RAO Chuanyan, YU Xiaohan, MEI Lihua, et al. Antioxidant Effect of Dietary Fiber in the Diet of Longevity Population on C57BL/6 Mice[J]. Science and Technology of Food Industry, 2021, 42(19): 342−349. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020080011.
Citation: RAO Chuanyan, YU Xiaohan, MEI Lihua, et al. Antioxidant Effect of Dietary Fiber in the Diet of Longevity Population on C57BL/6 Mice[J]. Science and Technology of Food Industry, 2021, 42(19): 342−349. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020080011.

Antioxidant Effect of Dietary Fiber in the Diet of Longevity Population on C57BL/6 Mice

More Information
  • Received Date: August 02, 2020
  • Available Online: July 26, 2021
  • In order to study the antioxidant effect of dietary fiber in long-lived people in Bemba, Guangxi, six-week-old healthy C57BL/6 mice were selected as study subjects. Seven kinds of dietary fiber (DF), which the most representative of longevity population in Bama, Guangxi, were selected, including banana, navel orange, pumpkin seedling, sweet potato leaf, water spinach, Ixeris sonchifolia and agrocybe chaxingu, and 10 feeding patterns were designed. Mice were fed with these 10 patterns for 4 weeks. The contents of malondialdehyde (MDA) and lipofuscin (Lip), activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC) in serum and liver tissues of the tested mice were determined. The results showed that except for Ixeris sonchifolia dietary fiber, the addition of single dietary fiber had no significant effect on the weight gain of mice. In a certain range, the larger the addition of compound dietary fiber, the slower the weight gain rate of mice. Among them, the heart coefficients of mice in the 7.5% and 15% compound dietary fiber addition groups were increased by 7.22 % (P<0.05) and 6.92 % (P<0.05), respectively. The spleen coefficients of mice were increased by 10.00%, 15.00% by adding pumpkin seedling dietary fiber isolate and 30% composite dietary fiber isolate. The dietary fiber isolates in each group could effectively reduce the levels of MDA and lipofuscin Lip in serum and liver of mice , and improve the activities of SOD, GSH-Px and T-AOC in serum and liver of mice. Comprehensive analysis shows that adding compound dietary fiber to the diet of mice has stronger antioxidant stress and better antioxidant effect.
  • [1]
    Zhao Y, Hu W, Zhang H, et al. Antioxidant and immunomodulatory activities of polysaccharides from the rhizome of Dryopteris crassirhizoma Nakai[J]. International Journal of Biological Macromolecules,2019,130:238−244. doi: 10.1016/j.ijbiomac.2019.02.119
    [2]
    Veronese N, Solmi M, Caruso M G, et al. Dietary fiber and health outcomes: An umbrella review of systematic reviews and meta-analyses[J]. American Journal of Clinical Nutrition,2018,107(3):436−444. doi: 10.1093/ajcn/nqx082
    [3]
    Song M, Wu K, Meyerhardt J A, et al. Fiber intake and survival after colorectal cancer diagnosis[J]. JAMA Oncology,2018,4(1):71−79. doi: 10.1001/jamaoncol.2017.3684
    [4]
    Sangaramoorthy M, Koo J, John E M. Intake of bean fiber, beans, and grains and reduced risk of hormone receptor-negative breast cancer: The san francisco bay area breast cancer study[J]. Cancer Medicine,2018,7(5):2131−2144. doi: 10.1002/cam4.1423
    [5]
    Raish M, Ahmad A, Ansari M A, et al. Momordica charantia polysaccharides ameliorate oxidative stress, inflammation, and apoptosis in ethanol-induced gastritis in mucosa through NF-kB signaling pathway inhibition[J]. International Journal of Biological Macromolecules,2018:111.
    [6]
    Carmona J J, Michan S. Biology of healthy aging and longevity[J]. Revista de Investigacion Clinica,2016,68(1):7.
    [7]
    D H. Aging: A theory based on free radical and radiation chemistry.[J]. Journal of Gerontology,1956,11(3):289−300.
    [8]
    宋奇, 艾连中, 鲁红岩, 等. 巴马长寿饮食模式在衰老小鼠模型中的抗氧化应激效果[J]. 食品科学,2018,39(19):147−153. [Song Q, Ai L Z, Lu H Y, et al. Effect of bama longevity dietary patterns on antioxidant stress in a mouse model of aging[J]. Food Science,2018,39(19):147−153. doi: 10.7506/spkx1002-6630-201819023
    [9]
    Wang F, Huang G H, Cai D, et al. Qualitative and semiquantitative analysis of fecal bifidobacterium species in centenarians living in Bama, Guangxi, China[J]. Current Microbiology,2015,71(1):143−149. doi: 10.1007/s00284-015-0804-z
    [10]
    王芳. 广西巴马长寿老人肠道菌群及其与膳食纤维多糖饮食关联性研究[D].南宁: 广西大学, 2015.

