Review on Nanomaterial-based Electrochemical Aptasensors for Heavy Metal Detection in Food

SHAO Yangyang; DONG Yanjie; FAN Lixia; WANG Lei; YUAN Xuexia; ZHANG Mei; LIU Bin; LI Dapeng; ZHAO Shancang

doi:10.13386/j.issn1002-0306.2020080068

Volume 42 Issue 19

Sep. 2021

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Science and Technology of Food Industry > 2021 > 42(19): 418-428. > DOI: 10.13386/j.issn1002-0306.2020080068

SHAO Yangyang, DONG Yanjie, FAN Lixia, et al. Review on Nanomaterial-based Electrochemical Aptasensors for Heavy Metal Detection in Food[J]. Science and Technology of Food Industry, 2021, 42(19): 418−428. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020080068.

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Review on Nanomaterial-based Electrochemical Aptasensors for Heavy Metal Detection in Food

1.
Institute of Quality Standard and Testing Technology for Agro-Products, Shandong Academy of Agricultural Sciences, Shandong Provincial Key Laboratory of Test Technology on Food Quality and Safety, Jinan 250100, China
2.
College of Food Science and Engineering, Shandong Agricultural University, Taian 271018, China
3.
School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo 255000, China

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Received Date: August 09, 2020
Available Online: August 05, 2021

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Abstract

Abstract

Heavy metal ions are highly toxic contaminants in food and environment, which can easily cause foodborne diseases and irreversible damage to human being. There are several limitations in traditional detection methods for heavy metal ions such as time consuming and expensive, so it’s urgent to develop a rapid technology for heavy metal detection in food. Due to their rapid, high sensitivity and specificity, nanomaterial-based electrochemical aptasensors are perspective in real-time detection of heavy metal ions. This paper summarize the characters of metallic nanomaterials (such as gold nanoparticles), metal oxide nanomaterials (such as Fe₃O₄ nanoparticles), and carbon nanomaterials (such as carbon nanotubes and graphene) and then review the application of electrochemical aptasensors based on nanomaterials in heavy metal detection (mainly lead (II), mercury (II), arsenic (III) and cadmium (II)), in order to provide inspiration for the development of heavy metal detection methods.
- nanomaterial,
- electrochemical methods,
- aptasensors,
- heavy metal detection

