Research Progress on the Anti-aging Effect of Marine Bioactive Substances

WANG Li; XIAO Meifang; LIU Bin; CHEN Fuquan; NI Hui; ZENG Feng

doi:10.13386/j.issn1002-0306.2020090202

Volume 42 Issue 22

Nov. 2021

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Science and Technology of Food Industry > 2021 > 42(22): 433-441. > DOI: 10.13386/j.issn1002-0306.2020090202

WANG Li, XIAO Meifang, LIU Bin, et al. Research Progress on the Anti-aging Effect of Marine Bioactive Substances[J]. Science and Technology of Food Industry, 2021, 42(22): 433−441. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020090202.

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Research Progress on the Anti-aging Effect of Marine Bioactive Substances

WANG Li^{1, 2, 3,},
XIAO Meifang^{1, 2},
LIU Bin^{1, 2},
CHEN Fuquan³,
NI Hui³,
ZENG Feng^{1, 2, 3, ,}

1.
Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou 350002, China
2.
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
3.
Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China

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Received Date: September 20, 2020
Available Online: August 25, 2021

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Abstract

Abstract

Aging will cause the function attenuation of multiple organs, leading to the occurrence and development of various related diseases such as metabolism, nervous system and cardiovascular . Anti-aging has become an important research topic in the field of modern life science, and the development of natural and effective active components of anti-aging food is of great significance for the promotion of human health development. Marine bioactive substances have good biocompatibility, easy absorption, low toxicity and other characteristics, and can also help the body to fight oxidation, regulate gut microbiota and regulate the expression of senescence related genes, therefore, they can be used as a rich source of raw materials for the development of anti-aging functional foods. In this paper, the aging mechanism theory, and the anti-aging effect of marine derived bioactive substances such as polypeptides, polysaccharides, unsaturated fatty acids and astaxanthin, and marine biological active substances on aging intervention mechanism were summarized. Furthermore, the anti-aging research directions of marine bioactive substances were discussed, in order to provide the theoretical reference basis for the research and development of anti-aging marine active substances.
- marine organism,
- bioactive substance,
- anti-aging,
- mechanism

