Research Progress on Extraction, Purification and Biological Activities of <i>Nostoc flagelliforme</i> Polysaccharides

ZHU Rongjing; CHEN Xuefeng; LIU Huan; MENG Guangyan; DANG Yue

doi:10.13386/j.issn1002-0306.2020090199

Volume 42 Issue 22

Nov. 2021

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Science and Technology of Food Industry > 2021 > 42(22): 423-432. > DOI: 10.13386/j.issn1002-0306.2020090199

ZHU Rongjing, CHEN Xuefeng, LIU Huan, et al. Research Progress on Extraction, Purification and Biological Activities of Nostoc flagelliforme Polysaccharides[J]. Science and Technology of Food Industry, 2021, 42(22): 423−432. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020090199.

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Research Progress on Extraction, Purification and Biological Activities of Nostoc flagelliforme Polysaccharides

School of Food and Bioengineering, Shaanxi University of Science and Technology, Xi’an 710021, China

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Received Date: September 20, 2020
Available Online: September 06, 2021

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Abstract

Abstract

Nostoc flagelliforme is a kind of terrestrial Nostoc, and can usually be used as food and medicine. It includes sugars, various amino acids and trace elements, vitamins, echinone, phycocyanophyll, phycocyanin, allophycocyanin and some other functional ingredients. Nostoc flagelliforme cells can synthesize a gelatinous substance, and its main functional ingredient is Nostoc flagelliforme polysaccharide. At present, a number of studies have shown that Nostoc flagelliforme polysaccharides have various bioactivities, such as antioxidant, antiviral, anti-tumor, anti-microbial, anti-inflammatory and immune regulation. Therefore, Nostoc flagelliforme polysaccharides have great potential in the fields of food and medicine. This paper mainly reviews the methods of extraction, separation, purification and the structural characteristics of Nostoc flagelliforme polysaccharides, and also summarizes the research progress on biosynthesis and bioactivities of Nostoc flagelliforme polysaccharides, expecting to provide theoretical basis for further researches and development of Nostoc flagelliforme polysaccharides.
- Nostoc flagelliforme polysaccharides,
- separation and purification,
- structural characteristics,
- biosynthesis,
- bioactivities

