WEI Yanli, JIANG Guoqing, PENG Jian, et al. A Review of Nutrition and Health Functions of Spirulina and Its Application in Food Industry[J]. Science and Technology of Food Industry, 2022, 43(8): 406−415. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021030179.
Citation: WEI Yanli, JIANG Guoqing, PENG Jian, et al. A Review of Nutrition and Health Functions of Spirulina and Its Application in Food Industry[J]. Science and Technology of Food Industry, 2022, 43(8): 406−415. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021030179.

A Review of Nutrition and Health Functions of Spirulina and Its Application in Food Industry

More Information
  • Received Date: March 14, 2021
  • Available Online: February 16, 2022
  • Spirulina (Arthrospira) is the largest microalgal product by tonnage and value. There are roughly 90% of Spirulina powder and tablets is sold as human nutritional supplements. Spirulina is recognized as a superfood growingly among people, and the mechanism beyond the functional phenomena is also ongoing researching. The relationship between recommended daily intake (RDI, 3 g/d) of Spirulina and recommended nutrition intake (RNI) or adequate intake (AI) is analyzed, and the Spirulina is a good supplement for premier protein, iron, vitamin A, vitamin B12, vitamin K1 and K2. Spirulina is also an effective supplement for manganese and iodine elements. This paper also briefly reviews the progress in the medical and pharmaceutical functions to human beings of Spirulina powder. The clinical trials show that Spirulina is a proficient nutraceuticals in controlling hypertension, diabetes, obese, etc. Finally, the progress of the application of Spirulina in food industry is also discussed. For the heat and light sensitivity of phycocyanin and chlorophyll, there is an urgent demand for the solution of stable Spirulina and new derivatives.
  • [1]
    SHAO W, EBAID R, EL-SHEEKH M, et al. Pharmaceutical applications and consequent environmental impacts of Spirulina (Arthrospira): An overview[J]. Grasas Aceites,2019,70(1):e292. doi: 10.3989/gya.0690181
    [2]
    HOSEINI S M, KHOSRAVI-DARANI K, MOZAFARI M R. Nutritional and medical applications of Spirulina microalgae[J]. Mini-Reviews in Medicinal Chemistry,2013,13(8):1231−1237. doi: 10.2174/1389557511313080009
    [3]
    KULSHRESHTHA A, ZACHARLA J A, JAROULIYA U, et al. Spirulina in health care management[J]. Current Pharmaceutical Biotechnology,2008,9(5):400−405. doi: 10.2174/138920108785915111
    [4]
    MA Z, AHMED F, YUAN B, et al. Fresh living Arthrospira as dietary supplements: Current status and challenges[J]. Trends in Food Science and Technology,2019,88:439−444. doi: 10.1016/j.jpgs.2019.04.010
    [5]
    SONI R A, SUDHAKAR K, RANA R S. Spirulina-from growth to nutritional product: A review[J]. Trends in Food Science & Technology, 2017, 69(Part A), 157−171.
    [6]
    国家市场监督管理总局. 特殊食品信息查询平台[EB/OL]. [2021-7-15]. http://tsspxx.gsxt.gov.cn//gcbjp/bjpindexquery.xhtml.

    State Administration for Market Regulation. Special food information inquiry platform[EB/OL]. [2021-7-15]. http://tsspxx.gsxt.gov.cn//gcbjp/bjpindexquery.xhtml.
    [7]
    国家药品监督管理总局. 国产药品数据库[EB/OL]. [2021-7-15]. http://app1.nmpa.gov.cn/data_nmpa/face3/.

    National Medical Products Administration. Domestic drug database[EB/OL]. [2021-7-15]. http://app1.nmpa.gov.cn/data_nmpa/face3/.
    [8]
    国家市场监督管理总局. 市场监管总局关于公开征求辅酶Q10等5种保健食品原料目录意见的公告[EB/OL]. [2019-6-20]. http://gkml.saic.gov.cn/nsjg/tssps/201904/t20190401_292491.html.

    State Administration of market supervision. Notice of the General Administration of Market Supervision on publicly soliciting opinions on the catalogue of five kinds of health food raw materials such as coenzyme Q10 [EB/OL]. [2019-6-20]. http://gkml.saic.gov.cn/nsjg/tssps/201904/t20190401_292491.html.
    [9]
    FAO/WHO. Codex guidelines for vitamin and mineral food supplements[S]. 2005.
    [10]
    中国营养学会. 中国居民膳食营养素参考摄入量(2013版)[M]. 北京: 科学出版社, 2014.

    Chinese nutrition society. chinese dietary reference intakes (2013 edition) [M]. Beijing: Science Press, 2014.
    [11]
    食品药品监管总局, 国家卫生计生委, 国家中医药管理局. 关于发布《保健食品原料目录(一)》和《允许保健食品声称的保健功能目录(一)》的公告(2016年第205号)[EB/OL]. [2021-7-23]. http://law.foodmate.net/show-189796.html.