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References

[1]	NICCOLI T, PARTRIDGE L. Ageing as a risk factor for disease[J]. Current Biology,2012,22(17):R741−752. doi: 10.1016/j.cub.2012.07.024
[2]	FLACKER J M. What is a geriatric syndrome anyway?[J]. Journal of the American Geriatrics Society,2010,51(4):574−576.
[3]	United Nations, Department of Economic and Social Affairs, Population Division(2019). World population ageing 2019: Highlights[EB/OL]. (2019-12-31)[2020-09-18]. https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/files/documents/2020/Jan/worldpopulationageing2019-highlights.pdf.
[4]	PODHORECKA M, IBANEZ B, ANNA D. Metformin-its potential anti-cancer and anti-aging effects[J]. Postepy Higieny I Medycyny Doswiadczalnej,2017,71(1):170−175.
[5]	SCHMEER C W, KRETZ, WENGERODT, et al. Dissecting aging and senescence-current concepts and open lessons[J]. Cells,2019,8(11):1446. doi: 10.3390/cells8111446
[6]	LARA J, SHERRATT M J, REES M. Aging and anti-aging[J]. Maturitas,2016,93:1−3. doi: 10.1016/j.maturitas.2016.08.020
[7]	SON D H, PARK W J, LEE Y J. Recent advances in anti-aging medicine[J]. Korean Journal of Family Medicine,2019,40(5):289−296. doi: 10.4082/kjfm.19.0087
[8]	何晨, 刘晶晶, 陈楠, 等. 抗衰老药物的研究进展[J]. 西北药学杂志,2020,35(1):154−157. [HE C, LIU J J, CHEN N, et al. Research advance of the anti-aging drugs[J]. Northwest Pharmaceutical Journal,2020,35(1):154−157. doi: 10.3969/j.issn.1004-2407.2020.01.035
[9]	蔡路昀, 年琳玉, 吕艳芳, 等. 海洋生物活性物质主要功能特性的研究进展[J]. 食品工业科技,2017,38(7):376−380, 384. [CAI L J, NIAN L Y, LV Y F, et al. Research progress on the main functional characteristics of marine bioactive substances[J]. Science and Technology of Food Industry,2017,38(7):376−380, 384.
[10]	KEANE M, SEMEIKS J, WEBB A E, et al. Insights into the evolution of longevity from the bowhead whale genome[J]. Cell Reports,2015,10(1):112−122. doi: 10.1016/j.celrep.2014.12.008
[11]	SEIM I, MA S, ZHOU X, et al. The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal[J]. Aging,2014,6(10):879−899. doi: 10.18632/aging.100699
[12]	HA M K, CHO J S, BAIK O R, et al. Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis[J]. Proteomics,2006,6(11):3339−3351. doi: 10.1002/pmic.200500395
[13]	SEMEIKS J, GRISHIN N V. A method to find longevity-selected positions in the mammalian proteome[J]. Plos One,2012,7(6):e38595. doi: 10.1371/journal.pone.0038595
[14]	TRIPLETT J C, SWOMLEY A, KIRK J, et al. Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: The naked mole-rat[J]. Journal of Neurochemistry,2015,134(3):538−550. doi: 10.1111/jnc.13149
[15]	林韬, 李谭, 赵育林, 等. 抗衰老药物的研究进展[J]. 中国临床药理学杂志,2018,34(20):2486−2488. [LIN T, LI T, ZHAO Y L, et al. Research progress in anti-aging drug[J]. The Chinese Journal of Clinical Pharmacology,2018,34(20):2486−2488.
[16]	郁兵, 王波. 中药抗衰老保健药物研发的进展[J]. 西安文理学院学报(自然科学版),2019,22(5):82−84. [YU B, WANG B. Progress in research and development of anti-aging and health-care drugs of traditional chinese medicine[J]. Journal of Xi'an University(Natural Science Edition),2019,22(5):82−84.
[17]	GEMS D. What is an anti-aging treatment?[J]. Experimental Gerontology,2014,58:14−18. doi: 10.1016/j.exger.2014.07.003
[18]	HARMAN D. About “Origin and evolution of the free radical theory of aging: A brief personal history, 1954-2009”[J]. Biogerontology,2009,10(6):783. doi: 10.1007/s10522-009-9253-z
[19]	HARMAN D. Free radical theory of aging: an update: Increasing the functional life span[J]. Annals of the New York Academy of Sciences,2006,1067:10−21. doi: 10.1196/annals.1354.003