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References

[1]	Li F Q, Yu Z G, Han X D, et al. Electrochemical aptamer-based sensors for food and water analysis: A review[J]. Analytica Chimica Acta,2019,1051:1−23. doi: 10.1016/j.aca.2018.10.058
[2]	隋佳辰, 于寒松, 代佳宇, 等. 核酸适配体生物传感技术在食品中重金属铅检测中的应用[J]. 中国食品学报,2017,17(8):203−209. [Sui Jiachen, Yu Hansong, Dai Jiayu, et al. Application of aptamer biosensor technology to detect heavy metal lead in food[J]. Journal of Chinese Institute of Food Science and Technology,2017,17(8):203−209.
[3]	N K S, C B M. Novel biofiltration methods for the treatment of heavy metals from industrial wastewater[J]. Journal of Hazardous Materials,2008,151(1):1−8. doi: 10.1016/j.jhazmat.2007.09.101
[4]	于寒松, 隋佳辰, 代佳宇, 等. 核酸适配体技术在食品重金属检测中的应用研究进展[J]. 食品科学,2015,36(15):229−233. [Yu Hansong, Sui Jiachen, Dai Jiayu, et al. Advances in the application of aptamers to detect heavy metals in foods[J]. Food Science,2015,36(15):229−233.
[5]	Chen H, Shao R B, Yu Y Q, et al. A dual-responsive biosensor for blood lead detection[J]. Analytica Chimica Acta,2020,1093:131−141. doi: 10.1016/j.aca.2019.09.062
[6]	Jiang J, Li Z J, Wang Y Y, et al. Rapid determination of cadmium in rice by portable dielectric barrier discharge-atomic emission spectrometer[J]. Food Chemistry,2020,310:125824. doi: 10.1016/j.foodchem.2019.125824
[7]	Jia M, Lun Y F, Wang R N, et al. Extended GR-5 DNAzyme-based autonomous isothermal cascade machine: An efficient and sensitive one-tube colorimetric platform for Pb²⁺ detection[J]. Sensors and Actuators B: Chemical,2020,304:127366. doi: 10.1016/j.snb.2019.127366
[8]	Liu X X, Yao Y, Ying Y B, et al. Recent advances in nanomaterial-enabled screen-printed electrochemical sensors for heavy metal detection[J]. TrAC Trends in Analytical Chemistry,2019,115:187−202. doi: 10.1016/j.trac.2019.03.021
[9]	Orkun A, Tosun G. A rapid on-line non-chromatographic hydride generation atomic fluorescence spectrometry technique for speciation of inorganic arsenic in drinking water[J]. Food Chemistry,2019,290:10−15. doi: 10.1016/j.foodchem.2019.03.119
[10]	Luciane B P, Geovani C B, Rennan G A, et al. Assessment of cadmium and lead in commercial coconut water and industrialized coconut milk employing HR-CS GF AAS[J]. Food Chemistry,2019,284:259−263. doi: 10.1016/j.foodchem.2018.12.116
[11]	Renata P, Jerzy W, Pawel C, et al. Concentrations of toxic heavy metals and trace elements in raw milk of Simmental and Holstein-Friesian cows from organic farm[J]. Environmental Monitoring and Assessment,2013,185(10):8383−8392. doi: 10.1007/s10661-013-3180-9
[12]	Gianluigi M L D, Fabio G, Giacomo D, et al. Toxic metal levels in cocoa powder and chocolate by ICP-MS method after microwave-assisted digestion[J]. Food Chemistry,2018,245:1163−1168. doi: 10.1016/j.foodchem.2017.11.052
[13]	Gan Y, Liang T, Hu Q W, et al. In-situ detection of cadmium with aptamer functionalized gold nanoparticles based on smartphone-based colorimetric system[J]. Talanta,2020,208:120231. doi: 10.1016/j.talanta.2019.120231
[14]	Andrew D E, Jack W S. In vitro selection of RNA molecules that bind specific ligands[J]. Nature,1990,346(6287):818−822. doi: 10.1038/346818a0
[15]	C T, L G. Systematic evolution of ligands by exponential en-richment: RNA ligands to bacteriophage T4 DNA polymerase[J]. Science,1990,249(4968):505−510. doi: 10.1126/science.2200121
