Research Progress of the Beneficial Effects of Fish Oil Supplementation on Inflammatory Aging and Related Diseases in Middle-aged and Elderly Population

JIA Hongxin; SU Miya; CHEN Wenliang; QI Xiaoyan; JIE Liang

doi:10.13386/j.issn1002-0306.2020090064

Volume 42 Issue 19

Sep. 2021

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2021 > 42(19): 443-450. > DOI: 10.13386/j.issn1002-0306.2020090064

JIA Hongxin, SU Miya, CHEN Wenliang, et al. Research Progress of the Beneficial Effects of Fish Oil Supplementation on Inflammatory Aging and Related Diseases in Middle-aged and Elderly Population[J]. Science and Technology of Food Industry, 2021, 42(19): 443−450. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020090064.

Citation:

PDF (2283 KB)

Research Progress of the Beneficial Effects of Fish Oil Supplementation on Inflammatory Aging and Related Diseases in Middle-aged and Elderly Population

Shanghai Engineering Research Center of Dairy Biotechnology, State Key Laboratory of Dairy Biotechnology, Dairy Research Institute, Bright Dairy and Food Co.,Ltd., Shanghai 200436, China

More Information

Received Date: September 09, 2020
Available Online: July 26, 2021

Graphical Abstract

Abstract

Abstract

Fish oil is rich in n-3 polyunsaturated fatty acids (n-3 PUFA), especially docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). DHA and EPA can produce eicosanoids with anti-inflammatory properties in the body, such as prostaglandins (PGs), thromboxanes (TX), resolvins (RV), leukotrienes (LTs) and other oxidative derivatives. Moreover, fish oil supplementation can reduce the levels of inflammatory aging related factors (serum IL-6, IL-1, TNF-α and CRP), and has positive preventive effect on inflammatory aging related diseases.In this paper, the icosahedron derivation of DHA and EPA and their relationship with the derivatization of arachidonic acid (AA) are introduced. Meanwhile, based on the relationship between fish oil supplement and inflammatory aging related factors, the effects of dietary fish oil on cardiovascular disease, rheumatoid arthritis, cognitive impairment and type 2 diabetes mellitus in middle-aged and elderly people were summarized. Data have shown that fish oil has a positive clinical effect in reducing inflammatory aging factors, improving dyslipidemia and reducing the symptoms of rheumatoid arthritis.However, there is insufficient evidence of a therapeutic or preventive effect on cognitive impairment and type 2 diabetes.
- fish oil,
- inflammatory aging,
- middle-aged and elderly,
- icosahedron,
- cardiovascular disease,
- rheumatoid arthritis,
- type 2 diabetes mellitus

FullText(HTML)

References (59)