    Food and Drug Administration, National Health and Family Planning Commission, State Administration of Traditional Chinese Medicine. Announcement of the publication of the dietary supplement and the functional list of permitted dietary supplement claims (No. 205, 2016)[EB/OL]. [2021-7-23]. http://law.foodmate.net/show-189796.html.
    [12]
    杨卫杰. 螺旋藻肠内营养制剂干预II型糖尿病实验动物代谢特性的研究[D]. 上海: 上海海洋大学, 2018.

    YANG Weijie. Metabolic mechanisms of Spirulina based enteral formula for supporting type 2 diabetes mellitus in experimental animals[D]. Shanghai: Shanghai Ocean University, 2018.
    [13]
    许洪高, 周琪乐, 鲁绯, 等. 螺旋藻养殖加工和安全性研究进展[J]. 江苏农业科学,2021,49(6):10−19. [XU H G, ZHOU Q L, LU F, et al. A review of progress in the cultivation and safety of Spirulina[J]. Jiangsu Agricultural Sciences,2021,49(6):10−19.
    [14]
    尹兴娟, 唐建国, 刘继宪, 等. 藻蓝素的提取及其光学性质研究[J]. 应用化工,2010,39(4):484−486,490. [YIN Xingjuan, TANG Jianguo, LIU Jixian, et al. Study on extraction of phycobilin and its optical property[J]. Applied Chemical Industry,2010,39(4):484−486,490. doi: 10.3969/j.issn.1671-3206.2010.04.006
    [15]
    杜林方, 付华龙. 钝顶螺旋藻藻胆蛋白的分离纯化及特性研究[J]. 四川大学学报(自然科学版),1994,31(4):576−578. [DU Linfang, FU Hualong. Purification and properties of phycobiliprotein from Spirulina platensis[J]. Journal of Sichuan University (Natural Science Edition),1994,31(4):576−578.
    [16]
    吕平平, 李传茂, 杨登亮, 等. 螺旋藻藻蓝蛋白稳定性的实验研究[J]. 广东化工,2019,46(5):60−61. [LV Pinigping, LI Chuanmao, YANG Dengliang, et al. The research of the stability of phycocyanin from Spirulina platensis[J]. Guangdong Chemical Industry,2019,46(5):60−61. doi: 10.3969/j.issn.1007-1865.2019.05.027
    [17]
    姜国庆, 闫秋丽, 李东, 等. 螺旋藻中藻蓝蛋白提取、纯化及稳态化研究进展[J]. 食品安全质量检测学报, 2021, 12(6): 2332−2338.

