Identification and Safety Assessment of the Migration of Intentionally and Non-intentionally Added Substances in Food Contact Recycled PET Product

DONG Ben; LI Zicheng; ZHENG Jianguo; LIU Zhongyong; CHEN Sheng; LI Dan; LIN Qinbao; ZHONG Huaining

doi:10.13386/j.issn1002-0306.2021010103

Volume 42 Issue 18

Sep. 2021

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2021 > 42(18): 252-260. > DOI: 10.13386/j.issn1002-0306.2021010103

DONG Ben, LI Zicheng, ZHENG Jianguo, et al. Identification and Safety Assessment of the Migration of Intentionally and Non-intentionally Added Substances in Food Contact Recycled PET Product[J]. Science and Technology of Food Industry, 2021, 42(18): 252−260. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021010103.

Citation:

PDF (1096 KB)

Identification and Safety Assessment of the Migration of Intentionally and Non-intentionally Added Substances in Food Contact Recycled PET Product

DONG Ben^1,,
LI Zicheng¹,
ZHENG Jianguo¹,
LIU Zhongyong²,
CHEN Sheng^{1, 4},
LI Dan¹,
LIN Qinbao^{3, 4},
ZHONG Huaining^{1, 4, ,}

1.
National Reference Laboratory for Food Contact Material (Guangdong), Guangzhou Customs District Technology Center, Guangzhou 510623, China
2.
China Certification and Inspection Group Guangdong Co., Ltd., Guangzhou 510623, China
3.
Key Laboratory of Product Packaging and Logistics, Packaging Engineering Institute, Jinan University, Zhuhai 519070, China
4.
Working Group on China Sustainable Development of Food Contact Materials, Guangzhou 510070, China

More Information

Received Date: January 14, 2021
Available Online: July 11, 2021

Graphical Abstract

Abstract

Abstract

In order to assess the migration risk of non-intentional/intentional added substances to recycled PET materials, a method of screening these substances for recycled PET products was established using liquid chromatography-quadrupole-time of flight-mass spectrometry, gas chromatography-mass spectrometry and head-space gas chromatography-mass spectrometry. Results showed that: A total of 6 compounds were screened in food simulations after migration experiments, of which 4 substances, such as methyl oleate, methyl palmitate, triethylene glycol bis(2-ethylhexanoate) and triethylene glycol caprate caprylate were intentional added substances, methyl linoleate and 1, 2-bis-(4-carboxy-benzoyloxy)-ethane were non-intentional added substances. The detected substances were not in the GB 9685-2016 substance list and not allowed to be used. Under the TTC law, the detected substances were Cramer I substances, their exposure was significantly lower than the safety exposure threshold of 1.8 mg/person/day, low probability of adverse health effects to human health.
- recycled PET,
- non-intentionally/intentionally added substances,
- migration,
- safety assessment

FullText(HTML)

References (36)

