CHENG Jinghe, CHEN Jiaji, GUO Chang'e, CUI Qingyu, ZHAO Zihan, LI Weidong. Effects of Cerasus humilis Fermentation Juice: Regulating Serum Lipids and Protecting Liver in Hyperlipidemia SD Rats[J]. Science and Technology of Food Industry, 2021, 42(5): 311-316. DOI: 10.13386/j.issn1002-0306.2020050195
Citation: CHENG Jinghe, CHEN Jiaji, GUO Chang'e, CUI Qingyu, ZHAO Zihan, LI Weidong. Effects of Cerasus humilis Fermentation Juice: Regulating Serum Lipids and Protecting Liver in Hyperlipidemia SD Rats[J]. Science and Technology of Food Industry, 2021, 42(5): 311-316. DOI: 10.13386/j.issn1002-0306.2020050195

Effects of Cerasus humilis Fermentation Juice: Regulating Serum Lipids and Protecting Liver in Hyperlipidemia SD Rats

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  • Received Date: May 17, 2020
  • Available Online: March 02, 2021
  • In order to evaluate the antihyperlipidemic and hepatoprotective effects of Cerasus humilis fermentation juice,a hyperlipidemia model of SD rats was established with high fat feed. After 7 days of adaptive feeding,thirty healthy male rats were randomly divided into three groups(each group 10 rats):Control group,high lipid model group and Cerasus humilis fermentation juice(CF)group(the concentration of fermentation juice was 40%,the gavage dose was 10 mL/kg bw). SD Rats were given by oral gavage,once a day,for 10 weeks. Blood samples were collected from the orbital venous plexus at the end of week 0,week 2,week 4,week 6,week 8 and week 10. The levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein-cholesterin(LDL-C)and high-density lipoprotein-cholesterin(HDL-C)in serum were measured by automatic biochemical analyzer. Frozen section of livers was stained with oil red O,to assess the accumulation of hepatic lipid droplets and calculate their area ratio. HE staining was performed to observe the histopathological changes of liver. The results showed that the blood lipids of rats fluctuated with the extension of the modeling time. Compared with the model group,the concentrations of TG in serum was reduced significantly by 57.20%(P<0.05)at the end of week 8. At the end of the experiment,compared with the model group,the TC concentration in serum of the CF group was reduced by 10.02%(P>0.05),and the LDL-C concentration in serum,which was similar to the control group,was significantly reduced by 35.48%(P<0.05). Besides,the organ index of liver and area ratio of lipid droplets of the CF group were significantly reduced by 20.92%(P<0.05)and 27.50%(P<0.05),respectively. The results of HE staining presented that the hepatocyte lipid vacuoles were evidently decreased. The experimental results comprehensively indicated that CF didn’t only have the effect of regulating dyslipidemia in hyperlipidemia SD rats,but also could significantly improve liver lesions due to lipid deposition.
  • [1]
    Mogensen S S,Schmiegelow K,Grell K,et al. Hyperlipidemia is a risk factor for osteonecrosis in children and young adults with acute lymphoblastic leukemia[J].Haematologica,2017,102(5):e175-e178.
    [2]
    钟询龙,丁金龙,罗朵生.中药调血脂有效成分的研究进展[J].食品与药品,2010,12(11):449-451.
    [3]
    王琼,马晓敏,黎显杰,等.二烯丙基二硫对高脂血症大鼠的降血脂作用及其抗氧化机制研究[J].毒理学杂志,2019,33(1):55-62.
    [4]
    聂春霞,何盼,郝艳艳,等.基于1H-NMR代谢组学的山楂不同炮制品对高脂血症大鼠模型的影响研究[J].中草药,2019,50(10):2362-2370.
    [5]
    楼招欢,张光霁,苏洁,等.抹茶和桑抹茶对高脂血症模型大鼠血脂水平的作用[J].中成药,2016,38(7):1594-1597.