    Wang F. Chinese centenarians gut microbiota and its correlation with high-fiber diet[D]. Nanning: Guangxi University, 2015.
    [11]
    Wei G, Ye Y, Yan X, et al. Effect of banana pulp dietary fibers on metabolic syndrome and gut microbiota diversity in high-fat diet mice[J]. Journal of Food Biochemistry,2020(5).
    [12]
    Liu Y, Dong M, Yang Z, et al. Anti-diabetic effect of citrus pectin in diabetic rats and potential mechanism via PI3K/Akt signaling pathway[J]. International Journal of Biological Macromolecules,2016:484−488.
    [13]
    高荫榆, 罗丽萍, 王应想, 等. 薯蔓多糖对高脂血症大鼠降血脂作用研究[J]. 食品科学,2005(2):197−201. [Gao Y Y, Luo L P, Wang Y X, et al. Antilipidemic effect of polysaccharides exfracted from sweet potato vines[J]. Food Science,2005(2):197−201. doi: 10.3321/j.issn:1002-6630.2005.02.045
    [14]
    高荫榆, 罗丽萍, 洪雪娥, 夏冬华, 陈才水. 甘薯叶柄藤多糖的免疫调节作用研究[J]. 食品科学,2006(6):200−202. [Gao Y Y, Luo L P, Hong X E. Study on immunoregulation effect polysaccharides from swet potato vines in mice[J]. Food Science,2006(6):200−202. doi: 10.3321/j.issn:1002-6630.2006.06.046
    [15]
    纪勇, 陈静瑜, 郑明峰, 等. 茶树菇多糖联合化疗对食管癌大鼠TNF-α和IFN-γ的影响[J]. 肠外与肠内营养,2012,19(5):293−296. [Ji Y, Chen J Y, Zheng M F, et al. Effects of agrocybe aegerita polysaccharide combined with chemotherapy on TNF-α and IFN-γ in Esophageal cancer rats[J]. Parenteral & Enteral Nutrition,2012,19(5):293−296. doi: 10.3969/j.issn.1007-810X.2012.05.011
    [16]
    蔡达. 广西长寿之乡老人饮食与代谢特征及其相关性研究[D]. 南宁: 广西大学, 2017.