[20]	薛立英, 高丽, 秦雪梅, 等. 药食同源中药抗衰老研究进展[J]. 食品科学,2017(38):309. [XUE L Y, GAO L, QIN X M, et al. A review of recent literature on anti-aging activity of medicinal and edible traditional Chinese herbs[J]. Food Science,2017(38):309.
[21]	杨超, 邸伟, 张飞雄. 伊丽莎白·布莱克本与端粒和端粒酶研究[J]. 遗传,2010,32(1):1−3. [YANG C, DI W, ZHANG F X. Elizabeth H. Blackburn studies telomeres and telomerase[J]. Hereditas(Beijing),2010,32(1):1−3.
[22]	ZANNI G R, WICK J Y. Telomeres: Unlocking the mystery of cell division and aging[J]. The Consultant Pharmacist: The Journal of the American Society of Consultant Pharmacists,2011,26(2):78. doi: 10.4140/TCP.n.2011.78
[23]	张博. 酵母端粒酶延伸端粒DNA分子机制的研究[D]. 陕西: 西北农林科技大学, 2016. ZHANG B. The study on molecule mechanism of candida telomerase extend telomeric DNA[D]. Shaanxi: Northwest A&F University, 2016.
[24]	王锋青, 陈秉初. 生物衰老机理研究进展[J]. 生物学教学,2004,29(2):4−7. [WANG F Q, CHEN B C. Advances in biological senescence mechanism[J]. Biology Teaching,2004,29(2):4−7. doi: 10.3969/j.issn.1004-7549.2004.02.004
[25]	蒋国, 高郡茹, 杨柳. 衰老分子机制及相关疾病的研究进展[J]. 实用医学杂志,2019,35(20):3248−3252. [JIANG G, GAO J R, YANG L. Research progress on molecular mechanisms of aging and aging-associated diseases[J]. The Journal of Practical Medicine,2019,35(20):3248−3252. doi: 10.3969/j.issn.1006-5725.2019.20.028
[26]	FAGAGNA D'ADDA DI F, REAPER P M, CLAY-FARRACE L, et al. A DNA damage checkpoint response in telomere-initiated senescence[J]. Nature,2003,426(6963):194−198. doi: 10.1038/nature02118
[27]	WHITTEMORE K, VERA E, MARTÍNEZ-NEVADO E, et al. Telomere shortening rate predicts species life span[J]. Proceedings of the National Academy of Sciences,2019,116(30):15122−15127. doi: 10.1073/pnas.1902452116
[28]	TAKUBO K, IZUMIYAMA S N, HONMA N, et al. Telomere lengths is characteristic in each human individual[J]. Experimental Gerontology,2002,37(4):523−531. doi: 10.1016/S0531-5565(01)00218-2
[29]	丁秋英. 金福菇多糖抗衰老作用研究[D]. 合肥: 安徽大学, 2016. DING Q Y. Anti-aging effect of polysaccharides from Tricholoma lobayense[D]. Hefei: Anhui University, 2016.
[30]	DIRKS A J, HOFER T, MARZETTI E, et al. Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle[J]. Ageing Research Reviews,2006,5(2):179−195. doi: 10.1016/j.arr.2006.03.002
[31]	田媛媛. 利用蜜蜂研究蜂王浆抗衰老的主要成分[D]. 福州: 福建农林大学, 2014. TIAN Y Y. The anti-aging effect of royal jelly component on honeybee[D]. Fuzhou: Fujian Agriculture and Forestry University, 2014.
[32]	卢春雪, 杨绍杰, 陶荟竹, 等. 衰老机制研究进展[J]. 中国老年学杂志,2018,38(1):248−250. [LU C X, YANG S J, TAO H Z, et al. Advances in aging mechanisms[J]. Chinese Journal of Gerontology,2018,38(1):248−250. doi: 10.3969/j.issn.1005-9202.2018.01.101
[33]	潘静, 陈金铃, 朱丹丹, 等. 细胞衰老机制的研究新进展[J]. 中国病原生物学杂志,2015,10(7):672−675. [PAN J, CHEN J L, ZHU D D, et al. Advances in study of the mechanisms of cellular senescence[J]. Journal of Pathogen Biology,2015,10(7):672−675.
[34]	ROBI T, DANIEL T, EMILY J, et al. Human ageing genomic resources: New and updated databases[J]. Nucleic Acids Research,2018(D1):D1083−D1091.
[35]	SZILARD L. On the nature of the aging process[J]. Proceedings of the National Academy of Sciences,1959,45(1):30−45. doi: 10.1073/pnas.45.1.30
[36]	VIJG J. Somatic mutations and aging: A re-evaluation[J]. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis,2000,447(1):117−135. doi: 10.1016/S0027-5107(99)00202-X
[37]	EROL A. Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair, apoptosis or senescence in response to damaging signals[J]. Cellular Signalling,2011,23(7):1076−1081. doi: 10.1016/j.cellsig.2010.11.023
