Research Progress on the Mechanism of Lactic Acid Bacteria in Improving Diabetes Metabolism

Longlong LUO; Weihe REN; Linhai CAI; Siru LIU; Ulamubek·duiSheikhdale; Alimat Sharizah; Gongtao DING; Li SONG; Li LUO; Shien CHEN

doi:10.13386/j.issn1002-0306.2020070270

Volume 42 Issue 8

Apr. 2021

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Science and Technology of Food Industry > 2021 > 42(8): 404-409. > DOI: 10.13386/j.issn1002-0306.2020070270

LUO Longlong, REN Weihe, CAI Linhai, et al. Research Progress on the Mechanism of Lactic Acid Bacteria in Improving Diabetes Metabolism[J]. Science and Technology of Food Industry, 2021, 42(8): 404−409. (in Chinese with English abstract). doi: 10.13386/ j.issn1002-0306.2020070270.

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Research Progress on the Mechanism of Lactic Acid Bacteria in Improving Diabetes Metabolism

Longlong LUO^{1, 2,},
Weihe REN^{1, 2},
Linhai CAI³,
Siru LIU^{1, 2},
Ulamubek·duiSheikhdale^{1, 2},
Alimat Sharizah⁴,
Gongtao DING^{1, 2},
Li SONG⁵,
Li LUO⁵,
Shien CHEN^{1, 2, 5, ,}

1.
College of Life Science and Engineering, Northwest University for Nationalities, Lanzhou 730124, China
2.
China-Malaysia National Joint Laboratory, Biomedical Research Center, Northwest University for Nationalities, Lanzhou 730124, China
3.
Gansu Provincial Institute of Agricultural Engineering Planning, Lanzhou 730046, China
4.
Center for Drinking Water, Food and Environmental Safety Analysis, Malaysian Chemical Bureau, Badaling Jaya 46661, Malaysia
5.
Gannan Research Institute of Yak Milk, Hezuo 747000, China

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Received Date: July 22, 2020
Available Online: January 31, 2021

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Abstract

Abstract

Lactic acid bacteria have a good therapeutic effect on diabetic patients, and the exploration of its mechanism has been intensified. Lactic acid bacteria can inhibit α-glucosidase in the intestine to reduce blood sugar, and reduce blood sugar levels by regulating insulin signal transduction, sugar metabolism, lipid metabolism and other related metabolic pathways. Promote insulin expression or reduce phosphorylation level to improve insulin resistance and affect the body. The glucose transport factors in turn affects glucose metabolism from the aspects of sugar reabsorption, down-regulates the expression of liposynthetase, inhibits adipogenesis, improves the abundance of intestinal flora and affects the integrity of intestinal flora, and affects inflammation and metabolic disorders to repair it. This article reviews the current research on the specific mechanism of lactic acid bacteria in improving diabetes, and provides references for the future prevention and treatment of diabetes by lactic acid bacteria.
- lactic acid bacteria,
- diabetes mellitus,
- hypoglycemia,
- mechanism

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References (43)

References

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