References

[1]	中国营养学会. 中国居民膳食营养素参考摄入量[M]. 北京: 科学出版社, 2014: 122−124. Chinese Nutrition Society. Chinese dietary reference intakes[M]. Beijing: Science Press, 2014: 122−124.
[2]	Ogunkalu O A. Omega-3 fatty acids and their health potentials to human life[J]. Journal of Animal Science and Products (JASP),2019,2(1):54−66.
[3]	Mir S M, Kanjilal S, Ahmed S U. Omega-3 fatty acids in inflammatory diseases[M]// Omega-3 Fatty Acids. Springer International Publishing, 2016: 141−155.
[4]	Li K, Huang T, Zheng J, et al. Effect of marine-derived n-3 polyunsaturated fatty acids on c-reactive protein, interleukin 6 and tumor necrosis factor α: A meta-analysis[J]. PLoS One,2014,9(2):e88103. doi: 10.1371/journal.pone.0088103
[5]	Eslick G D, Howe P R C, Smith C, et al. Benefits of fish oil supplementation in hyperlipidemia: Asystematic review and meta-analysis[J]. International Journal of Cardiology,2009,136(1):4−16. doi: 10.1016/j.ijcard.2008.03.092
[6]	Maki K C, Yurko Mauro K, Dicklin M R, et al. A new, microalgal DHA- and EPA-containing oil lowers triacylglycerols in adults with mild-to-moderate hypertriglyceridemia[J]. Prostaglandins Leukotrienes & Essential Fatty Acids,2014,91(4):141−148.
[7]	Wu J H Y, Cahill L E, Dariush M. Effect of fish oil on circulating adiponectin: Asystematic review and meta-analysis of randomized controlled trials.[J]. Journal of Clinical Endocrinology & Metabolism,2013,98(6):2451−2459.
[8]	Dangour A D, Allen E, Elbourne D, et al. Fish consumption and cognitive function among older people in the UK: Baseline data from the OPAL study[J]. JNHA - The Journal of Nutrition, Health and Aging,2009,13(3):198−202. doi: 10.1007/s12603-009-0057-2
[9]	Nilsson A, Radeborg K, Salo I, et al. Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: A randomized controlled cross-over study[J]. Nutrition Journal,2012,11(1):99−99. doi: 10.1186/1475-2891-11-99
[10]	高颐雄, 张坚. α-亚麻酸体内转化为二十碳五烯酸和二十二碳六烯酸的研究进展[J]. 中国油脂,2015,40(9):77−81. [Gao Y X, Zhang J. Review on endogenous conversion of α-linolenic acid to EPA and DHA[J]. Chinaoils and Fats,2015,40(9):77−81. doi: 10.3969/j.issn.1003-7969.2015.09.020
[11]	许友卿, 张海柱, 丁兆坤. 二十二碳六烯酸和二十碳五烯酸研究进展(2)[J]. 生物学通报,2007,42(12):3−5. [Xu Y Q, Zhang H Z, Ding Z K. Development of studies on docosahexaenoic and eicosapentaenoic acids(2)[J]. Bulletin of Biology,2007,42(12):3−5. doi: 10.3969/j.issn.0006-3193.2007.12.002
[12]	丁兆坤, 张海柱, 许友卿. 二十二碳六烯酸和二十碳五烯酸研究的综述[J]. 中国科技论文在线,2007,2(2):107−116. [Ding Z K, Zhang H Z, Xu Y Q. A review of studies on docosahexaenoic and eicosapentaenoic acids[J]. Sciencepaper Online,2007,2(2):107−116.
[13]	Lewis R A, Lee T H , Austen K F. Effects of omega-3 fattyacids on the generation of products of the 5-lipoxygenasepathway[A]. In: Simopoulos A P, Kifer R R, Martin RE(Eds.). Health Effects of Polyunsaturated Fatty Acids in Seafoods[C]. Orlando: Academic Press, 1986, 227−238.
[14]	Kulkarni P S, Srinivasan B D. Eicosapentaenoic acid metabolism in human and rabbit anterior uvea[J]. Prostaglandins,1986,31(6):1159−1164. doi: 10.1016/0090-6980(86)90217-0
[15]	Mcdaniel J, Ickes E, Holloman C. Beneficial n-3 polyunsaturated fatty acid levels and n6: n3 ratios after 4-week EPA + DHA supplementation associated with reduced CRP: A pilot study in healthy young adults[J]. Modern Research in Inflammation,2013,02(4):59−68. doi: 10.4236/mri.2013.24008
[16]	Serhan C N. Novel lipid mediators and resolution mechanisms in acute inflammation: To resolve or not?[J]. American Journal of Pathology,2010,177(4):1576−1591. doi: 10.2353/ajpath.2010.100322
