Analysis on Chemical Components in<i> Toricellia Angulata</i> Oliv.var.<i>intermedia</i> (Harms) Hu by HPLC-HESI-HRMS

HAN Zhongyao; HU Enming; DENG Xiankuo; LI Yan; ZHANG Linsu; CAO Fang; CHEN Jianyu; ZHOU Fujun

doi:10.13386/j.issn1002-0306.2020110190

Volume 42 Issue 17

Aug. 2021

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2021 > 42(17): 16-23. > DOI: 10.13386/j.issn1002-0306.2020110190

HAN Zhongyao, HU Enming, DENG Xiankuo, et al. Analysis on Chemical Components in Toricellia Angulata Oliv.var.intermedia (Harms) Hu by HPLC-HESI-HRMS [J]. Science and Technology of Food Industry, 2021, 42(17): 16−23. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020110190.

Citation:

PDF (927 KB)

Analysis on Chemical Components in Toricellia Angulata Oliv.var.intermedia (Harms) Hu by HPLC-HESI-HRMS

1.
Qiannan Medical College for Nationalities, Duyun 558000, China
2.
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China
3.
Pesticide National Engineering Research Center, Nankai University, Tianjin 300071, China
4.
Tianjin Institute of Pharmaceutical Research, Tianjin 300301, China

More Information

Received Date: November 19, 2020
Available Online: July 19, 2021

Graphical Abstract

Abstract

Abstract

In order to investigate the chemical components in Toricellia Angulata (Harms) Hu, this paper analyzed and inferred the chemical components in Toricellia Angulata (Harms) Hu based on the method of HPLC-HESI-HRMS.ThermoFisher Hypersil GOLD aQ C₁₈(100 mm×2.1 mm, 1.9 μm)column was adopted, with 0.1% formic acid- methyl cyanides(0.1% formic) as the mobile phase for gradient elution, the flow rate was 0.3 mL/min, the column temperature was 40 ℃; HESI-II ion source was used for mass spectra, the date were collected in positive and negative mode.Mass scanning range m/z: 100~1500 Da.Compound discoverer 3.0 database and coupled with the related literature were used to analyze the main chemical constituents of Toricellia Angulata (Harms) Hu.The results showed that thirty-six chemical components in Toricellia Angulata (Harms) Hu were inferred by analyzing positive and negative ion spectra information of high resolution mass spectrometer with date from relevant literature.Including 10 organic acids, 4 alkaloids, 1 amino acid, 2 phenylpropanoids, 2 esters, 2 terpenes, 2 aromatic oxygen derivatives, 4 amides, 9 other compounds.HPLC-HESI-HRMS provides the technical support for the quality control of Toricellia Angulata (Harms) Hu and contributes the reference data to elucidating the potential basis of Toricellia Angulata (Harms) Hu.
- Toricellia Angulata Oliv.var.intermedia (Harms) Hu,
- chemical components,
- HPLC-HESI-HRMS,
- HRMS

FullText(HTML)

References (31)

