Protective Effect of Total Glucosides of Paeony on Renal in Rats with Hyperuricemic Nephropathy

LIU Donglian; QIN Qin; YANG Ting; HE Xinyu; ZHANG Yuqin; WANG Yujiang

doi:10.13386/j.issn1002-0306.2021010142

Volume 42 Issue 22

Nov. 2021

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Science and Technology of Food Industry > 2021 > 42(22): 344-349. > DOI: 10.13386/j.issn1002-0306.2021010142

LIU Donglian, QIN Qin, YANG Ting, et al. Protective Effect of Total Glucosides of Paeony on Renal in Rats with Hyperuricemic Nephropathy[J]. Science and Technology of Food Industry, 2021, 42(22): 344−349. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021010142.

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Protective Effect of Total Glucosides of Paeony on Renal in Rats with Hyperuricemic Nephropathy

1.
Collaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Chengdu 610500, China
2.
Department of Pharmacy, Chengdu Medical College, Chengdu 610500, China

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Received Date: January 19, 2021
Available Online: August 30, 2021

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Abstract

Abstract

Objective: To investigate the renal-protective functions of total glucosides of paeony(TGP) on hyperuricemic renal damage(HN) rats. Methods: Fifty male SD rats were randomly divided into 5 groups: Normal group, model group, TGP low and high dose groups(100 and 300 mg·kg⁻¹·bw⁻¹), and allopurinol group(27.0 mg·kg⁻¹·bw⁻¹), with 10 rats in each group. At 7:00 a.m. and 20:00 p.m. every day, the model group, TGP low-dose group, TGP high-dose group and allopurinol group were given adenine 100 mg/kg+oteracil potassium 1500 mg/kg suspension respectively to make HN model. TGP and allopurinol were intragastrically administered at 12:00, the normal group and model group were given the same amount of normal saline every day. The observation time was 5 weeks. The body weight, serum uric acid, creatinine, urea nitrogen and other indicators of rats in each group were detected every two weeks. After 5 weeks, the ratio of bilateral kidney weight to body weight and the pathological section of kidney were observed. Results: At the 5th week, compared with the model group, TGP high-dose group could significantly reduce the renal weight(P<0.01), renal body ratio(P<0.01), serum uric acid(P<0.01), urea nitrogen(P<0.05) and creatinine(P<0.01) levels of HN model, alleviate the proliferation of glomerular mesangial cells, alleviate the expansion of renal tubules, and reduce tubulointerstitial injury and renal inflammatory cell infiltration of HN model. Conclusion: TGP had a protective effect on the kidney of HN rats.
- hyperuricemic nephropathy,
- total glucosides of paeony,
- uric acid,
- creatinine,
- urea nitrogen,
- glomerulus,
- renal tubule

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