[16]	Shi X H, Zhang J L, He F J. A new aptamer/polyadenylated DNA interdigitated gold electrode piezoelectric sensor for rapid detection of Pseudomonas aeruginosa[J]. Biosensors & Bioelectronics,2019,132:224−229.
[17]	Sun D P, Lu J, Zhang L Y, et al. Aptamer-based electrochemical cytosensors for tumor cell detection in cancer diagnosis: A review[J]. Analytica Chimica Acta,2019,1082:1−17. doi: 10.1016/j.aca.2019.07.054
[18]	Li W M, Wang S, Zhou L L, et al. An ssDNA aptamer selected by Cell-SELEX for the targeted imaging of poorly differentiated gastric cancer tissue[J]. Talanta,2019,199:634−642. doi: 10.1016/j.talanta.2019.03.016
[19]	Gao C, Wang Q X, Gao F, et al. A high-performance aptasensor for mercury(II) based on the formation of a unique ternary structure of aptamer–Hg²⁺–neutral red[J]. Chemical Communications,2014,50(66):9397−9400. doi: 10.1039/C4CC03275F
[20]	Li J P, Sun M, Wei X P, et al. An electrochemical aptamer biosensor based on “gate-controlled” effect using β-cyclodextrin for ultra-sensitive detection of trace mercury[J]. Biosensors & Bioelectronics 2015, 74: 423−426.
[21]	王辉. 农田土壤和灌溉水中重金属检测关键技术研究[D]. 北京: 中国农业大学, 2018. Wang Hui. Research on the key techniques for heavy metals detection in farmland soil and irrigation water[D]. Beijing: China Agricultural University, 2018.
[22]	王志强. 农产品及其产地环境中重金属快速检测关键技术研究[D]. 北京: 中国农业大学, 2014. Wang Zhiqiang. Key technologies for rapid detection of heavy metals in farmland environment and agricultural products[D]. Beijing: China Agricultural University, 2014.
[23]	Mojtaba S, Leila F, Mahmound A, et al. CdTe amplification nanoplatforms capped with thioglycolic acid for electrochemical aptasensing of ultra-traces of ATP[J]. Materials Science and Engineering: C,2016,69(1):1354−1360.
[24]	Bahareh B, Abdollah S, Rahman H. Switchable electrochemiluminescence aptasensor coupled with resonance energy transfer for selective attomolar detection of Hg²⁺ via CdTe@CdS/dendrimer probe and Au nanoparticle quencher[J]. Biosensors & Bioelectronics,2018,102:328−335.
[25]	Kong R M, Zhang X B, Zhang L L, et al. An ultrasensitive electrochemical "turn-on" label-free biosensor for Hg²⁺ with AuNP-functionalized reporter DNA as a signal amplifier[J]. Chemical Communications,2009(37):5633−5635. doi: 10.1039/b911163h
[26]	Lu X C, Dong X, Zhang K Y, et al. An ultrasensitive electrochemical mercury(II) ion biosensor based on a glassy carbon electrode modified with multi-walled carbon nanotubes and gold nanoparticles[J]. Analytical Methods,2012,4(10):3326−3331. doi: 10.1039/c2ay25634g
[27]	Feng D F, Li P H, Tan X C, et al. Electrochemiluminescence aptasensor for multiple determination of Hg²⁺ and Pb²⁺ ions by using the MIL-53(Al)@CdTe-PEI modified electrode[J]. Analytica Chimica Acta,2020,1100:232−239. doi: 10.1016/j.aca.2019.11.069
[28]	Wang H, Yin Y, Zhao G, et al. Graphene oxide/multi-walled carbon nanotubes/gold nanoparticle hybridfunctionalized disposable screen-printed carbon electrode to determine Cd(II) and Pb(II) in soil[J]. International Journal of Agricultural and Biological Engineering,2019,12(3):194−200. doi: 10.25165/j.ijabe.20191203.4300
[29]	Muhammad A S, Habib A B. Gold nanoparticle based microbial detection and identification[J]. Journal of Biomedical Nanotechnology,2011,7(2):229−237. doi: 10.1166/jbn.2011.1281