    JIANG Guoqing, YAN Qiuli, LI Dong, et al. Research progress on separation, purification and stabilization of phycocyanin from Spirulina[J] Journal of Food Safety and Quality, 2021, 12(6): 2332−2338.
    [18]
    TAVANANDI H A, VANJARI P, RAGHAVARAO K S M S. Synergistic method for extraction of high purity allophycocyanin from dry biomass of Arthrospira platensis and utilization of spent biomass for recovery of carotenoids[J]. Separation and Purification Technology,2019,225:97−111. doi: 10.1016/j.seppur.2019.05.064
    [19]
    HAYASHI, T, HAYASHI, K, MAEDA, M, et al. Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis[J]. Journal of Natural Products,1996,59:83−87. doi: 10.1021/np960017o
    [20]
    罗光宏, 马明辉, 张喜峰, 等. 三相萃取体系分离富集螺旋藻多糖及其结构特征分析[J]. 食品与发酵工业,2019,45(6):147−152. [LUO Gonghong, MA Minghui, ZHANG Xifeng, et al. Three-phase partitioning for efficient extraction and separation of polysaccharides from Spirulina platensis and its structural characterization[J]. Food and Fermentation Industries,2019,45(6):147−152.
    [21]
    刘玉环, 贺亚银, 张喜峰, 等. 内部沸腾法优化螺旋藻多糖提取工艺研究[J]. 牡丹江师范学院学报(自然科学版),2018(2):51−54,57. [LIU Yuhuan, HE Yayin, ZHANG Xifeng, et al. Process optimization for extraction of polysaccharides from Spirulina platensis using inner ebullition method[J]. Journal of Mudanjiang Normal University,2018(2):51−54,57.
    [22]
    MAJDOUB H, MANSOUR B M, CHAUBET F, et al. Anticoagulant activity of a sulfated polysaccharide from the green alga Arthrospira platensis[J]. Biochimica Biophysica Acta,2009,1790:1377−1381. doi: 10.1016/j.bbagen.2009.07.013
    [23]
    HAYASHI T, HAYASHI K, KOJIMA I. Antiviral polysaccharide: U. S, US5585365 A[P]. 1996.
    [24]
    PUGH N, ROSS A S, ELSOHLY N H, et al. Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, Aphanizomenon flos-aquae and Chlorella pyrenoidosa[J]. Planta Medica,2001,67:737−742. doi: 10.1055/s-2001-18358
    [25]
    CHAIKLAHANA R, CHIRASUWAN N, TRIRATANA P, et al. Polysaccharide extraction from Spirulina sp. and its antioxidant capacity[J]. International Journal of Biological Macromolecules,2013,58:73−78. doi: 10.1016/j.ijbiomac.2013.03.046
    [26]
    涂芳, 杨芳, 郑文杰, 等. 螺旋藻多糖的研究进展[J]. 天然产物研究与开发,2005,17(1):115−119. [TU Fang, YANG Fang, ZHENG Wenjie, et al. Progress in polysaccharide of Spirulina[J]. Natural Product Research and Development,2005,17(1):115−119. doi: 10.3969/j.issn.1001-6880.2005.01.026
    [27]
    MORAIS E D, DRUZIAN J I, NUNES I L, et al. Glycerol increases growth, protein production and alters the fatty acids profile of Spirulina (Arthrospira) sp LEB 18[J]. Process Biochemistry,2019,76:40−45. doi: 10.1016/j.procbio.2018.09.024
    [28]
    SASSANO C E N, GIOIELLI L A, CONVERTI A, et al. Urea increases fed-batch growth and gamma-linolenic acid production of nutritionally valuable Arthrospira (Spirulina) platensis cyanobacterium[J]. Engineering in Life Sciences,2014,14(5):530−537. doi: 10.1002/elsc.201400020
    [29]
    ESFA Panel on Dietetic Products, Nutrition and Allergies. Scientific opinion on the substantiation of health claims related to gamma-linolenic acid (GLA) and maintenance of normal blood LDL-cholesterol concentrations (ID 2661, 4452, 4453), maintenance of normal blood pressure (ID 2662), reduction of menstrual discomfort (ID 495, 640, 1773, 1775), contribution to normal cognitive function (ID 1770), maintenance of the barrier function of the skin (ID 499, 591, 639, 676, 1554, 2003, 2065), “function of the cell membrane” (ID 1769), maintenance of normal structure, elasticity and appearance of the skin (ID 2660, 4296) and “anti-inflammatory properties” (ID 4454) pursuant to Article 13(1) of Regulation (EC) No 1924/2006[J]. ESFA Journal,2011,9(4):2059.
    [30]
    RANGA R A, RAGHUNATH R R L, BASKARAN V, et al. Characterization of microalgal carotenoids by mass spectrometry and their bioavailability and antioxidant properties elucidated in rat model[J]. Journal of Agricultural and Food Chemistry,2010,58(15):8553−8559. doi: 10.1021/jf101187k
    [31]
    CEZARE-GOMES E A, MEJIA-DA-SILVAL D, PEREZ-MORA L S, et al. Potential of microalgae carotenoids for industrial application[J]. Applied Biochemistry and Biotechnology,2019,188(3):602−634. doi: 10.1007/s12010-018-02945-4
    [32]
    ANNAPURNA V, SHAN N, BHASKARAM P, et al. Bioavailability of Spirulina carotenes in preschool children[J]. Journal of Clinical Biochemical Nutrition,1991,10:145−151. doi: 10.3164/jcbn.10.145
    [33]
    王杰, 胡余明, 李梓民, 等. 膳食螺旋藻改善儿童维生素A营养状况的研究[C]// 中国食品科学技术学会儿童食品分会第十二届学术年会论文集, 2011: 102−106.