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References

[1]	钱珍, 江国荣. 多糖抗肿瘤作用的研究进展[J]. 中国药物警戒,2015,12(2):96−98. [QIAN Z, JIANG G R. Research process in anti-tumor effect of polysaccharides[J]. Chinese Journal of Pharmacovigilance,2015,12(2):96−98.
[2]	赵青松, 尹鸿萍. 多糖的免疫调节作用及多糖药物的研究进展[J]. 科学与财富,2018(5):258. [ZHAO Q S, YIN H P. Immunomodulatory activity of polysaccharide and research progresses of polysaccharide medicine[J]. Science and Wealth,2018(5):258. doi: 10.3969/j.issn.1671-2226.2018.05.257
[3]	王红雨, 李海峰, 黄泽波. 药食两用念珠藻生物活性成分的研究进展[J]. 广东药科大学学报,2017,33(4):561−564. [WANG H Y, LI H F, HUANG Z B. Progress on the bioactive components of medicinal and edible Nostoc species[J]. Journal of Guangdong Pharmaceutical University,2017,33(4):561−564.
[4]	李海峰, 李章伟, 李永梅, 等. 念珠藻多糖的研究现状与应用展望[J]. 中国农业科技导报,2011,13(1):105−110. [LI H F, LI Z W, LI Y M, et al. Prospect for present status and application of polysaccharides from Nostoc[J]. Journal of Agricultural Science and Technology,2011,13(1):105−110. doi: 10.3969/j.issn.1008-0864.2011.01.17
[5]	焦文冬. 发状念珠藻与集胞藻、小球藻的营养成分及在盐胁迫下Rubisco基因表达的比较[D]. 西安: 陕西科技大学, 2016. JIAO W D. Comparison of nutrients between Nostoc flagelliforme, Synechocystiss and Chlorella, and Rubisco gene expression under salt stress[D]. Xi’an: Shaanxi University of Science and Technology, 2016.
[6]	范华. 盐胁迫下发菜多糖代谢相关差异表达基因的克隆与原核表达[D]. 西安: 陕西科技大学, 2017. FAN H. Cloning and prokaryotic expression of polysaccharide metabolism-related differently expressed genes from Nostoc flagelliforme under salt stress[D]. Xi’an: Shaanxi University of Science and Technology, 2017.
[7]	JIA S R, YU H F, LIN Y X, et al. Characterization of extracellular polysaccharides from Nostoc flagelliforme cells in liquid suspension culture[J]. Biotechnology and Bioprocess Engineering,2007,12(3):271−275. doi: 10.1007/BF02931103
[8]	林永贤, 于海峰, 许鹏, 等. 发菜多糖的提取及性质研究[J]. 现代食品科技,2007,23(5):34−36, 49. [LIN Y X, YU H F, XU P, et al. Extraction and physicochemical properties of Nostoc flagelliform polysaccharide[J]. Modern Food Science and Technology,2007,23(5):34−36, 49.
[9]	陈雪峰, 李一当, 贾士儒. 发菜多糖的提取、纯化鉴定及理化特性研究[J]. 食品与发酵工业,2008,34(10):174−177. [CHEN X F, LI Y D, JIA S R. Study on extraction, purification identification and physical and chemical characteristics assay of Nostoc flagelliforme polysaccharides[J]. Food and Fermentation Industries,2008,34(10):174−177.
[10]	梁文裕, 马秀丽, 郑国旗, 等. 发状念珠藻多糖的提取及其对农作物种子发芽率的影响[J]. 安徽农业科学,2008,36(23):9944−9945, 9981. [LIANG W Y, MA X L, ZHENG G Q, et al. Extraction of polysaccharide from Nostoc flagelliforme and its effect on the germination rate of crop seeds[J]. Journal of Anhui Agricultural Science,2008,36(23):9944−9945, 9981. doi: 10.3969/j.issn.0517-6611.2008.23.018
[11]	沈杰, 马恩耀, 赵志敏, 等. 巴戟天多糖的提取、分离及生物活性研究进展[J]. 中药新药与临床药理,2020,31(2):246−250. [SHEN J, MA E Y, ZHAO Z M, et al. Research progress on extraction, separation, and biological activities of polysaccharides from Morindae officinalis Radix[J]. Traditional Chinese Drug Research and Clinical Pharmacology,2020,31(2):246−250.
[12]	刘鼎阔, 王立红, 张凤洪, 等. 一种发菜多糖提取方法: 中国, 106749713[P]. 2017-05-31. LIU D K, WANG L H, ZHANG F H, et al. Method for extracting polysaccharides from Nostoc flagelliforme: China, 106749713[P]. 2017-05-31.