[17]	吴迪. 促炎症消退脂质介质对干眼性别特异性及对眼表炎症消退调控的研究[D]. 天津: 天津医科大学, 2015. Wu D. Regulation of sex-specific difference and ocular surface resolution by pro-resolving lipid mediator circuits in dry eye[D]. Tianjin: Tianjin Medical University, 2015.
[18]	Calder P C, Bond J A, Harvey D J, et al. Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis[J]. Biochemical Journal,1990,269(3):807−814. doi: 10.1042/bj2690807
[19]	Gibney M J, Hunter B. The effects of short- and long-term supplementation with fish oil on the incorporation of n-3 polyunsaturated fatty acids into cells of the immune system in healthy volunteers[J]. European Journal of Clinical Nutrition,1993,47(4):255−259.
[20]	Fritsche K L, Alexander D W, Cassity N A, et al. Maternally-supplied fish oil alters piglet immune cell fatty acid profile and eicosanoid production[J]. Lipids,1993,28:677−682. doi: 10.1007/BF02535986
[21]	Franceschi C, Bonafè M, Valensin S, et al. Inflamm-aging. An evolutionary perspective on immunosenescence[J]. Annals of theNew York Academy of Sciences,2000,908:244−254.
[22]	宋博雅. 炎性衰老的发生机理研究[J]. 西安文理学院学报(自然科学版),2019,22(5):85−87. [Song B Y. Research on pathogenesis of inflamm-aging[J]. Journal of Xi’an University (Natural Science Edition),2019,22(5):85−87.
[23]	Wood S. EPA+DHA oral therapy reduces high levels of circulating pro-inflammatory cytokines in older adults with chronic wounds[D]. Columbus: The Ohio State University, 2018.
[24]	Sawyer J. The Effects of EPA+DHA supplements on CRP levels in patients with chronic venous legulcers: A pilot study in older adults[D]. Columbus: The Ohio State University College of Nursing, 2015.
[25]	Tan A, Sullenbarger B, Prakash R, et al. Supplementation with eicosapentaenoic acid and docosahexaenoic acid reduces high levels of circulating proinflammatory cytokines in aging adults: A randomized, controlled study[J]. Prostaglandins Leukotrienes & Essential Fatty Acids,2018,132:23−29.
[26]	丁庆, 宋佳, 杨波, 等. 鱼油补充对中老年人血脂及炎性因子影响的随机对照研究[J]. 营养学报,2015(3):300−302. [Ding Q, Song J, Yang B, et al. Effects of fish oil supplementation on serum lipids and inflammatory factors inmiddle aged and elderly people: A randomized controlled trail[J]. Acta Nutrimenta Sinica,2015(3):300−302.
[27]	Zhou Q, Zhang Z, Wang P, et al. EPA+DHA, but not ALA, improved lipids and inﬂammation status in hypercholesterolemic adults: A randomized, double-blind, placebo-controlled trial[J]. Molecular Nutrition & Food Research. 2018, 63(10): 1801157.
[28]	Lee, Roberts K, Midgette, et al. Fish oil derived omega 3 fatty acids suppress adipose NLRP3 inflammasome signaling in human obesity[J]. Journal of the Endocrine Society,2019,3(3):504−515. doi: 10.1210/js.2018-00220
[29]	Yang B, Ren X L, Li Z H, et al. Lowering effects of fish oil supplementations on proinflammatory markers in hypertension: Results form a randomized controlled trial[J]. Food & Function,2020,11(2):1779-1789.
[30]	Klek S, Mankowska-Wierzbicka D, Scislo L, et al. High dose intravenous fish oil reduces inflammation-a retrospective tale from two centers[J]. Nutrients,2020,12(9):2865. doi: 10.3390/nu12092865
[31]	Souza D R D, Pieri B L D S, Comim V H, et al. Fish oil reduces subclinical inflammation, insulin resistance, and atherogenic factors in overweight/obese type 2 diabetes mellitus patients: A pre-post pilot study[J]. Journal of Diabetes and Its Complications,2020,34(5):107553. doi: 10.1016/j.jdiacomp.2020.107553
[32]	孙晓静, 林海燕, 李晓红. 37160例健康体检者血脂异常结果分析[J]. 山东医药,2020,60(19):78−81. [Sun X J, Lin H Y, Li X H. Analysis of dyslipidemia in 37 160 healthy people[J]. Shandong Medical Journal,2020,60(19):78−81. doi: 10.3969/j.issn.1002-266X.2020.19.021