References

[1]	贵州省药品监督管理局. 贵州省中药材、民族药材质量标准[M]. 第一版. 贵阳: 贵州科技出版社, 2003: 107. Guizhou Medical Products Administration. Quality standard of Chinese medicinal materials and national medicinal materials in Guizhou Province[M]. First edition. Guiyang: Guizhou Science and Technology Press, 2003: 107.
[2]	贵阳中医学院. 中华本草: 苗药卷[M]. 贵阳: 贵州科技出版社, 2005: 164. Guiyang College of Traditional Chinese Medicine. Chinese materia medica (Miao medicinal volume)[M]. Guiyang: Guizhou Science and Technology Press, 2005: 164.
[3]	Hubei Provincial Health Bureau. Chinese herbal medicine records of Hubei Province(二)[M]. Wuhan: Hubei People's Publishing House, 1982: 677.
[4]	南京中医药大学. 中华大辞典[M]. 2版. 上海: 上海科学技术出版社, 1995: 197. Nanjing University of Traditional Chinese Medicine. Grand Chinese dictionary[M]. Second edition. Shanghai: Shanghai Science and Technology Press, 1995: 197.
[5]	司有奇. 黔南本草(上册)[M]. 贵阳: 贵州科技出版社, 2015: 107. SI Y Q. Qiannan herbs (Volume I)[M]. Guiyang: Guizhou Science and Technology Press, 2015: 107.
[6]	杨济秋, 杨济中. 贵州民间方药集[M]. 3版. 贵阳: 贵州人民出版社, 1978: 126. Yang J Q, Yang J Z. Guizhou folk prescription collection[M]. Third edition. Guiyang: Guizhou People's Publishing House, 1978: 126.
[7]	张锦文, 郭洁茹, 唐菲, 等. 大接骨丹化学成分研究[J]. 中药材,2010,33(11):1725−1727. [Zhang J W, Guo J R, Tang F, et al. Studies on the chemical constiuents of Toricellia angulata Oliv. var. intermedia (Harms) Hu[J]. Joural of Chinese Medicinal Materials,2010,33(11):1725−1727.
[8]	王燕燕, 涂念, 张勇慧, 等. 大接骨丹化学成分研究(Ⅱ)[J]. 中草药,2009,40(10):1551−1553. [Wang Y Y, Tu N, Zhang Y H, et al. Studies on the chemical constiuents of Toricellia angulata Oliv. var. intermedia (Harms) Hu (II)[J]. Chinese Traditional and Herbal Drugs,2009,40(10):1551−1553.
[9]	张锦文, 郭洁茹, 唐菲, 等. 大接骨丹的化学成分研究(Ⅲ)[J]. 中草药,2011,42(1):15−17. [Zhang J W, Guo J R, Tang F, et al. Studies on the chemical constiuents of Toricellia angulata Oliv. var. intermedia (Harms) Hu (Ⅲ)[J]. Chinese Traditional and Herbal Drugs,2011,42(1):15−17.
[10]	吴少华, 马云保, 罗晓东, 等. 大接骨丹的化学成分[J]. 云南植物研究,2000,22(2):214−218. [Wu S H, Ma Y B, Luo X D, et al. The chemical constiuents from Toricellia angulata[J]. Acta Botanica Yunnanica,2000,22(2):214−218. doi: 10.3969/j.issn.2095-0845.2000.02.021
[11]	韩忠耀, 向军, 陈建宇, 等. 不同产地水冬瓜叶HPLC指纹图谱建立、化学模式识别分析及含量测定[J]. 中国药房,2021,32(10):1224−1229. [Han Z Y, Xiang J, Chen J Y, et al. Establishment of HPLC fingerprint, chemical pattern recognition analysis and content determination of the leaves of Toricellia angulata from different regions[J]. China Pharmacy,2021,32(10):1224−1229. doi: 10.6039/j.issn.1001-0408.2021.10.11
[12]	李凤华, 郑凤家, 李蔚, 等. 同位素稀释-超高效液相色谱-串联质谱法测定中药材中的17种真菌毒素[J]. 理化检验-化学分册,2019,55(1):56−62. [Li F H, Zheng F J, Li W, et al. Determination of seventeen mycotoxins in Chinese herbal medicines by ultra-high performance liquid chromatography mass spectrometry with isotope dilution[J]. Physical Testing and Chemical Analysis(Part B: Chemical Analysis),2019,55(1):56−62.
[13]	任晓航, 石梦鸽, 刘博男, 等. UPLC-QQQ-MS法测定巴戟天炮制前后10种成分的含量[J]. 中药材,2019,42(3):588−593. [Ren X H, Shi M G, Liu B N, et al. Determination of ten components in morinda officinalis by UPLC-QQQ-MS[J]. Journal of Chinese Medicinal Materials,2019,42(3):588−593.
[14]	戴雪雯, 冯丽丽, 李海峰. 不同种植基地滇重楼根茎中甾体皂苷有效成分差异的研究[J]. 中药材,2018,41(4):777−783. [Dai X W, Feng L L, Li H F. Research on the differences of active ingredients of steroid saponins in rhizomes ofParis polyphylla var. yunnanensis in different planting base[J]. Journal of Chinese Medicinal Materials,2018,41(4):777−783.
[15]	黄泽玮, 闵宇航, 杜钢, 等. QuEChERS EMR-Lipid技术结合LC/MS/MS快速筛查与确证猪肉中55种兽药残留[J]. 食品工业科技,2019,40(11):270−276, 283. [Huang Z W, Min Y H, Du G, et al. Rapid screening and confirmation of 55 kinds of veterinary drug residues in pork by QuEChERS EMR-lipid technology and LC/MS/MS[J]. Science and Technology of Food Indusy,2019,40(11):270−276, 283.
[16]	朱群英, 索莉莉, 朱玉玲, 等. 全自动固相萃取-液质联用法测定动物源性食品中镇静剂类药物残留[J]. 食品工业科技,2016,37(24):83−87. [Zhu Q Y, Suo L L, Zhu Y L, et al. Determination of sedative drug residues in animal derived food by automatic SPE combined with ultra performance liquid chromatography-tandem mass spectrometry[J]. Science and Technology of Food Indusy,2016,37(24):83−87.