References

[1]	钟怀宁, 陈俊骐, 冯婕莉, 等. 食品接触材料中非有意添加物的安全评估[J]. 中国食品卫生杂志,2017,29(2):238−243. [Zhong H N, Chen J Q, Feng J L, et al. Safety assessment of non-intentionally added substance migrated from food contact material[J]. Chinese Journal of Food Hygiene,2017,29(2):238−243.
[2]	中华人民共和国国家卫生和计划生育委员会. GB 4806.1-2016 食品安全国家标准食品接触材料及制品通用安全要求[S]. 北京:中国标准出版社, 2016. National Health and Family Planning Commission of the People’s Republic of China, National Medical Products Administration. GB 4806.1-2016 National food safety standard. General safety requirements for food contact materials and articles[S]. Beijing: China Standards Press, 2016.
[3]	Nerin C, Alfaro P, Aznar M, et al. The challenge of identifying non-intentionally added substances from food packaging materials: A review[J]. Anal Chim Acta,2013,775:14−24. doi: 10.1016/j.aca.2013.02.028
[4]	Groh K J, Backhaus T, Carney-Almroth B, et al. Overview of known plastic packaging-associated chemicals and their hazards[J]. Science of the Total Environment,2019,651:3253−3268. doi: 10.1016/j.scitotenv.2018.10.015
[5]	Martínez-Bueno M J, Gómez Ramos M J, Bauer A, et al. An overview of non-targeted screening strategies based on high resolution accurate mass spectrometry for the identification of migrants coming from plastic food packaging materials[J]. TrAC Trends in Analytical Chemistry,2019,110:191−203. doi: 10.1016/j.trac.2018.10.035
[6]	Horodytska O, Cabanes A, Fullana A. Non-intentionally added substances (NIAS) in recycled plastics[J]. Chemosphere,2020,251:126373. doi: 10.1016/j.chemosphere.2020.126373
[7]	魏晓晓, 高峡, 刘伟丽. GC-MS和LC-MS技术用于食品接触高分子中非有意添加物的检测研究[J]. 分析仪器,2019(3):51−55. [Wei X X, Gao X, Liu W L. Determination of non-intentionally added substances in food contact polymer materials by GC-MS and LC-MS[J]. Analytical Instrumentation,2019(3):51−55. doi: 10.3969/j.issn.1001-232x.2019.03.011
[8]	魏帅, 鲍蕾. 食品接触材料中非有意添加物的检测方法[J]. 食品安全质量检测学报,2019,10(24):8195−8203. [Wei S, Bao L. Analytical methods of non-intentional added substance in food contact material[J]. Journal of Food Safety and Quality,2019,10(24):8195−8203.
[9]	王芳, 刘曙, 沈康俊, 等. 食品接触材料及制品非有意添加物风险评估与监管[J]. 中国塑料,2019,33(4):89−95. [Wang F, Liu S, Shen K J, et al. Risk assessment and supervision of non-intentionally added substances in food contact materials and articles[J]. China Plastics,2019,33(4):89−95.
[10]	Awaja F, Pavel D. Recycling of PET[J]. European Polymer Journal,2005,41(7):1453−1477. doi: 10.1016/j.eurpolymj.2005.02.005
[11]	Nisticò R. Polyethylene terephthalate (PET) in the packaging industry[J]. Polymer Testing,2020,90:106707. doi: 10.1016/j.polymertesting.2020.106707
[12]	Brouwer M T, Alvarado Chacon F, Thoden Van Velzen E U. Effect of recycled content and rPET quality on the properties of PET bottles, part III: Modelling of repetitive recycling[J]. Packag Technol Sci,2020,33(9):373−383. doi: 10.1002/pts.2489
[13]	Karayannidis G P, Psalida E A. Chain extension of recycled poly (ethylene terephthalate) with 2, 2′-(1,4-phenylene)bis(2-oxazoline)[J]. Journal of Applied Polymer Science,2000,77(10):2206−2211. doi: 10.1002/1097-4628(20000906)77:10<2206::AID-APP14>3.0.CO;2-D
[14]	Paci M, La Mantia F P. Influence of small amounts of polyvinylchloride on the recycling of polyethyleneterephthalate[J]. Polymer Degradation and Stability,1999,63(1):11−14. doi: 10.1016/S0141-3910(98)00053-6
[15]	Giannotta G, Po' R, Cardi N, et al. Processing effects on poly (ethylene terephthalate) from bottle scraps[J]. Polymer Engineering & Science,1994,34(15):1219−1223.
[16]	Scheirs J. Polymer recycling, science, technology and application[M]. Hoboken: John Wiley and Sons Ltd, 1998: 381-406.
[17]	Villain F, Coudane J, Vert M. Thermal degradation of polyethylene terephthalate: Study of polymer stabilization[J]. Polymer Degradation and Stability,1995,49(3):393−397. doi: 10.1016/0141-3910(95)00121-2
[18]	Demertzis P G, Johansson F, Lievens C, et al. Studies on the development of a quick inertness test procedure for multi-use PET containers-sorption behaviour of bottle wall strips[J]. Packag Technol Sci,1997,10(1):45−58. doi: 10.1002/(SICI)1099-1522(199701/02)10:1<45::AID-PTS383>3.0.CO;2-L
[19]	Franz R, Welle F. Contamination levels in recollected PET bottles from non-food applications and their impact on the safety of recycled PET for food contact[J]. Molecules,2020,25(21):4998−5018. doi: 10.3390/molecules25214998
