ZHANG Ying, WANG Xin, LIU Yajuan, et al. Research Progress on Improving Sleep Mechanism of L-theanine [J]. Science and Technology of Food Industry, 2021, 42(16): 361−366. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020070289.
Citation: ZHANG Ying, WANG Xin, LIU Yajuan, et al. Research Progress on Improving Sleep Mechanism of L-theanine [J]. Science and Technology of Food Industry, 2021, 42(16): 361−366. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020070289.

Research Progress on Improving Sleep Mechanism of L-theanine

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  • Received Date: July 23, 2020
  • Available Online: June 07, 2021
  • L-theanine is one kind of unique non-peptide amino acid of tea, which has a variety of physiological functions, such as protecting nerves, lowering blood pressure, anti-oxidative activity, regulating immune response, cognitive performance improvement and other physiological functions. Because of its tranquilizing and tranquilizing properties, the research of L-theanine in improving sleep increases gradually. In this paper, the metabolism and the mechanism of L-theanine in improving sleep were reviewed. This aims to provide a reference for the further research in the sleep improvement and the further exploitation and utilization of L-theanine.
  • [1]
    Xie Z, Chen F, Li W A, et al. A review of sleep disorders and melatonin[J]. Neurol Res,2017,39(6):559−565. doi: 10.1080/01616412.2017.1315864
    [2]
    裴清华, 李侠, 许静, 等. 308例原发性失眠患者的中医体质分布与睡眠质量的相关性研究[J]. 北京中医药大学学报,2018,41(10):859−862. doi: 10.3969/j.issn.1006-2157.2018.10.012
    [3]
    Yuen K M, Pelayo R. Socioeconomic impact of pediatric sleep disorders[J]. Sleep Med Clin,2017,12(1):23−30. doi: 10.1016/j.jsmc.2016.10.005
    [4]
    Wickwire E M, Shaya F T, Scharf S M. Health economics of insomnia treatments: The return on investment for a good night's sleep[J]. Sleep Med Rev,2016,30:72−82. doi: 10.1016/j.smrv.2015.11.004
    [5]
    Doghramji K, Jangro W C. Adverse effects of psychotropic medications on sleep[J]. Sleep Med Clin,2016,11(4):503−514. doi: 10.1016/j.jsmc.2016.08.001
    [6]
    Graham H N. Green tea composition, consumption, and polyphenol chemistry[J]. Prev Med,1992,21(3):334−350. doi: 10.1016/0091-7435(92)90041-F
    [7]
    Cicero A F G, Fogacci F, Banach M. Botanicals and phytochemicals active on cognitive decline: The clinical evidence[J]. Pharmacol Res,2018,130:204−212. doi: 10.1016/j.phrs.2017.12.029
    [8]
    Li C, Tong H, Yan Q, et al. L-theanine improves immunity by altering TH2/TH1 cytokine balance, brain neurotransmitters, and expression of phospholipase C in rat hearts[J]. Med Sci Monit,2016,22:662−669. doi: 10.12659/MSM.897077
    [9]
    Lopes Sakamoto F, Metzker Pereira Ribeiro R, Amador Bueno A, et al. Psychotropic effects of L-theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia[J]. Pharmacol Res,2019,147:104395. doi: 10.1016/j.phrs.2019.104395
    [10]
    Lin L, Zeng L, Liu A, et al. L-theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways[J]. Food Funct,2020,11(2):1798−1809. doi: 10.1039/C9FO02451D
    [11]
    Jang H S, Jung J Y, Jang I S, et al. L-theanine partially counteracts caffeine-induced sleep disturbances in rats[J]. Pharmacol Biochem Behav,2012,101(2):217−221. doi: 10.1016/j.pbb.2012.01.011
    [12]
    李靓, 林智, 郭丽, 等. 茶氨酸改善小鼠睡眠状况的实验研究[J]. 食品科学,2009,30(15):214−216. doi: 10.3321/j.issn:1002-6630.2009.15.050
    [13]
    陈子彤, 陈希民, 陈月晓, 等. 酸枣仁、茶氨酸、γ-氨基丁酸联合使用改善睡眠作用研究[J]. 食品科技,2020,45(6):81−85.
