volume 43 Issue 8

Apr. 2022

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2022 > 43(8): 342-347. > DOI: 10.13386/j.issn1002-0306.2021040247

DONG Ying, CHEN Xinpei, YANG Haoduo, et al. Hepatoprotective Effects of Grape Seed Oil on Acute Liver Injury[J]. Science and Technology of Food Industry, 2022, 43(8): 342−347. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021040247.

Citation:

PDF (5707 KB)

Hepatoprotective Effects of Grape Seed Oil on Acute Liver Injury

College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, China

More Information

Received Date: April 25, 2021
Available Online: February 11, 2022

Graphical Abstract

Abstract

Abstract

The hepatoprotective effects of grape seed oil (GSO) against carbon tetrachloride (CCl₄) induced acute liver injury in mice was investigated. The model of acute liver injury was induced by intraperitoneal injection of CCl₄. The body weight and food and water intake were measured, the relevant indexes of serum and liver tissue were detected, and the pathological changes of liver tissues in mice were observed. The results showed that compared mice-treated with CCl₄, the mice were oral administered middle dose (10 mL/kg·d) of GSO (MGSO) and high dose (20 mL/kg·d) of GSO (HGSO) could significantly reduce the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and the levels of total cholesterol (TC), triglyceride (TG) (P<0.05) in serum, could significantly increase the activities of glutathione (GSH), superoxide dismutase (SOD) and reduce concentrations of malondialdehyde (MDA) (P<0.05), and could significantly improve the pathological changes of liver tissue. Therefore, GSO had significant hepatoprotective effects against CCl₄ induced acute liver injury in mice, and the hepatoprotective effects was stronger with the increasing dose．
- hepatoprotective effects,
- grape seed oil,
- carbon tetrachloride,
- mice,
- acute liver injury

FullText(HTML)

References (30)