[20]	Franz R, Mauer A, Welle F. European survey on post-consumer poly (ethylene terephthalate) (PET) materials to determine contamination levels and maximum consumer exposure from food packages made from recycled PET[J]. Food Additives and Contaminants,2004,21(3):265−286. doi: 10.1080/02652030310001655489
[21]	EFSA Panel on Food Contact Materials, Flavourings, Aids. Scientific opinion on the criteria to be used for safety evaluation of a mechanical recycling process to produce recycled PET intended to be used for manufacture of materials and articles in contact with food[J]. EFSA Journal,2011,9(7):2184−2209.
[22]	刘宏, 王亮, 陈胜, 等. 食品接触塑料材料及制品中高关注化合物的高分辨质谱分析技术研究进展[J]. 食品安全质量检测学报,2020,11(13):4139−4149. [Liu H, Wang L, Chen S, et al. Research progress on high-resolution mass spectrometry analysis of high concern compounds in food contact plastic materials and products[J]. Journal of Food Safety and Quality,2020,11(13):4139−4149.
[23]	中华人民共和国卫生部. GB 9685-2016 食品安全国家标准食品接触材料及制品用添加剂使用标准[S]. 北京:中国标准出版社, 2016. Ministry of Health of the People′s Republic of China. GB 9685-2016 National food safety standard. Standard for use of additives in food contact materials and articles[S]. Beijing: China Standards Press, 2016.
[24]	隋海霞, 钟怀宁, 刘兆平, 等. 食品接触材料及制品中非有意添加物风险评估指南[M]. 北京: 人民卫生出版社, 2019. Sui H X, Zhong H N, Liu Z P, et al. Guidance on best practices on the risk assessment of non-intentionally added substance (NIAS) in food contact materials and articles[M]. Beijing: People's Medical Publishing House, 2019.
[25]	中华人民共和国卫生部. GB 31604.1-2015 食品安全国家标准食品接触材料及制品迁移试验通则[S]. 北京:中国标准出版社, 2015. Ministry of Health of the People′s Republic of China. GB 31604.1-2015 National food safety standard. General rules for migration test of food contact materials and products[S]. Beijing: China Standards Press, 2015.
[26]	Committee E S. Scientific opinion on Exploring options for providing advice about possible human health risks based on the concept of Threshold of Toxicological Concern (TTC)[J]. EFSA Journal,2012,10(7):2750−2853.
[27]	陈燕芬, 胡长鹰, 钟怀宁. 聚氯乙烯密封圈中环氧大豆油向食品中的迁移及其风险评估[J]. 食品安全质量检测学报, 2018, 9(12): 3040-3046. Chen Y F, Hu C Y, Zhong H N. Migration of epoxidized soybean oil from PVC gasket of lid into food and its risk assessment[J]. Journal of Food Safety and Quality, 2018, 9(12): 3040−3046.
[28]	Kroes R, Renwick A G, Cheeseman M, et al. Structure-based thresholds of toxicological concern (TTC): Guidance for application to substances present at low levels in the diet[J]. Food and Chemical Toxicology,2004,42(1):65−83. doi: 10.1016/j.fct.2003.08.006
[29]	Renwick A G. Structure-based thresholds of toxicological concern-guidance for application to substances present at low levels in the diet[J]. Toxicology and Applied Pharmacology,2005,207(2, Supplement):585−591. doi: 10.1016/j.taap.2005.01.034
[30]	Munro I C, Ford R A, Kennepohl E, et al. Correlation of structural class with no-observed-effect levels: A proposal for establishing a threshold of concern[J]. Food and Chemical Toxicology,1996,34(9):829−867. doi: 10.1016/S0278-6915(96)00049-X
[31]	Houben G, Blom M, Bilsen J van, et al. New developments in food safety assessment: Innovations in food allergy and toxicological safety assessment[M]. Cham: Springer International Publishing, 2014: 9−27.
[32]	Committee E S, More S J, Bampidis V, et al. Guidance on the use of the threshold of toxicological concern approach in food safety assessment[J]. EFSA Journal European Food Safety Authority,2019,17(6):5708−5725.
[33]	李浚宁. 油酸甲酯制备方法改进[J]. 石化技术,2018,25(11):46. [Li J N. Improvement of preparation method of methyl oleate[J]. Petrochemical Technology,2018,25(11):46. doi: 10.3969/j.issn.1006-0235.2018.11.032
[34]	刘群, 丁斌, 郝凤岭, 等. 棕榈酸甲酯的合成及其动力学研究[J]. 粮食与油脂,2015,28(7):26−29. [Liu Q, Ding B, Hao F L, et al. Synthesis and kinetics of methyl palmitate[J]. Cereals Oils,2015,28(7):26−29. doi: 10.3969/j.issn.1008-9578.2015.07.007
[35]	朱宝华. 三甘醇二异辛酸酯的生产工艺[J]. 安徽化工,2018,44(2):94−95. [Zhu B H. Production processing of the triglycol dioctate[J]. AnHui Chemical Industry,2018,44(2):94−95. doi: 10.3969/j.issn.1008-553X.2018.02.031
[36]	Pietropaolo E, Albenga R, Gosetti F, et al. Synthesis, identification and quantification of oligomers from polyester coatings for metal packaging[J]. Journal of Chromatography A,2018,1578:15−27. doi: 10.1016/j.chroma.2018.10.002

Supplements (0)

Cited By

Cited by

Periodical cited type(2)

1.	邱立，谷贵章，王欣宇，高兴杰，杨文鸽，徐大伦. 浒苔多酚对肥胖小鼠血脂代谢及肠道菌群的调节作用. 核农学报. 2022(08): 1638-1647 .
2.	王双燕. 壳聚糖及其衍生物在医药领域的研究进展. 云南化工. 2021(04): 7-8+16 .