[17]	王泽锋, 石玲, 苏一兰, 等. 液质联用技术检测紫薯蓣中5种氨基甲酸酯农药的方法研究[J]. 食品工业科技,2014,35(11):306−308, 314. [Wang Z F, Shi L, Su Y L, et al. Simultaneous determination of carbamate pesticide residues in purple yam by high performance liquid chromatography-tandem mass spectrometry[J]. Science and Technology of Food Indusy,2014,35(11):306−308, 314.
[18]	高瑶, 黄诗榕, 邓奕炜, 等. 液质联用平台测定水产品中抗生素残留的方法优化[J]. 光谱学与光谱分析,2020,40(S1):237−238. [Gao Y, Huang S R, Deng Y W, et al. Optimization of determination of antibiotic residues in aquatic products by UPLC-QTOFMS platform[J]. Spectroscopy and Spectral Analysis,2020,40(S1):237−238.
[19]	刘德明, 朱诗敏, 杨昊坤, 等. 黄山贡菊抗氧化活性成分提取工艺优化与HPLC-MS分析[J]. 食品工业科技,2020,41(22):150−156, 164. [Liu D M, Zhu S M, Yang H K, et al. Extraction optimization of active ingredients in huangshan gongju and analysis of HPLC-MS[J]. Science and Technology of Food Indusy,2020,41(22):150−156, 164.
[20]	冯艺飞, 李文钊, 王兆燃, 等. 响应面法优化茵陈总黄酮提取工艺及成分结构的初步表征[J]. 食品工业科技,2019,40(21):192−197, 215. [Feng Y F, Li W Z, Wang Z R, et al. Optimization of extraction technology by response surface methodology and preliminary structural characterization of the composition in flavonoids from Artemisia capillaris[J]. Science and Technology of Food Indusy,2019,40(21):192−197, 215.
[21]	陈华栋, 张锦文, 张勇慧. 大接骨丹干燥树皮抗炎镇痛活性有效部位筛选[J]. 海峡药学,2012,24(2):29−30. [Chen H D, Zhang J W, Zhang Y H, et al. Research on the active extracts of Torricellia angulata Oliv. of anti-inflammatory and analgesic effects[J]. Strait Pharmaceutical Journal,2012,24(2):29−30. doi: 10.3969/j.issn.1006-3765.2012.02.010
[22]	涂念. 大接骨丹免疫调节活性成分研究[D]. 武汉: 华中科技大学, 2009. Tu N. Study on immunomodulatory active components of Toricellia angulata Oliv. var. intermedia (Harms) Hu[D]. Wuhan: Huazhong University of Science and Technology, 2009.
[23]	贾于. 大接骨丹抗炎镇痛活性成分研究[D]. 武汉: 华中科技大学, 2008. Jia Y. Study on anti-inflammatory and analgesic active components of Toricellia angulata Oliv. var. intermedia (Harms) Hu[D]. Wuhan: Huazhong University of Science and Technology, 2008.
[24]	韩忠耀, 余跃生, 袁开伦, 等. 基于信息熵赋权法优化苗药水冬瓜根皮提取工艺[J]. 中药材,2019,42(2):390−392. [Han Z Y, Yu Y S, Yuan K L, et al. Optimization of Toricellia angulata Oliv. var. intermedia (Harms) Hu extraction process based on information entropy weighting method[J]. Journal of Chinese Medicinal Materials,2019,42(2):390−392.
[25]	韩忠耀, 余跃生, 董海平, 等. 声光可调滤光器-近红外光谱法快速测定苗药水冬瓜根皮药材中总黄酮和浸出物的含量[J]. 理化检验-化学分册,2019,55(6):668−671. [Han Z Y, Yu Y S, Dong H P, et al. Rapid determination of total flavonoids and extract in the miao medicine Toricellia angulata Oliv. var. intermedia (Harms) Hu based on AOTF- near infrared spectroscopy[J]. Physical Testing and Chemical Analysis(Part B: Chemical Analysis),2019,55(6):668−671.
[26]	韩忠耀, 宋伟, 李燕, 等. 黔产大接骨丹药材不同用药部位中紫丁香苷和总黄酮含量的经时变化特征分析[J]. 中国药房,2020,31(17):2124−2128. [Han Z Y, Song W, Li Y, et al. Analysis of ongoing change characteristics of the contents of syringin and total flavonoids in different medicinal parts of Toricellia angulata from guizhou[J]. China Pharmacy,2020,31(17):2124−2128. doi: 10.6039/j.issn.1001-0408.2020.17.14
[27]	韩忠耀, 余跃生, 魏学军, 等. 苗药水冬瓜根皮药材高效液相色谱指纹图谱研究[J]. 中国医院药学杂志,2017,37(2):126−129. [Han Z Y, Yu Y S, Wei X J, et al. Research on HPLC fingerprint of the miao medicine Toricellia angulata Oliv. var. intermedia (Harms) Hu[J]. Chinese Journal of Hospital Pharmacy,2017,37(2):126−129.
[28]	李俶, 戴涛涛, 程超, 等. 南酸枣及其枣糕有机酸组成与分析[J]. 食品与机械,2015,31(6):17−20. [Li T, Dai T T, Chen C, et al. Analysis on composition of organic acids in Choerospondias axillaris and its pastilles[J]. Food & Machinery,2015,31(6):17−20.
[29]	李静, 李娟, 贾金萍, 等. 基于UHPLC-Q Extractive轨道阱高分辨质谱的款冬花、叶的化学比较[J]. 药学学报,2018,53 (3):444−452. [Li Jing, Li Juan, Jia J P, et al. Comparison of flower buds and leaves of Tussilago farfara L. by UHPLC-Q Extractive Hybrid Quadrupole Orbitrap MS[J]. Acta Pharmaceutica Sinica,2018,53 (3):444−452.
[30]	张婕, 葛永辉, 杨慧, 等. LC-MS/MS法同时测定烟草中的16种游离氨基酸和6种Amadori化合物[J]. 烟草科技,2017,50(11):58−65. [Zhang J, Ge Y H, Yang H, et al. Simultaneous determination of sixteen free amino acids and six Amadori products in tobacco by LC-MS/MS[J]. Tobacco Science & Technology,2017,50(11):58−65.
[31]	谭洪根, 刘应泉. 北马兜铃根的化学成分研究[J]. 中国中药杂志,1994,19(11):677−678. [Ge H G, Liu Y Q. Study on chemical constituents of roots of Aristolochia aristolochia[J]. China Journal of Chinese Materia Medica,1994,19(11):677−678. doi: 10.3321/j.issn:1001-5302.1994.11.002

