CHEN Qiong, CHEN Peng, LI Junying, et al. Immunomodulatory Effects of Yeast β -Glucan and Zinc Compound Formula on Immunosuppressive in Immature Mice[J]. Science and Technology of Food Industry, 2021, 42(8): 313−319. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020060109.
Citation: CHEN Qiong, CHEN Peng, LI Junying, et al. Immunomodulatory Effects of Yeast β -Glucan and Zinc Compound Formula on Immunosuppressive in Immature Mice[J]. Science and Technology of Food Industry, 2021, 42(8): 313−319. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020060109.

Immunomodulatory Effects of Yeast β-Glucan and Zinc Compound Formula on Immunosuppressive in Immature Mice

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  • Received Date: June 08, 2020
  • Available Online: January 27, 2021
  • Objective: To study the immunomodulatory effects of yeast β-glucan and zinc compound formula on cyclophosphamide (CTX)-induced immunosuppression in immature mice. Methods: 48 BALB/c mice with 3-week old were randomly divided into three groups: The control group, the model group, and the compound-treated group. The mice in the compound-treated group were treated with yeast β-glucan and zinc complex (corresponding to yeast β-glucan: 90 mg/kg/d, zinc: 2.8 mg/kg/d), while the mice in the control group and model group were fed distilled water in the same volume. On the 14 and 15 d, model group and compound-treated group were injected with CTX to establish immunosuppressive model. After 28 day’s administration, each group was divided into two subgroups. Subgroup I was used to detect immune organ index, numbers and activities of immunocytes and cytokines. Subgroup II was used to conduct serum haemolysin test and hemolytic plaque test. Result: Compared to the model group, yeast β-glucan and zinc compound formula could significantly (P<0.05) improve mice immune organs indexes, promote the proliferation of spleen lymphocytes and increase the number of intestinal goblet cell, also could highly significantly (P<0.01) improve the serum half hemolysis value (HC50), increase the number of hemolytic plaques, enhance NK cell activity, raise the concentration of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in peripheral blood, the numbers of white blood cell (WBC), Peyer's patches. Conclusion: The yeast β-glucan and zinc compound formula had the function of enhancing humoral immunity, NK cell activity and intestinal mucosa immunity in immature mice.
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