[30]	刘丰源, 辛嘉英, 孙立瑞, 等. 纳米金的合成及其在重金属离子检测中的应用进展[J]. 食品科学,2020,41(7):218−227. [Liu Fengyuan, Xin Jiaying, Sun Lirui, et al. Recent progress in synthesis of gold nanoparticles and its application in detection of heavy metal ions[J]. Food Science,2020,41(7):218−227. doi: 10.7506/spkx1002-6630-20190225-174
[31]	Susom D, Guinevere S, Pradeep K. Gold nanostar electrodes for heavy metal detection[J]. Sensors and Actuators B: Chemical,2019,281:383−391. doi: 10.1016/j.snb.2018.10.111
[32]	Maâtouk F, Maâtouk M, Bekir K, et al. An electrochemical DNA biosensor for trace amounts of mercury ion quantification[J]. Journal of Water and Health,2016,14(5):808−815. doi: 10.2166/wh.2016.293
[33]	Cai W, Xie S, Zhang J, et al. An electrochemical impedance biosensor for Hg²⁺ detection based on DNA hydrogel by coupling with DNAzyme-assisted target recycling and hybridization chain reaction[J]. Biosensors and Bioelectronics,2017,98:466−472. doi: 10.1016/j.bios.2017.07.025
[34]	Murthy S C, Maria P N. Metal oxide nanoparticles and their applications in nanotechnology[J]. SN Applied Sciences,2019,1(6):607. doi: 10.1007/s42452-019-0592-3
[35]	甘小荣. 基于ExoIII和功能化MoS₂、H_xTiS₂纳米片信号放大的重金属离子电化学传感检测法[D]. 大连: 大连理工大学, 2017. Gan Xiaorong. Electrochemical sensing for heavy metal ions based on the signal amplification of exoiii and functionalized MoS₂, HxTiS₂Nanosheets[D]. Dalian: Dalian University of Technology, 2017.
[36]	Xu Z W, Fan X K, Ma Q Y, et al. A sensitive electrochemical sensor for simultaneous voltammetric sensing of cadmium and lead based on Fe₃O₄/multiwalled carbon nanotube/laser scribed graphene composites functionalized with chitosan modified electrode[J]. Materials Chemistry and Physics,2019,238(1):121877.
[37]	Wu D, Wang Y G, Zhang Y, et al. Facile fabrication of an electrochemical aptasensor based on magnetic electrode by using streptavidin modified magnetic beads for sensitive and specific detection of Hg²⁺[J]. Biosensors & Bioelectronics,2016,82:9−13.
[38]	Luo J Y, Jiang D F, Liu T, et al. High-performance electrochemical mercury aptasensor based on synergistic amplification of Pt nanotube arrays and Fe₃O₄/rGO nanoprobes[J]. Biosensors & Bioelectronics,2018,104:1−7.
[39]	Huang H, Chen T, Liu X Y, et al. Ultrasensitive and simultaneous detection of heavy metal ions based on three-dimensional graphene-carbon nanotubes hybrid electrode materials[J]. Analytica Chimica Acta,2014,852(10):45−54.
[40]	Wang M H; Zhang S.; Ye Z H, et al. A gold electrode modified with amino-modified reduced graphene oxide, ion specific DNA and DNAzyme for dual electrochemical determination of Pb(II) and Hg(II)[J]. Microchimica Acta,2015,182(13-14):2251−2258. doi: 10.1007/s00604-015-1569-6
[41]	Sumio I. Helical microtubules of graphitic carbon[J]. Nature,1991,354(6348):56−58. doi: 10.1038/354056a0
[42]	Sumio I, Toshinari I. Single-shell carbon nanotubes of 1-nm diameter[J]. Nature,1993,363(6430):603−605. doi: 10.1038/363603a0
[43]	Andrea B, Daniel M. Arsenic(III) detection in water by flow-through carbon nanotube membrane decorated by gold nanoparticles[J]. Electrochimica Acta,2019,318:496−503. doi: 10.1016/j.electacta.2019.06.114
[44]	Amir M A, Sandra C, Sanja M, et al. Antimony nanoparticle-multiwalled carbon nanotubes composite immobilized at carbon paste electrode for determination of trace heavy metals[J]. Sensors and Actuators B: Chemical,2014,191:320−325. doi: 10.1016/j.snb.2013.08.087