References

[1]	伍沙沙, 王延, 徐婷, 等. 八月瓜对四氯化碳所致肝损伤小鼠的保护作用[J]. 安徽农业科学,2021,49(4):163−165,174. [WU S S, WANG Y, XU T, et al. Protective effect of Holboellia latifolia Wall. on liver injury induced by carbon tetrachloride in mice[J]. Journal of Anhui Agricultural Sciences,2021,49(4):163−165,174.
[2]	夏娜, 陈义磊, 陶海燕, 等. 药桑多糖对四氯化碳所致大鼠肝损伤的保护作用[J]. 食品科学,2015,36(13):247−251. [XIA N, CHEN Y L, TAO H Y, et al. Protective effect of polysaccharides from Morus nigra Linn. fruits on CCl₄-induced liver damage in rats[J]. Food Science,2015,36(13):247−251. doi: 10.7506/spkx1002-6630-201513046
[3]	胡力夫, 苏沛文, 冯微, 等. 大蒜提取物制备及其对四氯化碳诱导小鼠肝损伤的保护作用研究[D]. 长春: 吉林大学, 2020. HU L F, SU P W, FEN W, et al. Preparation of garlic extract and its protective effect on liver injury induced by carbon tetrachloride in mice[D]. Changchun: Jilin University, 2020.
[4]	丁杰英, 李嘉斌, 郑妮. 滇黄精多糖对四氯化碳所致肝损伤大鼠氧化因子、凋亡因子的影响[J]. 广西医科大学学报,2020,37(10):1766−1771. [DING J Y, LI J B, ZHENG N. Effects of polysaccharide in Polygonatum kingianum on oxidative and apoptotic factors in rats with carbon tetrachloride-induced liver injury[J]. Journal of Guangxi Medical University,2020,37(10):1766−1771.
[5]	刘晓东, 温雯静, 赵志军. 多穗柯总黄酮对四氯化碳致小鼠急性肝损伤的保护作用[J]. 医药导报,2020,39(12):1626−1630. [LIU X D, WEN W J, ZHAO Z J. Protective effect of total flavonoids from Lithocarpus polystachyus Rehd. on CCl₄-induced acute liver injury in mice[J]. Herald of Medicine,2020,39(12):1626−1630.
[6]	黄小强, 丁辉, 刘顺和, 等. 马齿苋多糖对四氯化碳诱导的小鼠急性肝损伤的保护作用[J]. 食品工业科技,2020,41(23):315−319,324. [HUANG X Q, DING H, LIU S H, et al. Protective effect of purslane polysaccharide on CCl₄ induced acute liver injury in mice[J]. Science and Technology of Food Industry,2020,41(23):315−319,324.
[7]	FERNANDES L, CASAL S, CRUZ R, et al. Seed oils of ten traditional Portuguese grape varieties with interesting chemical and antioxidant properties[J]. Food Research International,2013,50:161−166. doi: 10.1016/j.foodres.2012.09.039
[8]	刘霞. 葡萄籽油的提取方法综述[J]. 河西学院学报,2020,36(5):75−79. [LIU X. Review on extraction methods of grape seeds oil[J]. Journal of Hexi University,2020,36(5):75−79.
[9]	BAIL S, STUEBIGER G, KRIST S, et al. Characterisation of various grape seed oils by volatile compounds, triacylglycerol composition, total phenols and antioxidant capacity[J]. Food Chemistry,2008,108(3):1122−1132. doi: 10.1016/j.foodchem.2007.11.063
[10]	王灿, 杨晨露, 王华, 等. 葡萄籽油生理功能及应用综述[J]. 中外葡萄与葡萄酒,2020(6):66−71. [WANG C, YANG C L, WANG H, et al. Review on physiological function and application of grape seed oil[J]. Sino-Overseas Grapevine & Wine,2020(6):66−71.
[11]	程碧君, 李天娇. 山葡萄籽油的脂肪酸组成研究[J]. 食品研究与开发,2019,40(15):73−77. [CHENG B J, LI T J. Study on fatty acid composition of mountain grape seed oil[J]. Food Research and Development,2019,40(15):73−77. doi: 10.12161/j.issn.1005-6521.2019.15.012
[12]	DUBA K S, FIORI L. Supercritical CO₂ extraction of grape seed oil: Effect of process parameters on the extraction kinetics[J]. Journal of Supercritical Fluids,2015,98:33−43. doi: 10.1016/j.supflu.2014.12.021
[13]	ANDREA N, CARLA D P. Kinetic models for conventional and ultrasound assistant extraction of polyphenols from defatted fresh and distilled grape marc and its main components skins and seeds[J]. Chemical Engineering Research and Design,2020,156:1−12. doi: 10.1016/j.cherd.2020.01.009
[14]	牛春艳, 孙静, 张健, 等. 超声波法提取葡萄籽甾醇的研究[J]. 广州化工,2016,44(14):65−66,98. [NIU C Y, SUN J, ZHANG J, et al. Optimization of ultrasound technology extraction parameters for phytosterol from grape seed[J]. Guangzhou Chemical Industry,2016,44(14):65−66,98. doi: 10.3969/j.issn.1001-9677.2016.14.025
[15]	周旭. 几种油溶性天然抗氧化剂在核桃油、葡萄籽油中的应用研究[J]. 中国油脂,2017,42(3):64−68. [ZOU X. Application of oil soluble natural antioxidants in walnut oil and grape seed oil[J]. China Oils and Fats,2017,42(3):64−68. doi: 10.3969/j.issn.1003-7969.2017.03.013