    Cai D. A correlation between diet and metabolic characteristics of healthy elderly people from longevous region in Guangxi[D]. Nanning: Guangxi University, 2017.
    [17]
    李全阳, 夏文水. 酸乳质量综合评价体系探讨[J]. 中国乳品工业,2003,31(6):29−33. [Li Q Y, Xia W S. A study on the methods of yoghurt quality evaluating system[J]. China Dairy Industry,2003,31(6):29−33. doi: 10.3969/j.issn.1001-2230.2003.06.008
    [18]
    刘畅, 崔敬爱, 王思霁, 等. 桦褐孔菌多糖对糖尿病肾病小鼠肾脏的保护作用[J]. 食品工业科技,2020:1−10. [Liu C, Cui J A, Wang S Q, et al. Protective effect ofInonotus obliquus polysaccharides on Kidneys of Diabetic Kideny[J]. Science and Technology of Food Industry,2020:1−10.
    [19]
    张玲, 陈代文, 余冰, 等. 两种类型膳食纤维对BALB/c小鼠结肠细菌群落结构的影响[J]. 微生物学通报,2018,45(2):395−404. [Zhang L, Chen D W, Yu B, et al. Two dietary fibers influence the bacterial community in the colon of BALB/c mice[J]. Microbiology China,2018,45(2):395−404.
    [20]
    王赛男, 于寒松, 谷春梅, 等. 大豆不溶性膳食纤维对高脂饮食诱导小鼠肥胖的预防作用[J]. 食品工业科技,2020,41(23):295−301, 314. [Wang S N, Yu H S, Gu C M, et al. Preventive effect of soybean insoluble dietary fiber on hing fat diet induced obesity in mice[J]. Science and Technology of Food Industry,2020,41(23):295−301, 314.
    [21]
    Zhuang J, Wen X, Zhang Y Q, et al. TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2', 4, 4'-tetrabromodiphenyl ether (BDE-47)-treated mice.[J]. Brain, Behavior, and Immunity,2017,65:99−110. doi: 10.1016/j.bbi.2017.05.014
    [22]
    龙婷婷, 夏莉莎, 方月月, 等. 百尾参多糖脱色脱蛋白工艺及其免疫活性研究[J]. 生物资源,2019,41(5):458−465. [Long T T, Xia L S, Fang Y Y, et al. Decoloration, deproteinization of disporum cantoniense (Lour.) Meer. polysaccharide (DCP) and its protective effect against cyclophoshanide-induced immunosuppression in mice[J]. Biotic Resources,2019,41(5):458−465.
    [23]
    Ren Z, Li J, Zhang J, et al. The regulation of inflammation and oxidative status against lung injury of residue polysaccharides by Lentinula Edodes[J]. International Journal of Biological Macromolecules,2018,106:185−192. doi: 10.1016/j.ijbiomac.2017.08.008
    [24]
    刘佳维, 岳超颖, 吴羴, 等. 红参多糖对小鼠抗氧化能力的研究[J]. 中国食品添加剂,2019,30(9):68−71. [Liu J W, Yue C Y, Wu S, et al. Study on antioxidant ability of red ginseng polysaccharide in mice[J]. China Food Additives,2019,30(9):68−71.
    [25]
    Nilsson S E, Sundelin S P, Wihlmark U, et al. Aging of cultured retinal pigment epithelial cells: Oxidative reactions, lipofuscin formation and blue light damage[J]. Doc Ophthalmol,2003,106(1):13−16. doi: 10.1023/A:1022419606629
    [26]
    李海飞, 崔美花, 姜成哲, 等. MS活性糖对自然衰老小鼠的唾液酸、脂褐素及抗氧化的影响[J]. 延边大学学报(自然科学版),2016,42(4):321−324. [Li H F, Cui M H, Jiang C Z, et al. The effect of ms bio sugar on the sialic acid, lipofuscin and antioxidant for the natural aging mice[J]. Journal of Yanbian University (Natural Science Edition),2016,42(4):321−324.
    [27]
    Pan W J, Ding Q Y, Wang Y, et al. A bioactive polysaccharide TLH-3 isolated from Tricholoma lobayense protects against oxidative stress-induced premature senescence in cells and mice[J]. Journal of Functional Foods,2018,42:159−170. doi: 10.1016/j.jff.2017.12.070
    [28]
    Oguntibeju O O. Type 2 diabetes mellitus, oxidative stress and inflammation: Examining the links[J]. International Journal of Physiology, Pathophysiology and Pharmacology,2019,11(3):45−63.