[33]	胡盛寿, 高润霖, 刘力生, 等. 《中国心血管病报告2018》概要[J]. 中国循环杂志,2019,34(3):209−220. [Hu S S, Gao R L, Liu L S, et al. Summary of the 2018 report on cardiovascular diseases in China[J]. Chinese Circulation Journal,2019,34(3):209−220. doi: 10.3969/j.issn.1000-3614.2019.03.001
[34]	Zhu W, Dong C, Du H, et al. Effects of fish oil on serum lipid profile in dialysis patients: A systematic review and meta-analysis of randomized controlled trials[J]. Lipids in Health and Disease, 2014, 13: 127.
[35]	代小维, 何丽萍, 张波, 等. 广州中老年居民膳食n-3脂肪酸摄入水平与血脂关系的研究[J]. 营养学报,2014,36(3):218−223. [Dai X W, He L P, Zhang B, et al. Associations between dietary n-3 fatty acid consumption andserum lipids in middle-aged and old adults in guangzhou[J]. Acta Nutrimenta Sinica,2014,36(3):218−223.
[36]	毛燕艳, 陈昆婵, 张帆. 深海鱼油辅助降低心血管亚健康人群血脂水平的效果[J]. 中国老年学杂志,2019,39(11):5456−5458. [Mao Y Y, Chen K C, Zhang F. Effect of deep sea fish oil on reducing blood lipid level in cardiovascular sub-health population[J]. Chinese Journal of Gerontology,2019,39(11):5456−5458.
[37]	李婷欣, 刘玉萍, 帅平, 等. 深海鱼油对心血管亚健康体检者的干预效果研究[J]. 四川医学,2018,39(5):22−26. [Li T X, Liu Y P, Shuai P, et al. Effect of deep sea fish oil on intervention of cardiovascular sub-healthy checkups[J]. Sichuan Medical Journal,2018,39(5):22−26.
[38]	王炎炎, 王锋, 杨贤, 等. 深海鱼油对2型糖尿病老年患者糖脂代谢影响: 一项双盲随机对照研究[J]. 营养学报,2017,39(2):127−133. [Wang Y Y, Wang F, Yang X, et al. Effect of deep sea fish oil on glucose and lipid metabolism in elderly patients with type 2 diabetes mellitus: A double-blind randomized placebo-controlled trial[J]. Acta Nutrimenta Sinica,2017,39(2):127−133. doi: 10.3969/j.issn.0512-7955.2017.02.005
[39]	丁凌玉, 汪艳蛟, 马晓慧, 等. 深海鱼油对血脂异常人群的血脂和血糖影响[J]. 营养学报,2020,42(1):25−29. [Ding L Y, Wang Y J, Ma X H, et al. Effects of marine fish oil on lipid profile and blood glucose in adultswith dyslipidemia[J]. Acta Nutrimenta Sinica,2020,42(1):25−29. doi: 10.3969/j.issn.0512-7955.2020.01.006
[40]	Zhu A S, Zhao J Z, Wang S Z, et al. Different postprandial metabolic patterns after the consumption of fish oil and lard in healthy Chinese individuals[J]. Nutrition Clinique EtMétabolisme,2017:S0985056216304307.
[41]	李琳, 李远红, 黄蔚, 等. n-3PUFAs对类风湿关节炎患者影响的随机对照试验[J]. 营养学报,2012,34(3):233−237. [Li L, Li Y H, Huang W, et al. Effects of fish oil on rheumatoid arthritis – randomized, double-blind, parallel trial[J]. Acta Nutrimenta Sinica,2012,34(3):233−237.
[42]	Choy E. Understanding the dynamics: Pathways involved in the pathogenesis of rheumatoid arthritis[J]. Rheumatology,2012,51(5):v3−v11.
[43]	Smolen J S, Steiner G. Therapeutic strategies for rheumatoid arthritis[J]. Nat Rev Drug Discov,2003,2:473−488. doi: 10.1038/nrd1109
[44]	Adam O, Beringer C, Kless T, et al. Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis[J]. Rheumatology International,2003,23(1):27−36. doi: 10.1007/s00296-002-0234-7
[45]	李琳, 李远红, 罗日强, 等. 补充深海鱼油对类风湿关节炎患者C反应蛋白的影响研究[J]. 中国全科医学,2012,15(12):1314−1318. [Li L, Li Y H, Luo R Q, et al. Effects of fish oil on c-reactive protein in rheumatoid arthritis patients[J]. Chinese General Practice,2012,15(12):1314−1318. doi: 10.3969/j.issn.1007-9572.2012.12.004
[46]	Lopez L B, Kritz-Silverstein D, Barrett-Connor E. High dietary and plasma levels of the omega-3 fatty acid docosahexaenoic acid are associated with decreased dementia risk: The Rancho Bernardo study[J]. Journal of Nutrition Health & Aging,2011,15(1):25−31.
[47]	Ruxton C, Derbyshire E. Omega 3-s for older adults[J]. NHD eArticle with CPD,2014:4.02.