[13]	徐翔. 超声波法提取麻黄草多糖的工艺条件优化[J]. 食品界,2018(4):156−157. [XU X. Optimization of extraction process conditions of Ephedra sinica polysaccharides by ultrasonic method[J]. Food Industry,2018(4):156−157. doi: 10.3969/j.issn.2095-638X.2018.04.111
[14]	杨杰, 李迎秋. 香菇多糖的提取、分离及应用研究综述[J]. 江苏调味副食品,2017(2):6−9. [YANG J, LI Y Q. Application study of extraction and separation of lentinan[J]. Jiangsu Condiment and Subsidiary Food,2017(2):6−9.
[15]	ZHOU C S, MA H L. Ultrasonic degradation of polysaccharide from a red algae(Porphyra yezoensis)[J]. Journal of Agricultural and Food Chemistry,2006,54(6):2223−2228. doi: 10.1021/jf052763h
[16]	曾凡珂, 李伟, 曹庸, 等. 金樱子多糖提取、纯化及生理活性研究进展[J]. 食品工业科技,2019,40(7):307−311. [ZENG F K, LI W, CAO Y, et al. Research progress on extraction, purification and physiological activities of polysaccharides from Rosa laevigata michx[J]. Science and Technology of Food Industry,2019,40(7):307−311.
[17]	李卓, 梁奇, 赵秀红. 超声波法提取发菜多糖工艺研究[J]. 农业科技与装备,2014(3):54−56. [LI Z, LIANG Q, ZHAO X H. Study on the extraction of polysaccharides from seaweed by ultrasonic method[J]. Agricultural Science and Technology and Equipment,2014(3):54−56. doi: 10.3969/j.issn.1674-1161.2014.03.023
[18]	张喜峰, 杨光, 郑雪. 发菜多糖絮凝纯化及体外清除自由基分析[J]. 牡丹江师范学院学报(自然科学版),2018(1):60−64. [ZHANG X F, YANG G, ZHENG X. Flocculating purification and free radical scavenging og polysaccharides from Nostoc flagelliforme[J]. Journal of Mudanjiang Normal University,2018(1):60−64.
[19]	韩伟, 豆欣欣. 猴头菇多糖的提取纯化工艺及抗氧化活性研究[J]. 徐州工程学院学报(自然科学版),2016,31(3):22−28. [HAN W, DOU X X. Study on the extraction and purification process and antioxidant activity of polysaccharides from Hericiumer inaceus[J]. Journal of Xuzhou Institute of Technology(Natural Science Edition),2016,31(3):22−28.
[20]	满宁, 孙盼, 韩伟. 灰树花子实体多糖的微波提取及絮凝纯化工艺[J]. 南京工业大学学报(自然科学版),2015,37(6):99−104. [MAN N, SUN P, HAN W. Application of microwave-flocculation technology in extraction and purification of polysaccharides from Grifola frondosa[J]. Journal of Nanjing Tech University(Natural Science Edition),2015,37(6):99−104.
[21]	罗文锋, 韩伟. 金针菇多糖的壳聚糖絮凝工艺优化[J]. 食用菌学报,2015,22(2):68−71. [LUO W F, HAN W. Optimization of chitosan-based flocculation and purification of polysaccharides from aqueous extracts of Flammulina velutipes fruit bodies[J]. Acta Edulis Fungi,2015,22(2):68−71.
[22]	吴芳, 李雄山, 陈乐斌. 超临界流体萃取技术及其应用[J]. 广州化工,2018,46(2):19−20, 23. [WU F, LI X S, CHEN L B. Supercritical fluid extraction technology and its application[J]. Guangzhou Chemical Industry,2018,46(2):19−20, 23. doi: 10.3969/j.issn.1001-9677.2018.02.008
[23]	冯丽琴. 富硒茶中茶多酚和茶多糖的分离纯化及抗氧化性研究[D]. 西安: 陕西科技大学, 2016. FENG L Q. Separation and purification, antioxidant activitives of tea polyphenols and tea polysaccharides from Se-enriched tea[D]. Xi’an: Shaanxi University of Science and Technology, 2016.
[24]	秦韶燕. 发菜多糖的分离纯化及结构研究[D]. 天津: 天津科技大学, 2010. QIN S Y. Study on the purification and structure of polysaccharides from Nostoc flagelliforme[D]. Tianjin: Tianjin University of Science and Technology, 2010.
[25]	秦韶燕, 戴玉杰, 贾士儒, 等. 不同型式和洗脱剂对离子交换树脂纯化发菜多糖的影响[J]. 食品工业科技,2010,31(5):252−255. [QIN S Y, DAI Y J, JIA S R, et al. Effect of different types of DEAE cellulose resin, elution regents and elution methods on the purification of extracellular poIysaccharjdes of Nostoc flagelliforme[J]. Science and Technology of Food Industry,2010,31(5):252−255.