    WANG Jie, HU Yuming, LI Zimin, et al. Study on dietary Spirulina improving vitamin A nutritional status in children [C]// Papers of the 12th Academic Annual Meeting of Children’ s Food Branch of China Food Science and Technology Association, 2011, 102−106.
    [34]
    KNAPEN M H J, BRAAM L A J L M, Drummen N E, et al. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: Double-blind randomised clinical trial[J]. Thrombosis and Haemostasis,2015,114(5):1135−1144.
    [35]
    SUMMEREN M V, BRAAM L, LILIEN M R, et al. The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children[J]. British Journal of Nutrition,2009,102(8):1171−1178. doi: 10.1017/S0007114509382100
    [36]
    INABA N, SATO T, YAMASHITA T. Low-dose daily intake of vitamin K2 (menaquinone-7) improves osteocalcin γ-carboxylation: A double-blind, randomized controlled trials[J]. Journal of Nutritional Science & Vitaminology,2016,61(6):471−480.
    [37]
    KNAPEN M H J, DRUMMEN N E, SMIT E, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women[J]. Osteoporos International,2013,24:2499−2507. doi: 10.1007/s00198-013-2325-6
    [38]
    VOSSEN L M, SCHURGERS L J, VAN VARIK B J, et al. Menaquinone-7 supplementation to reduce vascular calcification in patients with coronary artery disease: Rationale and study protocol (VitaK-CAC Trial)[J]. Nutrients,2015,7:8905−8915. doi: 10.3390/nu7115443
    [39]
    黄纪明, 白树民, 胡志祥, 等. 螺旋藻对模拟失重大鼠钙代谢和骨矿盐密度影响的初步研究[J]. 中国骨质疏松杂志,2002,8(1):55−58. [HUANG Jiming, Bai SHUMIN, HU Zhixiang, et al. Effects of Spirulina on changes of femur BMD and calcium metabolism in rats simulated weightlessness[J]. Chinese Journal of Osteoporosis,2002,8(1):55−58. doi: 10.3969/j.issn.1006-7108.2002.01.016
    [40]
    WATANABE F, KATSURA H, TAKENAKA S, et al. Pseudo vitamin B12 is the predominant cobamide of an algal health food, Spirulina tablets[J]. Journal of Agricultural and Food Chemistry,1999,47:4736−4741. doi: 10.1021/jf990541b
    [41]
    VAN DEN BERG H, BRANDSEN L, SINKELDAM B J. Vitamin B12 content and bioavailability of Spirulina and nori in rats[J]. Journal of Nutrition Biochemistry,1991,2:314−318. doi: 10.1016/0955-2863(91)90073-E
    [42]
    KUMUDHA S S, KUMAR M S, THAKUR G A, et al. Purification, identification, and characterization of methylcobalamin from Spirulina platensis[J]. Journal of Agricultural and Food Chemistry,2010,58:9925−9930. doi: 10.1021/jf102159j
    [43]
    WATANABEF, MIYAMOTO E, NAKANO Y. Inactive corrinoid-compound significantly decreases in Spirulina platensis grown in a cobalt-deficient medium[J]. Journal of Agricultural and Food Chemistry,2001,49:5685−5688. doi: 10.1021/jf010733i
    [44]
    王志忠. 鄂尔多斯高原碱湖钝顶螺旋藻生产加工关键因子研究[D]. 呼和浩特: 内蒙古农业大学, 2015.

    WANG Zhizhong. Study on key factors of production and processing for Spirulina platensis from the alkali lake in Ordos Plateau[D]. Hohhot: Inner Mongolia Agricultural University, 2015.
    [45]
    朱碧贞, 吴家园, 陆羡, 等. 螺旋藻在儿童缺铁性贫血患者营养治疗中的应用[J]. 中国实用医药,2009,4(6):78−80. [ZHU Bizhen, WU Jiayuan, LU Xian, et al. Application of Spirulina in nutrition therapeutic on patients with iron-deficiency anemia in children[J]. China Practical Medicine,2009,4(6):78−80. doi: 10.3969/j.issn.1673-7555.2009.06.043
    [46]
    GAO F, GUO W, ZENG M Y, et al. Effect of microalgae as iron supplements on iron-deficiency anemia in rats[J]. Food and Function,2019,10(2):723−732. doi: 10.1039/C8FO01834K
    [47]
    MATUFI F, MAGHSUDI H, CHOOPANI A. Spirulina and its role in immune system: A review[J]. Journal of Immunology Research and Therapy,2020,5(1):204−211.
    [48]
    谭玉燕, 谭伟硕, 邹玉清. 营养改善对预防维持性血透患者院内感染的临床效果[J]. 中国现代药物应用,2016,10(5):231−232. [TAN Yuyan, TAN Weiyan, ZOU Yuqing. Clinical effect of nutritional improvement on prevention of nosocomial infection in patients with maintenance hemodialysis[J]. Chinese Journal of Modern Drug Application,2016,10(5):231−232.
    [49]
    GE Y, KANG Y K, DONG L, et al. The efficacy of dietary Spirulina as an adjunct to chemotherapy to improve immune function and reduce myelosuppression in patients with malignant tumors[J]. Translation Cancer Research,2019,8(4):1065−1073. doi: 10.21037/tcr.2019.06.13
    [50]
    PARIKH P, MANI U, IYER U. Role of Spirulina in the control of glycemia and lipidemia in type 2 diabetes mellitus[J]. Journal of Medicinal Food,2001,4(4):193−199. doi: 10.1089/10966200152744463
    [51]
    MANI U V, DESAI S, IYER U. Studies on the long-term effect of Spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients[J]. Journal of Nutraceuticals, Functional and Medical Foods,2000,2(3):25−32. doi: 10.1300/J133v02n03_03
    [52]
    杨志芬, 刘洪斌, 汤治元, 等. 螺旋藻对2型糖尿病患者血清铁Hb及GHb的影响[J]. 浙江临床医学, 2002, 4(4): 264-265.