    [29]
    Zhao X M, Wang D Y, Qin L J, et al. Comparative investigation for hypoglycemic effects of polysaccharides from four substitutes of Lonicera japonica in Chinese medicine[J]. International Journal of Biological Macromolecules,2018,109:12−20. doi: 10.1016/j.ijbiomac.2017.12.073
    [30]
    Yang X, Lin C, Cai S, et al. Therapeutic effects of noni fruit water extract and polysaccharide on oxidative stress and inflammation in mice under high-fat diet[J]. Food & Function,2020,11(1):1133−1145.
    [31]
    Wang D, Li C, Fan W, et al. Hypoglycemic and hypolipidemic effects of a polysaccharide from fructus corni in streptozotocin-induced diabetic rats[J]. Int J Biol Macromol,2019,133:420−427. doi: 10.1016/j.ijbiomac.2019.04.160
    [32]
    Hung M Y, Fu Y C, Shih P, et al. Du-zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats[J]. Food and Chemical Toxicology,2006,44(8):1424−1431. doi: 10.1016/j.fct.2006.03.009
    [33]
    Wang W, Song X, Zhang J, et al. Antioxidation, hepatic- and renal-protection of water-extractable polysaccharides by dictyophora indusiata on obese mice[J]. International Journal of Biological Macromolecules,2019,134:290−301. doi: 10.1016/j.ijbiomac.2019.05.028
    [34]
    Wahid A, Mahmoud S M N, Attia E Z, et al. Dietary fiber of psyllium husk (Plantago ovata) as a potential antioxidant and hepatoprotective agent against CCl4-induced hepatic damage in rats[J]. South African Journal of Botany,2020,130:208−214. doi: 10.1016/j.sajb.2020.01.007
    [35]
    Zhao Y, Jayachandran M, Xu B. In vivo antioxidant and anti-inflammatory effects of soluble dietary fiber Konjac glucomannan in type-2 diabetic rats[J]. International Journal of Biological Macromolecules,2020,159:1186−1196. doi: 10.1016/j.ijbiomac.2020.05.105
    [36]
    林为艺, 颜美秋, 吕圭源, 等. 铁皮石斛茎非多糖与粗多糖体内外抗氧化活性的比较[J]. 中药药理与临床,2016,32(2):138−141. [Lin W Y, Yan M Q, Lv G Y, et al. Comparison of antioxidant activities between non-polysaccharide and crude polysaccharide from dendrobium candidum stem in vitro and in vivo[J]. Pharmacology and Clinics of Chinese Materia Medica,2016,32(2):138−141.
    [37]
    Niu Y, Dong J, Jiang H, et al. Effects of polysaccharide from malus halliana koehne flowers in cyclophosphamide-induced immunosuppression and oxidative stress on mice[J]. Oxidative Medicine and Cellular Longevity,2020,2020:1−10.
    [38]
    章海风, 姜明霞, 程音, 等. 三种膳食纤维对脂代谢紊乱大鼠糖脂代谢及氧化应激的作用[J]. 东南大学学报(医学版),2016,35(01):83−88. [Zhang H F, Jiang M X, Cheng Y, et al. Effects of three dietary fibers on glucose and lipid metabolism and oxidative stress in rats with lipid metabolism disorder[J]. Journal of Southeast University (Medical Science Edition),2016,35(01):83−88.
  • Cited by

    Periodical cited type(2)

    1. 宋瑶,谭凯燕,黄傲,马金克,李锐定,郑文轩,时凤翠,于晓涵,李全阳. 基于体外发酵研究膳食纤维复合体对老年人肠道菌群的调节作用. 现代食品科技. 2023(12): 78-88 .
    2. 马金克,宋瑶,韩坤宸,朱雯君,于晓涵,张钦任,张曦予,李全阳. 用随机森林回归算法辨析长寿人群饮食特征与健康指标间量化关系. 食品工业科技. 2022(08): 389-398 . 本站查看

    Other cited types(4)

Catalog

    Article Metrics

    Article views (416) PDF downloads (28) Cited by(6)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return