Research Progress of Probiotics in Alleviating Type 2 Diabetes Mellitus

LIU Jia; XIA Yongjun; XIONG Zhiqiang; SONG Xin; AI Lianzhong; WANG Guangqiang

doi:10.13386/j.issn1002-0306.2021010167

Volume 43 Issue 1

Dec. 2021

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Science and Technology of Food Industry > 2022 > 43(1): 466-471. > DOI: 10.13386/j.issn1002-0306.2021010167

LIU Jia, XIA Yongjun, XIONG Zhiqiang, et al. Research Progress of Probiotics in Alleviating Type 2 Diabetes Mellitus[J]. Science and Technology of Food Industry, 2022, 43(1): 466−471. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021010167.

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Research Progress of Probiotics in Alleviating Type 2 Diabetes Mellitus

Shanghai Engineering Research Center of Food Microbiology, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

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Received Date: January 20, 2021
Available Online: November 22, 2021

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Abstract

Diabetes is a chronic metabolic disease caused by multiple factors, and it is an epidemic worldwide in the 21st century. The intestinal flora of diabetic patients is imbalanced, with reduced antioxidant capacity and low-grade inflammation. Relevant studies have shown that probiotics, as a kind of living microorganisms that are beneficial to the health of the intestine, can relieve the symptoms of diabetes by balancing the intestinal flora, reducing the body's oxidative damage and regulating the body's immune factors. This article combs the two commonly used methods for screening hypoglycemic strains with α-glucosidase and DPP-IV as targets, and evaluates the hypoglycemic effect of probiotics through in vivo experiments. At the same time, it further summarizes the mechanism of probiotics in alleviating type 2 diabetes from five aspects such as intestinal flora, immune response, oxidative stress, short-chain fatty acids and intestinal barrier, in order to provide a certain reference for related research on type 2 diabetes.
- probiotics,
- type 2 diabetes,
- blood glucose,
- glucose tolerance test

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