Protective Effect of <i>Inonotus obliquus</i> Polysaccharides on Kidneys of Diabetic Kidney Disease Mice

LIU Chang; CUI Jing'ai; WANG Siji; YU Ting; PAN Jia; CHEN Xiaoping

doi:10.13386/j.issn1002-0306.2020050108

Volume 42 Issue 2

Jan. 2021

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2021 > 42(2): 321-325. > DOI: 10.13386/j.issn1002-0306.2020050108

LIU Chang, CUI Jing'ai, WANG Siji, YU Ting, PAN Jia, CHEN Xiaoping. Protective Effect of Inonotus obliquus Polysaccharides on Kidneys of Diabetic Kidney Disease Mice[J]. Science and Technology of Food Industry, 2021, 42(2): 321-325. DOI: 10.13386/j.issn1002-0306.2020050108

Citation:

PDF (1330 KB)

Protective Effect of Inonotus obliquus Polysaccharides on Kidneys of Diabetic Kidney Disease Mice

College of Food Science and Technology, Jilin Agricultural University, Changchun 130118, China

More Information

Received Date: May 10, 2020
Available Online: January 20, 2021

Graphical Abstract

Abstract

Abstract

To explore the protective effect of Inonotus obliquus polysaccharide(IOP)on the kidneys of diabetic nephropathy mice,Streptozocin(STZ)induction combined with high-sugar and high-fat feed was used to establish a diabetic nephropathy mouse model. The test mice were randomly divided into a control group,a model control group,and a positive control group(metformin hydrochloride)and low,medium,and high-dose groups of Inonotus obliquus polysaccharides. After continuous intragastric administration of the mice for 4 weeks,the growth status of the mice was observed,the body weight of the mice was measured,the kidney index,renal function index,and the antioxidant capacity of the kidneys were determined and the pathological sections of the kidneys of the mice was observed. The results showed that the Inonotus obliquus polysaccharide dose group could alleviate the abnormal body weight,kidney value increased and kidney enlarged in diabetic nephropathy mice. The high-dose group could extremly significantly inhibit kidney swelling,repair kidney tissue damage(P<0.01),improve kidney oxidase activity(P<0.01),and inhibit malondialdehyde production. In conclusion,it could be concluded that the protective effect of obliquus polysaccharides on the kidneys of diabetic nephropathy mice was related to the polysaccharides inhibiting the peroxidative damage of mice and reducing the synthesis of lipid peroxidation.
- Inonotus obliquus polysaccharide,
- diabetic nephropathy effect,
- antioxidant effect,
- protective effect

FullText(HTML)

References (23)