[45]	Ajayan P M. Nanotubes from carbon[J]. Chemical reviews,1999,99(7):1787−1800. doi: 10.1021/cr970102g
[46]	Xia Y N, Yang P D, Sun Y G, et al. One-dimensional nanostructures: Synthesis, characterization, and applications[J]. Advanced materials,2010,15(5):353−389.
[47]	Shiva K A, Gayathri C, Sivalingam G, et al. Current advances in the detection of neurotransmitters by nanomaterials: An update[J]. TrAC Trends in Analytical Chemistry,2020,123:115766. doi: 10.1016/j.trac.2019.115766
[48]	Xie F, Yang M, Jiang M, et al. Carbon-based nanomaterials – a promising electrochemical sensor toward persistent toxic substance[J]. TrAC Trends in Analytical Chemistry,2019,119:115624. doi: 10.1016/j.trac.2019.115624
[49]	Wang H, Liu Y, Liu G. Reusable resistive aptasensor for Pb(II) based onthe Pb(II)-induced despiralization of a DNA duplex and formation of a G-quadruplex[J]. Microchimica Acta,2018,185(2):1−8.
[50]	Wang Y H, Wang P, Wang Y Q, et al. Single strand DNA functionalized single wall carbon nanotubes as sensitive electrochemical labels for arsenite detection[J]. Talanta,2015,141:122−127. doi: 10.1016/j.talanta.2015.03.040
[51]	Abdulazeez T L. Progress in utilisation of graphene for electrochemical biosensors[J]. Biosensors& Bioelectronics,2018,106(30):149−178.
[52]	Shao Y Y, Wang J, Wu H, et al. Graphene based electrochemical sensors and biosensors: A review[J]. Electroanalysis,2010,22(10):1027−1036. doi: 10.1002/elan.200900571
[53]	代洪秀. 功能化聚吡咯纳米复合材料在电化学传感中的应用[D]. 济南: 山东大学, 2018. Dai Hongxiu. Study on functionalized polypyrrole nanocomposites-based electrochemical sensors[D]. Jinan: Shandong University, 2018.
[54]	K S N, A K G, S V M, et al. Electric field effect in atomically thin carbon films[J]. Science,2004,306(5696):666−669. doi: 10.1126/science.1102896
[55]	Craig E B, Trevor J D, Gregory G W, et al. Electrocatalysis at graphite and carbon nanotube modified electrodes: Edge-plane sites and tube ends are the reactive sites[J]. Chemical Communications,2005(7):829−841. doi: 10.1039/b413177k
[56]	Martin P, Adriano A, Alessandra B, et al. Graphene for electrochemical sensing and biosensing[J]. TrAC Trends in Analytical Chemistry,2010,29(9):954−965. doi: 10.1016/j.trac.2010.05.011
[57]	Varun P, Taekwon K, Majid B, et al. Three-dimensional graphene nanosheet encrusted carbon micropillar arrays for electrochemical sensing[J]. Nanoscale,2012,4(12):3673−3678. doi: 10.1039/c2nr30161j
[58]	Gao F, Gao C, He S Y, et al. Label-free electrochemical lead (II) aptasensor using thionine as the signaling molecule and graphene as signal-enhancing platform[J]. Biosensors & Bioelectronics,2016,81(15):15−22.
[59]	Zhang Y, Zeng G M, Tang L, et al. Electrochemical sensor based on electrodeposited graphene-Au modified electrode and nanoAu carrier amplified signal strategy for attomolar mercury detection[J]. Analytical Chemistry,2015,87(2):989−96. doi: 10.1021/ac503472p
[60]	Gan X R, Zhao H M, Quan X, et al. An electrochemical sensor based on p-aminothiophenol/Au nanoparticle-decorated HxTiS₂ nanosheets for specific detection of picomolar Cu(II)[J]. Electrochimica Acta,2016,190:480−489. doi: 10.1016/j.electacta.2015.12.145
[61]	Gan X R, Zhao H M, Chen S, et al. Three-dimensional porous HxTiS₂ nanosheet–polyaniline nanocomposite electrodes for directly detecting trace Cu(II) ions[J]. Analytical Chemistry,2015,87(11):5605−5613. doi: 10.1021/acs.analchem.5b00500