[26]	张媛媛, 张彬. 苯酚-硫酸法与蒽酮-硫酸法测定绿茶茶多糖的比较研究[J]. 食品科学,2016,37(4):158−163. [ZHANG Y Y, ZHANG B. Comparison of phenol-sulfuric acid and anthrone-sulfuric methods for determination of polysaccharide in green tea[J]. Food Science,2016,37(4):158−163. doi: 10.7506/spkx1002-6630-201604028
[27]	何佩娟, 张宇洁. 多糖含量测定的方法综述[J]. 现代食品,2019(2):27−31. [HE P J, ZHANG Y J. A review of methods for determination of polysaccharide[J]. Modern Food,2019(2):27−31.
[28]	白雪娟, 苏建宇, 赵树欣, 等. 发菜细胞培养液中多糖含量测定方法的比较研究[J]. 食品工业科技,2004(11):146−149. [BAI X J, SU J Y, ZHAO S X, et al. Comparative study on determination methods of polysaccharides in cell culture liquid of Nostoc flagelliforme[J]. Science and Technology of Food Industry,2004(11):146−149. doi: 10.3969/j.issn.1002-0306.2004.11.049
[29]	唐川, 李志, 王升贵, 等. 霍山石斛多糖的制备、功能和产品开发的研究进展[J]. 食品工业科技,2019,40(3):313−320. [TANG C, LI Z, WANG S G, et al. Research progress on preparation, function and product development of polysaccharide of Dendrobium huoshanense[J]. Science and Technology of Food Industry,2019,40(3):313−320.
[30]	张磊, 王锦旭, 杨贤庆, 等. 海洋动物多糖的研究进展[J]. 食品工业,2018,39(1):211−215. [ZHANG L, WANG J X, YANG X Q, et al. Research progress of marine animal polysaccharides[J]. The Food Industry,2018,39(1):211−215.
[31]	于海峰, 贾士儒. 发状念珠藻胞外多糖的纯化与性质分析[J]. 生物工程学报,2008(6):1029−1034. [YU H F, JIA S R. Purification and characterization of extracellular polysaccharides from Nostoc flagelliforme[J]. Chinese Journal of Biotechnology,2008(6):1029−1034. doi: 10.3321/j.issn:1000-3061.2008.06.020
[32]	KENJII K, JUNG B L, KYOKO H, et al. Isolation of an antiviral polysaccharide, nostoflan, from a terrestrial cyanobacterium, Nostoc flagelliforme[J]. Journal of Natural Products,2005,68(7):1037−1041. doi: 10.1021/np050056c
[33]	白雪娟. 发菜多糖及其制品的初步研究[D]. 天津: 天津科技大学, 2005. BAI X J. Primary study on polysaccharides and its production of Nostoc flagelliforme[D]. Tianjin: Tianjin University of Science and Technology, 2005.
[34]	HUANG Z B, LIU Y D, PAULSEN B S, et al. Studies on polysaccharides from three edible species of Nostoc(Cyanobacteria) with different colony morphologies: Comparison of monosaccharide compositions and viscosities of polysaccharides from field coloniesand suspension cultures[J]. Journal of Phycology,1998,34(6):962−968. doi: 10.1046/j.1529-8817.1998.340962.x
[35]	路苗, 陈雪峰, 赵秀霞, 等. 盐胁迫对发菜胞外多糖结构及其理化性质的影响[J]. 食品与发酵工业,2016,42(3):119−124. [LU M, CHEN X F, ZHAO X X, et al. Effects of salt stress on structural characteristics and functional properties of extracellular polysaccharide from Nostoc flagelliforme[J]. Food and Fermentation Industries,2016,42(3):119−124.
[36]	王贵春, 陈雪峰, 刘宁, 等. 柱前衍生化高效液相色谱法分析发菜胞外多糖的单糖组成[J]. 食品工业科技,2015,36(10):59−61. [WANG G C, CHEN X F, LIU N, et al. Analysis of monosaccharide compositions of Nostoc flagelliforme extracellular polysaccharide by pre-column derivation HPLC[J]. Science and Technology of Food Industry,2015,36(10):59−61.
[37]	梁文裕, 赵辉, 谢亚军, 等. 培养基类型、环境因子和激素对发菜细胞增殖的影响[J]. 宁夏大学学报(自然科学版),2007(3):264−267. [LIANG W Y, ZHAO H, XIE Y J, et al. Influence of tapes of medium, environmental factors and hormone on the multiplication of Nostoc flagelliforme cell[J]. Journal of Ningxia University(Natural Science Edition),2007(3):264−267.