References

[1]	向海燕,刘晔,陈莎莎,等.慢性肾脏病患者肾小球滤过率下降速率与疾病进展的关系[J].肾脏病与透析肾移植杂志,2015,24(6):518-523.
[2]	Zeni L,Norden A G W,Cancarini G,et al.A more telocentric view of diabetic kidney disease[J].Journal of Nephrology,2017,30(6):701-717.
[3]	吴照帆,李锐.糖尿病患者血糖监测指标、控制现况及影响因素[J].环境与职业医学,2016,33(1):57-64.
[4]	赵进喜,王世东,黄为钧.中医药防治糖尿病及其并发症研究述评[J].世界中医药,2017,12(1):10-15.
[5]	何丹丹,郑毅,陈闯,等.治疗糖尿病并发症的药物研究进展[J].中南药学,2017,15(6):714-721.
[6]	梁丽雅,张泽生,王玉本,等.桦褐孔菌抗氧化提取物体内抗氧化作用研究[J].食品科技,2009,34(7):146-148 ,154.
[7]	Staniszewska J,Szymański M,Ignatowicz E.Antitumor and immunomodulatory activity of Inonotus obliquus[J].Herba Polonica,2017,63(2):48-58.
[8]	Hu Y,Shi S Y,Lu L,et al.Effects of selenizing modification on characteristics and antioxidant activities of Inonotus obliquus polysaccharide[J].Macromolecular Research,2017,25(3):222-230.
[9]	邵珠领,吴艳丽,张宇,等.桦褐孔菌多糖的乙酰化修饰及其抗氧化活性[J].食品工业科技,2019,40(9):73-77.
[10]	玄光善,李青,王艳波.桦褐孔菌多糖脱色方法及其成分分析[J].食品科学,2014,35(10):207-211.
[11]	傅予,王宏,张岩,等.Box-Behnken设计-响应面法优化番石榴叶总黄酮提取工艺及总黄酮对糖尿病小鼠糖耐量的影响研究[J].中国药房,2018,29(1):49-53.
[12]	郁淼,张莉,秦兵.五项肾功能生化检测指标对糖尿病肾功能损伤的诊断价值[J].临床和实验医学杂志,2015,14(17):1440-1442.
[13]	周钰娟,廖前进,罗玉平,等.金樱子提取液对糖尿病肾病大鼠的肾脏保护作用[J].现代生物医学进展,2014,14(36):7019-7024.
[14]	郭晓媛,蔡月茹,孙广宇,等.扶正祛风方对膜性肾病大鼠蛋白尿及肾脏病理改变的影响[J].中国实验方剂学杂志,2018,24(1):136-141.
[15]	张亚楠,赵琼玥,岳可心,等.复方黄芪降糖颗粒对四氧嘧啶致高血糖小鼠的降糖作用研究[J].特产研究,2021,42(2):27-31.
[16]	李懿,张立颖.糖尿病肾病动物模型的研究进展[J].护理研究,2015,29(17):2049-2053.
[17]	刘培,王鹏飞,王科,等.基于PI₃K/Akt通路的中药治疗糖尿病研究进展[J].中国实验方剂学杂志,2019,25(5):220-228.
[18]	Wang L Q,Li Z,Wang C,et al.Overexpression of a peroxiredoxin gene from Tamarix hispida,ThPrx1,confers tolerance to oxidative stress in yeast and Arabidopsis[J].Journal of Plant Biology,2017,60(6):548-557.
[19]	Singh R,Randhawa S N S,Randhawa C S.Oxidative stress,hemato-biochemical and plasma mineral profile in transition buffaloes[J].Proceedings of the National Academy of Sciences,India Section B:Biological Sciences,2017,87(4):1091-1099.
[20]	Yang B Y,Mei H Y,Zuo F Y,et al.Expression of microRNAs associated with oxidative stress in the Hippocampus of piglets[J].Genes & Genomics,2017,39(7):701-712.
[21]	徐靖.超氧化物歧化酶及其应用的研究进展[J].食品工业科技,2013,34(12):387-391.
[22]	周丽萍,张悦,王化,等.蓓蕾蓝靛果花色苷对乙醇诱导小鼠氧化损伤的保护作用[J].食品工业科技,2017,38(19):293-297.
[23]	龚频,张梦璇,李晓凡,等.原花青素对糖尿病大鼠肾的保护作用[J].现代食品科技,2018,34(9):1-5 ,11.

Supplements (0)

Cited By

Cited by

Periodical cited type(9)

1.	徐嘉欣，罗哲，何安，黄潘钿，沈金鹏，郭俊斌，苗建银. 南珠贝壳珍珠层源抗氧化肽的制备及对酪氨酸酶的抑制活性. 食品工业科技. 2025(06): 242-251 . 本站查看
2.	刘洋，白家瑞，周先加，毛海峰. 牦牛皮酶法脱毛工艺优化及其对食用品质的影响. 中国皮革. 2024(04): 38-44 .
3.	和金泽，崔浩然，李钰芳，郑文涛，彭清雅，李丽，黄艾祥. 中甸牦牛乳酪蛋白源生物活性肽的鉴定及抗氧化活性. 乳业科学与技术. 2024(06): 1-7 .
4.	王增丽，付坚，何同，王雪峰，范江平，黄艾祥. 青刺果粕抗氧化肽的酶法制备工艺优化及体外抗氧化活性分析. 现代食品科技. 2024(12): 49-56 .
5.	李玉婷，张天宝，杜慧玲，郭继虎，张鸣慧，亢芬，张佳乐. 黄粉虫酶解产物的制备及活性研究. 食品科技. 2023(04): 245-251 .
6.	杨宝强，刘生杰. 响应面法优化猴头菇蛋白抗氧化肽工艺及抗运动疲劳活性研究. 粮食与油脂. 2023(05): 142-147 .
7.	马凤，叶灏铎，夏珍，徐燕，孙世利，曹庸，苗建银. 英红九号茶蛋白ACE抑制肽的制备、氨基酸组成及不同超滤组分的活性评价. 现代食品科技. 2023(07): 237-245 .
8.	张丙云，蔡早宁，王珈玮，潘立超，郭晓鹏，范文广，任海伟. 基于文献计量分析的动物源活性肽领域的态势分析. 食品工业科技. 2022(08): 320-328 . 本站查看
9.	康澳，巩思佳，陈可菁，李子豪，郑雪韵，陈冰冰，陈文浩，曹庸，苗建银. 固态发酵制备辣木叶活性肽及其抗氧化活性. 现代食品科技. 2022(06): 105-115 .