Research Progress in Biosynthesis of Microbial Hydroxyl Unsaturated Fatty Acids by Linoleic Acid Hydratase

PENG Shuyue; LIANG Nuanyi; ZHANG Yanzhen; GUO Qianwan; WANG Qi; ZHAO Meng; Michael G. Gänzle

doi:10.13386/j.issn1002-0306.2020100119

Volume 42 Issue 22

Nov. 2021

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Science and Technology of Food Industry > 2021 > 42(22): 449-456. > DOI: 10.13386/j.issn1002-0306.2020100119

PENG Shuyue, LIANG Nuanyi, ZHANG Yanzhen, et al. Research Progress in Biosynthesis of Microbial Hydroxyl Unsaturated Fatty Acids by Linoleic Acid Hydratase[J]. Science and Technology of Food Industry, 2021, 42(22): 449−456. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020100119.

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Research Progress in Biosynthesis of Microbial Hydroxyl Unsaturated Fatty Acids by Linoleic Acid Hydratase

1.
Key Laboratory of Fermentation Engineering Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Food Hydrocolloids, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China
2.
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton T6G 2P5, Canada

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Received Date: October 15, 2020
Available Online: August 30, 2021

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Abstract

Abstract

Emerging studies have shown the important bioactivities of hydroxy unsaturated fatty acids(HUFA). The bioproduction of HUFAs is highly specific and environmentally friendly, which has become one of the main preparation methods of HUFA. The sources, functions and applications of two most studied microbial HUFAs, namely 10-hydroxy-12-octadecenoic acid(10-HOE) and 13-hydroxy-9-octadecenoic acid(13-HOE), are first discussed. Then, the research progress of linoleic acid hydratases(LHT), one type of microbial enzymes responsible for the synthesis of 10-HOE and 13-HOE, is reviewed. Finally, the further researches of the bioactivities and biosynthesis of HUFA are proposed, in which the bioconversion efficiency of HUFA with LHT can be improved based on the theory of colloid and interface chemistry.

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