[38]	王捷, 李博, 张志雄, 等. 药食同源念珠藻的研究现状及其应用前景[J]. 太原师范学院学报(自然科学版),2019,18(3):91−96. [WANG J, LI B, ZHANG Z X, et al. Prospect forpresent status and application of medicinal and edible Nostoc species[J]. Journal of Taiyuan Normal University(Natural Science Edition),2019,18(3):91−96.
[39]	毕永红, 胡征宇. 温度、营养和光强对发状念珠藻生长的影响[J]. 过程工程学报,2004(3):245−249. [BI Y H, HU Z Y. Influence of temperature, nutrients and light intensity on the growth of Nostoc flagelliforme[J]. The Chinese Journal of Process Engineering,2004(3):245−249. doi: 10.3321/j.issn:1009-606X.2004.03.010
[40]	李彤辉. 发菜细胞多糖耦联循环发酵研究[D]. 洛阳: 河南科技大学, 2015. LI T H. Study on the fermentation of combined cycle of Nostoc flagelliforme polysaccharide coupling[D]. Luoyang: Henan University of Science and Technology, 2015.
[41]	于海峰, 贾士儒, 苏建宇. 发状念珠藻细胞液体悬浮培养的研究[J]. 化学工程,2008(3):47−51. [YU H F, JIA S R, SU J Y. Liquid suspension cultivation of Nostoc flagelliforme cells[J]. Chemical Engineering(China),2008(3):47−51. doi: 10.3969/j.issn.1005-9954.2008.03.012
[42]	YU H F, JIA S R, DAI Y J. Accumulation of exopolysaccharides in liquid suspension culture of Nostoc flagelliforme cells[J]. Applied Biochemistry and Biotechnology,2010,160(2):552−560. doi: 10.1007/s12010-008-8428-4
[43]	郭伟. 发状念珠藻不同培养方式及多糖分离纯化研究[D]. 天津: 天津科技大学, 2010. GUO W. Study on different cultivation methods of Nostoc flagelliforme and separation of its polysaccharides[D]. Tianjin: Tianjin University of Science and Technology, 2010.
[44]	DIAO X M. Study of natural conditions and ecological physiological characteristics for growth of Nostoc flagelliforme in Qinghai province[J]. Chinese Journal of Ecology,1996,15:8−13.
[45]	YE C P, ZHANG M C, YANG Y F, et al. Photosynthetic performance in aquatic and terrestrial colonies of Nostoc flagelliforme(Cyanophyceae) under aquatic and aerial conditions[J]. Journal of Arid Environments,2012,85:56−61. doi: 10.1016/j.jaridenv.2012.03.023
[46]	吴垠, 谷丽. 两种微藻在光生物反应器中的生长和胞内多糖含量研究[J]. 生物技术,2004(3):59−60. [WU Y, GU L. Study on the growth and intracellular polysaccharide content of two kinds of microalgae in photobioreactor[J]. Biotechnology,2004(3):59−60. doi: 10.3969/j.issn.1004-311X.2004.03.033
[47]	HAN P P, SHEN S G, WANG H Y, et al. Comparative metabolomic analysis of the effects of light quality on polysaccharide production of cyanobacterium Nostoc flagelliforme[J]. Algal Research-Biomass Biofuels and Bioproducts,2015,9:143−150.
[48]	HAN P P, SHEN S G, WANG H Y, et al. Applying the strategy of light environment control to improve the biomass and polysaccharide production of Nostoc flagelliforme[J]. Journal of Applied Phycology,2017,29(1):55−65. doi: 10.1007/s10811-016-0963-8
[49]	韩培培, 贾士儒. 发菜细胞培养的研究进展[J]. 天津科技大学学报,2016,31(2):1−5, 12. [HAN P P, JIA S R. Research progress in cell culture of Nostoc flagelliforme[J]. Journal of Tianjin University of Science & Technology,2016,31(2):1−5, 12.
[50]	YU H F. Effect of mixed carbon substrate on exopolysaccharide production of cyanobacterium Nostoc flagelliforme in mixotrophic cultures[J]. Journal of Applied Phycology,2012,24(4):669−673. doi: 10.1007/s10811-011-9684-1
[51]	汤俊, 万能, 胡征宇. 氮元素对发菜生长及多糖含量的影响[J]. 食品科学,2010,31(19):92−95. [TANG J, WAN N, HU Z Y. Effect of nitrogen on the growth and polysaccharide content of Nostoc flagelliforme[J]. Food Science,2010,31(19):92−95.
