Research Progress on Chemical and Biological Synthesis of Astaxanthin

CHEN Dan; WANG Feng; JIANG Shan; LIU Pengyang; ZHU Hangzhi; LI Xiangyu; WAN Xia

doi:10.13386/j.issn1002-0306.2020100037

Volume 42 Issue 21

Oct. 2021

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Science and Technology of Food Industry > 2021 > 42(21): 445-453. > DOI: 10.13386/j.issn1002-0306.2020100037

CHEN Dan, WANG Feng, JIANG Shan, et al. Research Progress on Chemical and Biological Synthesis of Astaxanthin[J]. Science and Technology of Food Industry, 2021, 42(21): 445−453. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020100037.

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Research Progress on Chemical and Biological Synthesis of Astaxanthin

CHEN Dan^{1, 2,},
WANG Feng¹,
JIANG Shan²,
LIU Pengyang²,
ZHU Hangzhi²,
LI Xiangyu^3, ,,
WAN Xia^{2, 4, 5, ,}

1.
Wuhan Institute of Technology, School of Chemical Engineering and Pharmacy, Wuhan 430205, China
2.
Oil Coops Research Institute of Chinese Academy of Agricultural Sciences, Wuhan 430062, China
3.
Cabio Biotechnology Co., Ltd., Wuhan 430073, China
4.
Laboratory of Oil Crops Biology and Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Wuhan 430062, China
5.
Laboratory of Oil Processing, Ministry of Agriculture and Rural Affairs, Wuhan 430062, China

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Received Date: January 04, 2021
Available Online: August 29, 2021

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Abstract

Abstract

Astaxanthin is an important secondary carotenoid with extremely strong antioxidative properties and is widely used in food, chemicals, pharmaceuticals, aquacultures and so on. The synthetic methods of astaxanthin include chemical synthesis and biosynthesis. Chemical synthesis of astaxanthin is the source of commercial astaxanthin, while biosynthesis of astaxanthin is safer and more popular in food and health products industries. This review summaries chemical synthetic and biosynthetic pathway of astaxanthin, with emphasizing on the biosynthetic pathways of astaxanthin, key genes involved in biosynthetic and metabolic network of astaxnathin in microorganisms and plants. The research progress of using random mutagenesis, metabolic engineering, enzyme engineering and other methods to improve the synthesis and accumulation of astaxanthin in bacteria, yeast, and marine eukaryotic microorganisms is summarized. This article can provide theoretical guidance for the research on the efficient synthesis of astaxanthin.
- astaxanthin,
- chemical synthesis,
- biosynthesis,
- metabolic pathway

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References (57)

References

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