    [14]
    李成舰, 罗乐, 黄春花. L-茶氨酸抗氧化作用的研究进展[J]. 食品科学技术学报,2018,36(4):69−75. doi: 10.3969/j.issn.2095-6002.2018.04.010
    [15]
    Deb S, Dutta A, Phukan B C, et al. Neuroprotective attributes of L-theanine, a bioactive amino acid of tea, and its potential role in Parkinson ’s disease therapeutics[J]. Neurochem Int,2019,129:104478. doi: 10.1016/j.neuint.2019.104478
    [16]
    Yamamoto S, Kimura T, Tachiki T, et al. The involvement of L-type amino acid transporters in theanine transport[J]. Biosci Biotechnol Biochem,2012,76(12):2230−2235. doi: 10.1271/bbb.120519
    [17]
    Yokogoshi H, Kobayashi M, Mochizuki M, et al. Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats[J]. Neurochem Res,1998,23(5):667−673. doi: 10.1023/A:1022490806093
    [18]
    Unno T, Suzuki Y, Kakuda T, et al. Metabolism of theanine, gamma-glutamylethylamide, in rats[J]. J Agric Food Chem,1999,47(4):1593−1596. doi: 10.1021/jf981113t
    [19]
    Vuong Q V, Bowyer M C, Roach P D. L-theanine: properties, synthesis and isolation from tea[J]. J Sci Food Agric,2011,91(11):1931−1939. doi: 10.1002/jsfa.4373
    [20]
    Scheid L, Ellinger S, Alteheld B, et al. Kinetics of L-theanine uptake and metabolism in healthy participants are comparable after ingestion of L-theanine via capsules and green tea[J]. J Nutr,2012,142(12):2091−2096. doi: 10.3945/jn.112.166371
    [21]
    Pijl P, Chen L, Mulder T. Human disposition of L-theanine in tea or aqueous solution[J]. Journal of Functional Foods,2010,2(4):239−244. doi: 10.1016/j.jff.2010.08.001
    [22]
    Amihaesei I C, Mungiu O C. Main neuroendocrine features and therapy in primary sleep troubles[J]. Rev Med Chir Soc Med Nat Iasi,2012,116(3):862−866.
    [23]
    Dopheide J A. Insomnia overview: Epidemiology, pathophysiology, diagnosis and monitoring, and nonpharmacologic therapy[J]. Am J Manag Care,2020,26(4 Suppl):S76−S84.
    [24]
    Mason B L, Davidov A, Minhajuddin A, et al. Focusing on insomnia symptoms to better understand depression: A STAR*D report[J]. J Affect Disord,2020,260:183−186. doi: 10.1016/j.jad.2019.08.094
    [25]
    Lyon M R, Kapoor M P, Juneja L R. The effects of L-theanine (suntheanine(R)) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): A randomized, double-blind, placebo-controlled clinical trial[J]. Altern Med Rev,2011,16(4):348−354.
    [26]
    Sarris J, Byrne G J, Cribb L, et al. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial[J]. J Psychiatr Res,2019,110:31−37. doi: 10.1016/j.jpsychires.2018.12.014
    [27]
    Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic L-theanine administration in patients with major depressive disorder: An open-label study[J]. Acta Neuropsychiatr,2017,29(2):72−79. doi: 10.1017/neu.2016.33
    [28]
    Ota M, Wakabayashi C, Sato N, et al. Effect of L-theanine on glutamatergic function in patients with schizophrenia[J]. Acta Neuropsychiatr,2015,27(5):291−296. doi: 10.1017/neu.2015.22
    [29]
    陈玲夫. 茶氨酸胶囊干预老年失眠症的临床疗效观察[J]. 海峡药学,2011,23(6):117−119. doi: 10.3969/j.issn.1006-3765.2011.06.055
    [30]
    Ozeki M, Juneja L R, Shirakawa S. The effects of L-theanine on sleep using the actigaph[J]. Japanese Journal of Physiological Anthropology,2004,9(4):143−150.
    [31]
    Ozeki M, Juneja L R, Shirakawa S. The effects of L-theanine on automatic nervous system during sleep in postmenopausal women[J]. Japanese Journal of Physiological Anthropology,2008,13(3):147−154.
    [32]
    Rao T P, Ozeki M, Juneja L R. In search of a safe natural sleep aid[J]. J Am Coll Nutr,2015,34(5):436−447. doi: 10.1080/07315724.2014.926153
    [33]
    Hidese S, Ogawa S, Ota M, et al. Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adults: A randomized controlled trial[J]. Nutrients,2019,11(10):2362. doi: 10.3390/nu11102362
    [34]
    Kim S, Jo K, Hong K B, et al. GABA and L-theanine mixture decreases sleep latency and improves NREM sleep[J]. Pharm Biol,2019,57(1):65−73.