[62]	鲁志伟. 构建特殊结构的碳基纳米复合材料: 高灵敏重金属离子电化学传感器的研究[D]. 广州: 华南理工大学, 2019. Lu Zhiwei. Fabrication of carbon-based nanocomposites with special structure: highly sensitive heavy metal ion electrochemical sensors[D]. Gunagzhou: South China University of Technology, 2019.
[63]	崔琳. 重金属离子电化学传感器的构建及其应用[D]. 南京: 南京大学, 2015. Cui Lin. Construction of electrochemical sensors for heavy metal ions and their application[D]. Nanjing: Nanjing University, 2015.
[64]	A K J, V K G, L P S, et al. A comparative study of Pb²⁺ selective sensors based on derivatized tetrapyrazole and calix[4]arene receptors[J]. Electrochimica Acta,2006,51(12):2547−2553. doi: 10.1016/j.electacta.2005.07.040
[65]	Seyed M T, Noor M D, Parirokh L, et al. An electrochemical aptasensor based on gold nanoparticles, thionine and hairpin structure of complementary strand of aptamer for ultrasensitive detection of lead[J]. Sensors and Actuators B: Chemical,2016,234(29):462−469.
[66]	Zhu Y, Zeng G M, Zhang Y, et al. Highly sensitive electrochemical sensor using a MWCNTs/GNPs-modified electrode for lead (II) detection based on Pb²⁺-induced G-rich DNA conformation[J]. Analyst,2014,139(19):5014−5020. doi: 10.1039/C4AN00874J
[67]	Peng Y J, Li Y, Li L, et al. A label-free aptasensor for ultrasensitive Pb²⁺ detection based on electrochemiluminescence resonance energy transfer between carbon nitride nanofibers and Ru(phen)₃²⁺[J]. Journal of Hazardous Materials,2018,359:121−128. doi: 10.1016/j.jhazmat.2018.07.033
[68]	Li F, Feng Y, Zhao C, et al. Crystal violet as a G-quadruplex-selective probe for sensitive amperometric sensing of lead[J]. Chemical Communications,2011,47(43):11909−11911. doi: 10.1039/c1cc15023e
[69]	V K G, A K S, M A K, et al. Neutral carriers based polymeric membrane electrodes for selective determination of mercury (II)[J]. Analytica Chimica Acta,2007,590(1):81−90. doi: 10.1016/j.aca.2007.03.014
[70]	He L L, Chen L, Lin Y, et al. A sensitive biosensor for mercury ions detection based on hairpin hindrance by thymine-Hg(II)-thymine structure[J]. Journal of Electroanalytical Chemistry,2018,814:161−167. doi: 10.1016/j.jelechem.2018.02.050
[71]	Yu Y J, Yu C, Gao R F, et al. Dandelion-like CuO microspheres decorated with Au nanoparticle modified biosensor for Hg(2+) detection using a T-Hg²⁺-T triggered hybridization chain reaction amplification strategy[J]. Biosensors & Bioelectronics,2019,131:207−213.
[72]	Ji H A, Seon J P, Oh S K, et al. High-performance flexible graphene aptasensor for mercury detection in mussels[J]. ACS NANO,2013,7(12):10563−10571. doi: 10.1021/nn402702w
[73]	Samira M M, Foad G, Abdollah S, et al. Transport properties of a molybdenum disulfide and carbon dot nanohybrid transistor and its applications as a Hg²⁺ aptasensor[J]. ACS Applied Electronic Materials,2020,2(3):635−645. doi: 10.1021/acsaelm.9b00632
[74]	Li H B, Xue Y, Wang W. Femtomole level photoelectrochemical aptasensing for mercury ions using quercetin-copper(II) complex as the DNA intercalator[J]. Biosensors & Bioelectronics,2014,54:317−322.
[75]	Xu N N, Hou T, Li F. A label-free photoelectrochemical aptasensor for facile and ultrasensitive mercury ion assay based on a solution-phase photoactive probe and exonuclease III-assisted amplification[J]. Analyst 2019, 144 (12): 3800−3806.