[38]	宋朝春, 魏冉磊, 樊晓兰, 等. 衰老及抗衰老药物的研究进展[J]. 中国生化药物杂志,2015,35(1):163−170. [SONG C C, WEI R L, FAN X L, et al. Advances in the study of aging and anti-aging drugs[J]. Chinese Journal of Biochemical and Pharmaceuticals,2015,35(1):163−170.
[39]	李娜丽, 闫俊卿, 魏锦, 等. 肠道菌群与衰老相关疾病关系的研究进展[J]. 中国全科医学,2019,22(27):3298−3301. [LI N L, YAN J Q, WEI J, et al. Research progress on the relationship between aging and its related diseases and gut microbiota[J]. Chinese General Practice,2019,22(27):3298−3301. doi: 10.12114/j.issn.1007-9572.2019.00.234
[40]	林端权, 郭泽镔, 张怡, 等. 海洋生物活性肽的研究进展[J]. 食品工业科技,2016,37(18):367−373. [LIN D Q, GUO Z B, ZHANG Y, et al. Research progress on the marine bioactive peptides[J]. Science and Technology of Food Industry,2016,37(18):367−373.
[41]	CHAI T T, LAW Y C, WONG F C, et al. Enzyme-assisted discovery of antioxidant peptides from edible marine invertebrates: A review[J]. Marine Drugs,2017,15(2):42. doi: 10.3390/md15020042
[42]	司玫, 展翔天. 海洋生物活性物质研究进展[J]. 中国海洋药物,2003,22(6):46−50. [SI M, ZHAN X T. Research progress of marine bioactive substances[J]. Chinese Journal of Marine Drugs,2003,22(6):46−50. doi: 10.3969/j.issn.1002-3461.2003.06.012
[43]	张志慧, 苏秀兰. 生物活性肽在医药领域的研究进展[J]. 中国医药导报,2019,16(10):37−40. [ZHANG Z H, SU X L. Research progress of bioactive peptides in the field of medicine[J]. China Medical Herald,2019,16(10):37−40.
[44]	崔琪, 陈敬蕊, 姜秀云, 等. 海洋生物活性肽药物应用的研究进展[J]. 中国海洋药物,2019,38(2):58−64. [CUI Q, CHEN J R, JIANG X Y, et al. Advances in the application of marine bioactive peptide drugs[J]. Chinese Journal of Marine Drugs,2019,38(2):58−64.
[45]	ZHONG Q, WEI B, WANG S, et al. The antioxidant activity of polysaccharides derived from marine organisms: An overview[J]. Marine Drugs,2019,17(12):674−708. doi: 10.3390/md17120674
[46]	WANG W, WANG S X, GUAN H S. The antiviral activities and mechanisms of marine polysaccharides: An overview[J]. Marine Drugs,2012,10(12):2795−2816. doi: 10.3390/md10122795
[47]	XU S Y, HUANG X S, CHEONG K L. Recent advances in marine algae polysaccharides: Isolation, structure, and activities[J]. Marine Drugs,2017,15(12):388−404. doi: 10.3390/md15120388
[48]	安晓羽, 杨慧娣. N-3多不饱和脂肪酸对非酒精性脂肪肝病的治疗作用[J]. 生理科学进展,2020,51(2):157−161. [AN X Y, YANG H D. Effect of N-3 polyunsaturated fatty acids on nonalcoholic fatty liver disease[J]. Progress in Physiological Sciences,2020,51(2):157−161. doi: 10.3969/j.issn.0559-7765.2020.02.019
[49]	王萍, 张银波, 江木兰. 多不饱和脂肪酸的研究进展[J]. 中国油脂,2008,33(12):42−46. [WANG P, ZHANG Y B, JIANG M L. Research advance in polyunsaturated fatty acid[J]. China Oils and Fats,2008,33(12):42−46. doi: 10.3321/j.issn:1003-7969.2008.12.011
[50]	HAMED I, ÖZOGUL F, ÖZOGUL Y. Marine bioactive compounds and their health benefits: A review[J]. Comprehensive Reviews in Food Science & Food Safety,2015,14(4):446−465.
[51]	陈翠娥. 具有抗衰老活性的海洋天然产物的发现研究[D]. 杭州: 浙江工业大学, 2016. CHEN C E. Studies on marine natural products with anti-aging activity[D]. Hangzhou: Zhejiang University of Technology, 2016.
[52]	张莉莉. 扇贝抗氧化活性肽的制备及其活性的研究[D]. 哈尔滨: 哈尔滨工业大学, 2013. ZHANG L L. Preparation of scallop oxidation active peptide and the activity research[D]. Harbin: Harbin Institute of Technology, 2013.
[53]	王军琦, 王祖哲, 刘心田, 等. 海参低聚肽对家蚕抗衰老功效的初步研究[J]. 海洋湖沼通报,2019(5):164−170. [WANG J Q, WANG Z Z, LIU X T, et al. Preliminary study on anti-aging effect of oligopeptides from sea cucumber on silkworm[J]. Transactions of Oceanology and Limnology,2019(5):164−170.
[54]	ZHOU Y, XU Q, DONG Y, et al. Supplementation of mussel peptides reduces aging phenotype, lipid deposition and oxidative stress in D-galactose-induce aging mice[J]. The Journal of Nutrition, Health & Aging,2016,21(10):1314−1320.