    [35]
    Gottesmann C. GABA mechanisms and sleep[J]. Neuroscience,2002,111(2):231−239. doi: 10.1016/S0306-4522(02)00034-9
    [36]
    Sharma E, Joshi R, Gulati A. L-theanine: An astounding sui generis integrant in tea[J]. Food Chem,2018,242:601−610. doi: 10.1016/j.foodchem.2017.09.046
    [37]
    Kimura R, Murata T. Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine[J]. Chem Pharm Bull (Tokyo),1971,19(6):1257−1261. doi: 10.1248/cpb.19.1257
    [38]
    Hageman I, Andersen H S, Jørgensen M B. Post-traumatic stress disorder: A review of psychobiology and pharmacotherapy[J]. Acta Psychiatr Scand,2001,104(6):411−422. doi: 10.1034/j.1600-0447.2001.00237.x
    [39]
    辛静. 刺人参改善睡眠作用的有效部位的筛选及其作用机制研究[D]. 哈尔滨: 黑龙江中医药大学, 2012.
    [40]
    Yamada T, Terashima T, Okubo T, et al. Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission[J]. Nutritional Neuroscience,2005,8(4):219−226. doi: 10.1080/10284150500170799
    [41]
    Kakuda T, Hinoi E, Abe A, et al. Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain[J]. J Neurosci Res,2008,86(8):1846−1856. doi: 10.1002/jnr.21637
    [42]
    Kakuda T. Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction[J]. Pharmacol Res,2011,64(2):162−168. doi: 10.1016/j.phrs.2011.03.010
    [43]
    Liu W L, Wu B F, Shang J H, et al. Moringa oleifera lam seed oil augments pentobarbital-induced sleeping behaviors in mice via GABAergic systems[J]. J Agric Food Chem,2020,68(10):3149−3162. doi: 10.1021/acs.jafc.0c00037
    [44]
    Li N, Liu J, Wang M, et al. Sedative and hypnotic effects of schisandrin B through increasing GABA/Glu ratio and upregulating the expression of GABAA in mice and rats[J]. Biomed Pharmacother,2018,103:509−516. doi: 10.1016/j.biopha.2018.04.017
    [45]
    Inoue K, Miyazaki Y, Unno K, et al. Stable isotope dilution HILIC-MS/MS method for accurate quantification of glutamic acid, glutamine, pyroglutamic acid, GABA and theanine in mouse brain tissues[J]. Biomed Chromatogr,2016,30(1):55−61. doi: 10.1002/bmc.3502
    [46]
    Juneja L R, Chu D C, Okubo T, et al. L-theanine-a unique amino acid of green tea and its relaxation effect in humans[J]. Trends Food Sci Tech,1999,10(6-7):199−204. doi: 10.1016/S0924-2244(99)00044-8
    [47]
    Turkozu D, Sanlier N. L-theanine, unique amino acid of tea, and its metabolism, health effects, and safety[J]. Crit Rev Food Sci Nutr,2017,57(8):1681−1687. doi: 10.1080/10408398.2015.1016141
    [48]
    Kobayashi K, Nagato Y, Aoi N, et al. Effects of L-theanine on the release of alpha-brain waves in human volunteers[J]. Nippon Nogeik Kaishi,1998,72(2):153−157. doi: 10.1271/nogeikagaku1924.72.153
    [49]
    Kim K S, Song C H, Oh H J. Effects of theanine on the release of brain alpha wave in adult males[J]. Faseb Journal,2004,18(4):A541−A542.
    [50]
    Micallef J, Soubrouillard C, Guet F, et al. A double blind parallel group placebo controlled comparison of sedative and mnesic effects of etifoxine and lorazepam in healthy subjects [corrected][J]. Fundam Clin Pharmacol,2001,15(3):209−216. doi: 10.1046/j.1472-8206.2001.00025.x
    [51]
    M Ishidate, T Sofuni, K Yoshikawa, et al. Primary mutagenicity screening of food additives currently used in Japan[J]. Food and Chemical Toxicology,1984,22(8):623−636. doi: 10.1016/0278-6915(84)90271-0
    [52]
    S Fujii, K Inai. Tumorigenicity study of L-theanine administrated orally to mice[J]. Food Chemistry,2008,110(3):643−646. doi: 10.1016/j.foodchem.2008.02.052
    [53]
    刘洋, 李颂, 王春玲. 茶氨酸健康功效研究进展[J]. 食品研究与开发,2016,37(17):211−214. doi: 10.3969/j.issn.1005-6521.2016.17.052
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