    YANG ZHIFEN, LIU HONGBIN, TANG ZHIYUAN et al, Effects of Spirulina on iron, hemoglobin, and glycated hemoglobin content in serum of non-insulin dependent diabetes[J]. Zhejiang Clinical Medical Journal, 2002, 4(4): 264-265.
    [53]
    MAZOKOPARKIS E E, PAPADOMANOLAKI M G, FOUSTERIS A A, et al. The hepatoprotective and hypolipidemic effects of Spirulina supplementation in a Cretan population with nonalcoholic fatty liver disease: A prospective pilot study[J]. Annals of Gastroenterology Quarterly Publication of the Hellenic Society of Gastroenterology,2014,27(4):387−394.
    [54]
    MARCEL A K, EKALI L G, EUGENE S. et al. The effect of Spirulina platensis versus soybean on insulin resistance in HIV-infected patients: A randomized pilot study[J]. Nutrients,2011,3(7):712−724. doi: 10.3390/nu3070712
    [55]
    LEE E H, PARK J E, CHOI Y J, et al. A randomized study to establish the effects of Spirulina in type 2 diabetes mellitus patients[J]. Nutrition Research and Practice,2008,2(4):295−300. doi: 10.4162/nrp.2008.2.4.295
    [56]
    PARK H J, LEE Y J, RYU H K, et al. A randomized double-blind, placebo-controlled study to establish the effects of Spirulina in elderly Koreans[J]. Annals of Nutrition and Metabolism,2008,52(4):322−328. doi: 10.1159/000151486
    [57]
    ORIQUAT G A, ALI M A, MAHMOUD S A, et al. Improving hepatic mitochondrial biogenesis as a postulated mechanism for the antidiabetic effect of Spirulina platensis in comparison with metformin[J]. Applied Physiology, Nutrition, and Metabolism,2019,44(4):357−364. doi: 10.1139/apnm-2018-0354
    [58]
    TORRES-DURAN P V, FERREIRA-HERMOSILIO A, JUAREZ-OROPEZA M A. Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of Mexican population: A preliminary report[J]. Lipids in Health and Disease,2007,6:33. doi: 10.1186/1476-511X-6-33
    [59]
    MARTINEZ-SAMANO J M, TORRES-MONTES DE OCA A, LUQUENO-BOCARDO O I, et al. Spirulina maxima decreases endothelial damage and oxidative stress indicators in patients with systemic arterial hypertension: Results from exploratory controlled clinical trial[J]. Marine Drugs,2018,16:496. doi: 10.3390/md16120496
    [60]
    CARRIZZO A, CONTE G M, SOMMELLA E, et al. Novel potent decameric peptide of Spirulina platensis reduces blood pressure levels through a PI3K/AKT/eNOS-dependent mechanism[J]. Hypertension,2019,73(2):449−457. doi: 10.1161/HYPERTENSIONAHA.118.11801
    [61]
    鲁军. 螺旋藻活性肽的纯化、鉴定及降压、护肝机制研究[D]. 北京: 北京林业大学, 2010.