[1]	ZHU Cheng-hao, TANG Hui, CHAI Sheng-feng, LIU Zhi-xin, WANG Ting, LI Yu-liang. Analysis and Evaluation of Nutritional Components from Leaves and Flowers of Camellia nitidissima in Grafted and Seedling Trees[J]. Science and Technology of Food Industry, 2019, 40(20): 329-333,347. DOI: 10.13386/j.issn1002-0306.2019.20.053
[2]	FANG Ling, MA Hai-xia, LI Lai-hao, YANG Xian-qing, RONG Hui, ZHU Chang-bo. Analysis and evaluation of nutrient composition in Ostrea rivularis from south China sea coast[J]. Science and Technology of Food Industry, 2018, 39(2): 301-307,313. DOI: 10.13386/j.issn1002-0306.2018.02.056
[3]	ZHU Yan-chao, LOU Yong-jiang, XIONG Guo-tong, LIU Jian, LIU Ting, LOU Yue. Composition analysis and evaluation of Goosefish liver nutrition[J]. Science and Technology of Food Industry, 2017, (05): 356-360. DOI: 10.13386/j.issn1002-0306.2017.05.059
[4]	WANG Ting-ting, GAO Guan-shi, WU Su-rui, YANG Zhen-fu, GUI Ming-ying. Analysis of nutritional compositions and evaluation of nutritional quality for Polyporus ellisii[J]. Science and Technology of Food Industry, 2016, (21): 342-346. DOI: 10.13386/j.issn1002-0306.2016.21.058
[5]	MA Yi- dan, LIU Hong, YAN Rui-xin, MA Si-cong, XUE Bing-xiang, WANG Qian. Analysis and evaluation of nutrient content of Synsepalum dulcificum seed[J]. Science and Technology of Food Industry, 2016, (13): 346-351. DOI: 10.13386/j.issn1002-0306.2016.13.063
[6]	CHE Yu-hong, YANG Bo, Aisajan·Mamat, GUO Chun-miao, ZHANG Jun, MA Wen-peng, JIANG Ping. Analysis and evaluation of nutritional composition of big quince in Shache county of Xinjiang[J]. Science and Technology of Food Industry, 2015, (24): 345-348. DOI: 10.13386/j.issn1002-0306.2015.24.067
[7]	JIANG Fang-yan, SONG Wen-ming, YANG Ning, HUANG Hai. Analysis and evaluation of nutrient content of Caulerpa lentillifera[J]. Science and Technology of Food Industry, 2014, (24): 356-359. DOI: 10.13386/j.issn1002-0306.2014.24.067
[8]	CUI Ling-jun, WANG Bao-ping, QIAO Jie, WANG Wei-wei, ZHANG Jian-guo. Analysis and evaluation of nutritive composition of four species of Paulownia flowers[J]. Science and Technology of Food Industry, 2014, (24): 338-341. DOI: 10.13386/j.issn1002-0306.2014.24.063
[9]	YU Gang, ZHANG Hong-jie, YANG Shao-ling, YANG Xian-qing, HAO Shu-xian, ZHANG Peng, LIN Wan-ling. Nutritional component analysis and quality evaluation of Ryukyu squid in South China sea[J]. Science and Technology of Food Industry, 2014, (18): 358-361. DOI: 10.13386/j.issn1002-0306.2014.18.072
[10]	LIU Shu-chen, LI Ren-wei, LIAO Ming-tao, ZHAO Qiao-ling, LIN Sen-sen, DAI Zhi-yuan. Nutritional components analysis and quality evaluation of different muscle parts of bigeye tuna[J]. Science and Technology of Food Industry, 2013, (23): 340-343. DOI: 10.13386/j.issn1002-0306.2013.23.065