[48]	姜淑卿, 李大鸣, 张静姝. 深海鱼油中主要生理活性成分影响认知功能的研究进展[J]. 中国慢性病预防与控制,2012,20(2):225−227. [Jiang S Q, Li D M, Zhang J S. Research progress on the effects of main physiological active components in deep sea fish oil on cognitive function[J]. Chinese Journal of Prevention and Control of Chronic Diseases,2012,20(2):225−227.
[49]	Vanessa D, Hosking D E, Ted N, et al. An 18-mo randomized, double-blind, placebo-controlled trial of DHA-rich fish oil to prevent age-related cognitive decline in cognitively normal older adults[J]. American Journal of Clinical Nutrition,2018,107(5):754−762. doi: 10.1093/ajcn/nqx077
[50]	Kuszewski J C, Howe P R C, Wong R H X. Evaluation of cognitive performance following fish-oil and curcumin supplementation in middle-aged and older adults with overweight or obesity[J]. The Journal of Nutrition,2020,12:1−10.
[51]	Sinn N, Milte Cm, Street Sj, et al. Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: A6-month randomised controlled trial.[J]. The British Journal of Nutrition,2012,107(11):1682−1693. doi: 10.1017/S0007114511004788
[52]	Zhang Y P, Miao R, Li Q, et al. Effects of DHA supplementation on hippocampal volume and cognitive function in older adults with mild cognitive impairment: A 12-month randomized, double-blind, placebo-controlled trial[J]. Journal of Alzheimers Disease,2016,55(2):497−507. doi: 10.3233/JAD-160439
[53]	Li Y, Teng D, Shi X, et al. Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: National cross sectional study[J]. The British Medical Journal,2020,369:m997.
[54]	宋佳, 丁庆, 杨波, 等. 鱼油补充对中老年人血清多不饱和脂肪酸构成脂联素水平及抗氧化能力影响的随机对照研究[J]. 营养学报,2016(2):128−132. [Song J, Ding Q, Yang B, et al. Effects of fish oil supplementation on serum polyunsaturated fatty acid composition, adiponectin level and antioxidant capacity in middle aged and elderly people: A randomized controlled trial[J]. Acta Nutrimenta Sinica,2016(2):128−132.
[55]	姥勇. 2型糖尿病患者血浆脂联素水平与糖尿病血管病变的相关性研究[D]. 石家庄: 河北医科大学, 2007. Lao Y. The relationship of plasma adiponectin and diabetic angiopathy in type 2 diabetes mellitus patients[D]. Shijiazhuang: Hebei Medical University, 2007.
[56]	Thota R N, Rosato J I, Burrows T L, et al. Docosahexaenoic acid-rich fish oil supplementation reduces kinase associated with insulin resistance in overweight and obese midlife adults[J]. Nutrients,2020,12:1612. doi: 10.3390/nu12061612
[57]	Abbott K A, Burrows T L, Acharya S, et al. DHA-enriched fish oil reduces insulin resistance in overweight and obese adults[J]. Prostaglandins Leukotrienes and Essential Fatty Acids,2020,159:102154. doi: 10.1016/j.plefa.2020.102154
[58]	Mansoori A, Sotoudeh G, Djalali M, et al. Docosahexaenoic acid-rich fish oil supplementation improves body composition without influence of the PPARγ Pro12Ala Polymorphism in Patients with Type 2 Diabetes: A randomized, double-blind, placebo-controlled clinical trial[J]. Journal of Nutrigenetics& Nutrigenomics,2015,8:195−204.
[59]	Kabir M, Skurnik G, Naour N, et al. Treatment for 2 mo with n 3polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type2 diabetes: A randomized controlled study[J]. The American Journal of Clinical Nutrition,2007,86(6):1670−1679. doi: 10.1093/ajcn/86.5.1670

Supplements (0)

Cited By

Cited by

Periodical cited type(3)

1.	陈孜旋，佟苗苗，吴庆林，孙佳婷，尹小溪，吕添熠，张睦清，李丽. 薏苡仁对葡聚糖硫酸钠诱导的溃疡性结肠炎小鼠肠道菌群的影响. 食品工业科技. 2025(06): 369-376 . 本站查看
2.	蔡国强，徐志杰，乔晓红，罗天骥，张蕾，何一波. 三叶青大孔树脂乙醇洗脱部位UPLC-Q-TOF-MS指纹图谱的建立及抗氧化谱效关系研究. 食品工业科技. 2024(15): 313-321 . 本站查看
3.	黄晓英，余海立，郑明山，刘晓雯，张彦. 酵母抽提物与姜黄素复合对急性酒精性肝损伤小鼠肠道菌群的调节作用. 食品工业科技. 2024(15): 25-33 . 本站查看