    [6]
    Feng K L,Zhu X A,Chen T,et al. Prevention of obesity and hyperlipidemia by heptamethoxyflavone in high-fat diet-induced rats[J].Journal of Agricultural and Food Chemistry,2019,67(9):2476-2489.
    [7]
    李艳,孙珂焕,白芳,等.高脂血症相关疾病发病机制研究进展[J].辽宁中医药大学学报,2019,21(4):84-87.
    [8]
    Papapanagiotou A,Siasos G,Kassi E,et al. Novel inflammatory markers in hyperlipidemia:Clinical implications[J].Current Medicinal Chemistry,2015,22(23):2727-2743.
    [9]
    Mancini G B J,Baker S,Bergeron J,et al. Diagnosis,prevention,and management of statin adverse effects and intolerance:Proceedings of a Canadian working group consensus conference[J].Canadian Journal of Cardiology,2011,27(5):635-662.
    [10]
    Sattar N,Preiss D,Murray H M,et al. Statins and risk of incident diabetes:A collaborative meta-analysis of randomised statin trials[J].Lancet,2010,375(9716):735-742.
    [11]
    罗飞,阮贵云,李向平.以他汀类药物为基础的降脂药物联合应用研究进展[J].中南药学,2015,13(11):1121-1125.
    [12]
    李晓青,刘俊江,陈宏运,等.植物发酵液的发展及其功效[J].农产品加工(学刊),2014(1):70-72.
    [13]
    Kuwaki S,Nakajima N,Tanaka H,et al. Plant-based paste fermented by lactic acid bacteria and yeast:Functional analysis and possibility of application to functional foods[J].Biochemistry Insights,2012,5(2):21-29.
    [14]
    Okada H,Fukushi E,Yamamori A,et al. Structural analysis of three novel trisaccharides isolated from the fermented beverage of plant extracts[J].Chemistry Central Journal,2009,3(1):8-10.
    [15]
    朱政,周常义,曾磊,等.酵素产品的研究进展及问题探究[J].中国酿造,2019,38(3):10-13.
    [16]
    韩宗元,李晓静,叶丰,等.固态酵素食品的研究进展[J].食品与发酵工业,2018,44(9):294-299.
    [17]
    赵芳芳,莫雅雯,蒋增良,等.功能性微生物酵素产品的研究进展[J].食品与发酵工业,2016,42(7):283-287.
    [18]
    Shikano A,Kuda T,Shibayama J,et al. Effects of Lactobacillus plantarum Uruma-SU4 fermented green loofah on plasma lipid levels and gut microbiome of high-fat diet fed mice[J].Food Research International,2019,121:817-824.
    [19]
    Guo C F,Zhang S,Yuan Y H,et al. Bile salt hydrolase and S-layer protein are the key factors affecting the hypocholesterolemic activity of Lactobacillus casei-fermented milk in hamsters[J].Molecular Nutrition & Food Research,2018,62(24):1800728.
    [20]
    Gao H,Wen J J,Hu J L,et al. Fermented Momordica charantia L.juice modulates hyperglycemia,lipid profile,and gut microbiota in type 2 diabetic rats[J].Food Research International,2019,121:367-378.
    [21]
    邓西贝,周贤,张楠,等.长柄侧耳发酵液预防小鼠高脂血症、护肝及抗氧化作用研究[J].中国食用菌,2015,34(3):37-40.
    [22]
    丁新泉,刘敏超,闫翠香.我国第三代水果产业现状与发展战略[J].广东农业科学,2013,40(19):206-209.
    [23]
    张士凯,郗良卿,张启月,等.欧李开发及利用的研究进展[J].食品工业科技,2020,41(4):361-367.
    [24]
    顾金瑞. 基于谱效关系的欧李酚类物质抗肿瘤关键成分研究[D]. 北京:北京中医药大学,2019.
    [25]
    张忠爽,李卫东,顾金瑞,等.欧李果汁酒精发酵前后香气成分变化[J].食品工业科技,2018,39(12):275-278

    ,306.
    [26]
    杨雪晗,杨波,车金营,等.复方五味子保健茶对大鼠高脂血症的降脂作用[J].吉林医药学院学报,2019,40(2):89-92.
    [27]
    宋春梅,杜鹃,葛红娟.沙棘果对高脂饲料大鼠血脂和肝脏的保护作用[J].卫生研究,2015,44(4):628-631.
    [28]
    侯少伟,罗颖颖,严新,等.泽泻苔对高脂血症大鼠血脂的影响[J].现代食品科技,2019,35(6):64-69.
    [29]
    雷艳,胡吉蕾,刘青青,等.决明子山药黄豆复配对高脂血症大鼠血脂代谢的影响[J].食品研究与开发,2019,40(5):48-53.
    [30]
    Song H Z,Wu T,Xu D D,et al. Dietary sweet cherry anthocyanins attenuates diet-induced hepatic steatosis by improving hepatic lipid metabolism in mice[J].Nutrition,2016,32(7/8):827-833.
    [31]
    孙琛,冯野,谢培,等.沙棘果渣总黄酮的降血脂及降血糖作用[J].世界中医药,2018,13(1):142-145.
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