    LU Jun. Purification, characterization and antihypertensive and hepatoprotective effects of bioactive peptides derived from Spirulina platensis [D]. Beijing: Beijing Forestry University, 2010.
    [62]
    AMARA-LEFFAD L O, RAMDANE H, NEKHOUL K, et al. Spirulina effect on modulation of toxins provided by food, impact on hepatic and renal functions[J]. Archives of Physiology and Biochemistry, 2019,DOI: 10.1080/13813455.2018.1444059.
    [63]
    SZULINSKA M, GIBAS-DORNA M, MILLER-KASPRZAK E, et al. Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension: A randomized double-blind placebo-controlled study[J]. European Review for Medical and Pharmacological Sciences,2017,21(10):2473−2481.
    [64]
    WINTER F S, EMAKAM F, KFUWAH A, et al. The effect of Arthrospira platensis capsules on CD4 T-Cells and antioxidative capacity in a randomized pilot study of adult women infected with human immunodeficiency virus ont under HAART in Yaoundé, Cameroon[J]. Nutrients,2014,6(7):2973−2986. doi: 10.3390/nu6072973
    [65]
    PARK H J, LEE H S. The influence of obesity on the effects of Spirulina supplementation in the human metabolic response of Korean elderly[J]. Nutrition Research and Practice,2016,10(4):418−423. doi: 10.4162/nrp.2016.10.4.418
    [66]
    ISMAIL M, HOSSAIN M F, TANU A R, et al. Effect of Spirulina intervention on oxidative stress, antioxidant status, and lipid profile in chronic obstructive pulmonary disease patients[J]. BioMed Research International, 2015.
    [67]
    KALAFATI M, JAMURTAS A Z, NIKOLAIDIS M G, et al. Ergogenic and antioxidant effects of Spirulina supplementation in humans[J]. Medicine and Science in Sports and Exercise,2010,42(1):142−151. doi: 10.1249/MSS.0b013e3181ac7a45
    [68]
    ESLAMPARAST T, EGHTESAD S, POUSTCHI H, et al. Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease[J]. World Journal of Hepatology,2015,7(2):204−212.
    [69]
    FEFFEIRA-HERMOSILLO A, TORRES-DURAN P V, JUAREZ-OROPEZA M A. Hepatoprotective effects of Spirulina maxima in patients with non-alcoholic fatty liver disease: A case series[J]. Journal of Medical Case Reports,2010,4:103. doi: 10.1186/1752-1947-4-103
    [70]
    KU C S, YANG Y, PARK Y, et al. Health benefits of blue-green algae: Prevention of cardiovascular disease and nonalcoholic fatty liver disease[J]. Journal of Medicinal Food,2013,16(2):103−111. doi: 10.1089/jmf.2012.2468
    [71]
    YOUSEFI R, SAIDPOUR A, MOTTAGHI, A. The effects of Spirulina supplementation on metabolic syndrome components, its liver manifestation and related inflammatory markers: A systematic review[J]. Complementary Therapies in Medicine,2019,42:137−144. doi: 10.1016/j.ctim.2018.11.013
    [72]
    ABDEL-DAIM M M, AHMED A, IJAZ H, et al. Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits[J]. Environmental Science and Pollution Research,2019,26:8080−8086. doi: 10.1007/s11356-019-04249-4
    [73]
    AL-QAHTANI W H, BINOBEAD M A. Anti-inflammatory, antioxidant and antihepatotoxic effects of Spirulina platensis against D-galactosamine induced hepatotoxicity in rats[J]. Saudi Journal of Biological Sciences,2019,26(4):647−652. doi: 10.1016/j.sjbs.2018.01.003
    [74]
    AL-HOMAIDAN A A, ALABDRLLATIF J A, AL-HAZZANI A A, et al. Adsorptive removal of cadmium ions by Spirulina platensis dry biomass[J]. Saudi Journal of Biological Sciences,2015,22(6):795−800. doi: 10.1016/j.sjbs.2015.06.010
    [75]
    吴新华, 焦建玲, 余淑芳. 螺旋藻治疗高血脂症49例疗效观察[J]. 中国心血管杂志,2000,5(4):233−234. [WU Xinhua, JIAO Jianling, YU Shufang. Therapeutic effect of Spirulina on 49 cases of hyperlipidemia[J]. Chinese Journal of Cardiovascular Medicine,2000,5(4):233−234.
    [76]
    韩启定, 吴新华, 匡时权, 等. 程海螺旋藻治疗高脂血症的临床应用[J]. 中国心血管杂志,2004,9(6):438−439,441. [HAN Qiding, WU Xinhua, KUANG Shiquan, et al. Effects of Chenghai Spirulina platensis on hyperlipidemia[J]. Chinese Journal of Cardiovascular Medicine,2004,9(6):438−439,441. doi: 10.3969/j.issn.1007-5410.2004.06.017
    [77]
    王健秀, 张锐, 王秀萍. 螺旋藻治疗高脂血症76例临床观察[J]. 泰山医学院学报,2004,9(6):438−439,441. [WANG Jianxiu, ZHANG Rui, WANG Xiuping. Clinical observation on 76 cases of hyperlipidemia treated by Spirulina[J]. Journal of Taishan Medical College,2004,9(6):438−439,441.
    [78]
    李艳玲, 毛富强. 螺旋藻治疗高脂血症的临床观察[J]. 中国临床营养杂志,2001,9(1):58−59. [LI Yanling, MAO Fuqiang. The therapeutic effect of Spirulina platensis on hyperlipidemia[J]. Chinese Journal of Clinical Nutrition,2001,9(1):58−59.
    [79]
    EL-SHEEKH M M, HAMAD S M, GOMAA M. Protective effects of Spirulina on the liver function and hyperlipidemia of rats and human[J]. Brazilian Archives of Biology and Technology,2014,57(1):77−86. doi: 10.1590/S1516-89132014000100012