[52]	SU J Y, JIA S R, CHEN X F, et al. Morphology, cell growth, and polysaccharide production of Nostoc flagelliforme in liquid suspension culture at different agitation rates[J]. Journal of Applied Phycology,2008,20(3):213−217. doi: 10.1007/s10811-007-9221-4
[53]	LIU X J, CHEN F. Cell differentiation and colony alteration of an edible terrestrial cyanobacterium Nostoc flagelliforme in liquid suspension cultures[J]. Folia Microbiol,2003,48(5):619−626. doi: 10.1007/BF02993468
[54]	陈雪峰, 王岳. 培养方法对发菜细胞中多糖和蛋白含量影响的研究[J]. 陕西科技大学学报(自然科学版),2010,28(2):77−81. [CHEN X F, WANG Y. Effect of different culture conditions on polysaccharide and protein content of Nostoc flagelliforme[J]. Journal of Shaanxi University of Science and Technology(Natural Science Edition),2010,28(2):77−81.
[55]	CHEN X F, JIA S R, YUE S J, et al. Effect of solid bed-materials on vegetative cells of Nostoc flagelliforme[J]. Journal of Applied Phycology,2010,22(3):341−347. doi: 10.1007/s10811-009-9464-3
[56]	CHEN X F, JIA S R, WANG Y, et al. Biological crust of Nostoc flagelliforme(Cyanobacteria) on sand bed materials[J]. Journal of Applied Phycology,2011,23(1):67−71. doi: 10.1007/s10811-010-9538-2
[57]	陈雪峰, 蔡国强, 范华, 等. 发菜中糖基转移酶基因的克隆及原核表达[J]. 陕西科技大学学报,2018,36(1):39−44. [CHEN X F, CAI G Q, FAN H, et al. Gene cloning and prokaryotic expression of glycosyl transferase from Nostoc flagelliforme[J]. Journal of Shaanxi University of Science and Technology,2018,36(1):39−44. doi: 10.3969/j.issn.1000-5811.2018.01.008
[58]	曾化伟, 郑惠华, 陈惠, 等. 微生物多糖的生物合成及代谢工程研究进展[J]. 陕西理工学院学报(自然科学版),2015,31(4):49−58. [ZENG H W, ZHENG H H, CHEN H, et al. Progress in research on biosynthesis and metabolic engineering of microbial polysaccharides[J]. Journal of Shaanxi University of Technology(Natural Science Edition),2015,31(4):49−58.
[59]	李欧. Paenibacillus elgii B69胞外多糖结构鉴定及生物合成途径研究[D]. 杭州: 浙江大学生科学院, 2014. LI O. Structual characterization and identification of biosynthetic pathway of the exopolysaccharide from Paenibacillus elgii B69[D]. Hangzhou: College of life science of Zhejiang University, 2014.
[60]	路苗. 盐胁迫对发菜胞外多糖结构及生物活性的影响[D]. 西安: 陕西科技大学, 2016. LU M. Effect of salt stress on chemical structure and biological activity of Nostoc flagelliforme extracellular polysaccharide[D]. Xi’an: Shaanxi University of Science and Technology, 2016.
[61]	HAN P P, YAO S Y, GUO R J, et al. The relationship between monosaccharide composition of extracellular polysaccharide and activities of related enzymes in Nostoc flagelliforme under different culture conditions[J]. Carbohydrate Polymers,2017,174:111−119. doi: 10.1016/j.carbpol.2017.05.093
[62]	常相娜, 陈雪峰, 龚频, 等. 盐胁迫环境下发菜胞外多糖抗氧化作用及镇痛抗炎活性[J]. 食品科学,2019:142−147. [CHANG X N, CHEN X F, GONG P, et al. Antioxidation activities, analgesic and anti-inflammatory activities of Nostoc flagelliforme extracellular polysaccharide under salt stress[J]. Food Science,2019:142−147. doi: 10.7506/spkx1002-6630-20181127-311
[63]	HAN P P, GUO R J, SHEN S G, et al. Proteomic profiling of Nostoc flagelliforme reveals the common mechanism in promoting polysaccharide production by different light qualities[J]. Biochemical Engineering Journal,2018,132:68−78. doi: 10.1016/j.bej.2017.12.006
[64]	HAN P P, SHEN S G, GUO R J, et al. ROS is a factor regulating the increased polysaccharide production by light quality in the edible cyanobacterium Nostoc flagelliforme[J]. Journal of Agricultural and Food Chemistry,2019,67(8):2235−2244. doi: 10.1021/acs.jafc.8b06176