[16]	CASTILLO J, BENAVENTE-GARCÍA O, LORENTE J, et al. Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (procyanidins) from grape seeds (Vitis vinifera): Comparative study versus other phenolic and organic compounds[J]. Journal of Agricultural and Food Chemistry,2000,48:1738−1745. doi: 10.1021/jf990665o
[17]	KANDASAMY M, NASIMUDDIN S, MALAYAN J, et al. A study on antibacterial effect of grape seed extracts in common clinical and dmg resistant isolates[J]. International Journal of Clinical Trials,2016,3(3):165−168. doi: 10.18203/2349-3259.ijct20162799
[18]	ZHAO L, YAGIZ Y, XU C, et a1. Muscadine grape seed oil as a novel source of tocotrienols to reduce adipogenesis and adipocyte inflammation[J]. Food & Function,2015,6(7):2293−2302.
[19]	XIA E Q, DENG G F, GUO Y J, et al. Bio1ogical activities of polyphenols from grapes[J]. International Journal of Molecular Sciences,2010,11(2):622−646. doi: 10.3390/ijms11020622
[20]	AL-AWWADI N A, CAROLINE A, AURÉLIE B, et al. Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats[J]. Journal of Agricultural and Food Chemistry,2005,53:151−157. doi: 10.1021/jf048919f
[21]	贾雪峰, 吴洪斌, 金新文, 等. 番茄籽油的提取及其影响因素和生理活性研究进展[J]. 中国食品添加剂,2013(1):203−207. [JIA X F, WU H B, JIN X W, et al. Review on the extraction and physiological activity of tomato seed oils[J]. China Food Additives,2013(1):203−207. doi: 10.3969/j.issn.1006-2513.2013.01.031
[22]	吴正平. 金花葵籽不饱和脂肪酸对实验性高脂血症大鼠血脂和肝功能的影响[J]. 中成药,2011,33(7):1245−1247. [WU Z P. Effect of the unsaturated fatty acids from Hibiscus manihot seeds on the blood lipid and liver function in experimental hyperlipidemia rats[J]. Chinese Traditional Patent Medicine,2011,33(7):1245−1247. doi: 10.3969/j.issn.1001-1528.2011.07.045
[23]	叶展. 典型膳食油脂胃肠道消化吸收特性及其对肠道健康的影响研究[D]. 无锡: 江南大学, 2020. YE Z. Studies on characteristics of typical dietary oil gastrointestinal digestion and absorption, and their influences on gut health[D]. Wuxi: Jiangnan University, 2020.
[24]	林文海. 芪苓散粗多糖对四氯化碳引起急性肝损伤雏鸡血清中ALT和AST的影响[J]. 福建畜牧兽医,2020,42(2):4−6. [LIN W H. Effect of Qilingsan crude polysaccharide on ALT and AST in serum of chickens with acute liver injury caused by carbon tetrachloride[J]. Fujian Journal of Animal Husbandry and Veterinary Medicine,2020,42(2):4−6. doi: 10.3969/j.issn.1003-4331.2020.02.002
[25]	张扬, 朱彩平, 林杨楠, 等. 平菇多糖对四氯化碳诱导雄性昆明种小鼠肝损伤的保护作用[J]. 食品科学,2019,40(23):157−162. [ZHANG Y, ZHU C P, LIN Y N, et al. Hepatoprotective effect of Pleurotus ostreatus polysaccharides on carbon tetrachloride-induced liver injury in male Kunming mice[J]. Food Science,2019,40(23):157−162. doi: 10.7506/spkx1002-6630-20181016-151
[26]	姚秀芬, 程栋, 王承明. 花生粗多糖对四氯化碳及酒精所致小鼠急性肝损伤的保护作用[J]. 食品科学,2011,32(9):261−266. [YAO X F, CHENG D, WANG C M. Hepatoprotective effect of crude peanut polysaccharide on carbon tetrachloride-or alcohol-induced acute liver injury in mice[J]. Food Science,2011,32(9):261−266.
[27]	李晨曦. 芝麻籽粒成熟过程成分分析、多糖的提取及其功能性研究[D]. 郑州: 河南工业大学, 2020. LI C X. Component analysis of ripening process of sesame seeds, extraction of polysaccharides and functional study[D]. Zhengzhou: Henan University of Technology, 2020.
[28]	WANG H L, SIT W H, TIPOE G L, et al. Differential protective effects of extra virgin olive oil and corn oil in liver injury: A proteomic study[J]. Food and Chemical Toxicology,2015,74:131−138.
[29]	SHABAN N Z, EL-KERSH M A, EL-RASHIDY F H, et al. Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats[J]. Food Chemistry,2013,141(3):1587−1596. doi: 10.1016/j.foodchem.2013.04.134
[30]	郑岳, 孙伟, 卢坤玲, 等. 龙葵多糖对四氯化碳致小鼠肝损伤的保护作用及其机制[J]. 山东医药,2016,56(8):23−25. [ZHENG Y, SUN W, LU K L, et al. Hepatoprotective effect and mechanism of nightshade polysaccharide on carbon tetrachloride -induced acute liver injury in mice[J]. Shandong Medical Journal,2016,56(8):23−25. doi: 10.3969/j.issn.1002-266X.2016.08.008