[55]	李娜. 鳕鱼鳔胶原蛋白和胶原肽特性及对细胞衰老进程干预作用与机制[D]. 上海: 上海海洋大学, 2019. LI N. Study on characteristics of collagen and collagen peptides in cod swim bladder and its effect and mechanism of intervention on cellular aging process[D]. Shanghai: Shanghai Ocean University, 2019.
[56]	LIN L, ZHU Q, ZHENG L, et al. Preparation of sea cucumber(Stichopus variegates) peptide fraction with desired organoleptic property and its anti-aging activity in fruit flies and D-galactose-induced aging mice[J]. Journal of Functional Foods,2020,69:103954. doi: 10.1016/j.jff.2020.103954
[57]	CHEN Y, LIU X, WU L, et al. Physicochemical characterization of polysaccharides from Chlorella pyrenoidosa and its anti-ageing effects in Drosophila melanogaster[J]. Carbohydrate Polymers,2018,185:120−126. doi: 10.1016/j.carbpol.2017.12.077
[58]	王雪, 兰丽, 原晶莹, 等. 3种海藻多糖抗氧化及其抗衰老活性的初步研究[J]. 药物生物技术,2020,27(1):29−32. [WANG X, LAN L, YUAN J Y, et al. Preliminary study on antioxidant and anti-aging activity of polysaccharides from three seaweed species[J]. Pharmaceutical Biotechnology,2020,27(1):29−32.
[59]	孔鹏, 姚翠鸾, 齐丽薇, 等. 海带多糖的抗衰老作用及其机理的研究[J]. 河北农业大学学报,2007(4):63−66. [KONG P, YAO C L, QI L W, et al. Anti-aging effect and mechanism of polysaccharide from Laminaria japonica on Drosophila melanogaster[J]. Journal of Hebei Agricultural University,2007(4):63−66. doi: 10.3969/j.issn.1000-1573.2007.04.015
[60]	李欣遥. 牡蛎多糖超声提取工艺及抗衰老作用研究[D]. 大连: 大连海洋大学, 2017. LI X Y. Ultrasonic extraction of oyster polysaccharide(CGPS-1) and its anti-aging effect[D]. Dalian: Dalian Ocean University, 2017.
[61]	WANG X M, ZHANG Z S, ZHOU H C, et al. The anti-aging effects of Gracilaria lemaneiformis polysaccharide in Caenorhabditis elegans[J]. International Journal of Biological Macromolecules,2019,140:600−604. doi: 10.1016/j.ijbiomac.2019.08.186
[62]	赵静. 南极磷虾磷脂提取纯化及抗衰老实验研究[D]. 青岛: 中国海洋大学, 2012. ZHAO J. Extraction and purification of Antarctic krill phospholipids and experimental study of its anti-aging effect[D]. Qindao: Ocean University of China, 2012.
[63]	郑霖波, 白冬, 虞舟, 等. 深海鲣鱼鱼油对D-半乳糖致衰老模型小鼠抗衰老的作用[J]. 食品科学,2019,40(5):202−206. doi: 10.7506/spkx1002-6630-20171214-174
[64]	廉桂芳. 鱿鱼肝脏鱼油抗衰老及预防肝损伤功能评价[D]. 重庆: 西南大学, 2018. LIAN G F. The functional evaluation of squid liver oil with anti-aging and prevent the liver injury ability[J]. Chongqing: Southwest University, 2018.
[65]	HUANG F J, LIU J, SUN Z, et al. Antiaging effects of astaxanthin-rich alga Haematococcus pluvialis on fruit flies under oxidative stress[J]. Journal of Agriculture and Food Chemistry,2013,61(32):7800−7804. doi: 10.1021/jf402224w
[66]	刘不悔, 何伟明, 万毅刚, 等. 虫草菌丝抑制自噬相关AMPK/ULK1信号活性改善肾小管上皮细胞衰老的分子机制[J]. 中国中药杂志,2019(6):1258−1265. [LIU B H, HE W M, WAN Y G, et al. Molecular mechanisms of mycelium of Cordyceps sinensis ameliorating renal tubular epithelial cells aging induced by D-galactose via inhibiting autophagy-related AMPK /ULK1 signaling activation[J]. China Journal of Chinese Materia Medica,2019(6):1258−1265.
[67]	DIKIC I, ELAZAR Z. Mechanism and medical implications of mammalian autophagy[J]. Nature Reviews Molecular Cell Biology,2018,19(6):349−364. doi: 10.1038/s41580-018-0003-4
[68]	SALMINEN A, KAARNIRANTA K. AMP-activated protein kinase(AMPK) controls the aging process via an integrated signaling network[J]. Ageing Research Reviews,2012,11(2):230−241. doi: 10.1016/j.arr.2011.12.005
[69]	JUNG C H, RO S H, CAO J, et al. mTOR regulation of autophagy[J]. FEBS Letters,2010,584(7):1287−1295. doi: 10.1016/j.febslet.2010.01.017