    [80]
    DINICOLANTONIO J J, BHAT A G, OKEEFE J. Effects of Spirulina on weight loss and blood lipids: A review[J]. Open Heart,2020,7:e001003. doi: 10.1136/openhrt-2018-001003
    [81]
    MORADI S, ZIAEI R, FOSHATI S, et al. Effects of Spirulina supplementation on obesity: a systematic review and meta-analysis of randomized clinical trials[J]. Complementary Therapies in Medicine,2019,47:102211. doi: 10.1016/j.ctim.2019.102211
    [82]
    ZEINALIAN R, FARHANGI M A, SHARIAT A, et al. The effects of Spirulina platensis on anthropometric indices, appetite, lipid profile and serum vascular endothelial growth factor (VEGF) in obese individuals: A randomized double blinded placebo controlled trial[J]. BMC Complementary and Alternative Medicine,2017,17:1−8. doi: 10.1186/s12906-016-1505-2
    [83]
    YOUSEFI R, MOTTAGHI A, SAIDPOUR A. Spirulina platensis effectively ameliorates anthropometric measurements and obesity-related metabolic disorders in obese or overweight healthy individuals: A randomized controlled trial[J]. Complementary Therapies in Medicine,2018,40:106−112. doi: 10.1016/j.ctim.2018.08.003
    [84]
    SHARIAT A, FARHANGI M A, ZEINALIAN R. Spirulina platensis supplementation, macrophage inhibitory cytokine-1 (MIC-1), oxidative stress markers and anthropometric features in obese individuals: A randomized controlled trial[J]. Journal of Herbal Medicine,2019(3):17−18.
    [85]
    HERNANDEZ-LEPE M A, WALL-MEDRANO A, LOPEZ-DIAZ J A, et al. Hypolipidemic effect Arthrospira (Spirulina) maxima supplementation and a systematic physical exercise program in overweight and obese men: A double-blind, randomized, and crossover controlled trial[J]. Marine Drugs,2019,17:270. doi: 10.3390/md17050270
    [86]
    HERNANDEZ-LEPE M A, LOPEZ-DIAZ J A, JUAREZ-OROPEZA M A, et al. Effect of Arthrospira (Spirulina) maxima supplementation and a systematic physical exercise program on the body composition and cardiorespiratory fitness of overweight or obese subjects: A double-blind, randomized, and crossover controlled trial[J]. Marine Drugs,2018,16:364. doi: 10.3390/md16100364
    [87]
    GOMEZ-TELLEZ A, SIERRA-PUENTE D, MUNOZ-GOMEZ R, et al. Effects of a low-dose Spirulina/Turmeric supplement on cardiometabolic and antioxidant serum markers of patients with abdominal obesity[J]. Frontiers in Nutrition,2020,7:65. doi: 10.3389/fnut.2020.00065
    [88]
    FUJMOTO M, TSUNEYAMA K, FUJIMOTO T, et al. Spirulina improves nonalcoholic steadohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome[J]. Digestive and Liver Disease,2012,44(9):767−774. doi: 10.1016/j.dld.2012.02.002
    [89]
    吴世林, 杨理伟, 顾思平, 等. 螺旋藻治疗消化性溃疡100例[J]. 世界华人消化杂志,2000,8(10):1194−1195. [WU Shilin, YANG Liwei, GU Siping, et al. 100 cases of peptic ulcer treated with Spirulina[J]. World Chinese Journal of Digestology,2000,8(10):1194−1195. doi: 10.3969/j.issn.1009-3079.2000.10.036
    [90]
    DESAI K M, HALLIKERMATH S, KALE A. Spirulina: an emerging treatment modality for the management of oral submucous fibrosis[J]. International Journal of Oral Care and Research,2017,5(4):328−331. doi: 10.5005/jp-journals-10051-0125
    [91]
    MODARRESI R, AMINSHARIFI A, FOROUGHINIA F. Impact of Spirulina supplementation on semen parameters in patients with idiopathic male infertility: A pilot randomized trial[J]. Urology Journal,2019,16(1):78−82.
    [92]
    HENRIKSON R. Earth Food Spirulina (Sixth edition)[EB/OL]. www. Spirulinasource. com, Ronore Enterprises, Inc. , Hana, Maui, Hawaii, USA, 2009.
    [93]
    MOHAMMADI-GOURAJI E, SOLEIMANIAN-ZAD S, GHIACI M. Phycocyanin-enriched yogurt and its antibacterial and physicochemical properties during 21 days of storage[J]. LWT-Food Science and Technology,2019,102:230−236. doi: 10.1016/j.lwt.2018.09.057
    [94]
    AGUSTINI T W, MA’RUF W F, WIDAYAT, et al. Application of Spirulina platensis on ice cream and soft cheese with respect to their nutritional and sensory perspectives[J]. Journal Teknologi (Science & Engineering),2016,78(4-2):245−251.
    [95]
    TOHAMY M M, SHAABAN H A, ALI M A, et al. Effect of Spirulina platensis as nutrition source on the chemical rheological and sensory properties of spreadable processed cheese[J]. Journal of Biological Sciences,2019,19(1):84−91.
    [96]
    MOSTOLIZADEH S, MORADI Y, MORTAZAVI M S, et al. Application effects of Spirulina powder on the fatty acid and amino acid composition of pasta[J]. Iranian Scientific Fisheries Journal,2017,26(4):119−130.
  • Cited by