Supplements (0)

Cited By

Cited by

Periodical cited type(10)

1.	白佳丽，崔思琪，张瀚文，李雨鑫，古昕雨，雷虹，李文辉. 果蔬清洗机对蔬菜中营养物质的影响. 黑龙江大学工程学报(中英俄文). 2024(01): 104-112 .
2.	王伟. 臭氧在植物保护实践中的应用与展望. 湖北植保. 2024(02): 18-20 .
3.	叶云霞，赵英杰. 去除果蔬农药残留方法的研究现状. 农机使用与维修. 2024(08): 119-121 .
4.	唐雪梅，纪铖臻，卢明瑞，温瑞明，魏静，吴龙. 热带果蔬农药残留处理方法及降解技术研究进展. 食品安全质量检测学报. 2024(19): 1-12 .
5.	陈思达，张凤英，罗秋水. 果蔬解毒清洗机清洗效果探讨. 生物灾害科学. 2023(02): 249-255 .
6.	杨书园，蔡颖婷，黄超，余叶贝，王珺菽，伍洋涛，卜令君，周石庆. 掺硼金刚石膜电极除菌除农药性能及机理探讨. 中国给水排水. 2023(13): 103-108 .
7.	黄友举，初梦圆，路晨，于延冲. 臭氧水降解土壤农药残留研究. 安徽农业科学. 2023(20): 70-72+117 .
8.	陆胜民，王璐，郑美瑜，汪丽霞，赵四清，朱卫东. 干燥方式和臭氧对胡柚小青果干品有效成分和农残的影响. 保鲜与加工. 2022(08): 71-75+81 .
9.	孙倩，吴洪生，丁军，王娜，张磊，程诚，石陶然，Faheem Mohamud，倪妮，田伟，吴云成，单正军. 活性氧降解水中乐果效率及机理分析. 环境科学与技术. 2022(S1): 1-6 .
10.	杨佳洁，李敏敏，肖欧丽，赵浩然，陈捷胤，戴小枫，张民伟，孔志强. 果蔬加工过程农药残留行为研究及加工因子在风险评估中的应用. 食品安全质量检测学报. 2022(22): 7255-7263 .