[65]	汤俊, 胡征宇. 3种念珠藻多糖对自由基的清除作用[J]. 武汉植物学研究,2006(1):63−66. [TANG J, HU Z Y. Radical scavenging activity of polysaccharides in three Nostoc species[J]. Journal of Wuhan Botanical Research,2006(1):63−66.
[66]	陈雪峰, 李一当. 发菜多糖清除自由基活性的研究[J]. 安徽农业科学,2008(8):3088−3089. [CHEN X F, LI Y D. Study on the activity of scavenging free radicals of Nostoc flagelliforme polysaccharides[J]. Journal of Anhui Agricultural Science,2008(8):3088−3089. doi: 10.3969/j.issn.0517-6611.2008.08.021
[67]	陈雪峰, 贾士儒, 王岳, 等. 发菜多糖的红外光谱分析与抗氧化活性的研究[J]. 食品与发酵工业,2009,35(7):133−137. [CHEN X F, JIA S R, WANG Y, et al. Infrared spectroscopy and anti-oxidation activity of Nostoc flagelliforme polysaccharides[J]. Food and Fermentation Industries,2009,35(7):133−137.
[68]	符宏磊, 侯茂霞, 孙紫悦, 等. 发菜多糖对小鼠血清中细胞因子及抗氧化能力的影响[J]. 食品工业科技,2015,36(6):351−354. [FU H L, HOU M X, SUN Z Y, et al. Effect of extracellular polysaccharides from Nostoc flagelliforme on the level of cytokine and antioxitation capacity of mice serum[J]. Science and Technology of Food Industry,2015,36(6):351−354.
[69]	朱蓓茹. 发菜胞外多糖化学修饰及免疫活性研究[D]. 洛阳: 河南科技大学, 2016. ZHU B R. Study on chemical modification and immunoregulation activity of exopolysaccharides from Nostoc flagelliforme[D]. Luoyang: Henan University of Science and Technology, 2016.
[70]	杜洁. 悬浮培养发菜胞外多糖生物活性研究[D]. 洛阳: 河南科技大学, 2014. DU J. Study on bioactivity of extracellular polysaccharides from Nostoc flagelliforme cells in liquid suspension culture[D]. Luoyang: Henan University of Science and Technology, 2014.
[71]	FISHMAN M, GUNTHET G. Induction of tumor cell resistance to macrophage-mediated lysis by preexposure to non-activated macrophages[J]. Cellular Immunology,1986,99(1):241−256. doi: 10.1016/0008-8749(86)90232-7
[72]	侯茂霞, 戴玉杰, 符宏磊, 等. 人工悬浮培养发菜胞外多糖对小鼠免疫功能的影响[J]. 天津科技大学学报,2014,29(4):16−20. [HOU M X, DAI Y J, FU H L, et al. Effect of extracellular polysaccharide from liquid-cultured Nostoc flagelliforme on the immune abilities of mice[J]. Journal of Tianjin University of Science & Technology,2014,29(4):16−20.
[73]	郭金英, 杜洁, 李彤辉, 等. 发状念珠藻胞外多糖的抑菌与抗炎作用[J]. 食品科学,2015,36(9):190−193. [GUO J Y, DU J, LI T H, et al. Antimicrobial and antiinflammatory activities of extracellular polysaccharides from Nostoc flageltiforme[J]. Food Science,2015,36(9):190−193. doi: 10.7506/spkx1002-6630-201509035
[74]	KENJI K, KYOKO H, HIROYUKI T, et al. Anti-herpes simplex virus target of an acidic polysaccharide, nostoflan, from the edible blue-green alga Nostoc flagelliforme[J]. Biological and Pharmaceutical Bulletin,2007,30:1573−1575. doi: 10.1248/bpb.30.1573
[75]	GEORGE K, LINDA K L, RICHARD E M, et al. Cytotoxic, antiviral indolocarbazoles from a blue green alga belonging to the Nostocaceae[J]. The Journal of Antibiotics,1990,43(10):1236−1239. doi: 10.7164/antibiotics.43.1236
[76]	苏振宏, 王芳, 尹美珍, 等. 发状念珠藻胞外聚合物分离纯化及抗肝癌活性初步研究[J]. 时珍国医国药,2012,23(11):2788−2789. [SU Z H, WANG F, YIN M Z, et al. Primary study on isolation, purification and anti-hepatocarcinoma activity of extracellular polymers of Nostoc flageltiforme[J]. Lishizhen Medicine and Materia Medica Research,2012,23(11):2788−2789. doi: 10.3969/j.issn.1008-0805.2012.11.056

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