    Periodical cited type(27)

    1. 戴明云,李斌,张朝阳,白富瑾,肖伟. 螺旋藻生长影响因素及功能特性应用研究进展. 现代农业科技. 2025(01): 161-165+179 .
    2. 李雪贤,刘洋,皮杰,桂雨婷,陆娟娟. 螺旋藻的主要成分及生理功能研究进展. 水产养殖. 2025(02): 37-42 .
    3. 韩佩,夏嵩,闫冰,姜钦亮,王一雯. 极大螺旋藻对四氧嘧啶性糖尿病小鼠的降血糖作用. 食品研究与开发. 2025(09): 44-51 .
    4. 吴朋徽,刘耀,张磊,肖芃颖,张玥. 微藻两阶段培养技术研究进展. 微生物学通报. 2024(01): 1-16 .
    5. 姜梦云,刘旭,衣然. 4种前处理方法-原子荧光光谱法测定螺旋藻中总砷含量. 食品安全导刊. 2024(03): 56-58 .
    6. 孙博,武晋海,李金凤,赵佳敏,刘金桃,黄凤丽. 螺旋藻口服液制备的工艺优化. 食品安全导刊. 2024(08): 127-131+135 .
    7. 唐魁延,龚艺松,田冬青,张晓宇,聂远洋,李波. 螺旋藻豆腐的研制开发. 河南科技学院学报(自然科学版). 2024(04): 15-27 .
    8. 薛宪辉,李思雨,郭睿,崔文凯,纪蓓. 螺旋藻风味酱的发酵工艺研究. 中国调味品. 2024(08): 69-73 .
    9. 王丽梅,西妮,穆文静,苏小军,张永明. 基于Cite Space对螺旋藻藻蓝蛋白的研究进展与热点分析. 食品与发酵工业. 2024(16): 313-323 .
    10. 宋盈萱,尹馨一,刘盈萱. 螺旋藻营养成分及生物活性研究进展. 食品安全导刊. 2024(27): 178-182 .
    11. 曾巧辉,余杏同,林妙銮. 螺旋藻蛋白-原花青素稳定亚麻籽油品质的研究. 佛山科学技术学院学报(自然科学版). 2024(05): 54-68 .
    12. 杨正磊,冯鑫,尹淑涛. 微藻资源概述及微藻多糖的生物活性研究进展. 中国食物与营养. 2024(09): 58-66 .
    13. 陈慧桢,吕莹果,陈洁,李雪琴. 螺旋藻方便面片制备工艺优化. 粮食与油脂. 2024(11): 135-142+162 .
    14. 柯善文,习向玉,陈翊可,张官鹏,宋富艳,韩栋敏,苏蓉,李晓雪,牛鑫,单华佳,梁倩倩. PDA培养基中添加不同有机氮源物质对黑木耳退化菌种复壮效果的影响. 山东农业科学. 2024(11): 121-126 .
    15. 袁泽文,高旭芳,田益玲. 响应面法优化乙酸锌对螺旋藻护色的研究. 粮食与油脂. 2023(04): 137-140 .
    16. 米顺利,竹烨,张艺,黄晓菊,蒋心怡,易湘茜. 螺旋藻复配代餐粉的研制. 保鲜与加工. 2023(07): 43-49 .
    17. 李平,吕莹果,李雪琴,陈洁. 螺旋藻粉对面团流变性质及面筋结构的影响. 食品科学. 2023(14): 63-71 .
    18. 王志忠,穆洁,巩东辉,郭彩凤,王志国,宝俊刚. 钝顶螺旋藻与五种常见食物营养成分对比分析. 食品与发酵科技. 2023(04): 111-115+121 .
    19. 郭旭,魏登枭,钟彩荣,兰英,何勇锦,陈必链. 正己烷与氯化钙介导法联产提取未破壁螺旋藻的藻蓝蛋白和油脂. 食品与发酵工业. 2023(17): 202-208 .
    20. 魏登,李美善,刘艳霞,金永燮,佟立爽. 精酿绿啤加工工艺优化及其挥发性风味鉴定分析. 中国食品添加剂. 2023(10): 217-225 .
    21. 魏登,刘艳霞,金永燮,佟立爽. 菠菜螺旋藻复合精酿小麦绿啤挥发性香气表征研究. 食品安全导刊. 2023(30): 88-91 .
    22. 吴慧. 螺旋藻曲奇饼干制作工艺的研究. 食品安全导刊. 2022(04): 128-131+135 .
    23. 付雨,姜雨,王进博,张铂瑾,宋宸,孙明霞. 螺旋藻类保健食品批准情况及问题. 食品与机械. 2022(08): 1-6+13 .
    24. 李青卓,张楠,梅兴国,吴基良. 新鲜螺旋藻中β-胡萝卜素提取与测定. 湖北科技学院学报(医学版). 2022(04): 287-291 .
    25. 刘璐璐,陈玟璇,刘小慧,李世乐,许志浩,陈洪彬,郑宗平,王宝贝. 雨生红球藻对戚风蛋糕品质的影响及其虾青素稳定性. 食品工业科技. 2022(19): 76-83 . 本站查看
    26. 佟立爽,王晏驰,周娜,李美善,魏登. 不同温度条件下精酿绿啤二次发酵的挥发性风味差异分析. 中国食品添加剂. 2022(11): 9-17 .
    27. 张春艳,张震,仇钧仪,初宇轩,彭磊磊,罗鹏,陈成勋. 饲料添加复合氨基酸对锦鲤生长和生理生化指标的影响. 经济动物学报. 2022(04): 261-267 .

    Other cited types(9)

Catalog

    Article Metrics

    Article views (1000) PDF downloads (91) Cited by(36)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return