[70]	MARIAYLOVA M M, SHAW R J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism[J]. Nature Cell Biology,2011,13(9):1016−1023. doi: 10.1038/ncb2329
[71]	MIZUSHIMA N. The role of the Atg1/ULK1 complex in autophagy regulation[J]. Current Opinion in Cell Biology,2010,22(2):132−139. doi: 10.1016/j.ceb.2009.12.004
[72]	房其军, 刘建璟, 万毅刚, 等. 基于自噬信号通路探究褐藻多糖硫酸酯改善人近端肾小管上皮细胞衰老的分子机制[J]. 中国中药杂志,2020(7):1−10. [FANG Q J, LIU J J, WAN Y G, et al. Exploring molecular mechanisms of fucoidan in improving human proximal renal tubular epithelial cells aging by targeting autophagy signaling pathways[J]. China Journal of Chinese Materia Medica,2020(7):1−10.
[73]	BLACKBURN E H, EPEL E S, LIN J. Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection[J]. Science,2015,350(6265):1193−1198. doi: 10.1126/science.aab3389
[74]	ERUSALIMSKY J D. Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link?[J]. Free Radical Biology and Medicine,2020,4(150):87−95.
[75]	SHAMMAS M A. Telomeres, lifestyle, cancer, and aging[J]. Current Opinion in Clinical Nutrition and Metabolic Care,2011,14(1):28−34. doi: 10.1097/MCO.0b013e32834121b1
[76]	SHIN J S, HONG A, SOLOMON M J, et al. The role of telomeres and telomerase in the pathology of human cancer and aging[J]. Pathology,2006,38(2):103−113. doi: 10.1080/00313020600580468
[77]	RAMIN F F, M D, Lin J, et al. Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease[J]. Jama Journal of the American Medical Association,2010,303(3):250−257. doi: 10.1001/jama.2009.2008
[78]	张强, 李伟华. 抗氧化肽的研究进展[J]. 食品与发酵工业,2020(9):1−9. [ZHANG Q, LI W H. Research progress of antioxidant peptides[J]. Food and Fermentation Industries,2020(9):1−9.
[79]	沈云辉, 陈长勋. 抗氧化应激研究进展[J]. 中成药,2019,41(11):2715−2719. [SHEN Y H, CHEN C X. Research progress of anti-oxidative stress[J]. Chinese Traditional Patent Medicine,2019,41(11):2715−2719. doi: 10.3969/j.issn.1001-1528.2019.11.031
[80]	张亚. 羊栖菜多糖SFPS组分抗衰老机制初步研究[D]. 温州: 温州大学, 2017. ZHANG Y. Preliminary study on anti-aging activity of polysaccharide from Sargassum fusiforme[D]. Wenzhou: Wenzhou University, 2017.
[81]	LI D D, LI W J, KONG S Z, et al. Protective effects of collagen polypeptide from tilapia skin against injuries to the liver and kidneys of mice induced by d-galactose[J]. Biomedicine & Pharmacotherapy,2019,117:109−204.
[82]	BAEK J, LEE M G. Oxidative stress and antioxidant strategies in dermatology[J]. Redox Report,2016,21(4):164−169. doi: 10.1179/1351000215Y.0000000015
[83]	WANG Z J, XIE J H, NIE S P, et al. Review on cell models to evaluate the potential antioxidant activity of polysaccharides[J]. Food & Function,2017,8(3):915−926.
[84]	徐晓珍. 海带多糖对自然衰老小鼠皮肤胶原蛋白影响的实验研究[D]. 南宁: 广西医科大学, 2016. XU X Z. The effect of laminarin polysaccharide on skin collagen in intrinsic aging mice[D]. Nanning: Guangxi Medical University, 2016.
[85]	O'Toole P W, Jeffery I B. Gut microbiota and aging[J]. Science,2015,350(6265):1214−1215. doi: 10.1126/science.aac8469
[86]	RAKOFF-NAHOUM S, pAGLINO J, ESLAMI-vARZANEH F, et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis[J]. Cell,2004,118(2):229−241. doi: 10.1016/j.cell.2004.07.002
[87]	兰兴成, 杨擎, 陈锡俊, 等. 肠道菌群与衰老相关疾病研究进展[J]. 吉林中医药,2020,40(3):410−413. [LAN X C, YANG Q, CHEN X J, et al. Research progress of intestinal flora and aging-related diseases[J]. Jilin Journal of Chinese Medicine,2020,40(3):410−413.
[88]	胡晨熙. 羊栖菜多糖SFPS抗氧化作用及对衰老作用的探讨[D]. 温州: 温州大学, 2018. HU C X. The anti-oxidation activity of Sargassum fusiforme polysaccharide(SFPS) and discussion on its effect on anti-aging[D]. Wenzhou: Wenzhou University, 2018.

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