Supplements (0)

Cited By

Cited by

Periodical cited type(15)

1.	韩雪，刘磊，樊志伟. 针刺联合通幽汤对痰瘀互结型食管癌术后患者康复的影响及机制. 北京中医药. 2024(01): 48-52 .
2.	詹海玲，赵瑾，潘美杉，任青，青艳，王同为. 基于文献计量的管花肉苁蓉研究态势分析. 农村经济与科技. 2024(01): 27-30 .
3.	匡怡，张晨，李雯. 益胃健脾方治疗脾肾亏虚型身高发育迟缓的疗效分析. 深圳中西医结合杂志. 2024(07): 49-51 .
4.	黄卫勇，刘可普，张新响. 香菊胶囊联合糠酸莫米松治疗慢性鼻窦炎的效果. 菏泽医学专科学校学报. 2024(02): 59-61 .
5.	卢迁，周远军. 黄芪当归汤对晚期肺癌化疗患者肿瘤标志物及骨髓抑制的影响. 智慧健康. 2024(11): 96-99 .
6.	赵丽，张娟，徐晓琴，卿德刚，刘天志，孙宇. 响应面法优化肉苁蓉玫瑰花片配方研究. 食品与发酵科技. 2024(03): 42-48 .
7.	Xiang Li，Xiao Xu，Ying Dong，Shusheng Fan，Xueyang Ren，Yuan Zheng，Jiamu Ma，Feng Zhang，Qingyue Deng，Xianxian Li，Yingyu He，Mengyu Sun，Wei Liu，Mengxia Li，Qing Xia，Yan Zhang，Gaimei She. Fufang E'jiao Jiang's effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysis. Food Science and Human Wellness. 2024(05): 2813-2832 .
8.	方逸倩，史培，张治峰，李红亮，李佳. 药食同源中药肉苁蓉中苯乙醇苷的研究进展. 食品工业. 2024(11): 281-285 .
9.	赵丽，徐晓琴，张娟，卿德刚，刘天志，孙宇. 肉苁蓉玫瑰花口服液增强免疫力作用的研究. 食品与发酵科技. 2023(05): 58-63 .
10.	赵志恒，毕经会，叶诗洁，黄永康，闵婷，王宏勋，王丽梅. 基于网络药理学和分子对接探究黄芪-女贞子治疗免疫缺陷病的作用机制. 食品工业科技. 2022(03): 374-383 . 本站查看
11.	张佳佳. 蒙药肉苁蓉的药理作用及临床应用研究. 中国民族医药杂志. 2022(05): 53-55 .
12.	周亚西，周士琦，冯朵，闫文杰. 肉苁蓉生物活性成分及其免疫功效研究进展. 食品科技. 2022(06): 133-139 .
13.	甄亚钦，范帅帅，支雅婧，田伟，麻景梅，牛丽颖. 基于UPLC指纹图谱及多成分含量测定的肉苁蓉药材质量控制研究. 中国中医药信息杂志. 2021(03): 81-86 .
14.	支雅婧，甄亚钦，田伟，麻景梅，牛丽颖. 肉苁蓉化学成分和药理作用研究进展及质量标志物（Q-Marker）的预测分析. 中草药. 2021(09): 2758-2767 .
15.	郝姗姗，陈素梅，闫东海，陈明霞，韩雅慧，易斌. 肉苁蓉在化妆品中的应用研究进展. 日用化学品科学. 2021(09): 36-41 .