Metabolic Regulation and Mechanism of Multi-Component Resistant Starch on High-Sugar and High-Fat Model Mice

CHEN Yanjun; LIU Jiahong; ZHANG Xiang; CUI Jingai; CHEN Xiaoping

doi:10.13386/j.issn1002-0306.2020100085

Volume 42 Issue 19

Sep. 2021

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Science and Technology of Food Industry > 2021 > 42(19): 357-362. > DOI: 10.13386/j.issn1002-0306.2020100085

CHEN Yanjun, LIU Jiahong, ZHANG Xiang, et al. Metabolic Regulation and Mechanism of Multi-Component Resistant Starch on High-Sugar and High-Fat Model Mice[J]. Science and Technology of Food Industry, 2021, 42(19): 357−362. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020100085.

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Metabolic Regulation and Mechanism of Multi-Component Resistant Starch on High-Sugar and High-Fat Model Mice

College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China

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Received Date: October 13, 2020
Available Online: August 01, 2021

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Abstract

Objective: To investigate the effect and mechanism of multiple composite resistant starch (RS) on glucose and lipid metabolism in high-sugar and high-fat model mice. Methods: The mice were divided into six groups, namely the normal control group, the high-sugar and high-fat model group, the positive control group and multiple composite RS low dose group, multiple composite RS middle dose group, multiple composite RS high dose group. The effects of multiple complex RS on body mass, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), liver glycogen in high-glycemic and high-fat mice and the influence of short chain fatty acids (SCFAs) in intestinal contents. Results: RS high dose group compared with the mice in the model control group, the body mass, blood glucose, TC, and TG in the serum of mice in the multiple composite RS group were significantly decreased by 9.23%, 59.71%, 31.22%, and 36.72%, respectively, and HDL-C was significantly increased by 58.93%; the content of liver glycogen was positively correlated with the dose of multiple composite RS, and the content of liver glycogen increased significantly by 207.86%. The contents of acetic acid, propionic acid and butyric acid in the intestines increased significantly. Conclusion: The multiple compound RS can reduce the blood sugar level of high-sugar and high-fat model mice, increase the content of acetic acid, propionic acid and butyric acid in the intestine.
- resistant starch,
- blood glucose,
- blood lipids,
- metabolic regulation,
- mechanism

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