[76]	Cui L, Wu J, Li M Q, et al. Highly sensitive electrochemical detection of mercury (II) via single ion-induced three-way junction of DNA[J]. Electrochemistry Communications,2015,59:77−80. doi: 10.1016/j.elecom.2015.07.012
[77]	隋佳辰, 于寒松, 代佳宇, 等. 生物传感器检测食品中重金属砷的研究进展[J]. 食品科学,2016,37(7):233−238. [Sui Jiachen, Yu Hansong, Dai Jiayu, et al. Advances in the application of biosensor technology for the detection of heavy metal arsenic in foods[J]. Food Science,2016,37(7):233−238. doi: 10.7506/spkx1002-6630-201607042
[78]	Mina K, Hyun U, Sunbaek B, et al. Arsenic removal from vietnamese groundwater using the arsenic-binding DNA aptamer[J]. Environmental Science & Technology,2009,43(24):9335−9340.
[79]	Cui L, Wu J, Ju H X. Electrochemical biosensor based on three-dimensional reduced graphene oxide and polyaniline nanocomposite for selective detection of mercury ions[J]. Sensors and Actuators B: Chemical,2015,214:63−69. doi: 10.1016/j.snb.2015.02.127
[80]	Wen S H, Wang L, Yuan Y H, et al. Electrochemical sensor for arsenite detection using graphene oxide assisted generation of prussian blue nanoparticles as enhanced signal label[J]. Analytical Chimica Acta,2018,1002:82−89. doi: 10.1016/j.aca.2017.11.057
[81]	Sorour S B, Abdollah N. Novel chitosan-Nafion composite for fabrication of highly sensitive impedimetric and colorimetric As (III) aptasensor[J]. Biosensors & Bioelectronics,2019,131:1−8.
[82]	Ali A E, F A, E H, et al. A novel aptasensor based on 3D-reduced graphene oxide modified gold nanoparticles for determination of arsenite[J]. Biosensors & Bioelectronics,2018,122:25−31.
[83]	Gu H D, Yang Y Y, Chen F, et al. Electrochemical detection of arsenic contamination based on hybridization chain reaction and RecJf exonuclease-mediated amplification[J]. Chemical Engineering Journal,2018,353:305−310. doi: 10.1016/j.cej.2018.07.137
[84]	赵静, 孙海娟, 冯叙桥. 食品中重金属镉污染状况及其检测技术研究进展[J]. 食品工业科技,2014,35(16):371−376. [Zhao Jing, Sun Haijuan, Feng Xuqiao. Research progress in pollution of heavy metals cadmium and its detection technology in food[J]. Science and Technology of Food Industry,2014,35(16):371−376.
[85]	Wang X F, Gao W Y, Yan W, et al. A novel aptasensor based on graphene/graphite carbon nitride nanocomposites for cadmium detection with high selectivity and sensitivity[J]. ACS Applied Nano Materials,2018,1(5):2341−2346. doi: 10.1021/acsanm.8b00380
[86]	Chang-Seuk L, Su Hwan Y, Su Hwan K. A “turn-on” electrochemical aptasensor for ultrasensitive detection of Cd²⁺ using duplexed aptamer switch on electrochemically reduced graphene oxide electrode[J]. Microchemical Journal 2020: 159.
[87]	Liu Y, Lai Y X, Yang G J, et al. Cd-aptamer electrochemical biosensor based on AuNPs/CS modified glass carbon electrode[J]. Journal of Biomedical Nanotechnology,2017,13(10):1253−1259. doi: 10.1166/jbn.2017.2424
[88]	Li Y, Ran G J, Lu G, et al. Highly sensitive label-free electrochemical aptasensor based on screen-printed electrode for detection of Cadmium (II) ions[J]. Journal of The Electrochemical Society,2019,166(6):B449−B455. doi: 10.1149/2.0991906jes
[89]	Colani T F, Omotayo A A, Nonhlangabezo M. Electrochemical aptasensing of cadmium (II) on a carbon black-gold nano-platform[J]. Journal of Electroanalytical Chemistry,2020:858.

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